Ras-GAP controls Rho-mediated cytoskeletal reorganization through its SH3 domain.

abstract：:A protein that binds specifically to Saccharomyces cerevisiae centromere DNA element I was purified on the basis of a nitrocellulose filter-binding assay. This protein, termed centromere-binding protein 1 (CP1), was heat stable and renaturable from sodium dodecyl sulfate (SDS), and assays of eluates from SDS gels indi...

journal_title：Molecular and cellular biology

authors： Bram RJ,Kornberg RD

更新日期：1987-01-01 00:00:00

abstract：:Budding yeast polo kinase Cdc5p localizes to the spindle pole body (SPB) and to the bud-neck and plays multiple roles during M-phase progression. To dissect localization-specific mitotic functions of Cdc5p, we tethered a localization-defective N-terminal kinase domain of Cdc5p (Cdc5pDeltaC) to the SPB or to the bud-ne...

journal_title：Molecular and cellular biology

authors： Park JE,Park CJ,Sakchaisri K,Karpova T,Asano S,McNally J,Sunwoo Y,Leem SH,Lee KS

更新日期：2004-11-01 00:00:00

abstract：:An increased level of unpolymerized tubulin caused by depolymerization of microtubules in sea urchin larvae resulted in a rapid loss of tubulin mRNA, which was prevented by nearly complete inhibition of protein synthesis. Results of an RNA run-on assay indicated that inhibition of protein synthesis does not alter tubu...

journal_title：Molecular and cellular biology

authors： Gong ZY,Brandhorst BP

更新日期：1988-08-01 00:00:00

abstract：:The mammalian ABL1 gene encodes the ubiquitously expressed nonreceptor tyrosine kinase ABL. In response to growth factors, cytokines, cell adhesion, DNA damage, oxidative stress, and other signals, ABL is activated to stimulate cell proliferation or differentiation, survival or death, retraction, or migration. ABL als...

journal_title：Molecular and cellular biology

authors： Wang JY

更新日期：2014-04-01 00:00:00

abstract：:The ErbB family includes four homologous transmembrane tyrosine kinases. Whereas ErbB-1 binds to the epidermal growth factor (EGF), both ErbB-3 and ErbB-4 bind to the Neu differentiation factors (NDFs, or neuregulins), and ErbB-2, the most oncogenic family member, is an orphan receptor whose function is still unknown....

journal_title：Molecular and cellular biology

authors： Tzahar E,Waterman H,Chen X,Levkowitz G,Karunagaran D,Lavi S,Ratzkin BJ,Yarden Y

更新日期：1996-10-01 00:00:00

abstract：:Hybridization-complementation studies indicated that mutations in multiple genes can render Chinese hamster cells resistant to the alkaloid translation inhibitor emetine. Two of the genes, emtA and emtB, recognized in Chinese hamster lung and ovary cell lines, respectively, are known to affect the ribosomes of the cel...

journal_title：Molecular and cellular biology

authors： Nielsen-Smith K,McGill S,Frahm M,Roufa DJ

更新日期：1983-02-01 00:00:00

abstract：:The divergently transcribed DIT1 and DIT2 genes of Saccharomyces cerevisiae, which belong to the mid-late class of sporulation-specific genes, are subject to Ssn6-Tup1-mediated repression in mitotic cells. The Ssn6-Tup1 complex, which is required for repression of diverse sets of coordinately regulated genes, is known...

journal_title：Molecular and cellular biology

authors： Rothfels K,Tanny JC,Molnar E,Friesen H,Commisso C,Segall J

更新日期：2005-08-01 00:00:00

abstract：:Recently, we demonstrated that the microRNA 424(322)/503 [miR-424(322)/503] cluster is transcriptionally controlled by transforming growth factor β (TGF-β) in the mammary epithelium. Induction of this microRNA cluster impacts mammary epithelium fate by regulating apoptosis and insulin-like growth factor 1 (IGF1) signa...

journal_title：Molecular and cellular biology

authors： Llobet-Navas D,Rodriguez-Barrueco R,de la Iglesia-Vicente J,Olivan M,Castro V,Saucedo-Cuevas L,Marshall N,Putcha P,Castillo-Martin M,Bardot E,Ezhkova E,Iavarone A,Cordon-Cardo C,Silva JM

更新日期：2014-12-01 00:00:00

abstract：:We employed a protein gel blotting procedure to search for nuclear proteins from rat pituitary cells that bind preferentially to the 5'-flanking region of the rat prolactin gene. By gel blots of chromatin proteins from GH3 rat pituitary tumor cells with a 32P-labeled prolactin genomic clone, we detected two major bind...

journal_title：Molecular and cellular biology

authors： White BA,Preston GM,Lufkin TC,Bancroft C

更新日期：1985-11-01 00:00:00

abstract：:Even though endothelin is recognized as an important vasoregulatory molecule, the roles of endothelin receptors in specific cell types are not yet fully understood. Mice with a null mutation in endothelin A receptor gene (ET(A)) or in the gene of its ligand (endothelin 1) die neonatally due to craniofacial and cardiac...

