Ropivacaine in ultrasound-guided femoral nerve block: what is the minimal effective anaesthetic concentration (EC90)?

Abstract:

:The objective of this study was to estimate the minimal effective anaesthetic concentrations of ropivacaine required to block the femoral nerve in 90% of patients. Forty-five patients who had knee surgery received ultrasound-guided femoral nerve block using 15 ml ropivacaine. The ropivacaine concentration given to a patient relied on the efficacy of the block in the previous patient, using the biased-coin design up-down sequential method. In the event of successful block, the next patient was randomly assigned to receive either the same ropivacaine concentration or a concentration 0.02% w/v less. In the event of a failed block, the next patient received a concentration 0.02% w/v higher. Successful block was defined as complete sensory and motor block before surgery together with pain-free surgery. The minimal effective ropivacaine concentration was estimated to be 0.167% w/v (95% CI 0.14-0.184%). Perineural injection of 15 ml ropivacaine 0.167% w/v under ultrasound guidance can provide successful femoral nerve block in 90% of patients.

journal_name

Anaesthesia

journal_title

Anaesthesia

authors

Taha AM,Abd-Elmaksoud AM

doi

10.1111/anae.12607

subject

Has Abstract

pub_date

2014-07-01 00:00:00

pages

678-82

issue

7

eissn

0003-2409

issn

1365-2044

journal_volume

69

pub_type

杂志文章
  • Optimisation of the organ donor and effects on transplanted organs: a narrative review on current practice and future directions.

    abstract::Mortality remains high for patients on the waiting list for organ transplantation. A marked imbalance between the number of available organs and recipients that need to be transplanted persists. Organs from deceased donors are often declined due to perceived and actual suboptimal quality. Adequate donor management off...

    journal_title:Anaesthesia

    pub_type: 杂志文章,评审

    doi:10.1111/anae.15037

    authors: Bera KD,Shah A,English MR,Harvey D,Ploeg RJ

    更新日期:2020-09-01 00:00:00

  • Impact of dose-finding studies on administration of oxytocin during caesarean section in the UK.

    abstract::Debate continues over the dose and methods of administration of oxytocin for the prevention of haemorrhage during caesarean section. We surveyed 206 lead obstetric anaesthetists in the UK to determine standard practice in their unit as well as any differences in practice for high-risk cases. There were 150 responses (...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/anae.12381

    authors: West R,West S,Simons R,McGlennan A

    更新日期:2013-10-01 00:00:00

  • The relationship between clinical effect and concentrations of temazepam in plasma and cerebrospinal fluid.

    abstract::The clinical pharmacodynamics of temazepam were investigated in patients who received spinal anaesthesia. Total plasma and cerebrospinal fluid temazepam concentrations were measured and correlated with the clinical effects. Sedation was measured by three separate methods. None, including an aggregated score of all thr...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1995.tb04503.x

    authors: Moffat AC,Osborne GA,Badcock NR,Maranucci P,Nyman T,Russell WJ

    更新日期:1995-01-01 00:00:00

  • Ventricular fibrillation after accidental injection of bupivacaine into the pericardium.

    abstract::A postoperative cardiac surgical patient developed ventricular fibrillation immediately after accidental pericardial injection of bupivacaine at room temperature. The possible causes, which include systemic toxicity, local vasoconstriction with myocardial ischaemia, local toxic effect of bupivacaine or local hypotherm...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1992.tb04202.x

    authors: Even BJ,De Jongh RF,De Hert SG

    更新日期:1992-12-01 00:00:00

  • Clinical evaluation of a simultaneous closed-loop anaesthesia control system for depth of anaesthesia and neuromuscular blockade*.

    abstract::We developed a closed-loop system to control the depth of anaesthesia and neuromuscular blockade using the bispectral index and the electromyogram simultaneously and evaluated the clinical performance of this combined system for general anaesthesia. Twenty-two adult patients were included in this study. Anaesthesia wa...

    journal_title:Anaesthesia

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1365-2044.2011.06875.x

    authors: Janda M,Simanski O,Bajorat J,Pohl B,Noeldge-Schomburg GF,Hofmockel R

    更新日期:2011-12-01 00:00:00

  • Obstetric pain relief using epidural morphine.

