A comparison of the predictive performance of three pharmacokinetic models for propofol using measured values obtained during target-controlled infusion.

Abstract:

:We compared the predictive performance of the existing Diprifusor and Schnider models, used for target-controlled infusion of propofol, with a new modification of the Diprifusor model (White) incorporating age and sex covariates. The bias and inaccuracy (precision) of each model were determined using computer simulation to replicate the infusion profiles in an earlier study of 41 patients undergoing surgery with propofol administered by target-controlled infusion and in which timed, measured blood propofol concentrations were available. Bias with the White model (5%) was significantly less (p < 0.0001) than with the Diprifusor (16%) or Schnider (15%) models. The White model showed a significant improvement in accuracy (inaccuracy 19%, p < 0.0001) relative to the Diprifusor (26%). Temporal changes were such that with all three models, bias differed at induction and recovery. None of the models accounted fully for the extent of inter-individual variation in propofol clearance, but the improved performance with the White model suggests it has merit.

journal_name

Anaesthesia

journal_title

Anaesthesia

authors

Glen JB,White M

doi

10.1111/anae.12631

subject

Has Abstract

pub_date

2014-06-01 00:00:00

pages

550-7

issue

6

eissn

0003-2409

issn

1365-2044

journal_volume

69

pub_type

杂志文章
  • Effect of perioperative steroids on renal function after liver transplantation.

    abstract::Subclinical renal dysfunction is thought to occur as a systemic manifestation of ischaemia-reperfusion injury of other organs. Liver transplantation is associated with major ischaemia-reperfusion injury. Thirty-four patients undergoing elective liver transplantation were randomly allocated to receive either saline or ...

    journal_title:Anaesthesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1365-2044.2006.04532.x

    authors: Turner S,Dhamarajah S,Bosomworth M,Bellamy MC,Leeds Liver Transplant Group.

    更新日期:2006-03-01 00:00:00

  • Initial experience with Minaxolone. A water-soluble steroid intravenous anaesthetic agent.

    abstract::Minaxolone has been used to induce anaesthesia, and in incremental doses to supplement nitrous oxide, in 100 patients undergoing minor surgical procedures. Half the patients received a small dose of fentanyl before induction. Minaxolone proved to be a satisfactory induction agent. The commonest complications were an i...

    journal_title:Anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1365-2044.1980.tb03805.x

    authors: Punchihewa VG,Morgan M,Lumley J,Whitwam JG

    更新日期:1980-02-01 00:00:00

  • Pulmonary embolism. Prophylaxis diagnosis and treatment.

    abstract::The natural history diagnosis and immediate treatment of patients suffering from pulmonary embolism has been discussed. Anaesthetists should use their influence to bring about a high standard of prophylactic care against deep venous thrombosis and consequently of pulmonary embolism. They are likely to be involved in t...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1976.tb11905.x

    authors: Price DG

    更新日期:1976-09-01 00:00:00

  • Profound hypocalcaemia in a patient being anticoagulated with citrate for continuous renal replacement therapy.

    abstract::Citrate, as an anticoagulant for continuous renal replacement therapy in critically ill patients, has some potential advantages over heparin, including a prolonged dialysis filter life and reduced risk of bleeding. The key parameter involved in monitoring the adequacy and safety of citrate anticoagulation during conti...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.2009.06078.x

    authors: Morgan DJ,Ho KM

    更新日期:2009-12-01 00:00:00

  • Conceptual and technical insights into the basis of neuromuscular monitoring.

    abstract::Unrecognised postoperative residual neuromuscular block remains a frequent occurrence in recovery rooms. Evidence indicates that current practice continues to perpetuate the status quo, in which 10-40% of patients experience postoperative residual weakness. A departure from the current practice requires small efforts ...

    journal_title:Anaesthesia

    pub_type: 杂志文章,评审

    doi:10.1111/anae.13738

    authors: Naguib M,Brull SJ,Johnson KB

    更新日期:2017-01-01 00:00:00

  • Pressure support ventilation during isoflurane anaesthesia.

    abstract::We have studied the respiratory effects of 5 and 10 cmH2O pressure support ventilation during anaesthesia with 1.5% end-tidal concentration of isoflurane in nine healthy, spontaneously breathing, adult patients. Some of the patients demonstrated an irregular respiratory pattern with periods of apnoea and we therefore ...