journal_title：Molecular and cellular biology

authors： Kedzierski RM,Grayburn PA,Kisanuki YY,Williams CS,Hammer RE,Richardson JA,Schneider MD,Yanagisawa M

更新日期：2003-11-01 00:00:00

abstract：:We recently identified Vav, the product of the vav proto-oncogene, as a guanine nucleotide exchange factor (GEF) for Ras. Vav is enzymatically activated by lymphocyte antigen receptor-coupled protein tyrosine kinases or independently by diglycerides. To further evaluate the physiological role of Vav, we assessed its G...

journal_title：Molecular and cellular biology

authors： Gulbins E,Coggeshall KM,Langlet C,Baier G,Bonnefoy-Berard N,Burn P,Wittinghofer A,Katzav S,Altman A

更新日期：1994-02-01 00:00:00

abstract：:Alpha interferon (IFN-alpha) and IFN-beta are able to interfere with viral infection. They exert a vast array of biologic functions, including growth arrest, cell differentiation, and immune system regulation. This regulation extends from innate immunity to cellular and humoral adaptive immune responses. A strict cont...

journal_title：Molecular and cellular biology

authors： Mesplède T,Island ML,Christeff N,Petek F,Doly J,Navarro S

更新日期：2005-10-01 00:00:00

abstract：:The transcription factor Nrf2 (NF-E2-related-factor 2) is essential for the oxidative and electrophilic stress responses. Keap1 (Kelch-like-ECH-associated-protein 1), an adaptor for a cullin-3 (Cul3)-based ubiquitin ligase, regulates Nrf2 activity through proteasomal degradation, and acts as a sensor for oxidative and...

journal_title：Molecular and cellular biology

authors： Iso T,Suzuki T,Baird L,Yamamoto M

更新日期：2016-11-28 00:00:00

abstract：:Special AT-rich sequence-binding protein 1 (SATB1) is a tissue-restricted genome organizer that provides a key link between DNA loop organization, chromatin modification/remodeling, and transcription factor association at matrix attachment regions (MARs). The SUMO E3 ligase PIAS1 enhances SUMO conjugation to SATB1 lys...

journal_title：Molecular and cellular biology

authors： Tan JA,Song J,Chen Y,Durrin LK

更新日期：2010-06-01 00:00:00

abstract：:We have probed the accessibility of the genes for rRNA in Physarum polycephalum by using the photoreactive DNA cross-linking agent 4,5',8-trimethyl psoralen. Nuclei isolated from actively growing Physarum were treated with trimethyl psoralen and irradiated with 360-nm light in order to form cross-links. The palindromi...

journal_title：Molecular and cellular biology

authors： Judelson HS,Vogt VM

更新日期：1982-03-01 00:00:00

abstract：:A novel protein, p55CDC, has been identified in cycling mammalian cells. This transcript is readily detectable in all exponentially growing cell lines but disappears when cells are chemically induced to fall out of the cell cycle and differentiate. The p55CDC protein appears to be essential for cell division, since tr...

journal_title：Molecular and cellular biology

authors： Weinstein J,Jacobsen FW,Hsu-Chen J,Wu T,Baum LG

更新日期：1994-05-01 00:00:00

abstract：:The hepatocyte nuclear factor 3alpha (HNF-3alpha) and 3beta proteins have homology in the winged helix/fork head DNA binding domain and regulate cell-specific transcription in hepatocytes and in respiratory and intestinal epithelia. In this study, we describe two novel isoforms of the winged helix transcription factor...

journal_title：Molecular and cellular biology

authors： Ye H,Kelly TF,Samadani U,Lim L,Rubio S,Overdier DG,Roebuck KA,Costa RH

更新日期：1997-03-01 00:00:00

abstract：:Transfection of a plasmid encoding the Epstein-Barr virus (EBV) nuclear antigen 2 (EBNA2) gene confers resistance to the antiproliferative effect of alpha interferon (IFN-alpha) in EBV-negative U968 cells (P. Aman and A. von Gabain, EMBO J. 9:147-152, 1990). We studied the expression of IFN-stimulated genes (ISGs) in ...

journal_title：Molecular and cellular biology

authors： Kanda K,Decker T,Aman P,Wahlström M,von Gabain A,Kallin B

更新日期：1992-11-01 00:00:00

abstract：:Yeast cells containing the recessive mas3 mutation display temperature-sensitive defects in both mitochondrial protein import and the cell division cycle. The import defect is characterized by two pools of mitochondrial precursors and a dramatically slower rate of posttranslational import. The effect of mas3 on cell c...

journal_title：Molecular and cellular biology

authors： Smith BJ,Yaffe MP

更新日期：1991-05-01 00:00:00

abstract：:Mutations in the Saccharomyces cerevisiae alpha-factor receptor that lead to improved response to Saccharomyces kluyveri alpha-factor were identified and sequenced. Mutants were isolated from cells bearing randomly mutagenized receptor gene (STE2) plasmids by an in vivo screen. Five mutations lead to substitutions in ...

journal_title：Molecular and cellular biology

authors： Marsh L

更新日期：1992-09-01 00:00:00

abstract：:Lipophilic compounds such as retinoic acid and long-chain fatty acids regulate gene transcription by activating nuclear receptors such as retinoic acid receptors (RARs) and peroxisome proliferator-activated receptors (PPARs). These compounds also bind in cells to members of the family of intracellular lipid binding pr...

