Abstract:
:We studied whether an intravenous bolus of cimetidine altered the disposition of extradurally administered lignocaine in the parturient. Mothers who requested extradural analgesia for elective Caesarean section were randomly pretreated with either cimetidine 200 mg intravenously (n = 5) or no H2-receptor antagonist (n = 5). No difference was found between peak plasma lignocaine levels or area under the plasma concentration/time curve between the two groups after administration of 6 mg/kg lignocaine 2% with adrenaline 1:200,000. There was no evidence for an effect of a single intravenous dose of cimetidine on lignocaine disposition in the obstetric patient. In addition, the extradural administration of 6 mg/kg lignocaine produces plasma levels well below toxic levels.
journal_name
Anaesthesiajournal_title
Anaesthesiaauthors
Flynn RJ,Moore J,Collier PS,Howard PJdoi
10.1111/j.1365-2044.1989.tb09259.xsubject
Has Abstractpub_date
1989-09-01 00:00:00pages
739-41issue
9eissn
0003-2409issn
1365-2044journal_volume
44pub_type
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