Comparison between propofol and thiopentone for induction of anaesthesia in children.

Abstract:

:Propofol 2.5 mg/kg was compared with thiopentone 5 mg/kg in a randomised open study, as an induction agent in paediatric anaesthesia. One hundred and twenty children who were to undergo elective surgery were included in the study. Both propofol and thiopentone produced a rapid and smooth induction with a low incidence of side effects. A similar decrease (10%) in mean arterial pressure was observed with both agents, but propofol showed better suppression of the haemodynamic response to tracheal intubation. Respiratory upsets occurred less frequently with propofol than with thiopentone, but propofol frequently induced discomfort on injection. Both agents provided satisfactory and controllable induction of anesthesia and no major adverse reactions occurred during or after anaesthesia. We conclude that propofol is a useful alternative as an induction agent in children.

journal_name

Anaesthesia

journal_title

Anaesthesia

authors

Valtonen M,Iisalo E,Kanto J,Tikkanen J

doi

10.1111/j.1365-2044.1988.tb04162.x

subject

Has Abstract

pub_date

1988-08-01 00:00:00

pages

696-9

issue

8

eissn

0003-2409

issn

1365-2044

journal_volume

43

pub_type

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