Effects of nitrous oxide on liver haemodynamics and oxygen consumption in the greyhound.

Abstract:

:The effects of increasing concentrations of nitrous oxide 30, 50 and 70% on the hepatic circulation and hepatic oxygen consumption were investigated in seven normocapnic greyhounds. Hepatic arterial and portal venous blood flows were measured continuously using electromagnetic flow probes, and mean arterial pressure and cardiac output monitored. The administration of nitrous oxide caused linear decreases in hepatic arterial, portal venous and total liver blood flows. Increases in mean arterial pressure, hepatic arterial resistance and mesenteric vascular resistance were noted. There were no significant changes in hepatic oxygen consumption. It is suggested that the decrease in liver blood flow may result from alpha-adrenoceptor stimulation.

journal_name

Anaesthesia

journal_title

Anaesthesia

authors

Thomson IA,Hughes RL,Fitch W,Campbell D

doi

10.1111/j.1365-2044.1982.tb01225.x

subject

Has Abstract

pub_date

1982-05-01 00:00:00

pages

548-53

issue

5

eissn

0003-2409

issn

1365-2044

journal_volume

37

pub_type

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