The differential effects of recombinant brain natriuretic peptide, nitroglycerine and dihydralazine on systemic oxygen delivery and gastric mucosal microvascular oxygenation in dogs.

Abstract:

:Brain natriuretic peptide has vasodilatory properties and may thus increase splanchnic perfusion and oxygenation. We compared the effects of recombinant brain natriuretic peptide on gastric mucosal microvascular haemoglobin oxygenation (reflectance spectrophotometry) and systemic variables with those of equi-hypotensive doses of two other vasodilators (nitroglycerine and dihydralazine). Chronically instrumented, healthy dogs were randomly allocated to receive on different days, one of the three drugs (nitroglycerine and dihydralazine doses titrated to reduce mean arterial pressure by ∼20%). Brain natriuretic peptide significantly increased gastric mucosal microvascular haemoglobin oxygenation selectively, i.e. without concomitant haemodynamic effects. In contrast, the other vasodilators either did not increase gastric mucosal microvascular haemoglobin oxygenation at all (nitroglycerine), or did so only with marked increases in other systemic haemodynamic variables (dihydralazine). Our data suggest a potential role of recombinant brain natriuretic peptide selectively for increasing microvascular mucosal oxygenation. Studies are required to extend these findings to the clinical setting.

journal_name

Anaesthesia

journal_title

Anaesthesia

authors

Schwarte LA,Schwartges I,Scheeren TW,Schober P,Picker O

doi

10.1111/j.1365-2044.2011.07047.x

subject

Has Abstract

pub_date

2012-05-01 00:00:00

pages

501-7

issue

5

eissn

0003-2409

issn

1365-2044

journal_volume

67

pub_type

杂志文章
  • Cardiovascular and catecholamine response to surgery in brain-dead organ donors.

    abstract::Eleven brain-dead organ donors were studied during surgery. Plasma levels of adrenaline and noradrenaline were measured before and after skin incision, upon sternotomy and 15, 30 and 45 min thereafter. Haemodynamic changes were measured continuously throughout the observation period. Blood pressure and heart rate incr...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1995.tb05989.x

    authors: Fitzgerald RD,Dechtyar I,Templ E,Fridrich P,Lackner FX

    更新日期:1995-05-01 00:00:00

  • A national survey of safe practice with epidural analgesia in obstetric units.

    abstract::The National Patient Safety Agency (NPSA) identified practice improvements with regard to epidural injections and infusions and released a patient safety alert on 28th March 2007. Prior to this, the Obstetric Anaesthetists' Association had considered the draft document and wished to assess current compliance in UK obs...

    journal_title:Anaesthesia

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1365-2044.2007.05398.x

    authors: Jones R,Swales HA,Lyons GR

    更新日期:2008-05-01 00:00:00

  • Spinal narcotics and central nervous system depression.

    abstract::A case of central nervous system depression which developed 7 hours after an intrathecal injection of 4 mg of morphine is described. The patient lapsed into coma with bradypnoea and "pin-point' pupils and there was no response to naloxone 0.4 mg. Treatment was continued for 3 hours. No postoperative analgesics were re...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1981.tb08679.x

    authors: Sidi A,Davidson JT,Behar M,Olshwang D

    更新日期:1981-11-01 00:00:00

  • HLA-DR expression and differential trafficking of monocyte subsets following low to intermediate risk surgery.

    abstract::Reduced HLA-DR expression on monocytes has been suggested as a predictive marker of immunosuppression following very high risk surgery, but there are few reports in lower risk surgery. In 32 patients undergoing low to intermediate risk surgery, blood samples were analysed by flow cytometry for HLA-DR expression and nu...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.2009.06161.x

    authors: Handy JM,Scott AJ,Cross AM,Sinha P,O'Dea KP,Takata M

    更新日期:2010-01-01 00:00:00

  • Clinical evaluation of doxacurium chloride.

    abstract::Doxacurium was administered to 50 adult patients for determination of potency (n = 10), onset and duration of clinical relaxation (n = 40). Cumulative dose-response showed the ED95 to be 33.24 micrograms.kg-1 (95% confidence limits 27.4-39.3). Doxacurium 33 micrograms.kg-1 was then administered to four groups of 10 pa...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1992.tb02322.x

    authors: Maddineni VR,Cooper R,Stanley JC,Mirakhur RK,Clarke RS

    更新日期:1992-07-01 00:00:00

  • Recovery times and side effects after propofol infusion and after isoflurane during ear surgery with additional infiltration anaesthesia.

    abstract::Two anaesthetic procedures that did not include nitrous oxide were compared in a randomised study of 50 patients for tympanoplasty and tympanoscopy: propofol given for induction and maintenance, and thiopentone-isoflurane given for induction and maintenance, respectively. Induction in the first group was with a bolus ...

