The effect of the addition of lignocaine on propofol emulsion stability.

Abstract:

:The stability of propofol emulsion following the addition of various amounts of lignocaine solution was investigated. The investigations used were macroscopic and microscopic observations and electroacoustic determination of both droplet size and zeta potential. Evidence of emulsion instability was present following the addition of even small amounts of lignocaine. Resultant changes are unlikely to be clinically important following the addition of less than 20 mg of lignocaine to 200 mg of propofol (20 ml of propofol emulsion). It is recommended, however, that anaesthetists consider the possibility of destabilisation of propofol emulsion when adding larger doses of lignocaine, or when there is a delay between formulation and administration of the propofol-lignocaine mixtures.

journal_name

Anaesthesia

journal_title

Anaesthesia

authors

Lilley EM,Isert PR,Carasso ML,Kennedy RA

doi

10.1111/j.1365-2044.1996.tb12607.x

subject

Has Abstract

pub_date

1996-09-01 00:00:00

pages

815-8

issue

9

eissn

0003-2409

issn

1365-2044

journal_volume

51

pub_type

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