Abstract:
PURPOSE:In the late 1960s, the management of fungal keratitis was a serious unresolved problem. Little was known of the epidemiology of the disease, and there were no antifungal agents formulated for use in the eye. METHODS:A thorough review of the literature was done back to 1969 on clinical reports and experimental studies for keratomycosis and Acanthamoeba keratitis. RESULTS:Since 1969, through basic and clinical research, the epidemiology of the disease worldwide is better understood. One new topical antifungal agent, natamycin, with efficacy against filamentous fungi has been developed and the pharmacokinetics of topically applied antifungal drops have been explored. Progress has been slow but the prognosis for keratomycosis has immeasurably improved over the period. Acanthamoeba was first recognized as an ocular pathogen in 1973 and was the cause of an epidemic in the 1980s caused by contaminated contact lens, although other risk factors were also identified. At the onset of the epidemic, there was no known treatment. but as a result of intense research efforts, within a few years a well-defined therapeutic approach had been developed that had a significant impact on the prognosis for this initially devastating infection. For both infections, the role of corticosteroids for controlling the inflammation remains controversial, but the place for keratoplasty is now well defined. CONCLUSIONS:Although there has been steady progress in the management of both infections, continued research is the way to define more effective medical and surgical therapy.
journal_name
Corneajournal_title
Corneaauthors
O'Day DM,Head WSdoi
10.1097/00003226-200009000-00013subject
Has Abstractpub_date
2000-09-01 00:00:00pages
681-7issue
5eissn
0277-3740issn
1536-4798journal_volume
19pub_type
杂志文章,评审相关文献
CORNEA文献大全abstract:PURPOSE:To investigate if amniotic membrane incubated with antibiotics could inhibit bacterial growth in vitro. METHODS:Amniotic membrane fragments were incubated with the antibiotics (netilmicin) solution; the washed and drained fragments were either tested after treatment or further incubated in antibiotic-free medi...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/01.ico.0000214207.06952.23
更新日期:2006-05-01 00:00:00
abstract::Secondary corneal amyloidosis is a rare finding and only 17 cases have been reported in the literature. A case of unilateral secondary localized corneal amyloidosis is presented in a patient with bilateral interstitial keratitis and other stigmata of tertiary syphilis. ...
journal_title:Cornea
pub_type: 杂志文章
doi:
更新日期:1990-04-01 00:00:00
abstract:PURPOSE:This study was designed to assess the success of surgical monovision in presbyopic patients. METHODS:A university refractive surgery center retrospective chart review of 82 patients who elected to undergo surgical monovision with laser in situ keratomileusis (LASIK) between January 2000 and January 2003 was co...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/01.ico.0000178722.19317.7b
更新日期:2006-02-01 00:00:00
abstract:PURPOSE:To describe the incidence and prevalence of glaucoma in a patient population with severe ocular surface disease (OSD). METHODS:A retrospective case series was compiled from all charts of patients in the Cincinnati Eye Institute/University of Cincinnati and University of Minnesota population with a diagnosis of...
journal_title:Cornea
pub_type: 杂志文章,多中心研究
doi:10.1097/01.ico.0000220776.93852.d9
更新日期:2006-06-01 00:00:00
abstract:PURPOSE:To minimize recurrence and improve graft stability after pterygium surgery, conjunctival autograft adherence is done using fibrin glue (FG) or autologous blood coagulum (ABC). But there are studies that have reported conflicting or inconclusive results. This meta-analysis was conducted to evaluate the postopera...
journal_title:Cornea
pub_type: 杂志文章,meta分析
doi:10.1097/ICO.0000000000001270
更新日期:2017-10-01 00:00:00
abstract:PURPOSE:To assess the endothelial cell loss after cataract extraction using a fluid-based system and compare it with conventional ultrasound. METHODS:A total of 46 eyes of 23 patients with up to 3+ bilateral cataract were included. The first eye was randomized to either fluid-based system or conventional ultrasound, a...
journal_title:Cornea
pub_type: 杂志文章,随机对照试验
doi:10.1097/01.ico.0000226366.64796.20
更新日期:2006-10-01 00:00:00
abstract::The iridocorneal-endothelial (ICE) syndrome is characterised clinically by a "hammered-silver" appearance of the corneal endothelium, corneal failure, glaucoma, and iris destruction. Specular photomicroscopic studies of the corneal endothelium have demonstrated a population of abnormal cells termed "ICE cells." The pu...
