Effect of amniotic fluid on coagulation and platelet function in pregnancy: an evaluation using thromboelastography.

Abstract:

:Amniotic fluid embolism is a rare obstetric complication. The exact pathogenesis of this syndrome remains unknown and significant controversy exists whether coagulopathy should always be present. We used thromboelastography to assess the effect of amniotic fluid on coagulation and platelet function in pregnant women. Different volumes of amniotic fluid (10-60 microl) were added to blood (330 microl) from pregnant women and thromboelastography variables determined. There were three important findings. R time, reflecting time to first clot formation, was significantly decreased with the addition of 10 microl amniotic fluid; platelet function, as determined by Reopro-TEG technique, was increased with the addition of 30 microl of amniotic fluid; and there was no evidence of fibrinolysis in any samples studied. In conclusion, our study substantiates the hypothesis that coagulation profile changes are invariable accompaniments of amniotic fluid embolism.

journal_name

Anaesthesia

journal_title

Anaesthesia

authors

Harnett MJ,Hepner DL,Datta S,Kodali BS

doi

10.1111/j.1365-2044.2005.04373.x

subject

Has Abstract

pub_date

2005-11-01 00:00:00

pages

1068-72

issue

11

eissn

0003-2409

issn

1365-2044

pii

ANA4373

journal_volume

60

pub_type

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