Abstract:
:The effects of thiopentone and propofol on delayed hypersensitivity reactions and T lymphocyte proliferation were studied in nine healthy volunteers (five women and four men). Thiopentone 5 mg.kg-1 and propofol 2.5 mg kg-1 were given as a 10 min infusion on two separate occasions. The volunteers were exposed to a skin multitest antigen before and after administration of the two agents and their skin reactions assessed. T lymphocyte responses were studied using phytohaemagglutinin (PHA)-induced proliferation. Results showed that both drugs caused a significant depression of skin reactions in vivo but no depression in the T lymphocyte proliferation.
journal_name
Anaesthesiajournal_title
Anaesthesiaauthors
Devlin EG,Clarke RS,Mirakhur RK,McNeill TAdoi
10.1111/j.1365-2044.1995.tb06037.xsubject
Has Abstractpub_date
1995-06-01 00:00:00pages
496-8issue
6eissn
0003-2409issn
1365-2044journal_volume
50pub_type
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