Abstract:
:The effect of neostigmine on neuromuscular function was examined after spontaneous recovery from an atracurium-induced neuromuscular blockade, which reached a train-of-four ratio of either 0.5 or 0.9. Two doses of neostigmine 2.5 mg were given 5 minutes apart. Neuromuscular recovery was assessed with train-of-four and tetanic stimuli. The first dose of neostigmine antagonised the neuromuscular blockade. The second dose diminished tetanic height and increased tetanic fade. The train-of-four measured mechanically was adversely affected to a small degree, but when measured with the electromyograph no significant change occurred. Neostigmine may adversely affect neuromuscular function after spontaneous recovery from a non-depolarising block. This is unlikely with a single modest dose and any effects are probably short-lived.
journal_name
Anaesthesiajournal_title
Anaesthesiaauthors
Goldhill DR,Wainwright AP,Stuart CS,Flynn PJdoi
10.1111/j.1365-2044.1989.tb11280.xsubject
Has Abstractpub_date
1989-04-01 00:00:00pages
293-9issue
4eissn
0003-2409issn
1365-2044journal_volume
44pub_type
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