Abstract:
SUMMARY:In a randomised, double-blinded study, we compared boluses of phenylephrine 100 microg with ephedrine 10 mg for treating hypotension (systolic blood pressure < 100 mmHg) in 204 patients having non-elective Caesarean section under spinal anaesthesia. Umbilical arterial (UA) and venous (UV) pH and base excess were similar between groups. In the ephedrine group, UA lactate concentration was higher (median 2.6 [interquartile range 2.3-3.3] vs 2.4 [1.9-3.0] mmolxl(-1), p = 0.002) and UV lactate concentration was higher (2.5 [2.2-3.2] vs 2.3 [1.9-2.8] mmolxl(-1), p = 0.016) and more patients had nausea or vomiting (12.7% vs 3.9%, p = 0.02). Clinical neonatal outcome was similar. Of the protocol-compliant patients (n = 148), UA Po(2) and UV Po(2) were lower in the phenylephrine group although oxygen content was similar. We conclude that phenylephrine and ephedrine are both suitable vasopressors for use in non-elective Caesarean sections.
journal_name
Anaesthesiajournal_title
Anaesthesiaauthors
Ngan Kee WD,Khaw KS,Lau TK,Ng FF,Chui K,Ng KLdoi
10.1111/j.1365-2044.2008.05635.xsubject
Has Abstractpub_date
2008-12-01 00:00:00pages
1319-26issue
12eissn
0003-2409issn
1365-2044pii
ANA5635journal_volume
63pub_type
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