Trophoblast cell-specific carcinoembryonic antigen cell adhesion molecule 9 is not required for placental development or a positive outcome of allotypic pregnancies.

abstract：:Interferon A (IFN-A) genes are differentially expressed after virus induction. The differential expression of individual IFN-A genes is modulated by the specific transcription activators IFN regulatory factor 3 (IRF3) and IRF-7 and the homeoprotein transcription repressor Pitx1. We now show that repression by Pitx1 do...

journal_title：Molecular and cellular biology

authors： Island ML,Mesplede T,Darracq N,Bandu MT,Christeff N,Djian P,Drouin J,Navarro S

更新日期：2002-10-01 00:00:00

abstract：:clk-1 encodes a demethoxyubiquinone (DMQ) hydroxylase that is necessary for ubiquinone biosynthesis. When Caenorhabditis elegans clk-1 mutants are grown on bacteria that synthesize ubiquinone (UQ), they are viable but have a pleiotropic phenotype that includes slowed development, behaviors, and aging. However, when gr...

journal_title：Molecular and cellular biology

authors： Branicky R,Nguyen PA,Hekimi S

更新日期：2006-05-01 00:00:00

abstract：:Beta-catenin plays multiple roles in cell-cell adhesion and Wnt signal transduction. Through the Wnt signal, the cellular level of beta-catenin is constitutively regulated by the multicomponent destruction complex containing glycogen synthase kinase 3beta, axin, and adenomatous polyposis coli. Here, we present multipl...

journal_title：Molecular and cellular biology

authors： Thyssen G,Li TH,Lehmann L,Zhuo M,Sharma M,Sun Z

更新日期：2006-12-01 00:00:00

abstract：:The minimal muscle-specific dystrophin promoter contains the consensus sequence CC(A/T)6GG, or the CArG element, which can be found in serum-inducible or muscle-specific promoters. The serum response factor (SRF), which mediates the transcriptional activation of the c-fos gene in response to serum stimulation, can bin...

journal_title：Molecular and cellular biology

authors： Galvagni F,Lestingi M,Cartocci E,Oliviero S

更新日期：1997-03-01 00:00:00

abstract：:The G protein-coupled alpha-factor receptor promotes polarized growth toward a mating partner. alpha-Factor induces the expression of AFR1, which acts together with the receptor C terminus to promote normal morphogenesis. The function of AFR1 was investigated by engineering cells to constitutively express AFR1 without...

journal_title：Molecular and cellular biology

authors： Konopka JB,DeMattei C,Davis C

更新日期：1995-02-01 00:00:00

abstract：:The retinoblastoma protein (RB) represses RNA polymerase III transcription effectively both in vivo and in vitro. Here we demonstrate that the general transcription factors snRNA-activating protein complex (SNAP(c)) and TATA binding protein (TBP) are important for RB repression of human U6 snRNA gene transcription by ...

journal_title：Molecular and cellular biology

authors： Hirsch HA,Gu L,Henry RW

更新日期：2000-12-01 00:00:00

abstract：:Epidermal growth factor (EGF) receptor (EGFR) has been implicated in tumor development and invasion. Dimerization and autophosphorylation of EGFR are the critical events for EGFR activation. However, the regulation of EGF-dependent and EGF-independent dimerization and phosphorylation of EGFR has not been fully underst...

journal_title：Molecular and cellular biology

authors： Arimoto K,Burkart C,Yan M,Ran D,Weng S,Zhang DE

更新日期：2014-10-01 00:00:00

abstract：:Signal transducer and activator of transcription 6 (Stat6) and NF-kappaB are widely distributed transcription factors which are induced by different stimuli and bind to distinct DNA sequence motifs. Interleukin-4 (IL-4), which activates Stat6, synergizes with activators of NF-kappaB to induce IL-4-responsive genes, bu...

journal_title：Molecular and cellular biology

authors： Shen CH,Stavnezer J

更新日期：1998-06-01 00:00:00

abstract：:In an effort to identify aberrantly expressed genes in v-rel-induced tumors, monoclonal antibodies were developed that reacted selectively with avian B-cell tumors. One antibody, HY78, immunoprecipitated a 120-kDa glycoprotein (p120) from cells that express v-rel. N-terminal amino acid sequencing of p120 identified a ...

journal_title：Molecular and cellular biology

authors： Zhang G,Slaughter C,Humphries EH

更新日期：1995-03-01 00:00:00

abstract：:Abundant approximately 28-nucleotide RNAs that are thought to direct histone H3 lysine 9 (H3K9) methylation and promote the elimination of nearly 15 Mbp of DNA from the developing somatic genome are generated during Tetrahymena thermophila conjugation. To identify the protein(s) that generates these small RNAs, we stu...

