Abstract:
:The duration of sleep following intravenous administration of three doses of disoprofol (1.2 and 3 mg/kg) was compared with that following methohexione 1 or 2 mg/kg. Disoprofol and methohexitone were shown to be approximately equipotent. Side-effects were dose-related for both drugs, but the incidence was significantly less following disoprofol than methohexitone 2 mg/kg. The most frequent side-effects were pain on injection, myoclonia and hiccup. Studies of blood concentrations of disoprofol show that the profile is dose-independent and conforms to a two-compartment model with a very short distribution phase (about 2 minutes) and short elimination phase (about 70 minutes). Waking blood levels gave no indication of acute tolerance. Disoprofol would appear to be particularly useful for induction of a short period of sleep using a small dose given quickly, or for maintenance of sleep by continuous infusion.
journal_name
Anaesthesiajournal_title
Anaesthesiaauthors
Kay B,Stephenson DKdoi
10.1111/j.1365-2044.1981.tb08858.xsubject
Has Abstractpub_date
1981-09-01 00:00:00pages
863-7issue
9eissn
0003-2409issn
1365-2044journal_volume
36pub_type
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