Abstract:
:There is currently no consensus regarding how to intervene in anaesthetic-induced hypotension. Whether or not the balance between cerebral oxygen supply and demand is maintained lacks adequate elucidation. It is thus intriguing to explore how cerebral tissue oxygen saturation is affected by anaesthetic-induced hypotension. Thirty-three patients scheduled for elective non-neurosurgical procedures were included in this study. Physiological measurements were performed immediately before induction with propofol and fentanyl and after tracheal intubation. Mean (SD) Bispectral index decreased from 84.3 (9.3) to 24.4 (8.0) (p<0.001). Mean arterial pressure decreased from 84.4 (10.6) mmHg to 53.6 (11.4) mmHg (p<0.001). However, cerebral tissue oxygen saturation remained stable (67.0 (9.4) % vs 67.5 (7.8) %, p=0.6). These results imply that the fine balance between cerebral oxygen supply and demand is not disrupted by anaesthetic-induced hypotension. An interpretation based on neurovascular coupling and cerebral autoregulation is proposed.
journal_name
Anaesthesiajournal_title
Anaesthesiaauthors
Meng L,Gelb AW,McDonagh DLdoi
10.1111/anae.12254subject
Has Abstractpub_date
2013-07-01 00:00:00pages
736-41issue
7eissn
0003-2409issn
1365-2044journal_volume
68pub_type
杂志文章相关文献
ANAESTHESIA文献大全abstract::The management of a case of status asthmaticus complicated by surgical emphysema is described. In view of voice changes, intubation was necessary but intermittent positive pressure ventilation was considered unwise, because of the surgical emphysema. A means of maintaining adequate sedation in an intubated patient whi...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1111/j.1365-2044.1982.tb01312.x
更新日期:1982-07-01 00:00:00
abstract::Coagulopathy in patients with traumatic brain injury is associated with an increase in morbidity and mortality. Although timely and aggressive treatment of coagulopathy is of paramount importance, excessive transfusion of blood products has been linked with poor long-term outcomes in patients with traumatic brain inju...
journal_title:Anaesthesia
pub_type: 杂志文章,多中心研究
doi:10.1111/anae.14670
更新日期:2019-07-01 00:00:00
abstract::We tried to determine if a blood conservation pressure transducer system reduced blood transfusions, increased haemoglobin concentration or reduced line infections in critically ill patients. One hundred patients were randomly allocated to conventional or blood conserving systems attached to systemic and pulmonary art...
journal_title:Anaesthesia
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1046/j.1365-2044.2000.01129.x
更新日期:2000-01-01 00:00:00
abstract::We assessed adequacy of ventilation in 20 critically ill patients with multiple organ failure using a Pneupac Ventipac portable ventilator and the effects on patients' haemodynamic stability. Baseline data were recorded over 15 min for a range of respiratory, haemodynamic and oxygen transport variables during ventilat...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1046/j.1365-2044.2001.02219.x
更新日期:2001-11-01 00:00:00
abstract::A case is presented in which the inhalation of a foreign body caused a respiratory arrest and was subsequently diagnosed and treated as an attack of acute asthma. The presentation, diagnosis, investigation and treatment of this condition is discussed and a review of the literature is presented. ...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1111/j.1365-2044.1986.tb13177.x
更新日期:1986-02-01 00:00:00
abstract::We evaluated a new, ultra-fast response continuous cardiac output monitor in 34 adult patients undergoing off-pump coronary artery bypass graft surgery. Cardiac output was measured with the TruCCOMS continuous cardiac output monitor (Aortech International plc, Lanarkshire, UK), using triplicate cold bolus thermodiluti...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1111/j.1365-2044.2004.03668.x
更新日期:2004-04-01 00:00:00
abstract::An anaesthetic technique for unpremedicated patients undergoing minor surgery is described. After the administration of atropine and fentanyl, anaesthesia was induced with methohexitone and maintained with nitrous oxide supplemented when necessary by further small doses of methohexitone. This technique provided good o...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1111/j.1365-2044.1977.tb11595.x
