Estimated costs before, during and after the introduction of the emergency laparotomy pathway quality improvement care (ELPQuIC) bundle.


:Implementation of a quality improvement bundle for peri-operative management of emergency laparotomy (ELPQuIC) improved mortality in a previous study. We used data from one site that participated in that study to examine whether it was associated with the cost of care. We collected data from 396 patients: 144 before, 144 during and 108 after implementation of the bundle. We estimated costs incurred using previously published methodology based on the time the patient spent in hospital, in the operating theatre and in critical care. Duration of stay in hospital and critical care did not differ between time periods, p = 0.14 and p = 0.28, respectively. The costs per patient and per survivor did not differ between the time periods, p = 0.87 and p = 0.17, respectively. Costs were similar for patients aged < 80 years vs. ≥ 80 years. Implementation of a quality improvement bundle for emergency laparotomy has the capacity to save lives without increasing hospital costs.






Eveleigh MO,Howes TE,Peden CJ,Cook TM




Has Abstract


2016-11-01 00:00:00












  • Comparison of analgesic efficacy of four-quadrant transversus abdominis plane (TAP) block and continuous posterior TAP analgesia with epidural analgesia in patients undergoing laparoscopic colorectal surgery: an open-label, randomised, non-inferiority tri

    abstract::Posterior transversus abdominis plane blocks have been reported to be an effective method of providing analgesia after lower abdominal surgery. We compared the efficacy of a novel technique of providing continuous transversus abdominis plane analgesia with epidural analgesia in patients on an enhanced recovery program...


    pub_type: 杂志文章,随机对照试验


    authors: Niraj G,Kelkar A,Hart E,Horst C,Malik D,Yeow C,Singh B,Chaudhri S

    更新日期:2014-04-01 00:00:00

  • Ventricular fibrillation after accidental injection of bupivacaine into the pericardium.

    abstract::A postoperative cardiac surgical patient developed ventricular fibrillation immediately after accidental pericardial injection of bupivacaine at room temperature. The possible causes, which include systemic toxicity, local vasoconstriction with myocardial ischaemia, local toxic effect of bupivacaine or local hypotherm...


    pub_type: 杂志文章


    authors: Even BJ,De Jongh RF,De Hert SG

    更新日期:1992-12-01 00:00:00

  • Peri-operative administration of tranexamic acid in lower limb arthroplasty: a multicentre, prospective cohort study.

    abstract::In the UK, tranexamic acid is recommended for all surgical procedures where expected blood loss exceeds 500 ml. However, the optimal dose, route and timing of administration are not known. This study aimed to evaluate current practice of peri-operative tranexamic acid administration. Patients undergoing primary total ...


    pub_type: 杂志文章,多中心研究


    authors: Lloyd TD,Neal-Smith G,Fennelly J,Claireaux H,Bretherton C,Carr AJ,Murphy M,Kendrick BJ,Palmer AJR,collaborators.

    更新日期:2020-08-01 00:00:00

  • The design and evaluation of a novel low-cost portable ventilator.

    abstract::Modern mechanical ventilator technologies broadly consist of digitally-controlled electronic devices and analogue systems driven by compressed gas sources. Drawbacks such as high cost, complex maintenance and the need for cumbersome sources of compressed driving gas hinder adoption in pre-hospital and low-resource env...


    pub_type: 杂志文章


    authors: Darwood A,McCanny J,Kwasnicki R,Martin B,Jones P

    更新日期:2019-11-01 00:00:00

  • Continuous regional analgesia in comparison with intravenous opioid administration for routine postoperative pain control.

    abstract::This study compares retrospectively the postoperative analgesia provided via intravenous opioids with continuous regional techniques (interpleural and epidural infusions) administered as a clinical routine by an anaesthesia-based Acute Pain Service. In 2630 patients no severe complications resulting in morbidity or mo...


    pub_type: 杂志文章


    authors: Schug SA,Fry RA

    更新日期:1994-06-01 00:00:00

  • Sand aspiration: a case report and review of the radiological features and management.

    abstract::We report a case of severe sand aspiration in association with near-drowning, which led to respiratory failure secondary to the acute respiratory distress syndrome, necessitating mechanical ventilation, repeated therapeutic bronchoscopic lavage, and a stay in the intensive care unit that exceeded one month. ...


