Abstract:
:We have proposed an equation for estimating the real-time mixed venous blood concentration (MVBC) of isoflurane in cardiac anaesthesia. However, information related to the application of our method to sevoflurane is lacking. We studied 12 patients undergoing cardiac surgery and anaesthetised with sevoflurane. At different time points, pulmonary arterial blood samples were collected for gas chromatography-mass spectrometry (GC-MS) to determine the real mixed venous concentrations of sevoflurane. The inspired and expired concentrations of sevoflurane, measured by a gas monitor, were used for the MVBC calculations. Using Bland-Altman analyses, we found that the calculated MVBCs accurately represent the actual concentrations of sevoflurane in pulmonary arterial blood, as shown by a near-zero percentage bias with a 0.14% precision between the two concentrations. The results demonstrated that our equation could be a useful method for estimating the pulmonary blood concentration of sevoflurane.
journal_name
Anaesthesiajournal_title
Anaesthesiaauthors
Ho WM,Hung WT,Wu CC,Shen CH,Yang NC,Hwang KL,Wong KCdoi
10.1111/j.1365-2044.2005.04280.xsubject
Has Abstractpub_date
2005-09-01 00:00:00pages
882-6issue
9eissn
0003-2409issn
1365-2044pii
ANA4280journal_volume
60pub_type
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