The effect of propofol on patient reaction time and its relationship with loss of verbal contact before induction of anaesthesia.

Abstract:

:Increasing the calculated plasma concentration of propofol has been shown to increase choice reaction time and visual and auditory response times. We studied the relationship of reaction to a vibrating handset as the effect-site target-controlled propofol concentration was incrementally increased in 20 patients during sedation, before induction of general anaesthesia. The reaction time increased, initially slowly and then more rapidly, as the calculated effect-site concentration of propofol increased, until the reaction to the vibrating handset was lost at a mean (SD) propofol effect-site concentration of 2.0 (0.6) μg.ml(-1) . The loss of response to verbal contact occurred at a propofol effect-site concentration of 2.4 (0.5) μg.ml(-1) . Reaction time may be of use clinically to warn of impending loss of verbal contact.

journal_name

Anaesthesia

journal_title

Anaesthesia

authors

Anderson KJ,Allam S,Chapman R,Kenny GN

doi

10.1111/anae.12035

subject

Has Abstract

pub_date

2013-02-01 00:00:00

pages

148-53

issue

2

eissn

0003-2409

issn

1365-2044

journal_volume

68

pub_type

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