Advances in the management of keratomycosis and Acanthamoeba keratitis.


PURPOSE:In the late 1960s, the management of fungal keratitis was a serious unresolved problem. Little was known of the epidemiology of the disease, and there were no antifungal agents formulated for use in the eye. METHODS:A thorough review of the literature was done back to 1969 on clinical reports and experimental studies for keratomycosis and Acanthamoeba keratitis. RESULTS:Since 1969, through basic and clinical research, the epidemiology of the disease worldwide is better understood. One new topical antifungal agent, natamycin, with efficacy against filamentous fungi has been developed and the pharmacokinetics of topically applied antifungal drops have been explored. Progress has been slow but the prognosis for keratomycosis has immeasurably improved over the period. Acanthamoeba was first recognized as an ocular pathogen in 1973 and was the cause of an epidemic in the 1980s caused by contaminated contact lens, although other risk factors were also identified. At the onset of the epidemic, there was no known treatment. but as a result of intense research efforts, within a few years a well-defined therapeutic approach had been developed that had a significant impact on the prognosis for this initially devastating infection. For both infections, the role of corticosteroids for controlling the inflammation remains controversial, but the place for keratoplasty is now well defined. CONCLUSIONS:Although there has been steady progress in the management of both infections, continued research is the way to define more effective medical and surgical therapy.






O'Day DM,Head WS




Has Abstract


2000-09-01 00:00:00














  • Keratitis and corneal melt with ketorolac tromethamine after conductive keratoplasty.

    abstract:PURPOSE:To report a case of keratitis and corneal melt after conductive keratoplasty (CK) enhancement. METHOD:Case report. RESULTS:A 52-year-old woman with emmetropic presbyopia had undergone previous CK for monovision and underwent CK enhancement 4 years later. Postoperatively, she was managed with ketorolac trometh...


    pub_type: 杂志文章


    authors: Khalifa YM,Mifflin MD

    更新日期:2011-04-01 00:00:00

  • Severe Corneal Hydrops With Suspected Posterior Stromal Rupture Managed With Ultrathin Descemet-Stripping Automated Endothelial Keratoplasty.

    abstract:PURPOSE:To describe severe acute corneal hydrops in a patient with previously undiagnosed keratoconus, in which anterior segment optical coherence tomography (AS-OCT) revealed a protruding ridge of tissue on either side of Descemet membrane (DM) break, treated successfully with ultrathin Descemet-stripping automated en...


    pub_type: 杂志文章


    authors: Blitzer AL,Liles CA,Harocopos GJ,Reidy JJ,Farooq AV

    更新日期:2020-09-09 00:00:00

  • The influence of age on the refractive index of the human corneal stroma resected using a mechanical microkeratome.

    abstract:PURPOSE:To measure the refractive index (RI) of the human corneal stroma in vivo using an objective Abbé refractometer (VCH-1) and to determine if RI of the stroma is related to age. METHODS:The VCH-1 was calibrated against a standard subjective Abbé refractometer using 7 randomly selected turbid semiliquid media. VCH...


    pub_type: 杂志文章


    authors: Patel S,Alió JL,Amparo F,Rodriguez-Prats JL

    更新日期:2011-12-01 00:00:00

  • Terrien marginal degeneration presenting with spontaneous corneal perforation.

    abstract:PURPOSE:To report spontaneous corneal perforation as a presenting sign of unilateral Terrien marginal degeneration in a young adult. METHODS:A 19-year-old woman presented with sudden loss of vision in her left eye of 1-day duration. Examination revealed superior corneal thinning with superficial vascularization and se...


    pub_type: 杂志文章


    authors: Srinivasan S,Murphy CC,Fisher AC,Freeman LB,Kaye SB

    更新日期:2006-09-01 00:00:00

  • Successful treatment of microsporidial keratoconjunctivitis with topical fumagillin in a patient with AIDS.

    abstract::There recently have been several reports of microsporidial keratoconjunctivitis caused by the organism Encephalitozoon hellem. However, treatment of this infection has been largely ineffective. We report a case of a 35-year-old Hispanic woman with AIDS and E. hellem keratoconjunctivitis confirmed with light, electron,...


    pub_type: 杂志文章


    authors: Rosberger DF,Serdarevic ON,Erlandson RA,Bryan RT,Schwartz DA,Visvesvara GS,Keenan PC

    更新日期:1993-05-01 00:00:00

  • Conjunctival flap surgery for calcified scleromalacia after cosmetic conjunctivectomy.

