Abstract:
:Harold King was an analytical chemist of distinction, who worked with Sir Henry Dale and his colleagues in the Medical Research Institute, later the Medical Research Council. He helped to quash the theory that the anaesthetic action of ether was attributable to its impurities. Interest in alkaloids led to the elucidation of the structure of hyoscine, the synthesis of muscarine and the first isolation of crystalline tubocurarine for which he proposed a structural formula, work which influenced Bovet in the synthesis of gallamine. He proposed the synthesis of the homologous series of methonium compounds which included relaxant and hypotensive drugs. His collaboration with Rosenheim was outstanding and opened the way for synthesis of cholesterol and the steroids. He was always encouraging clinicians, and gave a sample of tubocurarine to Ranyard West who was the first to inject d-tubocurarine into a human patient.
journal_name
Anaesthesiajournal_title
Anaesthesiaauthors
Gray TCdoi
10.1111/j.1365-2044.1991.tb09723.xsubject
Has Abstractpub_date
1991-08-01 00:00:00pages
679-82issue
8eissn
0003-2409issn
1365-2044journal_volume
46pub_type
传,历史文章,杂志文章相关文献
ANAESTHESIA文献大全abstract::A survey of nurses and anaesthetists in a 500-bed teaching hospital set out to discover how they located a drug container in order to read its label and verify its contents. Members of each group assessed the value of seven factors thought to help in this location and answered questions on personal errors in drug admi...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1111/j.1365-2044.1982.tb01063.x
更新日期:1982-02-01 00:00:00
abstract::Postmortem specimens of 10 patients who had received continuous epidural anaesthesia postoperatively (ranging from 2-21 days) were examined. Slight epidural haemorrhage was observed in six patients and a macroscopically visible haematoma in a thrombocytopenic patient. Nonspecific epidural inflammatory reactions were o...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1111/j.1365-2044.1990.tb14775.x
更新日期:1990-05-01 00:00:00
abstract::Anatomical, neurological and behavioural research has suggested differences between the brains of right- and non-right-handed individuals, including differences in brain structure, electroencephalogram patterns, explicit memory and sleep architecture. Some studies have also found decreased longevity in left-handed ind...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1111/anae.12676
更新日期:2014-08-01 00:00:00
abstract::Serratus anterior plane and pectoral nerves blocks are recently described alternatives to established regional anaesthesia techniques in cardiac surgery, thoracic surgery and trauma. We performed a systematic review to establish the current state of evidence for the analgesic role of these fascial plane blocks in thes...
journal_title:Anaesthesia
pub_type: 杂志文章,meta分析
doi:10.1111/anae.15000
更新日期:2020-10-01 00:00:00
abstract::Alkalinisation of local anaesthetic drugs is a controversial technique for improving regional blockade. Forty-two patients scheduled for upper limb surgery received axillary brachial plexus anaesthesia using a cannula technique. Patients were randomly allocated to receive either lignocaine 1.5% with 1 in 200,000 adren...
journal_title:Anaesthesia
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1365-2044.1996.tb07712.x
更新日期:1996-02-01 00:00:00
abstract::A review is presented of animal studies of the selective steroidal neuromuscular blocking drug binding agent sugammadex. These studies demonstrate that sugammadex is faster in onset than the currently used acetylcholinesterase inhibitors, has no muscarinic effects, and is characterised by lack of adverse effects on ot...
journal_title:Anaesthesia
pub_type: 杂志文章,评审
doi:10.1111/j.1365-2044.2008.05869.x
更新日期:2009-03-01 00:00:00
abstract::We assessed the resistance to air flow in four commonly used air inlets. The Avon A81 and Codan air inlets provide the least resistance to flow, followed by the Baxter CO413 and lastly the Braun air inlet. The presence of a valve confers an advantage when rapid infusion of fluid is attempted. The valve in the Codan ai...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1111/j.1365-2044.1994.tb14233.x
更新日期:1994-07-01 00:00:00
abstract::Using target-controlled infusions (TCI) we aimed to determine the most appropriate dose of remifentanil required for intubation, using a steady effect-site concentration of propofol and without the use of neuromuscular blocking drugs. Sixty ASA III patients presenting for elective surgery were randomly allocated to on...