更新日期:1977-02-01 00:00:00
abstract::We conducted a postal survey of cardiac anaesthetists in the UK, to determine the extent of magnesium sulphate (MgSO4) use and the main indications for its administration. Questionnaires were sent to anaesthetists at 35 UK hospitals undertaking adult cardiac surgery. Responses were received from 24 hospitals (69%) tot...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1046/j.1365-2044.2003.03082_1.x
更新日期:2003-04-01 00:00:00
abstract::We describe the management and recovery of a 28-year-old man following a history of overdose by nasal inhalation of cocaine. The patient was presented in a comatose state suffering from seizures and marked cardiovascularly instability. Intravenous lipid emulsion was administered following initial resuscitation and tra...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1111/j.1365-2044.2011.06895.x
更新日期:2011-12-01 00:00:00
abstract::The incidence and origin of contamination of the vocal cords in 53 trauma patients was studied when tracheal intubation was performed before hospital admission. Eighteen patients (34%) had gross contamination which was blood in 15 patients and gastric contents in three patients. This has implications for prehospital a...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1046/j.1365-2044.1999.00754.x
更新日期:1999-11-01 00:00:00
abstract::The incidence of pneumothorax in the neonatal period is reviewed. Most infants who developed a pneumothorax were undergoing intermittent positive pressure ventilation. The most common underlying pathology associated with pneumothorax was idiopathic respiratory distress syndrome. This was the only condition in which a ...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1111/j.1365-2044.1983.tb12024.x
更新日期:1983-10-01 00:00:00
abstract::Propofol has been shown to cause pain on injection. This study investigated the effect of warming propofol to 37 degrees C on the pain of intravenous injection. One hundred and one women on outpatient gynaecology lists were allocated to receive propofol either at room temperature or at 37 degrees C. Warming propofol d...
journal_title:Anaesthesia
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1365-2044.1996.tb07802.x
更新日期:1996-05-01 00:00:00
abstract::We compared the predictive performance of the existing Diprifusor and Schnider models, used for target-controlled infusion of propofol, with a new modification of the Diprifusor model (White) incorporating age and sex covariates. The bias and inaccuracy (precision) of each model were determined using computer simulati...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1111/anae.12631
更新日期:2014-06-01 00:00:00
abstract::During the past decade, there has been a dramatic increase in the number of thoracic surgical procedures carried out in the UK. The current financial climate dictates that more efficient use of resources is necessary to meet escalating demands on healthcare. One potential means to achieve this is through the introduct...
journal_title:Anaesthesia
pub_type: 杂志文章,评审
doi:10.1111/anae.12067
更新日期:2013-02-01 00:00:00
abstract::We measured the illumination generated by all 30 Macintosh size 3 laryngoscopes in our department with a lux-meter and a standardised laryngoscope holding tube. We found a large range in illumination generated (65-3130 lx). We then measured the effect on the illumination for each laryngoscope by covering the blade wit...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1046/j.1365-2044.2002.02691.x
更新日期:2002-08-01 00:00:00
abstract::The 'Diprifusor' target controlled infusion system has been developed as a standardised infusion system for the administration of propofol by target controlled infusion. A preferred set of pharmacokinetic parameters for propofol was selected using computer simulation of a known infusion scheme with pharmacokinetic par...
journal_title:Anaesthesia
pub_type: 杂志文章,评审
doi:10.1111/j.1365-2044.1998.53s115.x
更新日期:1998-04-01 00:00:00
abstract::There are numerous possible techniques for delivering local anaesthetic through peripheral nerve catheters. These include continuous infusions, patient-controlled boluses and programmed intermittent boluses. The optimal delivery regimen of local anaesthetic is yet to be conclusively established. In this review, we ide...
