Abstract：
BACKGROUND:Disturbance in calcium metabolism has been suggested in the pathogenesis of hypertension, however, membrane calcium content in humans has not been studied in detail yet in primary hypertension. We compared plasma, intracellular and membrane calcium concentrations in erythrocytes of patients with essential hypertension and in healthy, normotensive control subjects to determine a possible alteration of membrane calcium in primary hypertension. SUBJECTS AND METHODS:Thirty-four never treated patients with essential hypertension were included and 34 healthy, age- and sex-matched volunteers served as controls. Atomic absorption spectroscopy was used for measurement of intracellular and membrane calcium content in erythrocytes and plasmalemmal preparations. RESULTS:Plasma and intracellular Ca(++) concentrations were not significantly different between hypertensives and controls (plasma: 2.59 +/- 0.18 vs2.50 +/- 0.16 mmol/l, intracellular: 1.89 +/- 0.20 mmol/l vs 1.97 +/- 0.24 mmol/l, NS resp., mean +/- s.e.m.). However, membrane calcium content was significantly higher in hypertensive patients compared to control subjects (2.38 +/- 0.28 micromol/g membraneous protein vs0.86 +/- 0.32 micromol/g membrane protein, P < 0.01). Membrane calcium content was correlated to mean arterial blood pressure (r = 0.59, P < 0.01). CONCLUSION:Membrane calcium content is significantly increased in patients with untreated primary hypertension and correlates to blood pressure levels. This data suggest, that an membrane mechanism may contribute to alterations in calcium metabolism and to the pathogenesis of primary hypertension.
journal_name
J Hum Hypertensjournal_title
Journal of human hypertensionauthors
Kosch M,Hausberg M,Barenbrock M,Posadzy-Malaczynska A,Rahn KH,Kisters Kdoi
10.1038/sj.jhh.1001121subject
Has Abstractpub_date
2001-01-01 00:00:00pages
37-40issue
1eissn
0950-9240issn
1476-5527journal_volume
15pub_type
杂志文章abstract：:Hypertension prevalence rates remain comparatively low in Nigeria, although the associated morbidity and mortality including that due to malignant hypertension (MHT) is considerable. To determine the factors that may be associated with the development of MHT we compared 74 patients with essential MHT (age 48 +/- 9 yea...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/sj.jhh.1000963
更新日期：2000-03-01 00:00:00
abstract：:The association between masked hypertension and metabolic syndrome (MS) or insulin resistance is unclear. We investigated an untreated nationwide population sample (n = 1582, age 44-74 years). Duplicate office blood pressure (BP) measurements were taken on one visit and duplicate morning and evening home measurements ...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/jhh.2013.129
更新日期：2014-07-01 00:00:00
abstract：:The effect of sulindac on ACE inhibitor-induced cough was studied in eight hypertensive subjects in a randomised placebo-controlled double blind cross-over trial. There was no significant improvement in cough or sense of well-being. Blood pressure, renal function, plasma renin and ACE activity were unchanged. Sulindac...
journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1989-12-01 00:00:00
abstract：:Consistent reports indicate that hypertension is a particularly common finding in black populations. Hypertension occurs at younger ages and is often more severe in terms of blood pressure levels and organ damage than in whites, resulting in a higher incidence of cardiovascular disease and mortality. This review provi...
journal_title：Journal of human hypertension
pub_type： 杂志文章,评审
doi：10.1038/jhh.2017.18
更新日期：2017-08-01 00:00:00
abstract：:To identify the prevalence and magnitude of clinic changes in blood pressure and determine their effects on the diagnosis and treatment of hypertension, 268 patients with a BP greater than or equal to 160/95 mmHg on three consecutive occasions (twice in the general practitioner's surgery and once in the hospital clini...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1990-10-01 00:00:00
abstract：:The Chinese Hypertension Intervention Efficacy Study (CHIEF) is a multi-centre randomized controlled clinical trial comparing the effects of amlodipine+angiotensin II receptor blocker and amlodipine+diuretics on the incidence of cardiovascular events, represented as a composite of non-fatal stroke, non-fatal myocardia...