journal_title:Anaesthesia
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1046/j.1365-2044.2002.02624_3.x
更新日期:2002-12-01 00:00:00
abstract::One hundred patients undergoing microsurgery of the ear were anaesthetised using thiopentone, nitrous oxide, oxygen and either halothane or enflurane with spontaneous respiration. Blood pressure was reduced to approximately 70 mmHg by the use of hypotensive agents. The efficacy of halothane and enflurane in producing ...
journal_title:Anaesthesia
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1365-2044.1982.tb01718.x
更新日期:1982-10-01 00:00:00
abstract::Loop diuretics remain a fundamental pharmacological therapy to remove excess fluid and improve symptom control in acute decompensated heart failure. Several recent randomised controlled trials have examined the clinical benefit of continuous vs. bolus furosemide in acute decompensated heart failure, but have reported ...
journal_title:Anaesthesia
pub_type: 杂志文章,meta分析
doi:10.1111/anae.14038
更新日期:2018-02-01 00:00:00
abstract::Some of the acute metabolic derangements of unstable diabetes have been discussed. The management of patients undergoing surgical operations has also been considered. No problems are usually encountered in diabetic patients treated with diet alone or with oral hypoglycaemic compounds, although chlorpropamide may need ...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1111/j.1365-2044.1975.tb00900.x
更新日期:1975-07-01 00:00:00
abstract::Various antacid or antisecretory agents are used to reduce the risk to patients of aspiration of gastric contents during general anaesthesia and a trial of the gastric proton pump inhibitor, omeprazole, is reported here. Twenty women admitted for elective Caesarean section under general anaesthesia received a single 8...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1111/j.1365-2044.1989.tb11441.x
更新日期:1989-07-01 00:00:00
abstract::Extradural analgesia is well established for relief of pain but in certain cases unusual difficulties may be encountered. We report our experiences of a patient with congenital ichthyosis who required extradural analgesia for the relief of pain in labour. ...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1111/j.1365-2044.1984.tb09507.x
更新日期:1984-02-01 00:00:00
abstract::Two patients with dystrophia myotonica presented for urgent Caesarean section. Their per- and postoperative courses illustrate the anaesthetic problems posed by this disease. Respiratory difficulties are compounded by pregnancy and there is increased susceptibility to uterine haemorrhage. Choice of anaesthetic agent i...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1111/j.1365-2044.1990.tb14498.x
更新日期:1990-01-01 00:00:00
abstract::A postal questionnaire survey was carried out to determine the activities, motivation and barriers to continuing medical education amongst career grade anaesthetists in Scotland. Four hundred and ten consultants and 49 non-consultant career grade anaesthetists were surveyed with a response rate of 84.5%. All responden...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1046/j.1365-2044.2000.01615.x
更新日期:2000-12-01 00:00:00
abstract::We have proposed an equation for estimating the real-time mixed venous blood concentration (MVBC) of isoflurane in cardiac anaesthesia. However, information related to the application of our method to sevoflurane is lacking. We studied 12 patients undergoing cardiac surgery and anaesthetised with sevoflurane. At diffe...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1111/j.1365-2044.2005.04280.x
更新日期:2005-09-01 00:00:00
abstract::The admission of patients with acquired immune deficiency syndrome (AIDS) to intensive care units in the United Kingdom was surveyed in January 1986. Ninety-three intensive care units completed the questionnaire. Thirty-two patients had been admitted to 12 units up to that time. Twenty-five (78%) of these patients had...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1111/j.1365-2044.1988.tb05487.x
更新日期:1988-02-01 00:00:00
abstract::A case report of biliary colic induced by narcotic premedication and reversed by naloxone administration is described and the literature reviewed. ...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1111/j.1365-2044.1986.tb12960.x
更新日期:1986-11-01 00:00:00
abstract::We investigated whether magnesium sulphate combined with rocuronium priming shortens the onset of neuromuscular blockade, compared with these methods used alone. Ninety-two patients scheduled for general anaesthesia were randomly allocated to one of four groups: controls were given 0.6 mg.kg(-1) rocuronium; patients i...
