Abstract:
:The combination of vecuronium and atracurium was studied in 60 children of ASA physical status 1 or 2. In part I, the dose-response relationships were determined in 30 children who were randomly assigned to receive a single bolus of 0.02, 0.025 or 0.03 mg kg-1 of vecuronium or 0.075, 0.01 or 0.0125 mg.kg-1 of atracurium. The evoked electromyogram of the adductor pollicis brevis muscle to train-of-four stimulation was monitored. The speed of onset of the neuromuscular blockade was determined by a 95% depression of the train-of-four whereas the recovery index was established at 75% recovery of T1. In part II, 30 children were randomly assigned to receive 2 x ED95 of vecuronium, 2 x ED95 of atracurium, or a combination of 1 x ED95 of vecuronium + 1 x ED95 of atracurium. This study showed that the ED50 and ED95 for vecuronium were 0.021 mg.kg-1 and 0.037 mg.kg-1 and for atracurium 0.11 mg.kg-1 and 0.30 mg.kg-1, respectively. The slopes of the dose-response relationships were significantly different (p < 0.001). With vecuronium alone, the speed of onset of neuromuscular blockade was significantly slower (p < 0.001) and the duration of action less (p < 0.001) than that with atracurium alone or with the combination. There were no differences between atracurium and the combination of both medications. The recovery index was similar for all groups. We conclude that the dose-response relationships of vecuronium and atracurium in children undergoing halothane anaesthesia are not parallel and the neuromuscular effects of vecuronium and atracurium are neither additive nor synergistic. While vecuronium has a shorter duration of action than atracurium, this feature is not apparent when it is combined with atracurium in equipotent doses. Recovery is rapid and not prolonged when these two drugs are combined.
journal_name
Anaesthesiajournal_title
Anaesthesiaauthors
Sloan MH,Bissonnette B,Lerman Jdoi
10.1111/j.1365-2044.1998.00259.xsubject
Has Abstractpub_date
1998-01-01 00:00:00pages
36-40issue
1eissn
0003-2409issn
1365-2044journal_volume
53pub_type
临床试验,杂志文章,随机对照试验相关文献
ANAESTHESIA文献大全abstract::J waves appear on an electrocardiogram as an elevation of the J point in the terminal portion of the QRS complex. J waves are often benign, but may be associated with malignant ventricular arrhythmias. In some cases, such problems appear to have been precipitated by propofol infusions. We observed a sudden increase in...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1111/anae.12448
更新日期:2014-02-01 00:00:00
abstract::A new method to distinguish oesophageal from tracheal intubation using an end-tidal carbon dioxide detector was evaluated. In a prospective study on 50 healthy adult patients, the end-tidal carbon dioxide detector was reliably used to detect initial oesophageal intubation in 22 cases, and then to confirm tracheal intu...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1111/j.1365-2044.1990.tb14391.x
更新日期:1990-08-01 00:00:00
abstract::Lamotrigine, a sodium channel blocker that selectively inhibits the neuronal release of glutamate, has been shown to produce analgesia in acute and chronic pain models in rats without causing noticeable sedation. After oral administration it also reduces pain scores, as assessed by the cold pain test, in volunteers. T...
journal_title:Anaesthesia
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1046/j.1365-2044.1999.00959.x
更新日期:1999-08-01 00:00:00
abstract::Increasing numbers of elderly patients with severe co-existing medical diseases undergo major surgery. With these patients there is also an accompanying risk of age-related cardiovascular complications such as life-threatening myocardial ischaemia. We present a patient who suffered a myocardial infarction after a hemi...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1111/j.1365-2044.2004.04031.x
更新日期:2005-02-01 00:00:00
abstract::We measured the distance 112 patients walked in 6 min, as well as their peak oxygen consumption pedalling a bicycle, week before scheduled resection of benign or malignant colorectal disease. The distance walked correlated with peak oxygen consumption, the former 'accounting' for about half the variation in the latter...
journal_title:Anaesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1111/anae.12329
更新日期:2013-08-01 00:00:00
abstract::A case of transient sympathetic block of the arm following percutaneous intercostal nerve injections is described and the possible aetiology discussed. ...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1111/j.1365-2044.1987.tb05371.x
更新日期:1987-09-01 00:00:00
abstract::The role of the revised cardiac risk index in risk stratification has recently been challenged by studies reporting on the superior predictive ability of pre-operative B-type natriuretic peptides. We found that in 850 vascular surgical patients initially risk stratified using B-type natriuretic peptides, reclassificat...