journal_title:Cornea
pub_type: 杂志文章
doi:
更新日期:1996-01-01 00:00:00
abstract:PURPOSE:To report the potential risk of severe positive vitreous pressure during combined penetrating keratoplasty, cataract extraction, and intraocular lens implantation (triple procedure), using positive end-expiratory pressure (PEEP) during general endotracheal anesthesia. METHODS:This is a case report of a 32-year...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000000945
更新日期:2016-11-01 00:00:00
abstract:PURPOSE:To describe a new minimally invasive surgical technique for the symptomatic management of bullous keratopathy in blind eyes. METHODS:Four patients with severe corneal edema due to endothelial decompensation and no visual function in the affected eye presented for the relief of their ocular symptoms (pain and t...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000000081
更新日期:2014-05-01 00:00:00
abstract:PURPOSE:Hyperglycemia in diabetes mellitus (DM) might induce changes in corneal biomechanics. Therefore, biomechanical properties of the cornea were measured using the ocular response analyzer and the Corvis ST. METHODS:In the study, 35 eyes of 35 diabetic patients were included. After an ophthalmological examination,...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000001879
更新日期:2019-05-01 00:00:00
abstract:PURPOSE:To compare efficiency and safety of epithelium-off corneal cross-linking (CXL) and transepithelial cross-linking (TE-CXL) in pediatric patients with progressive keratoconus. METHODS:Uncorrected and corrected visual acuity, corneal topography and pachymetry (Pentacam; Oculus Pentacam), and in vivo confocal micr...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e31826cf32d
更新日期:2013-05-01 00:00:00
abstract:PURPOSE:To compare paired human corneas after storage at 4 degrees C in Chen medium (CM) and Optisol-GS medium (OM) for 7, 10, 14, and 21 days. METHODS:One cornea of each pair from nine human donors was randomly stored in either CM or OM, with its mate cornea stored in the other medium. Three pairs of corneas were sto...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-200011000-00005
更新日期:2000-11-01 00:00:00
abstract::The authors describe the clinical, molecular genetic, and pathologic findings of a patient with corneal decompensation associated with the mitochondrial ophthalmoplegia plus (Kearns-Sayre) syndrome. Ultrastructurally abnormal mitochondria were observed and possibly implicate this organelle in the pathogenesis of corne...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-199405000-00014
更新日期:1994-05-01 00:00:00
abstract:PURPOSE:To describe a case of bilateral peripheral ulcerative keratitis after Salmonella gastroenteritis. METHODS:Case report with description of treatment and outcome. RESULTS:The peripheral ulcerative keratitis gradually resolved in both eyes after appropriate systemic antibiotic therapy and local ocular care. CON...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-199811000-00017
更新日期:1998-11-01 00:00:00
abstract:PURPOSE:To describe the management and outcome of an ocular surface alkali burn in the setting of previous laser in situ keratomileusis (LASIK). METHODS:This is a case report and review of relevant literature. RESULTS:A 25-year-old man with a history of LASIK presented 4 weeks after a sodium hydroxide splash to his l...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000002604
更新日期:2020-12-03 00:00:00
abstract:PURPOSE:To study changes in structure and barrier function of the corneal epithelium after penetrating keratoplasty. METHODS:Sixty-nine eyes of 56 patients undergoing penetrating keratoplasty were studied. Fifty-six age-matched normal eyes served as controls. Corneal epithelial structure was studied by using specular ...