journal_title:Anaesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1365-2044.2012.07102.x
更新日期:2012-07-01 00:00:00
abstract::Target controlled infusion (TCI) pumps function using a programme based on a pharmacokinetic/pharmacodynamic model. We compared the Marsh and Schnider models to find out which better correlates with the clinically observed effect of propofol as assessed by the Observer Assessment of Alertness/Sedation (OAAS) score and...
journal_title:Anaesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1365-2044.2007.05059.x
更新日期:2007-07-01 00:00:00
abstract::The C-MAC comprises a Macintosh blade connected to a video unit. The familiarity of the Macintosh blade, and the ability to use the C-MAC as a direct or indirect laryngoscope, may be advantageous. We wished to compare the C-MAC with Macintosh, Glidescope and Airtraq laryngoscopes in easy and simulated difficult laryng...
journal_title:Anaesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1365-2044.2010.06307.x
更新日期:2010-05-01 00:00:00
abstract::The 50% and 95% effective doses of desflurane for removal of the classic laryngeal mask airway after suction of the upper airway, in anaesthetised spontaneously breathing adult patients, are not known. To determine these, we studied 38 healthy patients, aged between 18 and 44 years. The target desflurane concentration...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1111/j.1365-2044.2011.06620.x
更新日期:2011-04-01 00:00:00
abstract::We studied seven analytical methods of estimating the plasma volume from the decay curves of indocyanine green. Fifteen volunteers received 1.0 mg.kg-1 of the dye by intravenous injection and the plasma concentration was measured continuously using spectrophotometry. Plasma volumes were calculated using three single-r...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1111/j.1365-2044.1997.249-az0389.x
更新日期:1997-12-01 00:00:00
abstract::The Mental Capacity Act 2005 is due to come into force in April 2007. The Act provides a protective statutory framework for decision-making on behalf of incompetent adults, representing, in the main, a codification of the common law that had already developed in this area. For example, 'advance decisions' are now give...
journal_title:Anaesthesia
pub_type: 杂志文章,评审
doi:10.1111/j.1365-2044.2006.04533.x
更新日期:2006-04-01 00:00:00
abstract::Posterior transversus abdominis plane blocks have been reported to be an effective method of providing analgesia after lower abdominal surgery. We compared the efficacy of a novel technique of providing continuous transversus abdominis plane analgesia with epidural analgesia in patients on an enhanced recovery program...
journal_title:Anaesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1111/anae.12546
更新日期:2014-04-01 00:00:00
abstract::A fit 27-year-old man presented with severe facial trauma following an industrial accident. Initial assessment showed severe swelling around the lower jaw and haemorrhage from the mouth, nose, scalp and left ear. The patient was conscious with a Glasgow Coma Score of 13 but in respiratory distress. Following adoption ...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1111/j.1365-2044.1996.tb15004.x
更新日期:1996-11-01 00:00:00
abstract::A non-invasive technique of measuring cardiac output changes is described and studies of its accuracy and reproducibility are reviewed. Cardiac output changes in 11 patients undergoing Caesarean section under general anaesthesia were measured with this technique. Increases in cardiac output after induction and commenc...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1111/j.1365-2044.1982.tb01097.x
更新日期:1982-03-01 00:00:00
abstract::A continuous infusion of ketamine, following an initial dose of 1 mg/kg, has been used as sole anaesthetic in over 200 adult patients. The pre-operative use of 4 mg lorazepam has made this acceptable with respect to emergence sequelae and dreams. The technique can be used with neuromuscular blocking drugs and controll...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1111/j.1365-2044.1978.tb12414.x
更新日期:1978-04-01 00:00:00
abstract::Sixty patients, scheduled for Caesarean section were randomly allocated to receive by the epidural route in a double-blind fashion one of the following patient-controlled analgesia mixtures for the relief of postoperative pain: sufentanil 2 micrograms.ml-1 in 0.9% sodium chloride, sufentanil 2 micrograms.ml-1 + adrena...
journal_title:Anaesthesia
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1365-2044.1994.tb04447.x
更新日期:1994-09-01 00:00:00
abstract::The incidence severity, and degree of relief obtained from treatment has been estimated and evaluated in 117 patients suffering from terminal cancer. ...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1111/j.1365-2044.1977.tb10026.x
更新日期:1977-07-01 00:00:00