journal_title：Molecular and cellular biology

authors： Tan NS,Shaw NS,Vinckenbosch N,Liu P,Yasmin R,Desvergne B,Wahli W,Noy N

更新日期：2002-07-01 00:00:00

abstract：:The product of the EUG1 gene of Saccharomyces cerevisiae is a soluble endoplasmic reticulum protein with homology to both the mammalian protein disulfide isomerase (PDI) and the yeast PDI homolog encoded by the essential PDI1 gene. Deletion or overexpression of EUG1 causes no growth defects under a variety of conditio...

journal_title：Molecular and cellular biology

authors： Tachibana C,Stevens TH

更新日期：1992-10-01 00:00:00

abstract：:We have previously identified poly(A)-binding protein 1 (PABP1) as a ligand for paxillin and shown that the paxillin-PABP1 complex undergoes nucleocytoplasmic shuttling. By targeting the paxillin-binding subdomain sequences in PABP1, we have generated mutants of PABP1 that do not bind to cellular paxillin. Here we rep...

journal_title：Molecular and cellular biology

authors： Woods AJ,Kantidakis T,Sabe H,Critchley DR,Norman JC

更新日期：2005-05-01 00:00:00

abstract：:To overcome the difficulty of assessing oncogene action in human epithelial cell types, such as thyroid, which have limited proliferative potential in culture, we have explored the use of temperature-sensitive (ts) mutants of simian virus 40 (SV40) early region to create conditionally immortalized epithelial cell line...

journal_title：Molecular and cellular biology

authors： Wynford-Thomas D,Bond JA,Wyllie FS,Burns JS,Williams ED,Jones T,Sheer D,Lemoine NR

更新日期：1990-10-01 00:00:00

abstract：:Wound healing in certain individuals leads to the development of keloid tumors which exhibit abnormal collagen metabolism and an increased abundance of extracellular matrix components. Comparison of fibronectin levels in fibroblasts derived from keloids and normal dermis revealed a relative increase in intracellular a...

journal_title：Molecular and cellular biology

authors： Babu M,Diegelmann R,Oliver N

更新日期：1989-04-01 00:00:00

abstract：:Tumor suppressor genes regulate the antiviral host defense through molecular mechanisms that are not yet well explored. Here, we show that the tumor suppressor retinoblastoma (Rb) protein positively regulates Toll-like receptor 3 (TLR3) expression, the sensing receptor for viral double-stranded RNA and poly(I · C). TL...

journal_title：Molecular and cellular biology

authors： Taura M,Suico MA,Koyama K,Komatsu K,Miyakita R,Matsumoto C,Kudo E,Kariya R,Goto H,Kitajima S,Takahashi C,Shuto T,Nakao M,Okada S,Kai H

更新日期：2012-04-01 00:00:00

abstract：:Interleukin 1 (IL-1) induces the synthesis of kappa immunoglobulin light chains and the expression of surface immunoglobulin in the murine pre-B-cell line 70Z/3 (J. G. Giri, P. W. Kincade, and S. B. Mizel, J. Immunol. 132:223-228, 1984). In the present study, we found that these effects of IL-1 are mimicked by cyclic ...

journal_title：Molecular and cellular biology

authors： Shirakawa F,Chedid M,Suttles J,Pollok BA,Mizel SB

更新日期：1989-03-01 00:00:00

abstract：:A cDNA library enriched with Myc-responsive cDNAs but depleted of myc cDNAs was used in a functional screen for growth enhancement in c-myc-null cells. A cDNA clone for mitochondrial serine hydroxymethyltransferase (mSHMT) that was capable of partial complementation of the growth defects of c-myc-null cells was identi...

journal_title：Molecular and cellular biology

authors： Nikiforov MA,Chandriani S,O'Connell B,Petrenko O,Kotenko I,Beavis A,Sedivy JM,Cole MD

更新日期：2002-08-01 00:00:00

abstract：:CD146, an endothelial biomarker, has been shown to be aberrantly upregulated during pathological angiogenesis and functions as a coreceptor for vascular endothelial growth factor receptor 2 (VEGFR-2) to promote disease progression. However, the regulatory mechanisms of CD146 expression during angiogenesis remain uncle...

journal_title：Molecular and cellular biology

authors： Wang P,Luo Y,Duan H,Xing S,Zhang J,Lu D,Feng J,Yang D,Song L,Yan X

更新日期：2013-09-01 00:00:00

abstract：:The steady-state mRNA levels of the proliferating cell nuclear antigen (PCNA) gene are growth regulated. In a previous paper (L. Ottavio, C.-D. Chang, M. G. Rizzo, S. Travali, C. Casadevall, and R. Baserga, Mol. Cell. Biol. 10:303-309, 1990), we reported that introns (especially intron 4) participate in growth regulat...

journal_title：Molecular and cellular biology

authors： Chang CD,Ottavio L,Travali S,Lipson KE,Baserga R

更新日期：1990-07-01 00:00:00