Propofol for long-term sedation in the intensive care unit. A comparison with papaveretum and midazolam.

Abstract:

:Thirty-seven patients with a wide range of illnesses were studied during mechanical ventilation of the lungs in an intensive care unit. Fifteen were sedated with a continuous propofol infusion, with analgesia provided by bolus doses of papaveretum. Twelve received a continuous infusion of papaveretum, supplemented by bolus doses of midazolam. The level of sedation was assessed every four hours and measurements were made of haemodynamic and respiratory variables. Levels of sedation were generally satisfactory in both groups. Six patients who received propofol required the use of muscle relaxants, because of their strong respiratory drives, to achieve synchronisation with the ventilator. There was no significant difference in respiratory or haemodynamic variables between the groups, but several patients required inotropic support because of their disease. There was no evidence of inhibition of adrenal steroidogenesis in the propofol group. Propofol can be a useful sedative agent in the intensive care unit, but sedative regimens should be tailored to individual patient requirements.

journal_name

Anaesthesia

journal_title

Anaesthesia

authors

Harris CE,Grounds RM,Murray AM,Lumley J,Royston D,Morgan M

doi

10.1111/j.1365-2044.1990.tb14777.x

subject

Has Abstract

pub_date

1990-05-01 00:00:00

pages

366-72

issue

5

eissn

0003-2409

issn

1365-2044

journal_volume

45

pub_type

临床试验,杂志文章,随机对照试验
  • Bedside tests for predicting difficult airways: an abridged Cochrane diagnostic test accuracy systematic review.

    abstract::Although bedside screening tests are routinely used to identify people at high risk of having a difficult airway, their clinical utility is unclear. We estimated the diagnostic accuracy of commonly used bedside examination tests for assessing the airway in adult patients without apparent anatomical abnormalities sched...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/anae.14608

    authors: Roth D,Pace NL,Lee A,Hovhannisyan K,Warenits AM,Arrich J,Herkner H

    更新日期:2019-07-01 00:00:00

  • Effect of hypertonic saline on electrocardiography QRS duration in rabbit model of bupivacaine toxicity resuscitated by intravenous lipid.

    abstract::Intravenous lipid emulsion is established therapy for bupivacaine induced cardiotoxicity. The benefit of combined hypertonic saline and lipid treatment is unexplored. In this experiment, sedated rabbits were resuscitated from bupivacaine-induced asystole with intravenous lipid according to the Association of Anaesthet...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.2010.06373.x

    authors: Cave G,Harvey M,Prince G,Lahner D,Desmet J

    更新日期:2010-08-01 00:00:00

  • Remote ischaemic conditioning: cardiac protection from afar.

    abstract::For patients with ischaemic heart disease, remote ischaemic conditioning may offer an innovative, non-invasive and virtually cost-free therapy for protecting the myocardium against the detrimental effects of acute ischaemia-reperfusion injury, preserving cardiac function and improving clinical outcomes. The intriguing...

    journal_title:Anaesthesia

    pub_type: 杂志文章,评审

    doi:10.1111/anae.12973

    authors: Sivaraman V,Pickard JM,Hausenloy DJ

    更新日期:2015-06-01 00:00:00

  • A comparison of the Soft Seal disposable and the Classic re-usable laryngeal mask airway.

    abstract::Many new supraglottic airway devices have been recently introduced, their development motivated by the need for a single-use equivalent to the original re-usable laryngeal mask airway. We performed a randomised cross-over study in spontaneously breathing patients comparing the re-usable Laryngeal Mask Airway-Classic (...

    journal_title:Anaesthesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1365-2044.2005.04461.x

    authors: Shafik MT,Bahlman BU,Hall JE,Ali MS

    更新日期:2006-02-01 00:00:00

  • Comparison between propofol and thiopentone for induction of anaesthesia in children.

    abstract::Propofol 2.5 mg/kg was compared with thiopentone 5 mg/kg in a randomised open study, as an induction agent in paediatric anaesthesia. One hundred and twenty children who were to undergo elective surgery were included in the study. Both propofol and thiopentone produced a rapid and smooth induction with a low incidence...

    journal_title:Anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1365-2044.1988.tb04162.x

    authors: Valtonen M,Iisalo E,Kanto J,Tikkanen J

    更新日期:1988-08-01 00:00:00

  • The variable effect of low-dose volatile anaesthetics on the acute ventilatory response to hypoxia in humans: a quantitative review.

