Abstract:
:Increasing the calculated plasma concentration of propofol has been shown to increase choice reaction time and visual and auditory response times. We studied the relationship of reaction to a vibrating handset as the effect-site target-controlled propofol concentration was incrementally increased in 20 patients during sedation, before induction of general anaesthesia. The reaction time increased, initially slowly and then more rapidly, as the calculated effect-site concentration of propofol increased, until the reaction to the vibrating handset was lost at a mean (SD) propofol effect-site concentration of 2.0 (0.6) μg.ml(-1) . The loss of response to verbal contact occurred at a propofol effect-site concentration of 2.4 (0.5) μg.ml(-1) . Reaction time may be of use clinically to warn of impending loss of verbal contact.
journal_name
Anaesthesiajournal_title
Anaesthesiaauthors
Anderson KJ,Allam S,Chapman R,Kenny GNdoi
10.1111/anae.12035subject
Has Abstractpub_date
2013-02-01 00:00:00pages
148-53issue
2eissn
0003-2409issn
1365-2044journal_volume
68pub_type
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