journal_title:Anaesthesia
pub_type: 杂志文章,meta分析,评审
doi:10.1111/j.1365-2044.2011.06958.x
更新日期:2012-01-01 00:00:00
abstract::We systematically reviewed randomised controlled trials of peri-operative melatonin. We included 24 studies of 1794 participants that reported eight peri-operative outcomes: anxiety; analgesia; sleep quality; oxidative stress; emergence behaviour; anaesthetic requirements; steal induction; and safety. Compared with pl...
journal_title:Anaesthesia
pub_type: 杂志文章,meta分析,评审
doi:10.1111/anae.12717
更新日期:2014-10-01 00:00:00
abstract::A 30-gauge spinal needle was evaluated for Caesarean section, using a combined epidural/spinal technique, in 50 mothers. Spinal anaesthesia failed in six mothers and was inadequate in another six. General anaesthesia was required on one occasion. A 25% overall failure rate suggests that a 30-gauge needle is not a prac...
journal_title:Anaesthesia
pub_type: 临床试验,杂志文章
doi:10.1111/j.1365-2044.1990.tb14451.x
更新日期:1990-09-01 00:00:00
abstract::Eighty-three patients were given midazolam 0.1 mg.kg-1 by intramuscular injection as premedication before general anaesthesia with alfentanil-nitrous oxide. During anaesthesia patients were presented (through headphones) with either statements about common facts of some years ago (group A) (n = 43) or new verbal assoc...
journal_title:Anaesthesia
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1365-2044.1995.tb04553.x
更新日期:1995-03-01 00:00:00
abstract::Data related to the incidence of postoperative vomiting were collected during prospective studies on 607 ophthalmic surgical patients of all ages who underwent halothane anaesthesia with spontaneous ventilation. Analysis of data in respect of age, sex and surgical site variables, and time of onset of vomiting, identif...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1111/j.1365-2044.1989.tb11157.x
更新日期:1989-02-01 00:00:00
abstract::The purpose of this study was to review published studies (identified by a Medline-assisted search) on the effect of < or = 0.2 minimal alveolar concentration (MAC) halothane, isoflurane, enflurane and sevoflurane on the acute hypoxic ventilatory response in healthy subjects. Each article was examined for the anaesthe...
journal_title:Anaesthesia
pub_type: 杂志文章,meta分析,评审
doi:10.1046/j.1365-2044.2002.02604.x
更新日期:2002-07-01 00:00:00
abstract::To improve the analgesic efficiency and to simplify the administration of remifentanil for systemic analgesia in labour, we contrived a modified delivery regimen with a specific infusion profile and variable dosing and conducted a single-blind randomised crossover study to compare it with the previous 'classical' regi...
journal_title:Anaesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1111/anae.12038
更新日期:2013-03-01 00:00:00
abstract::Intravenous lipid emulsion is established therapy for bupivacaine induced cardiotoxicity. The benefit of combined hypertonic saline and lipid treatment is unexplored. In this experiment, sedated rabbits were resuscitated from bupivacaine-induced asystole with intravenous lipid according to the Association of Anaesthet...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1111/j.1365-2044.2010.06373.x
更新日期:2010-08-01 00:00:00
abstract::In this prospective study, cardiac output was measured in 38 intensive care unit patients before and after a fluid challenge, using both pulse contour analysis (Nexfin(®); BMEYE, Amsterdam, the Netherlands) and transthoracic echocardiography. The ability of the Nexfin device to detect significant changes in the veloci...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1111/anae.12341
更新日期:2013-09-01 00:00:00
abstract::Pregnanolone emulsion, a new steroid anaesthetic agent, was administered intravenously as bolus doses to six young healthy male volunteers in a preliminary pharmacokinetic and pharmacodynamic study. The plasma concentration-time curves fitted a two-compartment model. The elimination half-life was between 0.9 and 1.4 h...
journal_title:Anaesthesia
pub_type: 临床试验,杂志文章
doi:10.1111/j.1365-2044.1990.tb14683.x
更新日期:1990-03-01 00:00:00
abstract::Sixty patients took part in a randomised, double-blind study to compare the analgesic and side effects of three opioid-containing solutions for patient-controlled epidural analgesia following abdominal surgery. Patients in group 1 received a solution containing bupivacaine 0.125% with fentanyl 10 micrograms.ml-1, grou...
