Effect of intravenous cimetidine on lignocaine disposition during extradural caesarean section.

Abstract:

:We studied whether an intravenous bolus of cimetidine altered the disposition of extradurally administered lignocaine in the parturient. Mothers who requested extradural analgesia for elective Caesarean section were randomly pretreated with either cimetidine 200 mg intravenously (n = 5) or no H2-receptor antagonist (n = 5). No difference was found between peak plasma lignocaine levels or area under the plasma concentration/time curve between the two groups after administration of 6 mg/kg lignocaine 2% with adrenaline 1:200,000. There was no evidence for an effect of a single intravenous dose of cimetidine on lignocaine disposition in the obstetric patient. In addition, the extradural administration of 6 mg/kg lignocaine produces plasma levels well below toxic levels.

journal_name

Anaesthesia

journal_title

Anaesthesia

authors

Flynn RJ,Moore J,Collier PS,Howard PJ

doi

10.1111/j.1365-2044.1989.tb09259.x

subject

Has Abstract

pub_date

1989-09-01 00:00:00

pages

739-41

issue

9

eissn

0003-2409

issn

1365-2044

journal_volume

44

pub_type

临床试验,杂志文章,随机对照试验
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    pub_type: 临床试验,杂志文章,随机对照试验

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  • A comparison of thiopentone and propofol with respect to the incidence of postoperative shivering.

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    journal_title:Anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1365-2044.1994.tb04322.x

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    pub_type: 杂志文章,评审

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  • Sequential organ scoring as a measure of effectiveness of care in the high-dependency unit.

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    pub_type: 杂志文章

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    journal_title:Anaesthesia

    pub_type: 临床试验,杂志文章

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  • Haemodynamic and catecholamine stress responses to the Laryngeal Tube-Suction Airway and the Proseal Laryngeal Mask Airway.

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    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1365-2044.2006.04548.x

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  • Harold King. A notable contributor to anaesthesia.

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    pub_type: 传,历史文章,杂志文章

    doi:10.1111/j.1365-2044.1991.tb09723.x

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    pub_type: 临床试验,杂志文章,随机对照试验

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    更新日期:1982-09-01 00:00:00

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    pub_type: 临床试验,杂志文章,随机对照试验

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    pub_type: 临床试验,杂志文章,随机对照试验

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