Abstract:
:This study was conducted to determine the efficiency of delivery of drugs injected as boluses by the common routes available during cardiopulmonary bypass. Radioactive technetium (99mTc) was injected in a 50 microCi bolus into the central venous line or into the arterial or venous lines of the oxygenator and its passage monitored downstream by suitable radiation detectors. When injected into the central venous line, delivery was unpredictable and at times 50% or more of the dose may not appear for 5 min. When injected into the venous line of the oxygenator an average 5% of the total dose had not reached the detector during first passage, and had completely cleared at 2 min. No significant difference was found between the different oxygenators and it is concluded that the venous line of the oxygenator is the most efficient site for the achievement of rapid action of drugs.
journal_name
Anaesthesiajournal_title
Anaesthesiaauthors
Kamath BS,Thomson DM,Johnston Bdoi
10.1111/j.1365-2044.1980.tb03952.xsubject
Has Abstractpub_date
1980-09-01 00:00:00pages
908-13issue
9eissn
0003-2409issn
1365-2044journal_volume
35pub_type
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