    journal_title:Anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1365-2044.1988.tb09083.x

    authors: Ledderose H,Rester P,Carlsson P,Peter K

    更新日期:1988-03-01 00:00:00

  • Rectal premedication in children. Comparison of diazepam with a mixture of morphine, scopolamine and diazepam.

    abstract::Two hundred and eight healthy children who were to undergo minor elective surgery during halothane, nitrous oxide, oxygen anaesthesia were studied in a double blind investigation to evaluate the sedative and anticholinergic effects of two rectal premedications. Group I received diazepam 0.75 mg/kg rectally; Group II r...

    journal_title:Anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1365-2044.1985.tb10549.x

    authors: Haagensen RE

    更新日期:1985-10-01 00:00:00

  • The effect of low-dose ketamine on fentanyl-induced respiratory depression.

    abstract::This study evaluated if adding low-dose ketamine to fentanyl could offer a haemodynamically stable drug combination with little respiratory side-effects. Eight healthy, consenting male volunteers received in a random, cross-over and double-blind fashion both fentanyl 2 micrograms.kg-1 + ketamine 0.25 mg.kg-1 and fenta...

    journal_title:Anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1046/j.1365-2044.1998.00519.x

    authors: Mildh L,Taittonen M,Leino K,Kirvelä O

    更新日期:1998-10-01 00:00:00

  • Evaluation of a new continuous cardiac output monitor in off-pump coronary artery surgery.

    abstract::We evaluated a new, ultra-fast response continuous cardiac output monitor in 34 adult patients undergoing off-pump coronary artery bypass graft surgery. Cardiac output was measured with the TruCCOMS continuous cardiac output monitor (Aortech International plc, Lanarkshire, UK), using triplicate cold bolus thermodiluti...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.2004.03668.x

    authors: Leather HA,Vuylsteke A,Bert C,M'Fam W,Segers P,Sergeant P,Vandermeersch E,Wouters PF

    更新日期:2004-04-01 00:00:00

  • Propofol infusion for sedation in intensive care.

    abstract::Ten patients, with a range of illness severity, received a continuous 8-hour infusion of undiluted propofol for sedation while undergoing mechanical ventilation in a general intensive care unit. The level of sedation was assessed hourly and measurements were made of haemodynamic, respiratory, haematological and bioche...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1987.tb05362.x

    authors: Newman LH,McDonald JC,Wallace PG,Ledingham IM

    更新日期:1987-09-01 00:00:00

  • Vecuronium induced neuromuscular blockade. The effect of increasing dose on speed of onset.

    abstract::The speed of onset of neuromuscular blockade was measured for increasing doses of vecuronium. Onset times were found to be shorter with larger doses, up to a limit of ED95 X 3 (0.15 mg/kg). Thereafter, increasing the dose, even up to ED95 X 8 (0.4 mg/kg), did not appreciably shorten the time to full neuromuscular bloc...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1986.tb13217.x

    authors: Casson WR,Jones RM

    更新日期:1986-04-01 00:00:00

  • Aspiration pneumonia and the laryngeal mask airway.

    abstract::A case of aspiration pneumonia is reported after the use of a laryngeal mask airway in a young woman undergoing an elective cholecystectomy. The case illustrates the hazards of regurgitation with the laryngeal mask airway and the need for further evaluation when used with controlled mechanical ventilation. ...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1990.tb14882.x

    authors: Griffin RM,Hatcher IS

    更新日期:1990-12-01 00:00:00

  • Interaction between infusion equipment resulting in drug overdose in a critically ill patient.

    abstract::A critically ill septic patient on haemofiltration for acute renal failure suffered sudden circulatory and respiratory collapse. The cause of the collapse was traced to an interaction between mechanical devices (syringe driver infusion pumps and haemofiltration equipment) connected to two central venous catheters. ...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.2004.04012.x

    authors: Sundaram R,Dell AE

    更新日期:2005-01-01 00:00:00

  • An unusual complication of emergency tracheal intubation.

    abstract::A 68-year-old woman presented with dyspnoea having undergone a short period of tracheal intubation during an episode of congestive cardiac failure 10 days earlier. On the fourth day of admission, she suddenly developed acute respiratory distress followed by a cardiac arrest and was found to have an enlarging neck mass...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1997.72-az0069.x

    authors: Ooi GC,Irwin MG,Lam LK,Cheng SW

    更新日期:1997-02-01 00:00:00

  • A randomised controlled trial comparing rocuronium priming, magnesium pre-treatment and a combination of the two methods.