    abstract::The purpose of this study was to review published studies (identified by a Medline-assisted search) on the effect of < or = 0.2 minimal alveolar concentration (MAC) halothane, isoflurane, enflurane and sevoflurane on the acute hypoxic ventilatory response in healthy subjects. Each article was examined for the anaesthe...

    journal_title:Anaesthesia

    pub_type: 杂志文章,meta分析,评审

    doi:10.1046/j.1365-2044.2002.02604.x

    authors: Pandit JJ

    更新日期:2002-07-01 00:00:00

  • The safety of paediatric surgery between COVID-19 surges: an observational study.

    abstract::Despite the ongoing coronavirus disease 2019 (COVID-19) pandemic, elective paediatric surgery must continue safely through the first, second and subsequent waves of disease. This study presents outcome data from a children's hospital in north-west England, the region with the highest prevalence of COVID-19 in England....

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/anae.15264

    authors: Okonkwo INC,Howie A,Parry C,Shelton CL,Cobley S,Craig R,Permall N,El-Sheikha SH,Herbert N,Arnold P

    更新日期:2020-12-01 00:00:00

  • In vivo animal studies with sugammadex.

    abstract::A review is presented of animal studies of the selective steroidal neuromuscular blocking drug binding agent sugammadex. These studies demonstrate that sugammadex is faster in onset than the currently used acetylcholinesterase inhibitors, has no muscarinic effects, and is characterised by lack of adverse effects on ot...

    journal_title:Anaesthesia

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2044.2008.05869.x

    authors: Booij LH,van Egmond J,Driessen JJ,de Boer HD

    更新日期:2009-03-01 00:00:00

  • Convection warmers--not just hot air.

    abstract::We sought to determine whether the forced air convection warmers (nine Bair Huggers, Augustine Medical, and one Warm Touch, Mallinkrodt Medical) used in our operating theatres could be a source of microbial pathogens. Agar plates were placed directly in the air stream of the warmers. Four of these grew potentially pat...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1997.250-az0384.x

    authors: Avidan MS,Jones N,Ing R,Khoosal M,Lundgren C,Morrell DF

    更新日期:1997-11-01 00:00:00

  • Entonox analgesia--a method of reducing the delay between demand and supply.

    abstract::Mothers in labour using a self-administered 50% N2O and 50% O2 (Entonox) demand system, experience a time lag between making a demand at the onset of a contraction and pain relief. A practical method is described of reducing this time lag by supplementing the intermittent supply from the demand valve system with a con...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1977.tb10008.x

    authors: Willis BA,Rosen M

    更新日期:1977-06-01 00:00:00

  • The prevalence and association with transfusion, intensive care unit stay and mortality of pre-operative anaemia in a cohort of cardiac surgery patients.

    abstract::Anaemia is increasingly prevalent in the United Kingdom. Despite recommendations to the contrary, many patients undergo cardiac surgery with undiagnosed and untreated anaemia. According to the World Health Organization definition, 1463/2688 (54.4%) patients undergoing cardiac surgery between 2008 and 2009 in our insti...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.2011.06819.x

    authors: Hung M,Besser M,Sharples LD,Nair SK,Klein AA

    更新日期:2011-09-01 00:00:00

  • A national survey of safe practice with epidural analgesia in obstetric units.

    abstract::The National Patient Safety Agency (NPSA) identified practice improvements with regard to epidural injections and infusions and released a patient safety alert on 28th March 2007. Prior to this, the Obstetric Anaesthetists' Association had considered the draft document and wished to assess current compliance in UK obs...

    journal_title:Anaesthesia

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1365-2044.2007.05398.x

    authors: Jones R,Swales HA,Lyons GR

    更新日期:2008-05-01 00:00:00

  • Blood loss following tonsillectomy in children. A blind comparison of diclofenac and papaveretum.

    abstract::One hundred and ninety-eight children, aged 3 to 12 years, who were scheduled for tonsillectomy were randomly allocated to receive either diclofenac 1.0 mg.kg-1 or papaveretum 0.2 mg.kg-1 by intramuscular injection after induction of anaesthesia. There were no significant differences between the treatment groups in op...

    journal_title:Anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Thiagarajan J,Bates S,Hitchcock M,Morgan-Hughes J

    更新日期:1993-02-01 00:00:00

  • Time course of action of combinations of vecuronium and pancuronium.