    pub_type: 杂志文章


    authors: Appelboam R,Williams MP,Duffy MR

    更新日期:2010-08-01 00:00:00

  • Patient-controlled analgesia--the need for caution. A case report and review of adverse incidents.

    abstract::Respiratory depression and oversedation occurred during the administration of patient-controlled analgesia because of a broken syringe barrel. Possible complications in the use of patient-controlled analgesia are reviewed. These may be because of prescription or provision errors, patient factors or equipment problems....


    pub_type: 杂志文章,评审


    authors: Thomas DW,Owen H

    更新日期:1988-09-01 00:00:00

  • The role of serratus anterior plane and pectoral nerves blocks in cardiac surgery, thoracic surgery and trauma: a qualitative systematic review.

    abstract::Serratus anterior plane and pectoral nerves blocks are recently described alternatives to established regional anaesthesia techniques in cardiac surgery, thoracic surgery and trauma. We performed a systematic review to establish the current state of evidence for the analgesic role of these fascial plane blocks in thes...


    pub_type: 杂志文章,meta分析


    authors: Jack JM,McLellan E,Versyck B,Englesakis MF,Chin KJ

    更新日期:2020-10-01 00:00:00

  • Which intravenous induction agent for day surgery? A comparison of propofol, thiopentone, methohexitone and etomidate.

    abstract::Eighty day patients for the vaginal termination of pregnancy were randomly allocated to receive thiopentone, propofol, methohexitone or etomidate as intravenous induction agents. The same anaesthetist administered the anaesthesia and all the observers were blind to the agents used. The results show that thiopentone an...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Heath PJ,Kennedy DJ,Ogg TW,Dunling C,Gilks WR

    更新日期:1988-05-01 00:00:00

  • Evidence and triggers for the transfusion of blood and blood products.

    abstract::Allogeneic red cell transfusion is a commonly used treatment to improve the oxygen carrying capacity of blood during the peri-operative period. Increasing arterial oxygen content by increasing haemoglobin does not necessarily increase tissue oxygen delivery or uptake. Although the evidence-base for red cell transfusio...


    pub_type: 杂志文章,评审


    authors: Shah A,Stanworth SJ,McKechnie S

    更新日期:2015-01-01 00:00:00

  • Gas movement in the nonventilated lung at the onset of single-lung ventilation for video-assisted thoracoscopy.

    abstract::To assess the potential for atmospheric nitrogen to enter the nonventilated lung following the initiation of single-lung ventilation, the nonventilated lung of 10 patients undergoing video-assisted thoracoscopy was connected to the air in a water-filled spirometer, and gas movement out of and back into the lung was me...


    pub_type: 杂志文章


    authors: Pfitzner J,Peacock MJ,McAleer PT

    更新日期:1999-05-01 00:00:00

  • Interaction of vecuronium and atracurium during halothane anaesthesia in children.

    abstract::The combination of vecuronium and atracurium was studied in 60 children of ASA physical status 1 or 2. In part I, the dose-response relationships were determined in 30 children who were randomly assigned to receive a single bolus of 0.02, 0.025 or 0.03 mg kg-1 of vecuronium or 0.075, 0.01 or 0.0125 of atracuri...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Sloan MH,Bissonnette B,Lerman J

    更新日期:1998-01-01 00:00:00

  • Buscopan for the treatment of pain after laparoscopic sterilisation.

    abstract::We investigated the effect of Buscopan 20 mg, given at the end of surgery, on analgesic requirements in 44 ASA I and II patients presenting as day cases for laparoscopic sterilisation using Filshie clips. Patients were randomly allocated to receive either intravenous Buscopan 20 mg or saline placebo at the end of surg...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Habib A,Sharpe P,Anderson S,Francis S,Davidson AC,Smith G

    更新日期:2001-02-01 00:00:00

  • Variables associated with survival in patients with invasive bladder cancer with and without surgery.

    abstract::We recorded the survival of 141 patients assessed for radical cystectomy, which included cardiopulmonary exercise testing. The median Kaplan-Meier survival estimates were: 1540 days for the whole cohort; 2200 days after cystectomy scheduled (n = 108); and 843 days without surgery. The mortality hazard remained double ...


