A randomised, controlled, crossover trial of oral midazolam and nitrous oxide for paediatric dental sedation.

Abstract:

:A randomised, controlled, crossover trial was designed to assess the safety and effectiveness of oral midazolam sedation for orthodontic extractions. Forty-six ASA physical status I children aged 10-16 years were recruited. Each child required two treatment sessions. Sedation with either oral midazolam 0.5 mg.kg-1 or nitrous oxide in oxygen was used at the first visit, the alternative being used at the second visit. Blood pressure, heart rate, arterial oxygen saturation, and sedation and behavioural scores were recorded every 5 min. Anxiety levels and postoperative satisfaction were also recorded. Blood pressure, heart rate and arterial oxygen saturation in both groups were similar and within acceptable clinical limits. The median [range] lowest arterial oxygen saturation levels for subjects in the midazolam and nitrous oxide groups were 95 [90-100]% and 98 [93-100]%, respectively. The median [range] time to the maximum level of sedation in the midazolam group was 20 [5-65] min compared with 5 [5-10] min in the nitrous oxide group (p < 0.001). The median [range] duration of treatment was similar in both groups (midazolam group: 10 [5-30] min, nitrous oxide group: 10 [5-25] min). Seventy-four per cent of subjects were prepared to have oral midazolam sedation again, 54% preferring it. Oral midazolam appears to be a safe and acceptable form of sedation for 10-16-year-old paediatric dental patients.

journal_name

Anaesthesia

journal_title

Anaesthesia

authors

Wilson KE,Welbury RR,Girdler NM

doi

10.1046/j.1365-2044.2002.02784.x

subject

Has Abstract

pub_date

2002-09-01 00:00:00

pages

860-7

issue

9

eissn

0003-2409

issn

1365-2044

pii

2784

journal_volume

57

pub_type

临床试验,杂志文章,随机对照试验
  • Topical benzydamine hydrochloride for prevention of postoperative sore throat in adults undergoing tracheal intubation for elective surgery: a systematic review and meta-analysis.

    abstract::Postoperative sore throat has a negative impact on patient satisfaction and recovery. Benzydamine hydrochloride is a non-steroidal anti-inflammatory drug available for topical use. We performed a systematic review and meta-analysis to assess the efficacy and safety of topical application of benzydamine to prevent post...

    journal_title:Anaesthesia

    pub_type: 杂志文章,meta分析

    doi:10.1111/anae.14224

    authors: Kuriyama A,Aga M,Maeda H

    更新日期:2018-07-01 00:00:00

  • Peribulbar anaesthesia using a mixture of local anaesthetic and vecuronium.

    abstract::The aim of this double-blind, randomised study was to assess the effects of the addition of 0.5 mg of vecuronium bromide to a standard local anaesthetic mixture used for peribulbar anaesthesia. We studied 60 patients undergoing regional anaesthesia for intra-ocular surgery and were primarily interested in the quality ...

    journal_title:Anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1046/j.1365-2044.1998.00433.x

    authors: Reah G,Bodenham AR,Braithwaite P,Esmond J,Menage MJ

    更新日期:1998-06-01 00:00:00

  • Transtracheal illumination for optimal tracheal tube placement. A clinical study.

    abstract::The tracheas of 420 adult patients were intubated using the tip of a lighted stylet placed inside the lumen of the tracheal tube, just proximal to the tube cuff. The maximum point of transillumination was visible just distal to the cricoid cartilage, with proper cuff positioning. The lighted stylet was also introduced...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1989.tb09198.x

    authors: Mehta S

    更新日期:1989-12-01 00:00:00

  • Consensus guidelines for managing the airway in patients with COVID-19: Guidelines from the Difficult Airway Society, the Association of Anaesthetists the Intensive Care Society, the Faculty of Intensive Care Medicine and the Royal College of Anaesthetist

    abstract::Severe acute respiratory syndrome-corona virus-2, which causes coronavirus disease 2019 (COVID-19), is highly contagious. Airway management of patients with COVID-19 is high risk to staff and patients. We aimed to develop principles for airway management of patients with COVID-19 to encourage safe, accurate and swift ...

    journal_title:Anaesthesia

    pub_type: 杂志文章,实务指引

    doi:10.1111/anae.15054

    authors: Cook TM,El-Boghdadly K,McGuire B,McNarry AF,Patel A,Higgs A

    更新日期:2020-06-01 00:00:00

  • Anaesthetic manpower in the future in the UK.