    abstract::Vecuronium 0.1 mg/kg, pancuronium 0.1 mg/kg, vecuronium 0.075 mg/kg + pancuronium 0.025 mg/kg, vecuronium + pancuronium 0.05 mg/kg each and vecuronium 0.025 mg/kg + pancuronium 0.075 mg/kg were compared with respect to time taken to onset of effect, duration of clinical relaxation and intubation conditions in five gro...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1986.tb13170.x

    authors: Pandit SK,Ferres CJ,Gibson FM,Mirakhur RK

    更新日期:1986-02-01 00:00:00

  • Ketamine, midazolam and vecuronium infusion. Anaesthesia for Down's syndrome and congenital heart disease.

    abstract::A ketamine, midazolam and vecuronium infusion was used for total intravenous anesthesia in a patient with Down's syndrome, a ventricular septal defect and pulmonary hypertension. A mixture of ketamine 200 mg, midazolam 5 mg and vecuronium 12 mg in 50 ml of normal saline was infused at 0.5 ml/kg/hour. This simple techn...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1991.tb09356.x

    authors: Riley DP,McBride LJ

    更新日期:1991-02-01 00:00:00

  • Intermittent mandatory ventilation with "Manley" ventilators.

    abstract::A method is described whereby gas powered, minute volume divider, ventilators may be adapted to provide intermittent mandatory ventilation. ...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1976.tb11979.x

    authors: Manson HJ,Ross DG

    更新日期:1976-11-01 00:00:00

  • Effect of sufentanil on intracranial pressure in neurosurgical patients.

    abstract::The effects of sufentanil on intracranial pressure, mean arterial pressure, cerebral perfusion pressure and heart rate were studied in 20 neurosurgical intensive care unit patients. Epidural intracranial pressure probes were implanted in patients who suffered head injury, intracerebral haemorrhage or underwent tumour ...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1991.tb09596.x

    authors: Weinstabl C,Mayer N,Richling B,Czech T,Spiss CK

    更新日期:1991-10-01 00:00:00

  • Validation of a bedside activated clotting time test (Hemochron Jr II Signature) with low dose heparin therapy.

    abstract::The purpose of this study was to validate a device designed to measure activated clotting time in low-range heparin plasma concentrations (ACT-LR) prospectively during the post-operative period of vascular surgery. Measurement of ACT-LR and activated partial thromboplastin time (APTT) were performed before heparinisat...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.2008.05822.x

    authors: Racioppi L,Quinart A,Biais M,Nouette-Gaulain K,Revel P,Sztark F

    更新日期:2009-04-01 00:00:00

  • Total intravenous anaesthesia for military surgery. A technique using ketamine, midazolam and vecuronium.

    abstract::Ketamine and midazolam were used for induction of anaesthesia and by continuous intravenous infusion for maintenance to assess their suitability for use in a total intravenous anaesthetic technique in the management of battle casualties. Muscular relaxation was provided by vecuronium and the patients' lungs ventilated...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1988.tb05424.x

    authors: Restall J,Tully AM,Ward PJ,Kidd AG

    更新日期:1988-01-01 00:00:00

  • Comparison of remifentanil versus regional anaesthesia in children anaesthetised with isoflurane/nitrous oxide. International Remifentanil Paediatric Anaesthesia Study group.

    abstract::We compared the efficacy and safety of a remifentanil (0.25 microg x kg(-1) x min(-1)-based balanced anaesthetic technique with a bupivacaine-based regional anaesthetic technique in an open label, multicentre study in 271 ASA physical status 1 or 2 children aged 1-12 years. Subjects requiring major intra-abdominal, ur...

    journal_title:Anaesthesia

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1046/j.1365-2044.2000.01607.x

    authors: Prys-Roberts C,Lerman J,Murat I,Taivainen T,Lopez T,Lejus C,Spahr-Schopfer I,Splinter W,Kirkham AJ

    更新日期:2000-09-01 00:00:00

  • Which intravenous induction agent for day surgery? A comparison of propofol, thiopentone, methohexitone and etomidate.

    abstract::Eighty day patients for the vaginal termination of pregnancy were randomly allocated to receive thiopentone, propofol, methohexitone or etomidate as intravenous induction agents. The same anaesthetist administered the anaesthesia and all the observers were blind to the agents used. The results show that thiopentone an...

    journal_title:Anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1365-2044.1988.tb09014.x

    authors: Heath PJ,Kennedy DJ,Ogg TW,Dunling C,Gilks WR

    更新日期:1988-05-01 00:00:00

  • Comparison of anxiety before induction of anaesthesia in the anaesthetic room or operating theatre.