    abstract::We investigated whether magnesium sulphate combined with rocuronium priming shortens the onset of neuromuscular blockade, compared with these methods used alone. Ninety-two patients scheduled for general anaesthesia were randomly allocated to one of four groups: controls were given 0.6 mg.kg(-1) rocuronium; patients i...

    journal_title:Anaesthesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1365-2044.2012.07102.x

    authors: Kim MH,Oh AY,Jeon YT,Hwang JW,Do SH

    更新日期:2012-07-01 00:00:00

  • The relationship between obstructive sleep apnoea and postoperative delirium and pain: an observational study of a surgical cohort.

    abstract::Patients with obstructive sleep apnoea are at increased risk of adverse postoperative outcomes, such as cardiac and respiratory complications. It has been hypothesised that obstructive sleep apnoea also increases the risk for postoperative delirium and acute postoperative pain. We conducted a retrospective, observatio...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/anae.14855

    authors: Strutz PK,Kronzer V,Tzeng W,Arrington B,McKinnon SL,Ben Abdallah A,Haroutounian S,Avidan MS

    更新日期:2019-12-01 00:00:00

  • Anaesthesia for Angelman syndrome.

    abstract::We describe the administration of anaesthesia to a patient with Angelman syndrome, which is characterised by an abnormality of chromosome 15, where a subunit of the GABA receptor is coded. This has far-reaching anaesthetic implications as many drugs used in anaesthesia are thought to act via GABA receptors. Our patien...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.2008.05439.x

    authors: Ramanathan KR,Muthuswamy D,Jenkins BJ

    更新日期:2008-06-01 00:00:00

  • Lumbar epidurography with multi-orifice and single orifice epidural catheters.

    abstract::The spread of iohexol in the epidural space was studied using two types of epidural catheter. Twenty pre-menopausal women undergoing hysterectomy received lumbar epidural analgesia via either multi-orifice or single orifice catheters. Twenty-four hours after surgery, iohexol was injected before catheter removal with t...

    journal_title:Anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1365-2044.1996.tb07891.x

    authors: Magides AD,Sprigg A,Richmond MN

    更新日期:1996-08-01 00:00:00

  • Red blood cell transfusion in surgery: an observational study of the trends in the USA from 2011 to 2016.

    abstract::Guidelines recommend restrictive red blood cell transfusion strategies. We conducted an observational study to examine whether the rate of peri-operative red blood cell transfusion in the USA had declined during the period from 01 January 2011 to 31 December 2016. We included 4,273,168 patients from all surgical subsp...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/anae.14900

    authors: Nordestgaard AT,Rasmussen LS,Sillesen M,Steinmetz J,Eid AI,Meier K,Kaafarani HMA,Velmahos GC

    更新日期:2020-04-01 00:00:00

  • Anaesthesia for procedures on the larynx and pharynx. The use of the Bullard laryngoscope in conjunction with high frequency jet ventilation.

    abstract::Twenty patients undergoing elective procedures on the larynx and pharynx were anaesthetised using a propofol infusion and a bolus of vecuronium. High frequency jet ventilation was employed via a 7 French gauge catheter, with a second catheter being used to measure expired carbon dioxide levels. The Bullard laryngoscop...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1993.tb06916.x

    authors: Mendel P,Bristow A

    更新日期:1993-03-01 00:00:00

  • Electro-acupuncture and postoperative emesis.

    abstract::One hundred unpremedicated female patients of ASA grade 1 or 2 who underwent laparoscopy as outpatients were allocated randomly to one of four groups. All patients received general anaesthesia with fentanyl, thiopentone, halothane, nitrous oxide and oxygen; suxamethonium was given to facilitate tracheal intubation. In...

    journal_title:Anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1365-2044.1990.tb14744.x

    authors: Ho RT,Jawan B,Fung ST,Cheung HK,Lee JH

    更新日期:1990-04-01 00:00:00

  • Comparison of remifentanil versus regional anaesthesia in children anaesthetised with isoflurane/nitrous oxide. International Remifentanil Paediatric Anaesthesia Study group.

    abstract::We compared the efficacy and safety of a remifentanil (0.25 microg x kg(-1) x min(-1)-based balanced anaesthetic technique with a bupivacaine-based regional anaesthetic technique in an open label, multicentre study in 271 ASA physical status 1 or 2 children aged 1-12 years. Subjects requiring major intra-abdominal, ur...

    journal_title:Anaesthesia

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1046/j.1365-2044.2000.01607.x

    authors: Prys-Roberts C,Lerman J,Murat I,Taivainen T,Lopez T,Lejus C,Spahr-Schopfer I,Splinter W,Kirkham AJ