    abstract::The short-term objective of the DHSS of a 1:1 consultant: junior ratio by 1988 is compatible with current trends in consultant expansion and implies no reduction in registrars before then. The target of doubling the number of consultants in 15 years cannot be met in anaesthesia without a fairly sharp, and relatively s...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1982.tb01862.x

    authors: Vickers MD

    更新日期:1982-09-01 00:00:00

  • Anaesthetic implications of arrhythmogenic right ventricular dysplasia/cardiomyopathy.

    abstract::Arrhythmogenic right ventricular dysplasia, also called right ventricular cardiomyopathy, is a genetically determined heart muscle disease, characterised by life-threatening ventricular arrhythmias in apparently healthy young people. The primary myocardial pathology is that the myocardium of the right ventricular free...

    journal_title:Anaesthesia

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2044.2008.05660.x

    authors: Alexoudis AK,Spyridonidou AG,Vogiatzaki TD,Iatrou CA

    更新日期:2009-01-01 00:00:00

  • The TOF-Guard neuromuscular transmission monitor. A comparison with the Myograph 2000.

    abstract::The TOF-Guard neuromuscular monitor uses an accelerometer to measure the response to nerve stimulation. In this study, we have compared it to a standard mechanomyographic monitor, the Myograph 2000, for neuromuscular monitoring in 28 subjects. A train-of-four mode of stimulation was used in both cases. The times taken...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1995.tb06097.x

    authors: Loan PB,Paxton LD,Mirakhur RK,Connolly FM,McCoy EP

    更新日期:1995-08-01 00:00:00

  • Treatment of acute total atelectasis. Use of a double lumen tube.

    abstract::Three cases are described of complete collapse of a lung in the absence of bronchial obstruction. The condition was treated by the application of a sustained high pressure (6 kPa) to the affected lung through one limb of a double lumen bronchial tube whilst intermittent positive pressure ventilation was continued thro...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1985.tb10707.x

    authors: Murray JF

    更新日期:1985-02-01 00:00:00

  • Colloid osmotic pressure.

    abstract::Technical advances have made the bedside measurement of colloid osmotic pressure (COP) a rapid and reproducible test. The principles of measurement are described and the place of COP determinations in the recognition, treatment and prophylaxis of oedematous states is discussed. ...

    journal_title:Anaesthesia

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2044.1980.tb05094.x

    authors: Bevan DR

    更新日期:1980-03-01 00:00:00

  • Anabolic steroid abuse: physiological and anaesthetic considerations.

    abstract::This review summarises the physiological and pharmacological effects of the anabolic steroids used to enhance performance in sports. The anabolic steroids promote muscle growth and protein synthesis. Side-effects of anabolic steroids include cardiomyopathy, atherosclerosis, hypercoagulopathy, hepatic dysfunction, and ...

    journal_title:Anaesthesia

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2044.2005.04218.x

    authors: Kam PC,Yarrow M

    更新日期:2005-07-01 00:00:00

  • Vecuronium and atracurium infusions during hypothermic cardiopulmonary bypass.

    abstract::Two similar groups of patients undergoing coronary artery bypass grafting received either atracurium or vecuronium infusions for neuromuscular blockade. Both groups demonstrated a marked reduction in neuromuscular blocking requirements during hypothermic bypass at 30 C. The ratio of the dose rates at 30 C to that at 3...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1986.tb12916.x

    authors: Denny NM,Kneeshaw JD

    更新日期:1986-09-01 00:00:00

  • Measurement of extravascular lung water to diagnose severe reperfusion lung injury following pulmonary endarterectomy: a prospective cohort clinical validation study.

    abstract::The measurement of extravascular lung water is a relatively new technology which has not yet been well validated as a clinically useful tool. We studied its utility in patients undergoing pulmonary endarterectomy as they frequently suffer reperfusion lung injury and associated oedematous lungs. Such patients are there...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/anae.14744

    authors: Butchart AG,Zochios V,Villar SS,Jones NL,Curry S,Agrawal B,Jenkins DP,Klein AA

    更新日期:2019-10-01 00:00:00

  • Short Form 36 in the intensive care unit: assessment of acceptability, reliability and validity of the questionnaire.

    abstract::The aim of this study was to assess the acceptability, validity and reliability of the Short Form 36 quality of life questionnaire in 166 adult patients following discharge from a general intensive care unit. Reliability was quantified by measuring internal consistency using correlation among items and Cronbach's alph...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1997.015-az014.x

    authors: Chrispin PS,Scotton H,Rogers J,Lloyd D,Ridley SA

    更新日期:1997-01-01 00:00:00

  • A portable oxygen generator.

