RB-dependent S-phase response to DNA damage.

abstract：:The fucose alpha(1-->2) galactose beta structure is expressed by uterine epithelial cells in the mouse and has been implicated in blastocyst adhesion events thought to be required for murine implantation. Fucalpha(1-->2)Galbeta moieties and cognate fucosyltransferases are also expressed by epithelial cells of the male...

journal_title：Molecular and cellular biology

authors： Domino SE,Zhang L,Gillespie PJ,Saunders TL,Lowe JB

更新日期：2001-12-01 00:00:00

abstract：:The xCR1 protein is a maternal determinant and cofactor for nodal signaling in vertebrate embryos. The xCR1 protein accumulates specifically in the animal cells of Xenopus embryos, but maternal xCR1 mRNA is distributed equally throughout all embryonic cells. Here, we show that vegetal cell-specific translational repre...

journal_title：Molecular and cellular biology

authors： Zhang Y,Forinash KD,McGivern J,Fritz B,Dorey K,Sheets MD

更新日期：2009-07-01 00:00:00

abstract：:The basis for nucleolar dominance in mouse-human cell hybrids which contained all of the mouse chromosomes but an incomplete set of human chromosomes (M greater than H) was examined at the molecular level. S1 mapping data showed that these cells had the expected levels of steady-state rRNA transcribed from mouse ribos...

journal_title：Molecular and cellular biology

authors： Miesfeld R,Sollner-Webb B,Croce C,Arnheim N

更新日期：1984-07-01 00:00:00

abstract：:Aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor, is known to mediate a wide variety of pharmacological and toxicological effects caused by polycyclic aromatic hydrocarbons. Recent studies have revealed that AhR is involved in the normal development and homeostasis of many organs. Here, we demo...

journal_title：Molecular and cellular biology

authors： Sekine H,Mimura J,Oshima M,Okawa H,Kanno J,Igarashi K,Gonzalez FJ,Ikuta T,Kawajiri K,Fujii-Kuriyama Y

更新日期：2009-12-01 00:00:00

abstract：:The nucleotide sequence of 5'-noncoding and N-terminal coding regions of two coordinately regulated, repressible acid phosphatase genes from Saccharomyces cerevisiae were determined. These unlinked genes encode different, but structurally related polypeptides of molecular weights 60,000 and 56,000. The DNA sequences o...

journal_title：Molecular and cellular biology

authors： Thill GP,Kramer RA,Turner KJ,Bostian KA

更新日期：1983-04-01 00:00:00

abstract：:Splicing of the Saccharomyces cerevisiae mitochondrial DNA group II intron aI2 depends on the intron-encoded 62-kDa reverse transcriptase-maturase protein (p62). In wild-type strains, p62 remains associated with the excised intron lariat RNA in ribonucleoprotein (RNP) particles that are essential for intron homing. St...

journal_title：Molecular and cellular biology

authors： Huang HR,Chao MY,Armstrong B,Wang Y,Lambowitz AM,Perlman PS

更新日期：2003-12-01 00:00:00

abstract：:The chromatin structure of TDH3, one of three genes encoding glyceraldehyde phosphate dehydrogenases in Saccharomyces cerevisiae, was analyzed by nuclease digestion. A large hypersensitive region was found at the TDH3 promoter extending from the RNA initiation site at position -40 to position -560. This hypersensitive...

journal_title：Molecular and cellular biology

authors： Pavlović B,Hörz W

更新日期：1988-12-01 00:00:00

abstract：:We have reported that the papillomavirus E2 protein binds the nuclear factor AMF1 (also called G-protein pathway suppressor 2 or GPS2) and that their interaction is necessary for transcriptional activation by E2. It has also been shown that AMF1 can influence the activity of cellular transcription factors. These obser...

journal_title：Molecular and cellular biology

authors： Peng YC,Kuo F,Breiding DE,Wang YF,Mansur CP,Androphy EJ

更新日期：2001-09-01 00:00:00

abstract：:We analyzed the transcriptional properties of a repetitive sequence element, BmX, that belongs to a large gene family (approximately 2 x 10(4) copies) in the genome of the Bombyx mori silkworm. We discovered BmX elements because of their ability to direct transcription by polymerase III in vitro and used them to test ...

journal_title：Molecular and cellular biology

authors： Wilson ET,Condliffe DP,Sprague KU

更新日期：1988-02-01 00:00:00

abstract：:The v-vis gene encodes p28sis, the transforming protein of simian sarcoma virus. This gene resulted from a fusion of the env gene of simian sarcoma-associated virus and the woolly monkey gene for the B chain of platelet-derived growth factor (PDGF). Previous work has shown that the v-sis gene product undergoes signal ...