journal_title:Cornea
pub_type: 杂志文章
doi:
更新日期:1999-09-01 00:00:00
abstract:PURPOSE:To study the reliability and repeatability of anterior segment measurements in patients who underwent penetrating keratoplasty with swept light source Fourier domain anterior segment optical coherence tomography (SS-OCT) in comparison with a high-resolution Scheimpflug camera. METHODS:Keratometry (K) and eleva...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000001133
更新日期:2017-04-01 00:00:00
abstract:PURPOSE:To measure the refractive index (RI) of the human corneal stroma in vivo using an objective Abbé refractometer (VCH-1) and to determine if RI of the stroma is related to age. METHODS:The VCH-1 was calibrated against a standard subjective Abbé refractometer using 7 randomly selected turbid semiliquid media. VCH...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e31821008d5
更新日期:2011-12-01 00:00:00
abstract:PURPOSE:To evaluate and compare corneal thickness in normal and dry eyes. METHODS:The Orbscan corneal topography system was used to measure the corneal thickness at nine locations in the central and peripheral (superior, superonasal, nasal, inferonasal, inferior, inferotemporal, temporal, superotemporal) cornea in 38 ...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/00003226-199907000-00002
更新日期:1999-07-01 00:00:00
abstract:PURPOSE:The 27-kDa heat shock protein (HSP27) has been implicated in wound healing in multiple tissues. We investigated the expression and localization of phosphorylated HSP27 during epithelial wound healing in the murine cornea. METHODS:Corneas of 8- to 10-week-old C57BL6 mice were wounded by epithelial debridement (...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e31823f7685
更新日期:2012-07-01 00:00:00
abstract:PURPOSE:To find the level of dissection in keratoconic corneas undergoing deep anterior lamellar keratoplasty (DALK) using the big-bubble technique. METHODS:In 3 keratoconic eyes that underwent DALK, the operation was converted into penetrating keratoplasty after complete big-bubble formation because of extensive tear...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e3181ba7016
更新日期:2010-04-01 00:00:00
abstract:PURPOSE:To determine if superficial lamellar corneal excision with femtosecond laser followed by phototherapeutic keratectomy (PTK) using a masking substance improves visual acuity and optical quality of patients with severe corneal opacities. METHODS:Twelve eyes with corneal haze or scarring underwent confocal micros...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e3181eeb0c1
更新日期:2011-03-01 00:00:00
abstract:PURPOSE:To study the corneal biocompatibility of bevacizumab on various cultured human corneal cells. METHODS:Cell cultures of corneal keratinocytes (CKs), corneal fibroblasts (CFs), and corneal endothelial cells (CECs) were harvested from human donor eyes and exposed to various concentrations of bevacizumab (0.25-5.0...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0b013e3180de1d0a
更新日期:2007-09-01 00:00:00
abstract::Specular microscopy can provide a noninvasive morphologic analysis of the corneal endothelial cell layer from subjects enrolled in clinical trials. The analysis provides a measure of the endothelial cell physiologic reserve from aging, ocular surgical procedures, pharmaceutical exposure, and general health of the corn...
journal_title:Cornea
pub_type: 杂志文章,评审
doi:10.1097/ICO.0b013e31815892da
更新日期:2008-01-01 00:00:00
abstract::A modified relaxing incision technique for postkeratoplasty astigmatism is described in this article. Following the initial, standard relaxing incision techniques, a planned spreading and recutting of the initial relaxing incision was performed at 1-3-week intervals following the initial surgery. The wound may be deep...
journal_title:Cornea
pub_type: 杂志文章
doi:
更新日期:1988-01-01 00:00:00
abstract:PURPOSE:Recent new reports of possible iatrogenic transmission of Creutzfeldt-Jakob disease (CJD) in Europe have prompted renewed scrutiny of current Eye Bank Association of America criteria for evaluation of potential corneal donors in this country. A prior study evaluated the risk of CJD occurring in U.S. corneal don...
journal_title:Cornea
pub_type: 杂志文章,评审
doi:
更新日期:1999-01-01 00:00:00
abstract:PURPOSE:To investigate the in vivo, corneal, biomechanical changes after corneal collagen cross-linking (CXL) using the Ocular Response Analyzer (ORA) in patients with keratoconus and post-laser in situ keratomileusis (LASIK) ectasia. METHODS:Single-center, prospective, randomized, controlled, clinical trial. After CX...
journal_title:Cornea
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1097/ICO.0b013e31821eea66
更新日期:2012-01-01 00:00:00
abstract:PURPOSE:Previous work has suggested that Descemet membrane (DM) folds arise in response to corneal swelling. However, their origin has not been closely explored. In this study, we used optical coherence tomography to evaluate whether DM folds arise secondary to folds in the middle stroma. METHODS:Serial optical cohere...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000001908
更新日期:2019-06-01 00:00:00
abstract:PURPOSE:The aim of this study was to investigate the corneal thickness asymmetry indices in a large pool of patients with keratoconus derived using anterior segment optical coherence tomography (AS-OCT) in comparison with established Scheimpflug imaging-derived keratoconus classification indices. METHODS:Six specific ...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000000275
更新日期:2014-12-01 00:00:00
abstract:PURPOSE:To analyze whether plasma rich in growth factors (PRGF) eye drops preserve their biological characteristics and activity after storage for 3 and 6 months at -20°C, at 4°C, and at room temperature for 72 hours, compared with fresh samples (t0). METHODS:Blood from 6 healthy donors was harvested and centrifuged t...
journal_title:Cornea
pub_type: 杂志文章
doi:10.1097/ICO.0000000000000489
更新日期:2015-09-01 00:00:00