    abstract::The use of a portable generator which liberates oxygen from hydrogen peroxide solutions has been investigated in veterinary anaesthesia to assess its potential as an alternative to conventional oxygen supplies both in emergency situations and in the event of failure of cylinder systems. The reliability of the supply a...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1986.tb13277.x

    authors: Hall LW,Kellagher RE,Fleet KJ

    更新日期:1986-05-01 00:00:00

  • Propofol for long-term sedation in the intensive care unit. A comparison with papaveretum and midazolam.

    abstract::Thirty-seven patients with a wide range of illnesses were studied during mechanical ventilation of the lungs in an intensive care unit. Fifteen were sedated with a continuous propofol infusion, with analgesia provided by bolus doses of papaveretum. Twelve received a continuous infusion of papaveretum, supplemented by ...

    journal_title:Anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1365-2044.1990.tb14777.x

    authors: Harris CE,Grounds RM,Murray AM,Lumley J,Royston D,Morgan M

    更新日期:1990-05-01 00:00:00

  • A national survey of obstetric early warning systems in the United Kingdom: five years on.

    abstract::The Confidential Enquiries into Maternal Deaths in the UK have recommended obstetric early warning systems for early identification of clinical deterioration to reduce maternal morbidity and mortality. This survey explored early warning systems currently used by maternity units in the UK. An electronic questionnaire w...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/anae.12708

    authors: Isaacs RA,Wee MY,Bick DE,Beake S,Sheppard ZA,Thomas S,Hundley V,Smith GB,van Teijlingen E,Thomas PW,Members of the Modified Obstetric Early Warning Systems Research Group.

    更新日期:2014-07-01 00:00:00

  • A thermographic study of paravertebral analgesia.

    abstract::Six patients undergoing paravertebral blocks for chronically painful conditions of the chest wall were thermographically imaged so that the extent of cutaneous vasodilatation and hence sympathetic block could be correlated with the distribution of the somatic block. All blocks were performed by a single experienced op...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1995.tb15092.x

    authors: Cheema SP,Ilsley D,Richardson J,Sabanathan S

    更新日期:1995-02-01 00:00:00

  • Effect of hypertonic saline on electrocardiography QRS duration in rabbit model of bupivacaine toxicity resuscitated by intravenous lipid.

    abstract::Intravenous lipid emulsion is established therapy for bupivacaine induced cardiotoxicity. The benefit of combined hypertonic saline and lipid treatment is unexplored. In this experiment, sedated rabbits were resuscitated from bupivacaine-induced asystole with intravenous lipid according to the Association of Anaesthet...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.2010.06373.x

    authors: Cave G,Harvey M,Prince G,Lahner D,Desmet J

    更新日期:2010-08-01 00:00:00

  • Eating in labour. A randomised controlled trial assessing the risks and benefits.

    abstract::The aim of this study was to determine whether permitting women in labour to eat a light diet would: (i) alter their metabolic profile, (ii) influence the outcome of labour, and (iii) increase residual gastric volume and consequent risk of pulmonary aspiration. Women were randomised to receive either a light diet (eat...

    journal_title:Anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1046/j.1365-2044.1999.00750.x

    authors: Scrutton MJ,Metcalfe GA,Lowy C,Seed PT,O'Sullivan G

    更新日期:1999-04-01 00:00:00

  • Molecular sieves: an alternative method of carbon dioxide removal which does not generate compound A during simulated low-flow sevoflurane anaesthesia.

    abstract::Molecular sieves are used in industry to 'scrub' industrial gases. We examined, during simulated low-flow closed system anaesthesia, (1) the carbon dioxide adsorbing potential of molecular sieves and (2) the reactivity of the sieves compared to soda lime using sevoflurane as an indicator. A low-flow anaesthetic system...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1995.tb05847.x

    authors: Fee JP,Murray JM,Luney SR

    更新日期:1995-10-01 00:00:00

  • Cardiopulmonary complications during anaesthesia and surgery for severe thoracic lordoscoliosis.

    abstract::A 15-year old girl underwent a posterior spinal fusion procedure for severe lordoscoliosis. On turning to the prone position acute posture-related upper airway obstruction occurred. During surgery, manipulation of the spine caused several episodes of loss of cardiac output. Retrospective assessment of the pre-operativ...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1995.tb05857.x

    authors: Bagshaw ON,Jardine A

    更新日期:1995-10-01 00:00:00

  • Ketamine, midazolam and vecuronium infusion. Anaesthesia for Down's syndrome and congenital heart disease.