    abstract:PURPOSE:To investigate the long-term clinical course of scleromalacia with calcified plaque as a complication of cosmetic conjunctivectomy with topical mitomycin C (MMC) application and to introduce a surgical method for this complication using calcified plaque removal and/or conjunctival flap surgery. METHODS:Eleven ...


    pub_type: 杂志文章


    authors: Kwon HJ,Nam SM,Lee SY,Ahn JM,Seo KY

    更新日期:2013-06-01 00:00:00

  • Treatment of aniridia with Boston type I keratoprosthesis.

    abstract:PURPOSE:To report the outcomes of Boston keratoprosthesis (K-pro) type I implantation for congenital aniridia. METHODS:A retrospective review of the medical records of every patient with congenital aniridia who underwent Boston K-pro type I implantation at the University of Iowa Hospitals and Clinics from January 1, 2...


    pub_type: 杂志文章


    authors: Rixen JJ,Cohen AW,Kitzmann AS,Wagoner MD,Goins KM

    更新日期:2013-07-01 00:00:00

  • Endothelial rejection following penetrating keratoplasty using Healon or BSS.

    abstract::In order to evaluate the effect of a commonly used sodium hyaluronate preparation (Healon, Pharmacia AB, Uppsala, Sweden) on the incidence of endothelial rejection, endothelial cell loss, intraocular pressure, and corneal thickness after penetrating keratoplasty, we conducted a randomized clinical trial. Patients were...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Musch DC,Meyer RF,Sugar A,Soong HK

    更新日期:1990-10-01 00:00:00

  • Peripheral ulcerative keratitis after Salmonella gastroenteritis.

    abstract:PURPOSE:To describe a case of bilateral peripheral ulcerative keratitis after Salmonella gastroenteritis. METHODS:Case report with description of treatment and outcome. RESULTS:The peripheral ulcerative keratitis gradually resolved in both eyes after appropriate systemic antibiotic therapy and local ocular care. CON...


    pub_type: 杂志文章


    authors: Yang J,Baltatzis S,Foster CS

    更新日期:1998-11-01 00:00:00

  • Anterior Segment Findings in Patients With Osteogenesis Imperfecta: A Case-Control Study.

    abstract:PURPOSE:To evaluate the anterior segment parameters in patients with osteogenesis imperfecta (OI) compared with healthy control subjects. METHODS:Seventeen patients with OI and 19 age-matched healthy controls were included into this cross-sectional case-control study. Corneal topographic, topometric and Belin-Ambrósio...


    pub_type: 杂志文章


    authors: Keleş A,Doğuizi S,Şahin NM,Koç M,Aycan Z

    更新日期:2020-08-01 00:00:00

  • Ocular surface squamous neoplasia: a survey of changes in the standard of care from 2003 to 2012.

    abstract:PURPOSE:To evaluate the current standard of care of ophthalmologists who are likely to encounter ocular surface squamous neoplasia (OSSN) in their practices and to compare this with data gathered in 2003. METHODS:Invitations to a web-based survey were sent to members of the Ocular Microbiology and Immunology Group. In...


    pub_type: 杂志文章


    authors: Adler E,Turner JR,Stone DU

    更新日期:2013-12-01 00:00:00

  • Quantitation of ultraviolet light-absorbing fractions of the cornea.

    abstract::This study attempts to measure the quantitative contribution of major chemical fractions of the whole bovine cornea to ultraviolet (UV) absorption between 240 and 300 nm, with special attention to the biologically significant range of 290-300 nm. The cornea was divided into water-insoluble, nonprotein small water-solu...


    pub_type: 杂志文章


    authors: Mitchell J,Cenedella RJ

    更新日期:1995-05-01 00:00:00

  • Survival of rabbit limbal stem cell allografts after administration of cyclosporin A.

    abstract:OBJECTIVES:To evaluate the efficacy of systemic or topical administration of cyclosporin A (CsA) after limbal transplantation of stem cell allografts in rabbits. METHODS:Thirty-six rabbits underwent corneal epithelial debridement and limbal ablation to induce ocular surface disease and were then treated by limbal allo...


    pub_type: 杂志文章


    authors: Xu KP,Wu Y,Zhou J,Zhang X

    更新日期:1999-07-01 00:00:00

  • Pachymetry-guided intrastromal air injection ("pachy-bubble") for deep anterior lamellar keratoplasty.

    abstract::To evaluate an innovative technique for intrastromal air injection to achieve deep anterior lamellar keratoplasty (DALK) with bare Descemet membrane (DM). Thirty-four eyes with anterior corneal pathology, including 27 with keratoconus, underwent DALK. After 400 μm trephination with a suction trephine, ultrasound pachy...