    abstract::Epidural injections of morphine (2.5 or 4 mg) were given to 25 patients in labour. Forty-eight per cent had good relief of pain lasting from 3 1/4 to 11 hours (average 5 1/4 hours). Sixteen per cent of patients had transient or partial relief, and in 36% there was no discernible effect at all. No serious side effects ...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1980.tb05123.x

    authors: Booker PD,Wilkes RG,Bryson TH,Beddard J

    更新日期:1980-04-01 00:00:00

  • An unusual complication of lithotripsy.

    abstract::The case described illustrates a most unusual course of events due to a perforation in the wall of the bladder during transurethral lithotripsy. Irrigation fluid forced its way retroperitoneally to the mediastinum. The differential diagnostic problems encountered are discussed. ...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1983.tb12160.x

    authors: Sundnes KO,Vaagenes P,Kvarstein B

    更新日期:1983-07-01 00:00:00

  • Effect of intravenous cimetidine on lignocaine disposition during extradural caesarean section.

    abstract::We studied whether an intravenous bolus of cimetidine altered the disposition of extradurally administered lignocaine in the parturient. Mothers who requested extradural analgesia for elective Caesarean section were randomly pretreated with either cimetidine 200 mg intravenously (n = 5) or no H2-receptor antagonist (n...

    journal_title:Anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1365-2044.1989.tb09259.x

    authors: Flynn RJ,Moore J,Collier PS,Howard PJ

    更新日期:1989-09-01 00:00:00

  • The recognition of critical incidents: quantification of monitor effectiveness.

    abstract::We have conducted a prospective analysis of all reported critical incidents which occurred during the period from admission to the anaesthetic room until discharge from the operating theatre complex over a 1-year. The aim was to identify which monitors were most effective for initial recognition of those incidents. Al...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1046/j.1365-2044.1998.00401.x

    authors: Findlay GP,Spittal MJ,Radcliffe JJ

    更新日期:1998-06-01 00:00:00

  • Intra-articular infiltration analgesia for arthroscopic shoulder surgery: a systematic review and meta-analysis.

    abstract::Phrenic-sparing analgesic techniques for shoulder surgery are desirable. Intra-articular infiltration analgesia is one promising phrenic-sparing modality, but its role remains unclear because of conflicting evidence of analgesic efficacy and theoretical concerns regarding chondrotoxicity. This systematic review and me...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/anae.15172

    authors: Yung EM,Got TC,Patel N,Brull R,Abdallah FW

    更新日期:2020-06-29 00:00:00

  • Conceptual and technical insights into the basis of neuromuscular monitoring.

    abstract::Unrecognised postoperative residual neuromuscular block remains a frequent occurrence in recovery rooms. Evidence indicates that current practice continues to perpetuate the status quo, in which 10-40% of patients experience postoperative residual weakness. A departure from the current practice requires small efforts ...

    journal_title:Anaesthesia

    pub_type: 杂志文章,评审

    doi:10.1111/anae.13738

    authors: Naguib M,Brull SJ,Johnson KB

    更新日期:2017-01-01 00:00:00

  • Patient-controlled oral analgesia versus nurse-controlled parenteral analgesia after caesarean section: a randomised controlled trial.

    abstract::We assessed the effectiveness of early patient-controlled oral analgesia compared with parenteral analgesia in a randomised controlled non-inferiority trial of women undergoing elective caesarean section under regional anaesthesia. Seventy-seven women received multimodal paracetamol, ketoprofen and morphine analgesia....

    journal_title:Anaesthesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/anae.13406

    authors: Bonnal A,Dehon A,Nagot N,Macioce V,Nogue E,Morau E

    更新日期:2016-05-01 00:00:00

  • Patient blood management during the COVID-19 pandemic: a narrative review.

    abstract::As COVID-19 disease escalates globally, optimising patient outcome during this catastrophic healthcare crisis is the number one priority. The principles of patient blood management are fundamental strategies to improve patient outcomes and should be given high priority in this crisis situation. The aim of this expert ...

    journal_title:Anaesthesia

    pub_type: 杂志文章,评审

    doi:10.1111/anae.15095

    authors: Baron DM,Franchini M,Goobie SM,Javidroozi M,Klein AA,Lasocki S,Liumbruno GM,Muñoz M,Shander A,Spahn DR,Zacharowski K,Meybohm P

    更新日期:2020-08-01 00:00:00

  • Airway management guidance for the endemic phase of COVID-19.

    abstract::It is now apparent that severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and coronavirus disease 2019 (COVID-19) will remain endemic for some time. Improved therapeutics and a vaccine may shorten this period, but both are far from certain. Plans must be put in place on the assumption that the virus and its...