    pub_type: 杂志文章


    authors: Longdon E,Mistry H,Pratt O,Donnelly A,O'Neill S,Nachiappan M,Darwin L,Clarke N,Hartley R

    更新日期:2020-07-01 00:00:00

  • Acute cardiac herniation after radical pleuropneumonectomy.

    abstract::Acute cardiac herniation after radical pneumonectomy is extremely rare and is associated with an immediate mortality greater than 50%. We report a patient in whom cardiac herniation produced no signs or symptoms. The heart was returned to its correct position and the pericardial defect was repaired. ...


    pub_type: 杂志文章


    authors: Self RJ,Vaughan RS

    更新日期:1999-06-01 00:00:00

  • Ropivacaine plasma levels following high-dose local infiltration analgesia for total knee arthroplasty.

    abstract::We measured total and free plasma concentrations of ropivacaine following high-volume, high-dose local infiltration analgesia in 28 patients aged 65 years or over undergoing unilateral total knee arthroplasty. Patients received infiltration of ropivacaine 400 mg followed by infusion at 20 mg.h(-1) through an intra-art...


    pub_type: 杂志文章


    authors: Brydone AS,Souvatzoglou R,Abbas M,Watson DG,McDonald DA,Gill AM

    更新日期:2015-07-01 00:00:00

  • Where is T5? A survey of anaesthetists.

    abstract::The extent of a regional block for Caesarean section must be tested and documented before surgery commences. In recent years a block to 'touch' that includes T5 has increasingly been considered the best predictive test for a pain-free Caesarean section. Our survey examines the consistency with which different anaesthe...


    pub_type: 杂志文章,多中心研究


    authors: Congreve K,Gardner I,Laxton C,Scrutton M

    更新日期:2006-05-01 00:00:00

  • The effect of midazolam premedication on implicit memory activation during alfentanil-nitrous oxide anaesthesia.

    abstract::Eighty-three patients were given midazolam 0.1 by intramuscular injection as premedication before general anaesthesia with alfentanil-nitrous oxide. During anaesthesia patients were presented (through headphones) with either statements about common facts of some years ago (group A) (n = 43) or new verbal assoc...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: De Roode A,Jelicic M,Bonke B,Bovill JG

    更新日期:1995-03-01 00:00:00

  • Postoperative convulsions due to iophendylate (Myodil). Report of a case and review of the causes of postoperative convulsions.

    abstract::A previously fit 58-year-old man underwent lumbar laminectomy following a myelogram. Postoperatively convulsions occurred. He was successfully treated and made a complete recovery. Large quantities of intracranial iophendylate (Myodil) were seen on postoperative skull X-rays. In the absence of other likely causes, a d...


    pub_type: 杂志文章


    authors: Jones DF

    更新日期:1980-01-01 00:00:00

  • The development of apparatus for intermittent negative pressure respiration. (2) 1919-1976, with special reference to the development and uses of cuirass respirators.

    abstract::This paper and the one that preceded it1 have traced the development of the design and use of negative pressure ventilators from their origins in the early nineteenth century to the present day. Their maximum use was in the nineteen-forties and the early fifties after which they were quite rapidly replaced in the trea...


    pub_type: 历史文章,杂志文章


    authors: Woollam CH

    更新日期:1976-06-01 00:00:00

  • A thermographic study of paravertebral analgesia.

    abstract::Six patients undergoing paravertebral blocks for chronically painful conditions of the chest wall were thermographically imaged so that the extent of cutaneous vasodilatation and hence sympathetic block could be correlated with the distribution of the somatic block. All blocks were performed by a single experienced op...


    pub_type: 杂志文章


    authors: Cheema SP,Ilsley D,Richardson J,Sabanathan S

    更新日期:1995-02-01 00:00:00

  • Damage to the laryngeal mask by residual fluid in the cuff.

    abstract::It has been suggested that, in some situations, the cuff of the laryngeal mask should be filled with fluid. We speculated that this practice might damage the device during sterilisation in an autoclave. We studied whether injection of a small volume of water into the cuff of the laryngeal mask and subsequent sterilisa...


