The relationship between the concentration of temazepam in cerebrospinal fluid and sedation in man.

Abstract:

:Twenty-six patients received oral temazepam and subsequently spinal anaesthesia. Blood and lumbar cerebrospinal fluid temazepam levels were measured together with the degree of sedation. The plasma and cerebrospinal fluid concentrations correlated well with the temazepam dose but even better with the weight standardised dose (r = 0.65, p = 0.0003 and r = 0.75, p = 0.00001 respectively). Both the plasma and cerebrospinal fluid concentrations of temazepam were correlated with the patient's sedation (r = 0.42 p = 0.037, and r = 0.46 p = 0.021 respectively), but neither was strong. Thus, although the drug concentration at the receptor may be a major factor in producing sedation, other factors, possibly the receptor population or their responsiveness, are also important contributors.

journal_name

Anaesthesia

journal_title

Anaesthesia

authors

Osborne GA,Badcock NR,McGrath PM,Russell WJ,Frewin DB

doi

10.1111/j.1365-2044.1992.tb02169.x

subject

Has Abstract

pub_date

1992-04-01 00:00:00

pages

303-6

issue

4

eissn

0003-2409

issn

1365-2044

journal_volume

47

pub_type

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