journal_title：Molecular and cellular biology

authors： Malone CD,Anderson AM,Motl JA,Rexer CH,Chalker DL

更新日期：2005-10-01 00:00:00

abstract：:The binding of the U1 small nuclear ribonucleoprotein (snRNP)-specific proteins C, A, and 70K to U1 small nuclear RNA (snRNA) was analyzed. Assembly of U1 snRNAs from bean and soybean and a set of mutant Xenopus U1 snRNAs into U1 snRNPs in Xenopus egg extracts was studied. The ability to bind proteins was analyzed by ...

journal_title：Molecular and cellular biology

authors： Hamm J,van Santen VL,Spritz RA,Mattaj IW

更新日期：1988-11-01 00:00:00

abstract：:Activation of adult myoblasts called satellite cells during muscle degeneration is an important aspect of muscle regeneration. Satellite cells are believed to be the only myogenic stem cells in adult skeletal muscle and the source of regenerating muscle fibers. Upon activation, satellite cells proliferate, migrate to ...

journal_title：Molecular and cellular biology

authors： Taylor JM,Dupont-Versteegden EE,Davies JD,Hassell JA,Houlé JD,Gurley CM,Peterson CA

更新日期：1997-09-01 00:00:00

abstract：:The NF-kappa B/Rel family of transcription factors participates in the control of a wide array of genes, including genes involved in embryonic development and regulation of immune, inflammation, and stress responses. In most cells, inhibitory I kappa B proteins sequester NF-kappa B/Rel in the cytoplasm. Cellular stimu...

journal_title：Molecular and cellular biology

authors： Antonsson A,Hughes K,Edin S,Grundström T

更新日期：2003-02-01 00:00:00

abstract：:Histone acetylation and deacetylation have been implicated in the regulation of gene expression. Molecular studies have shown that histone deacetylases (HDACs) function as transcriptional repressors. However, very little is known about their roles during development in multicellular organisms. We previously demonstrat...

journal_title：Molecular and cellular biology

authors： Dufourcq P,Victor M,Gay F,Calvo D,Hodgkin J,Shi Y

更新日期：2002-05-01 00:00:00

abstract：:Each of two severely defective mouse kappa-chain genes has acquired a different intracisternal A particle (IAP) element within one of its introns. One IAP element generated 6-base-pair direct repeats upon insertion. In contrast, the other IAP element was not flanked by direct repeats and was missing a single nucleotid...

journal_title：Molecular and cellular biology

authors： Hawley RG,Shulman MJ,Hozumi N

更新日期：1984-12-01 00:00:00

abstract：:In Saccharomyces cerevisiae, the GTP-binding Ypt1 protein (Ypt1p) is essential for endoplasmic reticulum-to-Golgi protein transport. By exploiting a GAL10-YPT1 fusion to regulate YPT1 expression, three multicopy suppressors, SLY2, SLY12, and SLY41, and a single-copy suppressor, SLY1-20, that allowed YPT1-independent g...

journal_title：Molecular and cellular biology

authors： Dascher C,Ossig R,Gallwitz D,Schmitt HD

更新日期：1991-02-01 00:00:00

abstract：:Ribosome biogenesis in eukaryotes is a major cellular activity mobilizing the products of over 200 transcriptionally coregulated genes referred to as the rRNA and ribosome biosynthesis regulon. We investigated the function of an essential, uncharacterized gene of this regulon, renamed RRP36. We show that the Rrp36p pr...

journal_title：Molecular and cellular biology

authors： Gérus M,Bonnart C,Caizergues-Ferrer M,Henry Y,Henras AK

更新日期：2010-03-01 00:00:00

abstract：:Proteins of the Ras superfamily, Ras, Rac, Rho, and Cdc42, control the remodelling of the cortical actin cytoskeleton following growth factor stimulation. A major regulator of Ras, Ras-GAP, contains several structural motifs, including an SH3 domain and two SH2 domains, and there is evidence that they harbor a signall...

journal_title：Molecular and cellular biology

authors： Leblanc V,Tocque B,Delumeau I

更新日期：1998-09-01 00:00:00

abstract：:Oxygen radicals regulate many physiological processes, such as signaling, proliferation, and apoptosis, and thus play a pivotal role in pathophysiology and disease development. There are at least two thioredoxin reductase/thioredoxin/peroxiredoxin systems participating in the cellular defense against oxygen radicals. ...

journal_title：Molecular and cellular biology

authors： Conrad M,Jakupoglu C,Moreno SG,Lippl S,Banjac A,Schneider M,Beck H,Hatzopoulos AK,Just U,Sinowatz F,Schmahl W,Chien KR,Wurst W,Bornkamm GW,Brielmeier M

更新日期：2004-11-01 00:00:00

abstract：:We determined the nature of mutations occurring at the autosomal APRT locus in mismatch-repair-proficient and -deficient colorectal carcinoma cell lines. The analysis of mutations that result in APRT deficiency in a mismatch-repair-deficient strain of DLD-1 heterozygous for this locus enabled us to measure the rate of...