    abstract::Anxiety before induction of anaesthesia was studied in 100 patients who were allocated randomly to one of two groups. Patients in one group were anaesthetised in an anaesthetic room and those in the other group were anaesthetised inside the operating theatre. Both subjective and objective induces of anxiety were used ...

    journal_title:Anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1365-2044.1989.tb13586.x

    authors: Soni JC,Thomas DA

    更新日期:1989-08-01 00:00:00

  • Is there a need for a new inhalational anaesthetic agent?

    abstract::New anaesthetic agents are continually being developed in an effort to prepare the ideal agent. Isoflurane is the first choice of many anaesthetists, although it clearly falls short of the ideal on a number of counts. The need and place for any new agent depends on comparing the properties of a theoretically ideal age...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1995.tb06181.x

    authors: Jones RM,Ward PM

    更新日期:1995-10-01 00:00:00

  • Routine pre-operative chest radiography. 1977 compared with 1955 at Peterborough District General Hospital.

    abstract::Routine pre-operative chest X-rays have been taken for 22 years. There has been recent criticism of this investigation. 1000 such X-rays taken in 1977 are compared with the same number in 1955. It appears now that routine pre-operative chest X-rays are not necessary under 30 years of age but that they are essential ov...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1978.tb08334.x

    authors: Loder RE

    更新日期:1978-11-01 00:00:00

  • Appropriate laryngeal mask airway size for overweight and underweight children.

    abstract::The aim of this study was to compare conventional laryngeal mask airway sizing by weight with sizing by age in over- or underweight children. We studied 26 overweight (body mass index > 85th centile) and 26 underweight (body mass index < 15th centile) children. After general anaesthesia was induced, laryngeal mask air...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.2009.06160.x

    authors: Kim HJ,Park MJ,Kim JT,Kim CS,Kim SD,Kim HS

    更新日期:2010-01-01 00:00:00

  • Meptazinol versus pethidine for postoperative pain relief in children.

    abstract::A double-blind, randomised, clinical trial was undertaken comparing intramuscular meptazinol (1 mg/kg) with intramuscular pethidine (1 mg/kg) for the relief of post-tonsillectomy pain, in 100 children under 15 years of age. Pethidine provided better analgesia in those patients who were awake after 30 minutes, but ther...

    journal_title:Anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1365-2044.1986.tb12785.x

    authors: Ridley SA,Matthews NC,Dixon J

    更新日期:1986-03-01 00:00:00

  • An unusual complication of emergency tracheal intubation.

    abstract::A 68-year-old woman presented with dyspnoea having undergone a short period of tracheal intubation during an episode of congestive cardiac failure 10 days earlier. On the fourth day of admission, she suddenly developed acute respiratory distress followed by a cardiac arrest and was found to have an enlarging neck mass...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1997.72-az0069.x

    authors: Ooi GC,Irwin MG,Lam LK,Cheng SW

    更新日期:1997-02-01 00:00:00

  • Assessing the position of the tracheal tube. The reliability of different methods.

    abstract::Various methods have been developed to confirm proper intubation of the trachea. This blind, randomised study evaluates some of these quantitatively and qualitatively. Forty patients had both their trachea and oesophagus intubated. A procedure that included auscultation of the upper abdomen and lungs was 100% reliable...

    journal_title:Anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1365-2044.1989.tb09203.x

    authors: Andersen KH,Hald A

    更新日期:1989-12-01 00:00:00

  • Morphine compared with diamorphine. A comparison of dose requirements and side-effects after hip surgery.

    abstract::The dose requirements and side effects of morphine were compared with those of diamorphine administered by patient-controlled analgesia in 40 patients following elective total hip replacement. Patients were allocated randomly to receive in a double-blind manner either morphine or diamorphine for postoperative pain rel...

    journal_title:Anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1365-2044.1991.tb09650.x

    authors: Robinson SL,Rowbotham DJ,Smith G

    更新日期:1991-07-01 00:00:00

  • Anaesthesia for fetal surgery.

    abstract::Anaesthesia for fetal surgery is described as used for thirteen procedures in seven patients. Analgesia was accomplished by local infiltration of lignocaine 1% by the surgeons and small incremental doses of intravenous medication by the anaesthetist as needed to make the mother comfortable and reduce fetal movement. T...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1984.tb06517.x

    authors: Spielman FJ,Seeds JW,Corke BC

    更新日期:1984-08-01 00:00:00