journal_title：Molecular and cellular biology

authors： Lee BA,Maher DW,Hannink M,Donoghue DJ

更新日期：1987-10-01 00:00:00

abstract：:CAP, a protein from Saccharomyces cerevisiae that copurifies with adenylyl cyclase, appears to be required for yeast cells to be fully responsive to RAS proteins. CAP also appears to be required for normal cell morphology and responsiveness to nutrient deprivation and excess. We describe here a molecular and phenotypi...

journal_title：Molecular and cellular biology

authors： Gerst JE,Ferguson K,Vojtek A,Wigler M,Field J

更新日期：1991-03-01 00:00:00

abstract：:Eukaryotic flagella are complex organelles composed of more than 200 polypeptides. Little is known about the regulatory mechanisms governing synthesis of the flagellar protein subunits and their assembly into this complex organelle. The unicellular green alga Chlamydomonas reinhardtii is the premier experimental model...

journal_title：Molecular and cellular biology

authors： Periz G,Keller LR

更新日期：1997-07-01 00:00:00

abstract：:AIRE is a transcriptional activator that directs the ectopic expression of many tissue-specific genes in medullary thymic epithelial cells, which plays an important role in the negative selection of autoreactive T cells. However, its mechanism of action remains poorly understood. In this study, we found that AIRE regu...

journal_title：Molecular and cellular biology

authors： Oven I,Brdicková N,Kohoutek J,Vaupotic T,Narat M,Peterlin BM

更新日期：2007-12-01 00:00:00

abstract：:The gene encoding human hemojuvelin (HJV) is one of the genes that, when mutated, can cause juvenile hemochromatosis, an early-onset inherited disorder associated with iron overload. The 5' untranslated region of the human HJV mRNA has two upstream open reading frames (uORFs), with 28 and 19 codons formed by two upstr...

journal_title：Molecular and cellular biology

authors： Onofre C,Tomé F,Barbosa C,Silva AL,Romão L

更新日期：2015-04-01 00:00:00

abstract：:Elevation of cellular cyclic AMP (cAMP) levels inhibits cell cycle reentry in a variety of cell types. While cAMP can prevent the activation of Raf-1 and extracellular signal-regulated kinases 1 and 2 (ERK1/2) by growth factors, we now show that activation of ERK1/2 by DeltaRaf-1:ER is insensitive to cAMP. Despite thi...

journal_title：Molecular and cellular biology

authors： Balmanno K,Millar T,McMahon M,Cook SJ

更新日期：2003-12-01 00:00:00

abstract：:The int-1 proto-oncogene is a target for insertional activation of transcription by mouse mammary tumor virus in many murine mammary tumors. Whereas no expression of int-1 is seen in normal mammary tissue, int-1 RNA can be detected in normal mice in the neural tubes of midgestation embryos and in postmeiotic spermatoc...

journal_title：Molecular and cellular biology

authors： Papkoff J

更新日期：1989-08-01 00:00:00

abstract：:Aromatic aminotransferase II, product of the ARO9 gene, catalyzes the first step of tryptophan, phenylalanine, and tyrosine catabolism in Saccharomyces cerevisiae. ARO9 expression is under the dual control of specific induction and nitrogen source regulation. We have here identified UASaro, a 36-bp upstream element ne...

journal_title：Molecular and cellular biology

authors： Iraqui I,Vissers S,André B,Urrestarazu A

更新日期：1999-05-01 00:00:00

abstract：:The Fanconi anemia (FA) pathway is a DNA damage-activated signaling pathway which regulates cellular resistance to DNA cross-linking agents. Cloned FA genes and proteins cooperate in this pathway, and monoubiquitination of FANCD2 is a critical downstream event. The cell cycle checkpoint kinase ATR is required for the ...

journal_title：Molecular and cellular biology

authors： Ho GP,Margossian S,Taniguchi T,D'Andrea AD

更新日期：2006-09-01 00:00:00

abstract：:Histone H3 lysine 9 (H3K9) methylation has broad roles in transcriptional repression, gene silencing, maintenance of heterochromatin, and epigenetic inheritance of heterochromatin. Using Xenopus laevis oocytes, we have previously shown that targeting G9a, an H3K9 histone methyltransferase, to chromatin increases H3K9 ...

journal_title：Molecular and cellular biology

authors： Stewart MD,Sommerville J,Wong J

更新日期：2006-09-01 00:00:00

abstract：:Our recent studies implicated key and distinct roles for the highly related RalA and RalB small GTPases (82% sequence identity) in pancreatic ductal adenocarcinoma (PDAC) tumorigenesis and invasive and metastatic growth, respectively. How RalB may promote PDAC invasion and metastasis has not been determined. In light ...