    pub_type: 杂志文章


    authors: Ghanem RC,Ghanem MA

    更新日期:2012-09-01 00:00:00

  • Treatment of Refractory Keratitis After a Boston Type I Keratoprosthesis With Corneal Collagen Cross-Linking.

    abstract:PURPOSE:To report a patient with refractory keratitis after a Boston type I keratoprosthesis treated with corneal collagen cross-linking (CXL). METHODS:Case report. RESULTS:A 29-year-old man with a history of chemical burn in the left eye underwent keratoprosthesis implantation. He developed infectious keratitis 4 mo...


    pub_type: 杂志文章


    authors: Zarei-Ghanavati S,Irandoost F

    更新日期:2015-09-01 00:00:00

  • Corneal Stiffness and Its Relationship With Other Corneal Biomechanical and Nonbiomechanical Parameters in Myopic Eyes of Chinese Patients.

    abstract:PURPOSE:To investigate corneal stiffness and analyze its possible influence on other corneal biomechanical and nonbiomechanical parameters in myopic eyes of Chinese patients. METHODS:A total of 387 healthy (right) myopic eyes were included in this study. Corneal visualization Scheimpflug technology was used to measure...


    pub_type: 杂志文章


    authors: Zhang Y,Wang Y,Li L,Dou R,Wu W,Wu D,Jhanji V

    更新日期:2018-07-01 00:00:00

  • Cellular senescence as a stress response.

    abstract:PURPOSE:This review discusses cellular senescence, the state in which normal cells do not respond to growth stimuli, and shows characteristic alterations in their cytologic and biochemical properties and their gene expression profiles. METHODS AND RESULTS:Cellular senescence is elicited by various stresses. It was rec...


    pub_type: 杂志文章,评审


    authors: Ishikawa F

    更新日期:2006-12-01 00:00:00

  • Glaucoma progression and role of glaucoma surgery in patients with Boston keratoprosthesis.

    abstract:PURPOSE:The aim of this study was to evaluate glaucoma onset and progression after implantation of Boston Keratoprostheses (B-KPro) and the role of glaucoma surgery. METHODS:Records of patients with B-KPro implantation during 2004 to 2009 were reviewed. Parameters relevant to B-KPro surgery and glaucoma status were re...


    pub_type: 杂志文章


    authors: Crnej A,Paschalis EI,Salvador-Culla B,Tauber A,Drnovsek-Olup B,Shen LQ,Dohlman CH

    更新日期:2014-04-01 00:00:00

  • Potentiation by cyclic AMP of the stimulatory effect of epidermal growth factor on corneal epithelial migration.

    abstract:PURPOSE:To provide insight into the mechanism by which epidermal growth factor (EGF) stimulates corneal epithelial migration, we investigated the possible interaction between EGF and cyclic AMP (cAMP) signaling pathways during epithelial migration with an organ culture system for the rabbit cornea. METHODS:Rabbit corn...


    pub_type: 杂志文章


    authors: Nakamura M,Nishida T

    更新日期:2003-05-01 00:00:00

  • Review of corneal endothelial specular microscopy for FDA clinical trials of refractive procedures, surgical devices, and new intraocular drugs and solutions.

    abstract::Specular microscopy can provide a noninvasive morphologic analysis of the corneal endothelial cell layer from subjects enrolled in clinical trials. The analysis provides a measure of the endothelial cell physiologic reserve from aging, ocular surgical procedures, pharmaceutical exposure, and general health of the corn...


    pub_type: 杂志文章,评审


    authors: McCarey BE,Edelhauser HF,Lynn MJ

    更新日期:2008-01-01 00:00:00

  • Late-onset traumatic flap dislocation and diffuse lamellar inflammation after laser in situ keratomileusis.

    abstract:PURPOSE:To report a case of traumatic flap partial dislocation and subsequent diffuse lamellar inflammation 14 months after laser in situ keratomileusis (LASIK) retreatment. METHODS:Case report of a late flap dislocation that occurred during routine recreational activity (struck with a finger in the right eye while pl...


    pub_type: 杂志文章,评审


    authors: Aldave AJ,Hollander DA,Abbott RL

    更新日期:2002-08-01 00:00:00

  • Who pays the toll for solving the enigma of corneal herpes?

    abstract::In herpetic stromal keratitis (HSK), herpes simplex virus type-1 DNA fragments and herpes simplex virus-immunoglobulin G immune complexes are present in corneas long after the infective virus has disappeared. These viral components are highly immunogenic and potentiate the production of proinflammatory cytokines and c...


