Propofol infusion for sedation in intensive care.

Abstract:

:Ten patients, with a range of illness severity, received a continuous 8-hour infusion of undiluted propofol for sedation while undergoing mechanical ventilation in a general intensive care unit. The level of sedation was assessed hourly and measurements were made of haemodynamic, respiratory, haematological and biochemical variables. Sedation remained satisfactory in most patients throughout the study period, with only occasional alterations in infusion rate, and eight patients required further sedative therapy within 45 minutes of discontinuation of the propofol infusion. Arterial pressure tended to decrease from baseline values; mean and diastolic pressures demonstrated a significant decrease (p less than 0.05) at 4, 7 and 8 hours during the infusion. Adrenal steroidogenesis was not inhibited significantly. Propofol infusion proved to be a useful and readily controllable sedative agent, and discontinuation of the drug was followed by rapid recovery in most cases. The critically ill may be particularly sensitive to the cardiovascular depressant properties of the drug.

journal_name

Anaesthesia

journal_title

Anaesthesia

authors

Newman LH,McDonald JC,Wallace PG,Ledingham IM

doi

10.1111/j.1365-2044.1987.tb05362.x

subject

Has Abstract

pub_date

1987-09-01 00:00:00

pages

929-37

issue

9

eissn

0003-2409

issn

1365-2044

journal_volume

42

pub_type

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