The effects of thiopentone and propofol on delayed hypersensitivity reactions.

Abstract:

:The effects of thiopentone and propofol on delayed hypersensitivity reactions and T lymphocyte proliferation were studied in nine healthy volunteers (five women and four men). Thiopentone 5 mg.kg-1 and propofol 2.5 mg kg-1 were given as a 10 min infusion on two separate occasions. The volunteers were exposed to a skin multitest antigen before and after administration of the two agents and their skin reactions assessed. T lymphocyte responses were studied using phytohaemagglutinin (PHA)-induced proliferation. Results showed that both drugs caused a significant depression of skin reactions in vivo but no depression in the T lymphocyte proliferation.

journal_name

Anaesthesia

journal_title

Anaesthesia

authors

Devlin EG,Clarke RS,Mirakhur RK,McNeill TA

doi

10.1111/j.1365-2044.1995.tb06037.x

subject

Has Abstract

pub_date

1995-06-01 00:00:00

pages

496-8

issue

6

eissn

0003-2409

issn

1365-2044

journal_volume

50

pub_type

临床试验,杂志文章,随机对照试验
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    更新日期:2006-11-01 00:00:00

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    pub_type: 杂志文章

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    pub_type: 杂志文章,随机对照试验

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    pub_type: 临床试验,杂志文章,随机对照试验

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