Sensitivity to propofol in the elderly.

Abstract:

:Two studies were carried out on 609 fit, unpremedicated patients to assess the influence of patient age on the response to the rapidly-acting hindered phenol, propofol, which is being evaluated for induction of anaesthesia. In the first study, 1.25 mg/kg was injected over 20 seconds followed by 10-mg increments every 15 seconds until loss of verbal contact. This showed a great individual variation in response to the drug. A reduction in the 'induction' dose was found in elderly patients, which became marked around 60 years. In the second (340), doses ranging from 1.5-3.0 mg/kg in patients under 60 years and 1.25-2.25 mg/kg in those over 60 years were injected as a bolus over 20 seconds. Doses of 2.25-2.5 mg/kg were required to induce anaesthesia in patients under 60 years, whilst 1.5-1.75 mg/kg was adequate in those over 60 years. Side effects were more marked with the rapid injection and doses in excess of 1.75 mg/kg caused significant hypotension and apnoea in the elderly. These studies reveal marked sensitivity to propofol in the elderly with respect to both induction dose and acute toxicity.

journal_name

Anaesthesia

journal_title

Anaesthesia

authors

Dundee JW,Robinson FP,McCollum JS,Patterson CC

doi

10.1111/j.1365-2044.1986.tb13271.x

subject

Has Abstract

pub_date

1986-05-01 00:00:00

pages

482-5

issue

5

eissn

0003-2409

issn

1365-2044

journal_volume

41

pub_type

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