    journal_title:Anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1365-2044.1995.tb05944.x

    authors: Bhatt SB,Chui PT,Gin T,Tam YH,Oh TE

    更新日期:1995-12-01 00:00:00

  • Infusions of propofol to supplement nitrous oxide-oxygen for the maintenance of anaesthesia. A comparison with halothane.

    abstract::The peri-operative and postoperative effects of propofol given by infusion were compared with halothane as a supplement to nitrous oxide-oxygen anaesthesia for body surface surgery in patients who breathed spontaneously. Anaesthesia was induced after opioid premedication, with either propofol 2.5 mg/kg or thiopentone ...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1988.tb09062.x

    authors: Sear JW,Shaw I,Wolf A,Kay NH

    更新日期:1988-03-01 00:00:00

  • Anticipated difficult airway during obstetric general anaesthesia: narrative literature review and management recommendations.

    abstract::We reviewed the literature on management of general and regional anaesthesia in pregnant women with anticipated airway difficulty. We identified 138 publications comprising 158 cases; these either described equipment or techniques for the provision of general anaesthesia, or the management of women with regional analg...

    journal_title:Anaesthesia

    pub_type: 杂志文章,评审

    doi:10.1111/anae.15007

    authors: Mushambi MC,Athanassoglou V,Kinsella SM

    更新日期:2020-07-01 00:00:00

  • Intermittent mandatory ventilation with "Manley" ventilators.

    abstract::A method is described whereby gas powered, minute volume divider, ventilators may be adapted to provide intermittent mandatory ventilation. ...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1976.tb11979.x

    authors: Manson HJ,Ross DG

    更新日期:1976-11-01 00:00:00

  • All that wheezes is not asthma.

    abstract::A case is presented in which the inhalation of a foreign body caused a respiratory arrest and was subsequently diagnosed and treated as an attack of acute asthma. The presentation, diagnosis, investigation and treatment of this condition is discussed and a review of the literature is presented. ...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1986.tb13177.x

    authors: Lloyd-Thomas AR,Bush GH

    更新日期:1986-02-01 00:00:00

  • The Mental Capacity Act 2005--implications for anaesthesia and critical care.

    abstract::The Mental Capacity Act 2005 is due to come into force in April 2007. The Act provides a protective statutory framework for decision-making on behalf of incompetent adults, representing, in the main, a codification of the common law that had already developed in this area. For example, 'advance decisions' are now give...

    journal_title:Anaesthesia

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2044.2006.04533.x

    authors: White SM,Baldwin TJ

    更新日期:2006-04-01 00:00:00

  • Patient-controlled oral analgesia versus nurse-controlled parenteral analgesia after caesarean section: a randomised controlled trial.

    abstract::We assessed the effectiveness of early patient-controlled oral analgesia compared with parenteral analgesia in a randomised controlled non-inferiority trial of women undergoing elective caesarean section under regional anaesthesia. Seventy-seven women received multimodal paracetamol, ketoprofen and morphine analgesia....

    journal_title:Anaesthesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/anae.13406

    authors: Bonnal A,Dehon A,Nagot N,Macioce V,Nogue E,Morau E

    更新日期:2016-05-01 00:00:00

  • Hypercholinesterasaemia and suxamethonium resistance.

    abstract::A case is reported of resistance to the muscle relaxing action of suxamethonium due to the rare inherited condition of hypercholinesterasaemia. Family studies suggest dominant inheritance. It is suggested the condition should be considered whenever there is unexpected resistance to the muscle relaxing action of suxame...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1987.tb04110.x

    authors: Warran P,Theeman M,Bold AM,Jones S

    更新日期:1987-08-01 00:00:00

  • A national survey of safe practice with epidural analgesia in obstetric units.

    abstract::The National Patient Safety Agency (NPSA) identified practice improvements with regard to epidural injections and infusions and released a patient safety alert on 28th March 2007. Prior to this, the Obstetric Anaesthetists' Association had considered the draft document and wished to assess current compliance in UK obs...

