Vecuronium induced neuromuscular blockade. The effect of increasing dose on speed of onset.

Abstract:

:The speed of onset of neuromuscular blockade was measured for increasing doses of vecuronium. Onset times were found to be shorter with larger doses, up to a limit of ED95 X 3 (0.15 mg/kg). Thereafter, increasing the dose, even up to ED95 X 8 (0.4 mg/kg), did not appreciably shorten the time to full neuromuscular blockade. The clinical implications of, and pharmacokinetic basis for, these findings are discussed.

journal_name

Anaesthesia

journal_title

Anaesthesia

authors

Casson WR,Jones RM

doi

10.1111/j.1365-2044.1986.tb13217.x

subject

Has Abstract

pub_date

1986-04-01 00:00:00

pages

354-7

issue

4

eissn

0003-2409

issn

1365-2044

journal_volume

41

pub_type

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