    更新日期:2000-09-01 00:00:00

  • Oxytocin at elective caesarean delivery: a dose-finding study in women with obesity.

    abstract::Prophylactic oxytocin administration at the third stage of labour reduces blood loss and the need for additional uterotonic drugs. Obesity is known to be associated with an increased risk of uterine atony and postpartum haemorrhage. It is unknown whether women with obesity require higher doses of oxytocin in order to ...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/anae.15322

    authors: Peska E,Balki M,Maxwell C,Ye XY,Downey K,Carvalho JCA

    更新日期:2020-11-23 00:00:00

  • Randomised double-blinded comparison of phenylephrine vs ephedrine for maintaining blood pressure during spinal anaesthesia for non-elective Caesarean section*.

    abstract:SUMMARY:In a randomised, double-blinded study, we compared boluses of phenylephrine 100 microg with ephedrine 10 mg for treating hypotension (systolic blood pressure < 100 mmHg) in 204 patients having non-elective Caesarean section under spinal anaesthesia. Umbilical arterial (UA) and venous (UV) pH and base excess wer...

    journal_title:Anaesthesia

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1365-2044.2008.05635.x

    authors: Ngan Kee WD,Khaw KS,Lau TK,Ng FF,Chui K,Ng KL

    更新日期:2008-12-01 00:00:00

  • Evaluation of the HemoCue for measuring intra-operative haemoglobin concentrations: a comparison with the Coulter Max-M.

    abstract::We compared haemoglobin concentration values obtained using a portable haemoglobinometer, the HemoCue, in the operating theatre with the results obtained by the Coulter Max-M in the laboratory. Haemoglobin concentrations were measured on 52 arterial blood samples obtained from 13 patients during aortic surgery, in the...

    journal_title:Anaesthesia

    pub_type: 临床试验,杂志文章

    doi:10.1046/j.1365-2044.1998.00328.x

    authors: Lardi AM,Hirst C,Mortimer AJ,McCollum CN

    更新日期:1998-04-01 00:00:00

  • The effect of celecoxib on intrathecal morphine-induced pruritus in patients undergoing Caesarean section.

    abstract::Pruritus associated with intrathecal opioid administration is particularly common in pregnancy. Nonsteroidal anti-inflammatory drugs (NSAIDs) can reduce the severity of this pruritus but have undesirable side effects. The recent development of drugs that can specifically inhibit the cyclooxygenase 2 isoenzyme have bec...

    journal_title:Anaesthesia

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1365-2044.2004.03797.x

    authors: Lee LH,Irwin MG,Lim J,Wong CK

    更新日期:2004-09-01 00:00:00

  • Prediction of prolonged laryngoscopy.

    abstract::Duration of laryngoscopy must be kept as short as possible to prevent disturbances of oxygenation and ventilation. Because the factors associated with prolonged laryngoscopy are not well known, we studied 1000 patients undergoing tracheal intubation under general anaesthesia to determine the possible effects of their ...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1046/j.1365-2044.2001.02084-5.x

    authors: Saghaei M,Safavi MR

    更新日期:2001-12-01 00:00:00

  • The nature of pre-operative anxiety.

    abstract::In a study of 247 patients who had general anaesthesia for dental procedures, the incidence of individual anxieties was noted using a questionnaire completed by the patient. The most common anxieties related to the period before transfer to the operating theatre, intra-operative awareness and postoperative pain. These...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2044.1990.tb14285.x

    authors: McCleane GJ,Cooper R

    更新日期:1990-02-01 00:00:00

  • Body position and late postoperative nocturnal hypoxaemia.

    abstract::Thirteen patients were monitored for nocturnal body position (supine vs. side) and arterial oxygen saturation pre-operatively and on the second postoperative night after major abdominal surgery. The number of positional changes were significantly decreased after operation (p < 0.05) with a trend towards more time spen...

    journal_title:Anaesthesia

    pub_type: 杂志文章

    doi:10.1111/j.1365-2222.1997.128-az0124.x

    authors: Rosenberg-Adamsen S,Stausholm K,Edvardsen L,Zwarts M,Kehlet H,Rosenberg J

    更新日期:1997-06-01 00:00:00

  • Postoperative recovery and outcomes--what are we measuring and for whom?

    abstract::Recovery is an abstract quantity the definition of which varies according to the pre-dilection of individual institutions, clinicians or patients. While traditionally focused on immediate postoperative restitution of function and readiness for discharge, recovery assessment has progressively expanded its focus to incl...

    journal_title:Anaesthesia

    pub_type: 杂志文章,评审

    doi:10.1111/anae.13312

    authors: Bowyer AJ,Royse CF

    更新日期:2016-01-01 00:00:00