    abstract::A ketamine, midazolam and vecuronium infusion was used for total intravenous anesthesia in a patient with Down's syndrome, a ventricular septal defect and pulmonary hypertension. A mixture of ketamine 200 mg, midazolam 5 mg and vecuronium 12 mg in 50 ml of normal saline was infused at 0.5 ml/kg/hour. This simple techn...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1991.tb09356.x

    authors: Riley DP,McBride LJ

    更新日期:1991-02-01 00:00:00

  • Respiratory effects of 'lissive" anaesthesia using gallamine.

    abstract::'Lissive anaesthesia', the administration of a small dose of a non-depolarising muscle relaxant to a patient breathing nitrous oxide, oxygen and an anaesthetic vapour, is a technique popularly employed for minor procedures. In this study, the effects of intravenous gallamine triethiodide (40 mg) on the blood-gas statu...

    journal_title:Anaesthesia

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1365-2044.1976.tb11791.x

    authors: Macfarlane DW,Downing JW,Mahomedy MC

    更新日期:1976-03-01 00:00:00

  • Delirium after transcatheter aortic valve implantation via the femoral or apical route.

    abstract::We thought that delirium might be less frequent after transcatheter aortic valve implantation via the femoral artery compared with via the cardiac apex. We reviewed 210 patients who underwent transcatheter aortic valve implantation between January 2009 and October 2014. The proportion (95% CI) of patients who suffered...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/anae.13524

    authors: Sharma V,Katznelson R,Horlick E,Osten M,Styra R,Cusimano RJ,Carroll J,Djaiani G

    更新日期:2016-08-01 00:00:00

  • An evaluation of the Universal PAC and Oxford Miniature Vaporizers for paediatric field anaesthesia.

    abstract::A laboratory study has demonstrated that the Universal PAC and Oxford Miniature Vaporizers can be used for paediatric anaesthesia in drawover mode at varying ambient temperatures. Changes in tidal volume have minimal effect on the delivered concentration of halothane from either vaporizer but varying ambient temperatu...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1995.tb06142.x

    authors: Craig GR,Berry CB,Yeats MJ

    更新日期:1995-09-01 00:00:00

  • Effect of epidural block on the lag time of pulse oximeter response.

    abstract::Thirty-six healthy patients, ASA 1, aged 16-41 years, scheduled for elective plastic surgery were studied to determine if thoracocervical or lumbar epidural blocks affected the lag time of the pulse oximeter response. Patients were allocated to receive thoracocervical epidural block (n = 20) (group 1) (lignocaine 1%) ...

    journal_title:Anaesthesia

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1365-2044.1996.tb15041.x

    authors: Xue FS,Liao X,Tong SY,Liu QH,An G,Luo LK

    更新日期:1996-12-01 00:00:00

  • Bedside tests for predicting difficult airways: an abridged Cochrane diagnostic test accuracy systematic review.

    abstract::Although bedside screening tests are routinely used to identify people at high risk of having a difficult airway, their clinical utility is unclear. We estimated the diagnostic accuracy of commonly used bedside examination tests for assessing the airway in adult patients without apparent anatomical abnormalities sched...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/anae.14608

    authors: Roth D,Pace NL,Lee A,Hovhannisyan K,Warenits AM,Arrich J,Herkner H

    更新日期:2019-07-01 00:00:00

  • Total intravenous anaesthesia for neurosurgery and neuroradiology.

    abstract::A method of total intravenous anaesthesia for neurosurgery and neuroradiology is described using a continuous infusion of alphaxalone/alphadolone (Althesin) with analgesics and muscle relaxants. It has been used successfully on 272 occasions in 243 patients. The reasons for using such a technique and the advantages a...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1980.tb03823.x

    authors: Dallas SH

    更新日期:1980-05-01 00:00:00

  • The Triservice anaesthetic apparatus.

    abstract::The Triservice anaesthetic apparatus is a draw-over using ambient air as the primary carrier gas. Its modules are a self-inflating bag, a vaporiser, a supplementary oxygen regulator and a ventilator; each is described. The outputs of halothane and trichloroethylene were measured with changes of temperature, continuous...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1981.tb08696.x

    authors: Houghton IT

    更新日期:1981-12-01 00:00:00

  • Potentially modifiable risk factors for atrial fibrillation following lung resection surgery: a retrospective cohort study.

    abstract::Atrial fibrillation is the most frequent arrhythmia after thoracic surgery and is associated with increased hospital costs, morbidity and mortality. In this study, we aimed to identify potentially modifiable risk factors for postoperative atrial fibrillation following lung resection surgery and to suggest possible mea...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/anae.13644

    authors: Lee SH,Ahn HJ,Yeon SM,Yang M,Kim JA,Jung DM,Park JH

    更新日期:2016-12-01 00:00:00