    journal_title:Anaesthesia

    pub_type: 杂志文章,评审

    doi:10.1111/anae.15253

    authors: Cook TM,McGuire B,Mushambi M,Misra U,Carey C,Lucas N,O'Sullivan E,Harrop-Griffiths W

    更新日期:2021-02-01 00:00:00

  • Spontaneous movement after injection of propofol.

    abstract::Spontaneous movement following injection of propofol at induction was studied in 303 patients. Two hundred patients were Caucasians and 103 were Asians. In a pilot study carried out prior to the main study, 26% of the Asians moved at induction as compared with 6% of the Caucasians. The patients were studied in relatio...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1996.tb07850.x

    authors: Chan A,Nickoll E,Thornton C,Doré C,Newton DE

    更新日期:1996-07-01 00:00:00

  • Implicit memory tested in children during inhalation anaesthesia.

    abstract::Memory for stimuli presented during inhalation anaesthesia was tested in 80 children undergoing eye surgery. Two groups were exposed, in a random double-blind study, to repeated neutral phrases including either the colour orange or green. A postoperative colouring task was used as a test of implicit memory to detect a...

    journal_title:Anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1365-2044.1992.tb03251.x

    authors: Bonke B,Van Dam ME,Van Kleff JW,Slijper FM

    更新日期:1992-09-01 00:00:00

  • A constant pressure infusor.

    abstract::A device for maintaining a constant pressure in a pressure infusor is described. ...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1976.tb11749.x

    authors: Houghton IT

    更新日期:1976-01-01 00:00:00

  • Association of Anaesthetists: anaesthesia and peri-operative care for Jehovah's Witnesses and patients who refuse blood.

    abstract::There are approximately 8.5 million Jehovah's Witnesses and around 150,000 live in Great Britain and Ireland. Based on their beliefs and core values, Jehovah's Witnesses refuse blood component transfusion (including red cells, plasma and platelets). They regard non-consensual transfusion as a physical violation. Conse...

    journal_title:Anaesthesia

    pub_type: 信件

    doi:10.1111/anae.14441

    authors: Klein AA,Bailey CR,Charlton A,Lawson C,Nimmo AF,Payne S,Ruck Keene A,Shortland R,Smith J,Torella F,Wade P

    更新日期:2019-01-01 00:00:00

  • Attitudes of patients and anaesthetists to informed consent for specialist airway techniques.

    abstract::We investigated the attitudes of 96 patients and 163 anaesthetists to the need for obtaining informed consent before specialist airway techniques. Participants were asked to score six questions using a numerical scale, as to whether they thought consent was necessary before specific procedures, particularly in relatio...

    journal_title:Anaesthesia

    pub_type: 杂志文章,多中心研究

    doi:10.1046/j.1365-2044.2002.02749.x

    authors: Bray JK,Yentis SM

    更新日期:2002-10-01 00:00:00

  • Epidural anaesthesia and analgesia for liver resection.

    abstract::Although epidural analgesia is routinely used in many institutions for patients undergoing hepatic resection, there are unresolved issues regarding its safety and efficacy in this setting. We performed a review of papers published in the area of anaesthesia and analgesia for liver resection surgery and selected four a...

    journal_title:Anaesthesia

    pub_type: 杂志文章,评审

    doi:10.1111/anae.12191

    authors: Tzimas P,Prout J,Papadopoulos G,Mallett SV

    更新日期:2013-06-01 00:00:00

  • Haemodynamic changes following buprenorphine and morphine.

    abstract::Twenty-five women were investigated on the day after lower abdominal surgery in a single-blind non-cross-over trial to assess and compare the haemodynamic effects of intravenous injections of buprenorphine 0.3 mg and morphine 7.5 mg. Arterial blood pressure was measured by sphygmomanometry and cardiac output by thorac...

    journal_title:Anaesthesia

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1365-2044.1980.tb04993.x

    authors: Scott DH,Arthur GR,Scott DB

    更新日期:1980-10-01 00:00:00

  • Pharyngeal abscess presenting with upper airway obstruction and atlanto-axial subluxation in a small infant.