    journal_title:Anaesthesia

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1365-2044.2007.05398.x

    authors: Jones R,Swales HA,Lyons GR

    更新日期:2008-05-01 00:00:00

  • An international consensus statement on the management of postoperative anaemia after major surgical procedures.

    abstract::Despite numerous guidelines on the management of anaemia in surgical patients, there is no pragmatic guidance for the diagnosis and management of anaemia and iron deficiency in the postoperative period. A number of experienced researchers and clinicians took part in a two-day expert workshop and developed the followin...

    journal_title:Anaesthesia

    pub_type: 共识发展会议,杂志文章,评审

    doi:10.1111/anae.14358

    authors: Muñoz M,Acheson AG,Bisbe E,Butcher A,Gómez-Ramírez S,Khalafallah AA,Kehlet H,Kietaibl S,Liumbruno GM,Meybohm P,Rao Baikady R,Shander A,So-Osman C,Spahn DR,Klein AA

    更新日期:2018-11-01 00:00:00

  • Automatic ventilation with the Ayre's T-piece. A modification of the Nuffield Series 200 ventilator for neonatal and paediatric use.

    abstract::A simple modification to an existing adult ventilator has been designed to permit mechanical ventilation of neonates and small children with the Ayre's T-piece circuit. The Nuffield Anaesthesia Ventilator Series 200 has been modified by replacing the piston in the patient valve with a fixed leak. This arrangement avoi...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1981.tb08595.x

    authors: Newton NI,Hillman KM,Varley JG

    更新日期:1981-01-01 00:00:00

  • Pain on injection of propofol: the effect of injectate temperature.

    abstract::A double-blind, randomised clinical study was undertaken to compare the effect of temperature on the incidence and severity of the pain experienced on injection of propofol. The number of patients who experienced pain and the severity of the pain were reduced significantly when propofol was administered at a temperatu...

    journal_title:Anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1365-2044.1990.tb14329.x

    authors: McCrirrick A,Hunter S

    更新日期:1990-06-01 00:00:00

  • The effect of the European Working Time Directive on anaesthetic working patterns and training.

    abstract::There is concern that the European Working Time Directive 2009 has led to reduced time available for training, and this study examined if this has been the case. For two identical six-month periods in 1999 (pre-Directive) and 2009 (post-Directive), weekly data were collected on the total number of sessions attended by...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.2012.07227.x

    authors: Paul RG,Bunker N,Fauvel NJ,Cox M

    更新日期:2012-09-01 00:00:00

  • Pulmonary shunts in the prone position.

    abstract::Pulmonary shunting (Qs/Qt with the FIO2 = 1) was determined in ten young healthy non-obese patients prior to anaesthesia, 30 min after induction in the supine position and 1 h later during surgery in the prone position. Respiration was spontaneous in awake patients and was controlled following the induction of anaesth...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1978.tb08387.x

    authors: Stone JG,Khambatta HJ

    更新日期:1978-06-01 00:00:00

  • Impact of caudal block on postoperative complications in children undergoing tubularised incised plate urethroplasty for hypospadias repair: a retrospective cohort study.

    abstract::This study aimed to assess the association between caudal block and postoperative complications after tubularised incised plate urethroplasty. The medical records of 388 paediatric patients who underwent urethroplasty at a tertiary medical centre were analysed retrospectively. Among the 342 patients included, 216 pati...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/anae.13463

    authors: Kim MH,Im YJ,Kil HK,Han SW,Joe YE,Lee JH

    更新日期:2016-07-01 00:00:00

  • The effect of celecoxib on intrathecal morphine-induced pruritus in patients undergoing Caesarean section.

    abstract::Pruritus associated with intrathecal opioid administration is particularly common in pregnancy. Nonsteroidal anti-inflammatory drugs (NSAIDs) can reduce the severity of this pruritus but have undesirable side effects. The recent development of drugs that can specifically inhibit the cyclooxygenase 2 isoenzyme have bec...

    journal_title:Anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1365-2044.2004.03797.x

    authors: Lee LH,Irwin MG,Lim J,Wong CK

    更新日期:2004-09-01 00:00:00

  • Plasma volume estimation using indocyanine green with biexponential regression analysis of the decay curves.