journal_title:Anaesthesia
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1365-2044.1996.tb14993.x
更新日期:1996-11-01 00:00:00
abstract::In resource-constrained settings, where inequalities in access to and quality of surgical care results in excess mortality, peri-operative care registries are uncommon. A south-south collaboration supported the implementation of a context specific, clinician-led, multicentre real-time peri-operative registry in Ethiop...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1111/anae.15394
更新日期:2021-01-25 00:00:00
abstract::The incidence and origin of contamination of the vocal cords in 53 trauma patients was studied when tracheal intubation was performed before hospital admission. Eighteen patients (34%) had gross contamination which was blood in 15 patients and gastric contents in three patients. This has implications for prehospital a...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1046/j.1365-2044.1999.00754.x
更新日期:1999-11-01 00:00:00
abstract::Most anaesthetists using target-controlled infusion systems will have observed that the calculated effect-site concentration at loss of consciousness is usually higher than the concentration at emergence. Inertia is the ability of biological systems to keep a functional state at rest or in activity and is an active pr...
journal_title:Anaesthesia
pub_type: 杂志文章,评审
doi:10.1111/anae.14609
更新日期:2019-06-01 00:00:00
abstract::The Laryngeal Tube S and the LMA-ProSeal are supraglottic instruments with an improved airway seal and a drainage tube to protect against regurgitation and to facilitate passage of a gastric tube. We compared the feasibility of these two instruments in a randomised, controlled clinical trial. One hundred and sixty pat...
journal_title:Anaesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1365-2044.2007.05073.x
更新日期:2007-07-01 00:00:00
abstract::This study of 100 day case patients having cataract surgery under local anaesthesia compared patient acceptance of two peri-ocular techniques; a transcutaneous method and a transconjunctival method. A significant difference was found in relation to the pain felt on injection such that all peri-ocular blocks at our uni...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1111/j.1365-2044.1993.tb06958.x
更新日期:1993-04-01 00:00:00
abstract::The purpose of this study was to validate a device designed to measure activated clotting time in low-range heparin plasma concentrations (ACT-LR) prospectively during the post-operative period of vascular surgery. Measurement of ACT-LR and activated partial thromboplastin time (APTT) were performed before heparinisat...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1111/j.1365-2044.2008.05822.x
更新日期:2009-04-01 00:00:00
abstract::A caudal epidural injection was performed on a middle-aged woman for pain in her right foot. Although the procedure was uncomplicated and a good epidurogram was obtained, the patient went on to develop an orthostatic headache with generalised weakness and syncopal episodes that were treated successfully by epidural bl...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1111/j.1365-2044.2011.06980.x
更新日期:2012-04-01 00:00:00
abstract::Free radical species are ubiquitous in plant and animal life. This article describes briefly the formation of certain oxygen-centred free radicals which are essential for aerobic metabolism and host defences in humans. The mechanism of cytotoxicity of excess or inappropriate free radical production is described. The p...
journal_title:Anaesthesia
pub_type: 杂志文章,评审
doi:
更新日期:1988-04-01 00:00:00
abstract::A patient with Kugelberg-Welander disease presented as an unexpected difficult intubation. Tracheal intubation was achieved through the laryngeal mask airway, while regurgitation was prevented with continuous cricoid pressure. Regurgitation occurred after cricoid pressure was released. ...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1111/j.1365-2044.1994.tb04401.x
更新日期:1994-08-01 00:00:00
abstract::We assessed the effectiveness of early patient-controlled oral analgesia compared with parenteral analgesia in a randomised controlled non-inferiority trial of women undergoing elective caesarean section under regional anaesthesia. Seventy-seven women received multimodal paracetamol, ketoprofen and morphine analgesia....
journal_title:Anaesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1111/anae.13406
更新日期:2016-05-01 00:00:00
abstract::We studied the potentiation of analgesia for labour by the addition of clonidine to epidural low-concentration levobupivacaine with sufentanil in a randomised, double-blinded study. We enrolled primiparous women who were in spontaneous labour. The study solutions, made of 100 ml levobupivacaine 0.0625% plus sufentanil...
journal_title:Anaesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1365-2044.2011.06785.x
更新日期:2011-09-01 00:00:00
abstract::Malignant obstructive jaundice is associated with poor aerobic capacity. We measured oxygen consumption and oxygen extraction (arterial-venous oxygen content) in the legs of nine patients during cardiopulmonary exercise testing before pancreaticoduodenectomy. The median (IQR [range]) peak oxygen consumption was 67 (49...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1111/anae.12478
更新日期:2014-01-01 00:00:00
abstract::A prospective, randomised, double-blind study was conducted to compare the efficacy of two doses of levobupivacaine combined with sufentanil for continuous epidural infusion following thoractomy. A total of 72 patients undergoing lobectomy or pneumonectomy were enrolled. An epidural catheter was inserted between the l...
journal_title:Anaesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1365-2044.2007.05184.x
更新日期:2007-10-01 00:00:00