journal_title：Molecular and cellular biology

authors： Phear G,Bhattacharyya NP,Meuth M

更新日期：1996-11-01 00:00:00

abstract：:In Saccharomyces cerevisiae, many amino acid biosynthetic pathways are coregulated by a complex general control system: starvation for a single amino acid results in the derepression of amino acid biosynthetic genes in multiple pathways. Derepression of these genes is mediated by positive (GCN) and negative (GCD) regu...

journal_title：Molecular and cellular biology

authors： Myers PL,Skvirsky RC,Greenberg ML,Greer H

更新日期：1986-09-01 00:00:00

abstract：:Interferon (IFN) regulatory factor 1 (IRF-1) and IRF-2 were originally identified as transcription factors involved in the regulation of the IFN system. IRF-1 functions as a transcriptional activator, while IRF-2 represses IRF-1 function. More recently, evidence has been provided that IRF-1 and IRF-2 manifest antionco...

journal_title：Molecular and cellular biology

authors： Tanaka N,Kawakami T,Taniguchi T

更新日期：1993-08-01 00:00:00

abstract：:To overcome the difficulty of assessing oncogene action in human epithelial cell types, such as thyroid, which have limited proliferative potential in culture, we have explored the use of temperature-sensitive (ts) mutants of simian virus 40 (SV40) early region to create conditionally immortalized epithelial cell line...

journal_title：Molecular and cellular biology

authors： Wynford-Thomas D,Bond JA,Wyllie FS,Burns JS,Williams ED,Jones T,Sheer D,Lemoine NR

更新日期：1990-10-01 00:00:00

abstract：:Induction of the prodynorphin gene has been implicated in medium and long-term adaptation during memory acquisition and pain. By 5' deletion mapping and site-directed mutagenesis of the human prodynorphin promoter, we demonstrate that both basal transcription and protein kinase A (PKA)-induced transcription in NB69 an...

journal_title：Molecular and cellular biology

authors： Carrión AM,Mellström B,Naranjo JR

更新日期：1998-12-01 00:00:00

abstract：:The rRNA genes in most eucaryotic organisms are present in a tandem array. There is substantial evidence that transcription of one of these genes may not be independent of transcription of others. In particular, in the yeast Saccharomyces cerevisiae, the enhancer of rRNA transcription that lies 2.2 kilobases 5' of the...

journal_title：Molecular and cellular biology

authors： Johnson SP,Warner JR

更新日期：1989-11-01 00:00:00

abstract：:The Epstein-Barr virus BRLF1 and BZLF1 genes are the first viral genes transcribed upon induction of the viral lytic cycle. The protein products of both genes (referred to here as Rta and Zta, respectively) activate expression of other viral genes, thereby initiating the lytic cascade. Among the viral antigens express...

journal_title：Molecular and cellular biology

authors： Flemington EK,Lytle JP,Cayrol C,Borras AM,Speck SH

更新日期：1994-05-01 00:00:00

abstract：:Krüppel-like factors 3 and 8 (KLF3 and KLF8) are highly related transcriptional regulators that bind to similar sequences of DNA. We have previously shown that in erythroid cells there is a regulatory hierarchy within the KLF family, whereby KLF1 drives the expression of both the Klf3 and Klf8 genes and KLF3 in turn r...

journal_title：Molecular and cellular biology

authors： Funnell AP,Mak KS,Twine NA,Pelka GJ,Norton LJ,Radziewic T,Power M,Wilkins MR,Bell-Anderson KS,Fraser ST,Perkins AC,Tam PP,Pearson RC,Crossley M

更新日期：2013-08-01 00:00:00

abstract：:The function of the p53 tumor suppressor to inhibit proliferation or initiate apoptosis is often abrogated in tumor cells. Mdm2 and its homolog, Mdm4, are critical inhibitors of p53 that are often overexpressed in human tumors. In mice, loss of Mdm2 or Mdm4 leads to embryonic lethal phenotypes that are completely resc...

journal_title：Molecular and cellular biology

authors： Grier JD,Xiong S,Elizondo-Fraire AC,Parant JM,Lozano G

更新日期：2006-01-01 00:00:00

abstract：:To distinguish among possible mechanisms of repair of a double-strand break (DSB) by gene conversion in budding yeast, Saccharomyces cerevisiae, we employed isotope density transfer to analyze budding yeast mating type (MAT) gene switching in G2/M-arrested cells. Both of the newly synthesized DNA strands created durin...

journal_title：Molecular and cellular biology

authors： Ira G,Satory D,Haber JE

更新日期：2006-12-01 00:00:00

abstract：:To investigate whether the human pro alpha 1(I) collagen chain could form an in vivo functional interspecies heterotrimer with the mouse pro alpha 2(I) collagen chain, we introduced the human COL1A1 gene into Mov13 mice which have a functional deletion of the endogenous COL1A1 gene. Transgenic mouse strains (HucI and ...

journal_title：Molecular and cellular biology

authors： Wu H,Bateman JF,Schnieke A,Sharpe A,Barker D,Mascara T,Eyre D,Bruns R,Krimpenfort P,Berns A

更新日期：1990-04-01 00:00:00