    abstract::We studied seven analytical methods of estimating the plasma volume from the decay curves of indocyanine green. Fifteen volunteers received 1.0 mg.kg-1 of the dye by intravenous injection and the plasma concentration was measured continuously using spectrophotometry. Plasma volumes were calculated using three single-r...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1997.249-az0389.x

    authors: Sekimoto M,Fukui M,Fujita K

    更新日期:1997-12-01 00:00:00

  • Ropivacaine in ultrasound-guided femoral nerve block: what is the minimal effective anaesthetic concentration (EC90)?

    abstract::The objective of this study was to estimate the minimal effective anaesthetic concentrations of ropivacaine required to block the femoral nerve in 90% of patients. Forty-five patients who had knee surgery received ultrasound-guided femoral nerve block using 15 ml ropivacaine. The ropivacaine concentration given to a p...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/anae.12607

    authors: Taha AM,Abd-Elmaksoud AM

    更新日期:2014-07-01 00:00:00

  • An unusual complication of lithotripsy.

    abstract::The case described illustrates a most unusual course of events due to a perforation in the wall of the bladder during transurethral lithotripsy. Irrigation fluid forced its way retroperitoneally to the mediastinum. The differential diagnostic problems encountered are discussed. ...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1983.tb12160.x

    authors: Sundnes KO,Vaagenes P,Kvarstein B

    更新日期:1983-07-01 00:00:00

  • Evaluation of the Datex 'Normac' anaesthetic agent monitor.

    abstract::The Datex 'Normac' infrared anaesthetic agent monitor has been evaluated for accuracy of calibration, stability and speed of response. Accuracy was assessed by comparing with a gas chromatograph calibrated using volumetric standards and was found to be very good for isoflurane and enflurane but was slightly less accur...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1985.tb10895.x

    authors: Luff NP,White DC

    更新日期:1985-06-01 00:00:00

  • Halothane hepatitis in an 11-month-old child.

    abstract::Halothane hepatitis is extremely rare in childhood. However, this occurred in an 11-month-old infant, following multiple exposure to halothane. The diagnosis was confirmed by detection of specific antibodies to halothane-sensitised rabbit hepatocytes. The anaesthetic technique for a subsequent procedure with a halotha...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1986.tb13053.x

    authors: Whitburn RH,Sumner E

    更新日期:1986-06-01 00:00:00

  • Heart rate variability as a predictor of hypotension following spinal for elective caesarean section: a prospective observational study.

    abstract::Post-spinal hypotension remains a common and clinically-important problem during caesarean section, and accurate pre-operative prediction of this complication might enhance clinical management. We conducted a prospective, single-centre, observational study of heart rate variability in 102 patients undergoing elective ...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/anae.13813

    authors: Bishop DG,Cairns C,Grobbelaar M,Rodseth RN

    更新日期:2017-05-01 00:00:00

  • Tracheal versus intravenous atropine. A comparison of the effects on heart rate.

    abstract::Atropine 600 micrograms was given either intravenously or intratracheally and the change in heart rate noted in a double-blind, randomised study of 40 anaesthetised patients. There was no significant difference between the two groups in the maximum increase in heart rate, 20.3 beats/minute in the tracheal compared to ...

    journal_title:Anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1365-2044.1987.tb05226.x

    authors: Bray BM,Jones HM,Grundy EM

    更新日期:1987-11-01 00:00:00

  • Cardiopulmonary complications during anaesthesia and surgery for severe thoracic lordoscoliosis.

    abstract::A 15-year old girl underwent a posterior spinal fusion procedure for severe lordoscoliosis. On turning to the prone position acute posture-related upper airway obstruction occurred. During surgery, manipulation of the spine caused several episodes of loss of cardiac output. Retrospective assessment of the pre-operativ...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1995.tb05857.x

    authors: Bagshaw ON,Jardine A

    更新日期:1995-10-01 00:00:00

  • Prospective survey of the use of the laryngeal mask airway in 2359 patients.

    abstract::Patients undergoing anaesthesia in which the laryngeal mask airway was used were prospectively audited over a 6-month period. A simple record sheet was completed at the time of anaesthetic administration and 2359 completed forms were analysed to assess problems encountered with its use. It was used successfully in 235...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1993.tb06794.x

    authors: Verghese C,Smith TG,Young E

    更新日期:1993-01-01 00:00:00