Application of MVBC equation to predict mixed venous blood concentrations of sevoflurane in cardiac anaesthesia.

Abstract:

:We have proposed an equation for estimating the real-time mixed venous blood concentration (MVBC) of isoflurane in cardiac anaesthesia. However, information related to the application of our method to sevoflurane is lacking. We studied 12 patients undergoing cardiac surgery and anaesthetised with sevoflurane. At different time points, pulmonary arterial blood samples were collected for gas chromatography-mass spectrometry (GC-MS) to determine the real mixed venous concentrations of sevoflurane. The inspired and expired concentrations of sevoflurane, measured by a gas monitor, were used for the MVBC calculations. Using Bland-Altman analyses, we found that the calculated MVBCs accurately represent the actual concentrations of sevoflurane in pulmonary arterial blood, as shown by a near-zero percentage bias with a 0.14% precision between the two concentrations. The results demonstrated that our equation could be a useful method for estimating the pulmonary blood concentration of sevoflurane.

journal_name

Anaesthesia

journal_title

Anaesthesia

authors

Ho WM,Hung WT,Wu CC,Shen CH,Yang NC,Hwang KL,Wong KC

doi

10.1111/j.1365-2044.2005.04280.x

subject

Has Abstract

pub_date

2005-09-01 00:00:00

pages

882-6

issue

9

eissn

0003-2409

issn

1365-2044

pii

ANA4280

journal_volume

60

pub_type

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