journal_title:Anaesthesia
pub_type: 杂志文章,meta分析
doi:10.1111/anae.14864
更新日期:2020-03-01 00:00:00
abstract::Neurotoxicity manifesting as convulsions is a recognised complication of the administration of local anaesthetic drugs as part of a regional anaesthetic technique. We describe a case of self-limiting convulsions following the institution of an axillary brachial plexus block with levobupivacaine. Although the occurrenc...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1046/j.1365-2044.2002.02860.x
更新日期:2002-12-01 00:00:00
abstract::We sought to determine whether the forced air convection warmers (nine Bair Huggers, Augustine Medical, and one Warm Touch, Mallinkrodt Medical) used in our operating theatres could be a source of microbial pathogens. Agar plates were placed directly in the air stream of the warmers. Four of these grew potentially pat...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1111/j.1365-2044.1997.250-az0384.x
更新日期:1997-11-01 00:00:00
abstract::There are conflicting results with regard to the use of catheter-based techniques for continuous paravertebral block. Local anaesthetic spread within the paravertebral space is limited and the clinical effect is often variable. Discrepancies between needle tip position and final catheter position can also be problemat...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1111/j.1365-2044.2011.06988.x
更新日期:2012-03-01 00:00:00
abstract::We studied the repeated effect of sterilisation on light intensity in laryngoscopes from Penlon, Riester, Heine (two different blades), Medicon and Upsher. Light intensity was measured by a light meter using two methods. Measurements were performed before the decontamination procedure was carried out and subsequently ...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1046/j.1365-2044.1999.00948.x
更新日期:1999-09-01 00:00:00
abstract::A case is described in which a woman with well controlled epilepsy and minor abnormalities of peripheral nerve function in the lower limbs experienced intense pain during the onset of a spinal anaesthetic for operation on burns on her thighs. Possible mechanisms and treatments are discussed. ...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1111/j.1365-2044.1990.tb14335.x
更新日期:1990-06-01 00:00:00
abstract::The effect of subhypnotic doses of propofol on intrathecal morphine-induced pruritus was studied in a prospective, randomly allocated, double-blind controlled trial. Fifty-eight women undergoing elective lower segment Caesarean section for a singleton fetus received spinal anaesthesia with 2.5 ml hyperbaric 0.5% bupiv...
journal_title:Anaesthesia
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1365-2044.1997.069-az0060.x
更新日期:1997-03-01 00:00:00
abstract::We assessed the effectiveness of early patient-controlled oral analgesia compared with parenteral analgesia in a randomised controlled non-inferiority trial of women undergoing elective caesarean section under regional anaesthesia. Seventy-seven women received multimodal paracetamol, ketoprofen and morphine analgesia....
journal_title:Anaesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1111/anae.13406
更新日期:2016-05-01 00:00:00
abstract::This prospective, observational study explored the need for pain-related unscheduled contact with healthcare services after outpatient surgery. We hypothesised that 10% of outpatients would have pain-related unscheduled contact with healthcare services, and that the incidence would differ depending on the type of surg...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1111/anae.13876
更新日期:2017-07-01 00:00:00
abstract::Sixty patients, scheduled for Caesarean section were randomly allocated to receive by the epidural route in a double-blind fashion one of the following patient-controlled analgesia mixtures for the relief of postoperative pain: sufentanil 2 micrograms.ml-1 in 0.9% sodium chloride, sufentanil 2 micrograms.ml-1 + adrena...
journal_title:Anaesthesia
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1365-2044.1994.tb04447.x
更新日期:1994-09-01 00:00:00
abstract::Pre-operative anaemia is associated with poor outcomes after elective surgery but its relationship with outcomes after emergency surgery is unclear. We analysed National Emergency Laparotomy Audit data from 1 December 2013 to 30 November 2017, excluding laparotomy for haemorrhage. Anaemia was classified as 'mild' 129-...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1111/anae.15021
更新日期:2020-07-01 00:00:00
abstract::Artificial nasopharyngeal airway position and performance were assessed in 120 anaesthetised adult patients. Using a fibreoptic laryngoscope mean distances from nares to larynx were measured at 209 mm (SD 11) in males and 180 mm (SD 11) in females; those from nares to epiglottis were 159 mm (SD 12) in males and 140 mm...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1111/j.1365-2044.1993.tb07119.x
更新日期:1993-07-01 00:00:00
abstract::Various methods by which the Cape Minor ventilator may be used in the circle absorber system are described and the problems of the circuits described are considered. A new valve system is described which overcomes most of the problems encountered with other circuits. The economic advantages of an inexpensive ventilato...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1111/j.1365-2044.1978.tb08327.x
更新日期:1978-11-01 00:00:00
abstract::Halothane hepatitis is extremely rare in childhood. However, this occurred in an 11-month-old infant, following multiple exposure to halothane. The diagnosis was confirmed by detection of specific antibodies to halothane-sensitised rabbit hepatocytes. The anaesthetic technique for a subsequent procedure with a halotha...
journal_title:Anaesthesia
pub_type: 杂志文章
doi:10.1111/j.1365-2044.1986.tb13053.x
更新日期:1986-06-01 00:00:00