Dose-response relationship for disoprofol (ICI 35868; Diprivan). Comparison with methohexitone.

Abstract:

:The duration of sleep following intravenous administration of three doses of disoprofol (1.2 and 3 mg/kg) was compared with that following methohexione 1 or 2 mg/kg. Disoprofol and methohexitone were shown to be approximately equipotent. Side-effects were dose-related for both drugs, but the incidence was significantly less following disoprofol than methohexitone 2 mg/kg. The most frequent side-effects were pain on injection, myoclonia and hiccup. Studies of blood concentrations of disoprofol show that the profile is dose-independent and conforms to a two-compartment model with a very short distribution phase (about 2 minutes) and short elimination phase (about 70 minutes). Waking blood levels gave no indication of acute tolerance. Disoprofol would appear to be particularly useful for induction of a short period of sleep using a small dose given quickly, or for maintenance of sleep by continuous infusion.

journal_name

Anaesthesia

journal_title

Anaesthesia

authors

Kay B,Stephenson DK

doi

10.1111/j.1365-2044.1981.tb08858.x

subject

Has Abstract

pub_date

1981-09-01 00:00:00

pages

863-7

issue

9

eissn

0003-2409

issn

1365-2044

journal_volume

36

pub_type

临床试验,杂志文章,随机对照试验
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    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

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    更新日期:1993-02-01 00:00:00

  • The potencies of edrophonium and neostigmine as antagonists of pancuronium.

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    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1985.tb11044.x

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    doi:10.1111/j.1365-2044.1994.tb14233.x

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    journal_title:Anaesthesia

    pub_type: 杂志文章,随机对照试验

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    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1984.tb06535.x

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    pub_type: 杂志文章

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    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.2004.03760.x

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    更新日期:2004-07-01 00:00:00

  • Vecuronium induced neuromuscular blockade. The effect of increasing dose on speed of onset.

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    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1986.tb13217.x

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    更新日期:1986-04-01 00:00:00

  • Narcotic-induced choledochoduodenal sphincter spasm reversed by naloxone. A case report and review.

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    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1986.tb12960.x

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    pub_type: 杂志文章,meta分析,评审

    doi:10.1111/j.1365-2044.2007.05233.x

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    pub_type: 杂志文章

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    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1985.tb10612.x

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    pub_type: 杂志文章

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    更新日期:1984-11-01 00:00:00

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    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1992.tb02010.x

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    更新日期:1992-02-01 00:00:00

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    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1982.tb01097.x

    authors: Newman B

    更新日期:1982-03-01 00:00:00

  • Systemic side-effects of extradural steroids.

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    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1980.tb03858.x

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    更新日期:1980-06-01 00:00:00

  • Relationship between the inability to climb two flights of stairs and outcome after major non-cardiac surgery: implications for the pre-operative assessment of functional capacity.

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    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2044.2005.04181.x

    authors: Biccard BM

    更新日期:2005-06-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1991.tb09362.x

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    更新日期:1991-02-01 00:00:00

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    pub_type: 杂志文章

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