    pub_type: 杂志文章


    authors: Asai T,Koga K,Morris S

    更新日期:1997-10-01 00:00:00

  • The association of pre-operative anaemia with morbidity and mortality after emergency laparotomy.

    abstract::Pre-operative anaemia is associated with poor outcomes after elective surgery but its relationship with outcomes after emergency surgery is unclear. We analysed National Emergency Laparotomy Audit data from 1 December 2013 to 30 November 2017, excluding laparotomy for haemorrhage. Anaemia was classified as 'mild' 129-...


    pub_type: 杂志文章


    authors: Boyd-Carson H,Shah A,Sugavanam A,Reid J,Stanworth SJ,Oliver CM

    更新日期:2020-07-01 00:00:00

  • Temperature course and distribution during plasma heating with a microwave device.

    abstract::In spite of the much shorter thawing times, the use of microwave devices for heating units of fresh frozen plasma is still being discussed. Concerns about general and localised overheating are the main arguments against the use of microwave devices. We evaluated the warming of fresh frozen plasma using the recently in...


    pub_type: 杂志文章


    authors: Hirsch J,Bach R,Menzebach A,Welters ID,Dietrich GV,Hempelmann G

    更新日期:2003-05-01 00:00:00

  • Perineuronal morphine: a comparison with epidural morphine.

    abstract::In a double-blind, randomised controlled cross-over study the effects of perineuronal (perifemoral) injections of morphine were compared with epidural injections with the same amount of morphine in patients after knee surgery. Better pain scores were achieved during treatment with epidural morphine. We have not been a...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Dahl JB,Daugaard JJ,Kristoffersen E,Johannsen HV,Dahl JA

    更新日期:1988-06-01 00:00:00

  • The effect of propofol on patient reaction time and its relationship with loss of verbal contact before induction of anaesthesia.

    abstract::Increasing the calculated plasma concentration of propofol has been shown to increase choice reaction time and visual and auditory response times. We studied the relationship of reaction to a vibrating handset as the effect-site target-controlled propofol concentration was incrementally increased in 20 patients during...


    pub_type: 杂志文章


    authors: Anderson KJ,Allam S,Chapman R,Kenny GN

    更新日期:2013-02-01 00:00:00

  • Recovery times and side effects after propofol infusion and after isoflurane during ear surgery with additional infiltration anaesthesia.

    abstract::Two anaesthetic procedures that did not include nitrous oxide were compared in a randomised study of 50 patients for tympanoplasty and tympanoscopy: propofol given for induction and maintenance, and thiopentone-isoflurane given for induction and maintenance, respectively. Induction in the first group was with a bolus ...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Ledderose H,Rester P,Carlsson P,Peter K

    更新日期:1988-03-01 00:00:00

  • Vecuronium induced neuromuscular blockade. The effect of increasing dose on speed of onset.

    abstract::The speed of onset of neuromuscular blockade was measured for increasing doses of vecuronium. Onset times were found to be shorter with larger doses, up to a limit of ED95 X 3 (0.15 mg/kg). Thereafter, increasing the dose, even up to ED95 X 8 (0.4 mg/kg), did not appreciably shorten the time to full neuromuscular bloc...


    pub_type: 杂志文章


    authors: Casson WR,Jones RM

    更新日期:1986-04-01 00:00:00

  • A comparison of droperidol and cyclizine in the prevention of postoperative nausea and vomiting associated with patient-controlled analgesia.

    abstract::Fifty ASA 1 or 2 patients scheduled to undergo major gynaecological surgery were allocated randomly to one of two groups. All patients received a standard anaesthetic regimen. Patients in group 1 received droperidol 1.25 mg given intravenously 20 min prior to the end of surgery and a patient-controlled analgesia infus...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Walder AD,Aitkenhead AR

    更新日期:1995-07-01 00:00:00

  • Profound hypocalcaemia in a patient being anticoagulated with citrate for continuous renal replacement therapy.

    abstract::Citrate, as an anticoagulant for continuous renal replacement therapy in critically ill patients, has some potential advantages over heparin, including a prolonged dialysis filter life and reduced risk of bleeding. The key parameter involved in monitoring the adequacy and safety of citrate anticoagulation during conti...


    pub_type: 杂志文章


    authors: Morgan DJ,Ho KM

    更新日期:2009-12-01 00:00:00