journal_title：Molecular and cellular biology

authors： Neel NF,Rossman KL,Martin TD,Hayes TK,Yeh JJ,Der CJ

更新日期：2012-04-01 00:00:00

abstract：:Mutations in mitochondrial DNA (mtDNA) cause a variety of relatively rare human diseases and may contribute to the pathogenesis of other, more common degenerative diseases. This stimulates interest in the capacity of mitochondria to repair damage to mtDNA. Several recent studies have shown that some types of damage to...

journal_title：Molecular and cellular biology

authors： Pinz KG,Bogenhagen DF

更新日期：1998-03-01 00:00:00

abstract：:Phosphorylation is one of the key mechanisms that regulate centrosome biogenesis, spindle assembly, and cell cycle progression. However, little is known about centrosome-specific phosphorylation sites and their functional relevance. Here, we identified phosphoproteins of intact Drosophila melanogaster centrosomes and ...

journal_title：Molecular and cellular biology

authors： Habermann K,Mirgorodskaya E,Gobom J,Lehmann V,Müller H,Blümlein K,Deery MJ,Czogiel I,Erdmann C,Ralser M,von Kries JP,Lange BM

更新日期：2012-09-01 00:00:00

abstract：:The expression of CD154 (CD40 ligand) by activated T lymphocytes plays a central role in humoral and cellular immunity. The fundamental importance of this protein in mounting an immune response has made it an attractive target for immunomodulation. Several studies have demonstrated that CD154 expression is regulated a...

journal_title：Molecular and cellular biology

authors： Hamilton BJ,Genin A,Cron RQ,Rigby WF

更新日期：2003-01-01 00:00:00

abstract：:In the budding yeast Saccharomyces cerevisiae, Cdc37 is required for the productive formation of Cdc28-cyclin complexes. The cdc37-1 mutant arrests at Start with low levels of Cdc28 protein, which is predominantly unphosphorylated at Thr169, fails to bind cyclin, and has little protein kinase activity. We show here th...

journal_title：Molecular and cellular biology

authors： Farrell A,Morgan DO

更新日期：2000-02-01 00:00:00

abstract：:Mammalian B-cell lymphoid malignancies frequently display aberrant translocations involving the c-myc proto-oncogene and one of the immunoglobulin loci. We have observed and characterized such a translocation in the immunoglobulin E-producing rat immunocytoma IR162 by using recombinant DNA technology. We show here for...

journal_title：Molecular and cellular biology

authors： Tian SS,Faust C

更新日期：1987-07-01 00:00:00

abstract：:The recruitment of corepressors by DNA-bound repressors is likely to be a critical rate-limiting step in the transcriptional regulation of many genes. An excellent paradigm for such an interaction is the association of the basic helix-loop-helix zipper protein Mad1 with the corepressor mSin3A. When bound together, the...

journal_title：Molecular and cellular biology

authors： Cowley SM,Kang RS,Frangioni JV,Yada JJ,DeGrand AM,Radhakrishnan I,Eisenman RN

更新日期：2004-04-01 00:00:00

abstract：:The Ste12p transcription factor controls the expression of Ty1 transposable element insertion mutations and genes whose products are required for mating in Saccharomyces cerevisiae. The binding site for Ste12p is a consensus DNA sequence known as a pheromone response element (PRE). Upstream activating sequences (UASs)...

journal_title：Molecular and cellular biology

authors： Baur M,Esch RK,Errede B

更新日期：1997-08-01 00:00:00

abstract：:Protein sumoylation plays an important but poorly understood role in controlling genome integrity. In Saccharomyces cerevisiae, the Slx5-Slx8 SUMO-targeted Ub ligase appears to be needed to ubiquitinate sumoylated proteins that arise in the absence of the Sgs1 DNA helicase. WSS1, a high-copy-number suppressor of a mut...

journal_title：Molecular and cellular biology

authors： Mullen JR,Chen CF,Brill SJ

更新日期：2010-08-01 00:00:00

abstract：:Determining the roles of Rel/NF-kappaB transcription factors in mouse skin development with loss-of-function mutants has been limited by redundancy among these proteins and by embryonic lethality associated with the absence of RelA. Using mice lacking RelA and c-rel, which survive throughout embryogenesis on a tumor n...

journal_title：Molecular and cellular biology

authors： Gugasyan R,Voss A,Varigos G,Thomas T,Grumont RJ,Kaur P,Grigoriadis G,Gerondakis S

更新日期：2004-07-01 00:00:00

abstract：:The location in the mouse genome of the 149-base pair MES-1 element, previously isolated by its ability to restore expression to an enhancerless selectable gene, was analyzed. The active moiety of the single-copy MES-1 element is located between the 5' ends of two divergent transcription units, SURF-1 and SURF-2, both...

journal_title：Molecular and cellular biology

authors： Williams TJ,Fried M

更新日期：1986-12-01 00:00:00