journal_title：Journal of human hypertension
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1038/jhh.2010.45
更新日期：2011-04-01 00:00:00
abstract：:The presence of hepatic steatosis was determined in 180 middle-aged male workers by ultrasonography and was found in 39 (22%) of them. Body mass index (BMI), systolic and diastolic blood pressure (BP) and serum levels of asparate aminotransferase (AST), alanine aminotransferase (ALT) and gamma-glutamyl transpeptidase ...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1995-02-01 00:00:00
abstract：:Preeclampsia (PE) is one of the most common pregnancy-specific pathologic complications, and is characterised by onset of hypertension and proteinuria. Placental trophoblast cell apoptosis is generally accepted as a major cause of PE. However, the details of the mechanism underlying the condition remain unclear. Here,...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/jhh.2017.65
更新日期：2017-12-01 00:00:00
abstract：:It has been shown in animal experiments that angiotensin II and aldosterone have mitogenic effects on the cardiovascular system, whereas atrial natriuretic peptide has antimitogenic properties. The aim of the present study was to relate plasma renin activity, angiotensin II, aldosterone and atrial natriuretic peptide ...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/sj.jhh.1000590
更新日期：1998-03-01 00:00:00
abstract：:In a 10 year prospective study, we investigated the utility of the level of serum gamma-glutamyl transferase (GGT), a biological marker of alcohol consumption, in predicting the development of hypertension in Japanese male drinkers, all of whom lived in a rural community. The study included 77 men, aged 30-69 years, w...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1994-06-01 00:00:00
abstract：:A random sample of 200 East Anglian general practitioners was surveyed to establish current trends in the management of hypertension, including measurement of blood pressure (BP), patient investigation, treatment and follow-up. A total of 125 (62.5%) completed questionnaires was returned. Responses were used to assess...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1995-10-01 00:00:00
abstract：:The aim of the present paper was to evaluate the influence of a family history of hypertension and the degree of obesity as indicated by tertiles of body mass index on ambulatory blood pressure (BP) values in large number (n = 406) of young mild essential hypertensives. Positive family history of hypertension was asso...
journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章,多中心研究
doi：
更新日期：1995-07-01 00:00:00
abstract：:Exercise has been proved to promote the number and activity of circulating endothelial progenitor cells (EPCs) in humans, which contributes to improvement in endothelial function and maintenance of cardiovascular homoeostasis. However, the mechanism underlying the effect of exercise on circulating EPCs in healthy subj...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/sj.jhh.1002171
更新日期：2007-06-01 00:00:00
abstract：:Sodium-lithium countertransport activity has been proposed as a marker for hypertension and is lower in black compared to Caucasian subjects both with and without vascular disease. The question arises of what is the primary kinetic locus of the altered behaviour of the countertransporter in black subjects and whether ...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/sj.jhh.1000555
更新日期：1998-01-01 00:00:00
abstract：:Left ventricular hypertrophy (LVH) is a powerful cardiovascular risk factor and has previously been related to endothelium-dependent vasodilation (EDV) in hypertensive patients. In the Prospective Investigation of the Vasculature in Uppsala Seniors study, different techniques to evaluate EDV in different types of vess...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/jhh.2008.61
更新日期：2008-11-01 00:00:00
abstract：:The Guangzhou Biobank Cohort Study (GBCS, n=30 519, age >or=50 years) was established to examine the effects of genetic and environmental influences on health problems and chronic disease development. Guangzhou is undergoing massive economic development, but from a baseline that had remained unchanged for millennia. T...
journal_title：Journal of human hypertension
pub_type： 杂志文章,多中心研究
doi：10.1038/jhh.2009.52
更新日期：2010-02-01 00:00:00
abstract：:Hypertension has been associated with hyperinsulinemia and insulin resistance. The elevations in plasma insulin are the apparent adaptation of the pancreatic beta cell to the resistance to insulin. Maintenance of normal insulin release is therefore of great importance for subjects with hypertension. The potassium chan...
journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1996-04-01 00:00:00
abstract：:Aortic pulse wave velocity has emerged as an important predictor of cardiovascular events, but data on ethnic differences in pulse wave velocity remain scarce. We explored differences in pulse wave velocity between people of Asian and African ancestry. Data were used from the cross-sectional Healthy Life in Suriname (...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/s41371-018-0144-0
更新日期：2020-02-01 00:00:00
abstract：:The anti-hypertensive efficacy and safety of extended-release (ER) felodipine (5, 10 or 20 mg) and amlodipine (5 or 10 mg) once daily were compared in patients with mild to moderate essential hypertension in a double-blind, double-dummy, randomised, comparative study. One hundred and eighteen patients were randomised ...
journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1995-03-01 00:00:00
abstract：:The objective of this study was to determine the electrocardiographic left ventricular hypertrophy (LVH) criterion that best correlated with vascular structure and function parameters in hypertensive patients. A cross-sectional study involving 347 hypertensive patients was performed. The mean age of the subjects was 5...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/jhh.2013.87
更新日期：2014-03-01 00:00:00
abstract：:The aim of this study was to assess the effect of alcohol on blood pressure and arterial compliance over 24 h in a group of volunteers, comparing the same group of subjects on two consecutive but separate days, one with alcohol intake (alcohol day) and one free of alcohol (control day). We studied 18 healthy subjects ...
journal_title：Journal of human hypertension
pub_type： 杂志文章,随机对照试验
doi：10.1038/jhh.2015.19
更新日期：2016-01-01 00:00:00
abstract：:The aim of this study was to describe the pattern of blood pressure (BP) distribution in a multiethnic primary care practice in relation to sociodemographic characteristics, lifestyle and risk factors. Another aim was to analyse the quality of diagnosis and effectiveness of hypertension (HT) treatment. In all, 470 adu...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/sj.jhh.1001902
更新日期：2005-10-01 00:00:00
abstract：:Hypertension (HTN) related to health-promoting behaviors (HPB) and quality of life (QOL) in older Chinese has not been clearly identified. We sought to compare the HPB and QOL of elderly adults (aged ≥60) living with HTN in China to a community normotensive control group. Using multistage stratified cluster sampling, ...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/s41371-018-0073-y
更新日期：2018-09-01 00:00:00
abstract：:Blood pressure and other risk factors of cardiovascular diseases were studied in two rural communities of 631 adults (greater than or equal to 18 years old) with different socio-economic statuses, populations A and B. Population A (n = 381) lived in a tourist village on an island, and population B (n = 250) in a remot...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1990-08-01 00:00:00
abstract：:Primary aldosteronism (PA) is the most common endocrine form of hypertension and may carry an increased risk of atrial flutter or fibrillation (AFF). The primary goal of this multicentre cohort study is thus to prospectively establish the prevalence of PA in consecutive hypertensive patients referred for lone (non-val...
journal_title：Journal of human hypertension
pub_type： 杂志文章,多中心研究
doi：10.1038/jhh.2012.21
更新日期：2013-03-01 00:00:00
abstract：:Several studies have reported an association between the abnormal duration of sleep and chronic conditions including hypertension. However, the existing body of evidence is not entirely significant; as insignificant associations between poor sleep and blood pressure (BP) have been found across different studies. The a...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/s41371-020-0320-x
更新日期：2021-01-01 00:00:00
abstract：:Early exercise engagement elicits meaningful changes in peripheral blood pressure in patients diagnosed with transient ischaemic attack (TIA) or minor stroke. However, central hemodynamic markers may provide clinicians with important diagnostic and prognostic information beyond that provided by peripheral blood pressu...
journal_title：Journal of human hypertension
pub_type： 杂志文章,随机对照试验
doi：10.1038/jhh.2016.72
更新日期：2017-03-01 00:00:00
abstract：:We compared the effects on blood pressure (BP) of three isocaloric diets with reduced total fat and saturated fatty acid (SAFA) contents but with different proportions of monounsaturated (MUFA) and polyunsaturated fatty acids (PUFA). Diet LF (low fat) provided 20 en% fat (7.9% SAFA, 7.8% MUFA, 3.0% PUFA); diet HP (hig...
journal_title：Journal of human hypertension
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/sj.jhh.1000610
更新日期：1998-06-01 00:00:00
abstract：:Despite the availability of multiple nonpharmacological and pharmacological antihypertensive regimens large scale control of BP on a population basis is still unsatisfactory. To achieve a better quality in hypertension care we have developed and evaluated a structured outpatient hypertension treatment and teaching pro...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：
更新日期：1993-12-01 00:00:00
abstract：:In the pre-awakening hours, diastolic blood pressure (DBP) is normally at its lowest, and diastolic hypotension is a risk factor for cardiac ischemia. We investigated pre-awakening DBP values and its predictors in treated hypertensive patients who underwent ambulatory blood pressure monitoring. The pre-awakening perio...
journal_title：Journal of human hypertension
pub_type： 杂志文章
doi：10.1038/jhh.2015.80
更新日期：2016-05-01 00:00:00