    pub_type: 杂志文章


    authors: Hayashi K,Hooper LC,Shimomura Y

    更新日期:2013-11-01 00:00:00

  • Posterior amorphous corneal dystrophy: ultrasound biomicroscopy findings in two cases.

    abstract::We present two cases of posterior amorphous corneal dystrophy in members of the same family. We correlated the clinical findings with refraction, topography, and ultrasound biomicroscopy (UBM). This is the first report of UBM findings in amorphous corneal dystrophy and we describe the depth of stromal opacification me...


    pub_type: 杂志文章


    authors: Castelo Branco B,Chalita MR,Casanova FH,Castelo Branco AB,Allemann N,de Freitas D

    更新日期:2002-03-01 00:00:00

  • The corneal-thickness profile in Hong Kong Chinese.

    abstract:PURPOSE:This study investigated the topographic corneal thickness in four groups of Hong Kong Chinese. METHODS:The corneal thickness was determined with an ultrasound pachometer mounted on a X-Y plate. A head rest was used to reduce further any movement from the subject during the measurement. After the central cornea...


    pub_type: 杂志文章


    authors: Lam AK,Douthwaite WA

    更新日期:1998-07-01 00:00:00

  • Incidence and Outcomes of Positive Donor Rim Cultures and Infections in the Cornea Preservation Time Study.

    abstract:PURPOSE:To assess donor rim culture results and outcomes of ocular infections in the Cornea Preservation Time Study (CPTS). METHODS:Donor corneal rim cultures were optional. Donor characteristics were assessed for association with positive cultures using the Fisher exact test and Poisson regression analyses. Incidence...


    pub_type: 杂志文章,多中心研究


    authors: Mian SI,Aldave AJ,Tu EY,Ayres BD,Jeng BH,Macsai MS,Nordlund ML,Penta JG,Pramanik S,Szczotka-Flynn LB,Ayala AR,Liang W,Maguire MG,Lass JH

    更新日期:2018-09-01 00:00:00

  • Method for expressing clinical and statistical significance of ocular and corneal wave front error aberrations.

    abstract:PURPOSE:The significance of ocular or corneal aberrations may be subject to misinterpretation whenever eyes with different pupil sizes or the application of different Zernike expansion orders are compared. A method is shown that uses simple mathematical interpolation techniques based on normal data to rapidly determine...


    pub_type: 杂志文章


    authors: Smolek MK

    更新日期:2012-03-01 00:00:00

  • Ocular streptococcal infections.

    abstract::Streptococcal infections are an important cause of corneal ulcers, endophthalmitis, conjunctivitis, and dacryocystitis. We retrospectively reviewed 53 ocular streptococcal infections diagnosed and followed at Wills Eye Hospital between January 1, 1984, and July 1, 1986. Corneal ulcers (23 of 53; 43%) and endophthalmit...


    pub_type: 杂志文章


    authors: Jones S,Cohen EJ,Arentsen JJ,Laibson PR

    更新日期:1988-01-01 00:00:00

  • Scheimpflug Corneal Densitometry Changes After Trabeculectomy.

    abstract:PURPOSE:To study the possible changes in Scheimpflug corneal densitometry 6 months after mitomycin C-augmented trabeculectomy and to compare these measurements with healthy controls. METHODS:Corneal densitometry was monitored with the Pentacam HR3 before and 6 months after first-time uncomplicated mitomycin C-augmente...


    pub_type: 杂志文章


    authors: Pillunat KR,Orphal J,Haase M,Pillunat LE,Herber R

    更新日期:2020-07-27 00:00:00

  • Evaluation of corneal topography with Orbscan II in first-degree relatives of patients with keratoconus.

    abstract:PURPOSE:To evaluate the corneal topographic characteristics of first-degree relatives of patients with keratoconus with corneal topography to determine the incidence of clinical keratoconus and topographic abnormalities. METHODS:Between February and August 2006, Orbscan II analysis was done in 144 eyes of 72 cases who...


    pub_type: 杂志文章


    authors: Kaya V,Utine CA,Altunsoy M,Oral D,Yilmaz OF

    更新日期:2008-06-01 00:00:00

  • Spontaneous resolution of descemet membrane detachment after deep anterior lamellar keratoplasty.

    abstract:PURPOSE:To describe a patient whose Descemet membrane detachment following deep lamellar keratoplasty failed to respond to 2 attempts at gas tamponade but later resolved spontaneously. METHODS:A 77-year-old woman with bilateral anterior corneal stromal scarring underwent a right deep lamellar keratoplasty with the Mel...


    pub_type: 杂志文章


    authors: Tu KL,Ibrahim M,Kaye SB

    更新日期:2006-01-01 00:00:00