    abstract::We describe an infant who presented with a combination of upper airway obstruction and atlanto-axial subluxation, secondary to a pharyngeal abscess resulting from cosmetic ear piercing. This combination posed a number of difficulties for the anasthetist and a detailed plan was formulated to prepare the child for anast...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1046/j.1365-2044.2000.01278.x

    authors: Brookes A,Moriarty A

    更新日期:2000-05-01 00:00:00

  • A prospective randomised comparison of two insertion methods for i-gel placement in anaesthetised paralysed patients: standard vs. rotational technique.

    abstract::In this prospective randomised study, we compared two techniques for i-gel(™) insertion. One hundred and eighty-one anaesthetised, paralysed adult patients were randomly allocated into one of two groups. In the standard group (n = 91), the i-gel was inserted using the standard technique. In the rotation group (n = 90)...

    journal_title:Anaesthesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/anae.12680

    authors: Kim HC,Yoo DH,Kim HJ,Jeon YT,Hwang JW,Park HP

    更新日期:2014-07-01 00:00:00

  • Trans-septal left atrial catheterisation.

    abstract::A newly designed 4 FG double-lumen catheter with the second port located either 5 or 7 cm proximal to the tip was tested in five children undergoing open heart surgery. The catheter was inserted percutaneously and initially positioned in the superior vena cava, right atrium or inferior vena cava. During cardiopulmonar...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1993.tb07015.x

    authors: Fukutome T,Kohjiro M,Sese A,Ueno Y

    更新日期:1993-05-01 00:00:00

  • Propofol use in children with allergies to egg, peanut, soybean or other legumes.

    abstract::Propofol is the most commonly administered intravenous agent for anaesthesia in children. However, there are concerns that the emulsified preparation may not be safe in children with an allergy to egg, peanut, soybean or other legumes. We conducted a retrospective study of children with immunologically confirmed egg, ...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/anae.14693

    authors: Sommerfield DL,Lucas M,Schilling A,Drake-Brockman TFE,Sommerfield A,Arnold A,von Ungern-Sternberg BS

    更新日期:2019-10-01 00:00:00

  • Clinical indicators and other complications in the recovery room or postanaesthetic care unit.

    abstract::Clinical indicators and complications occurring in the recovery room or post anaesthetic care unit were recorded for patients who had an anaesthetic procedure during 1995, 1996 and 1997 (n = 13 266). Clinical indicators measured were those developed by the Australian Council on Healthcare Standards in conjunction with...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1046/j.1365-2044.1999.01077.x

    authors: Peskett MJ

    更新日期:1999-12-01 00:00:00

  • Plasma morphine levels produced by continuous infusion in children.

    abstract::Blood samples were taken from six children aged between 10 months and 15 years, at intervals over a period of 40 hours while they were receiving continuous morphine infusions. The plasma morphine values obtained showed similar and consistent levels 15-30 minutes after starting the infusions. ...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1986.tb12847.x

    authors: Bray RJ,Beeton C,Hinton W,Seviour JA

    更新日期:1986-07-01 00:00:00

  • Evidence and triggers for the transfusion of blood and blood products.

    abstract::Allogeneic red cell transfusion is a commonly used treatment to improve the oxygen carrying capacity of blood during the peri-operative period. Increasing arterial oxygen content by increasing haemoglobin does not necessarily increase tissue oxygen delivery or uptake. Although the evidence-base for red cell transfusio...

    journal_title:Anaesthesia

    pub_type: 杂志文章,评审

    doi:10.1111/anae.12893

    authors: Shah A,Stanworth SJ,McKechnie S

    更新日期:2015-01-01 00:00:00

  • Respiratory injury in the burned patient. The role of flexible bronchoscopy.

    abstract::The purpose of the study was to investigate the role of flexible bronchoscopy in the management of patients admitted to a busy Regional burns unit, with particular reference to possible smoke inhalation injury. The basic procedure employed was that used in routine bronchoscopy for the diagnosis of bronchial carcinoma,...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1983.tb10370.x

    authors: Clark CJ,Reid WH,Telfer AB,Campbell D

    更新日期:1983-01-01 00:00:00

  • Dose-response relationship for disoprofol (ICI 35868; Diprivan). Comparison with methohexitone.

    abstract::The duration of sleep following intravenous administration of three doses of disoprofol (1.2 and 3 mg/kg) was compared with that following methohexione 1 or 2 mg/kg. Disoprofol and methohexitone were shown to be approximately equipotent. Side-effects were dose-related for both drugs, but the incidence was significantl...

    journal_title:Anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1365-2044.1981.tb08858.x

    authors: Kay B,Stephenson DK

    更新日期:1981-09-01 00:00:00