Abstract:
:Thirty-seven patients with a wide range of illnesses were studied during mechanical ventilation of the lungs in an intensive care unit. Fifteen were sedated with a continuous propofol infusion, with analgesia provided by bolus doses of papaveretum. Twelve received a continuous infusion of papaveretum, supplemented by bolus doses of midazolam. The level of sedation was assessed every four hours and measurements were made of haemodynamic and respiratory variables. Levels of sedation were generally satisfactory in both groups. Six patients who received propofol required the use of muscle relaxants, because of their strong respiratory drives, to achieve synchronisation with the ventilator. There was no significant difference in respiratory or haemodynamic variables between the groups, but several patients required inotropic support because of their disease. There was no evidence of inhibition of adrenal steroidogenesis in the propofol group. Propofol can be a useful sedative agent in the intensive care unit, but sedative regimens should be tailored to individual patient requirements.
journal_name
Anaesthesiajournal_title
Anaesthesiaauthors
Harris CE,Grounds RM,Murray AM,Lumley J,Royston D,Morgan Mdoi
10.1111/j.1365-2044.1990.tb14777.xsubject
Has Abstractpub_date
1990-05-01 00:00:00pages
366-72issue
5eissn
0003-2409issn
1365-2044journal_volume
45pub_type
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