Abstract:
:The reduction in acute pain perception following dextromethorphan has previously been investigated in patients undergoing general anaesthesia. This random and double-blind study examined the effects of pre-incisional oral dextromethorphan on postoperative pain and intravenous patient-controlled morphine demand in 60 day-surgery patients undergoing lower body surgery under lidocaine (1.6%-16 ml) epidural anaesthesia after receiving placebo, 60 or 90 mg dextromethorphan, 90 min pre-operatively. Postoperative pain was scored on a visual analogue scale from 1 to 10. In-hospital observation continued for 6 h and for 3 days at home; diclofenac was available throughout. Dextromethorphan-treated patients reported significantly (p < 0.05) less pain and sedation, and felt better. Patients who received dextromethorphan 90 mg had significantly (p < 0.05) lower heart and respiratory rates than those who received 60 mg. Medicated patients required half the morphine and diclofenac of placebo patients: 38% of patients who received 90 mg and 21% who received dextromethorphan 60 mg used no morphine or diclofenac whatsoever, a previously unreported finding.
journal_name
Anaesthesiajournal_title
Anaesthesiaauthors
Weinbroum AA,Lalayev G,Yashar T,Ben-Abraham R,Niv D,Flaishon Rdoi
10.1046/j.1365-2044.2001.02088.xsubject
Has Abstractpub_date
2001-07-01 00:00:00pages
616-22issue
7eissn
0003-2409issn
1365-2044pii
ana2088journal_volume
56pub_type
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