Harold King. A notable contributor to anaesthesia.

Abstract:

:Harold King was an analytical chemist of distinction, who worked with Sir Henry Dale and his colleagues in the Medical Research Institute, later the Medical Research Council. He helped to quash the theory that the anaesthetic action of ether was attributable to its impurities. Interest in alkaloids led to the elucidation of the structure of hyoscine, the synthesis of muscarine and the first isolation of crystalline tubocurarine for which he proposed a structural formula, work which influenced Bovet in the synthesis of gallamine. He proposed the synthesis of the homologous series of methonium compounds which included relaxant and hypotensive drugs. His collaboration with Rosenheim was outstanding and opened the way for synthesis of cholesterol and the steroids. He was always encouraging clinicians, and gave a sample of tubocurarine to Ranyard West who was the first to inject d-tubocurarine into a human patient.

journal_name

Anaesthesia

journal_title

Anaesthesia

authors

Gray TC

doi

10.1111/j.1365-2044.1991.tb09723.x

subject

Has Abstract

pub_date

1991-08-01 00:00:00

pages

679-82

issue

8

eissn

0003-2409

issn

1365-2044

journal_volume

46

pub_type

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