The retinoblastoma tumor suppressor protein targets distinct general transcription factors to regulate RNA polymerase III gene expression.

abstract：:To understand the mechanism of retinoid resistance, we studied the subcellular localization and function of retinoid receptors in human breast cancer cell lines. Retinoid X receptor alpha (RXR alpha) localized throughout the nucleoplasm in retinoid-sensitive normal human mammary epithelial cells and in retinoid-respon...

journal_title：Molecular and cellular biology

authors： Tanaka T,Dancheck BL,Trifiletti LC,Birnkrant RE,Taylor BJ,Garfield SH,Thorgeirsson U,De Luca LM

更新日期：2004-05-01 00:00:00

abstract：:The xCR1 protein is a maternal determinant and cofactor for nodal signaling in vertebrate embryos. The xCR1 protein accumulates specifically in the animal cells of Xenopus embryos, but maternal xCR1 mRNA is distributed equally throughout all embryonic cells. Here, we show that vegetal cell-specific translational repre...

journal_title：Molecular and cellular biology

authors： Zhang Y,Forinash KD,McGivern J,Fritz B,Dorey K,Sheets MD

更新日期：2009-07-01 00:00:00

abstract：:Signal transduction by antigen receptors and some Fc receptors requires the activation of a family of receptor-associated transmembrane accessory proteins. One common feature of the cytoplasmic domains of these accessory molecules is the presence is at least two YXXA repeats that are potential sites for interaction wi...

journal_title：Molecular and cellular biology

authors： Burkhardt AL,Costa T,Misulovin Z,Stealy B,Bolen JB,Nussenzweig MC

更新日期：1994-02-01 00:00:00

abstract：:The 5' ends of dihydrofolate reductase (DHFR)-specific transcripts have been mapped in the 5'-flanking region of the amplified DHFR gene of the human methotrexate-resistant cell line 6A3 by primer extension and S1 protection experiments. The main 5' end, at position -71 relative to the first nucleotide of the DHFR rea...

journal_title：Molecular and cellular biology

authors： Masters JN,Attardi G

更新日期：1985-03-01 00:00:00

abstract：:Previously we demonstrated that the heat shock transcription factor Hsf1 is indispensable for transformation of mammary epithelial cells by the Her2 oncogene. Since Hsf1 affects oncogene-induced senescence (OIS), these findings suggest that Hsf1 affects tumor initiation when OIS plays a role. Indeed, here we report th...

journal_title：Molecular and cellular biology

authors： Gabai VL,Meng L,Kim G,Mills TA,Benjamin IJ,Sherman MY

更新日期：2012-03-01 00:00:00

abstract：:During investigations on the regulation of the Pax-6 gene, we characterized a cDNA from quail neuroretina showing a 5' untranslated region distinct from that previously described and initiated from an internal promoter. Using RNase protection and primer extension mapping, we localized this second quail Pax-6 promoter,...

journal_title：Molecular and cellular biology

authors： Plaza S,Dozier C,Turque N,Saule S

更新日期：1995-06-01 00:00:00

abstract：:We investigated the recognition of the conserved 5-bp repeated motif NGAAN, which occurs in heat shock gene promoters of Drosophila melanogaster and other eukaryotic organisms, by human heat shock transcription factor (HSF). Extended heat shock element mutants of the human HSP70 gene promoter, containing additional NG...

journal_title：Molecular and cellular biology

authors： Cunniff NF,Wagner J,Morgan WD

更新日期：1991-07-01 00:00:00

abstract：:Heparin is required for the binding of basic fibroblast growth factor (bFGF) to high-affinity receptors on cells deficient in cell surface heparan sulfate proteoglycan. So that this heparin requirement could be evaluated in the absence of other cell surface molecules, we designed a simple assay based on a genetically ...

journal_title：Molecular and cellular biology

authors： Ornitz DM,Yayon A,Flanagan JG,Svahn CM,Levi E,Leder P

更新日期：1992-01-01 00:00:00

abstract：:We investigated the possible interactions between pp39mos and p34cdc2 kinase in NIH 3T3 cells transformed by c-mosxe. pp39mos is coprecipitated with p34cdc2 when using either anti-PSTAIR antibody or p13suc1-Sepharose beads. Likewise, p34cdc2 is coprecipitated with pp39mos when using anti-mos antibody. However, pp39mos...

journal_title：Molecular and cellular biology

authors： Zhou R,Daar I,Ferris DK,White G,Paules RS,Vande Woude G

更新日期：1992-08-01 00:00:00

abstract：:With v-yes DNA as the probe, a human cDNA library made from placental RNA was screened under relaxed conditions, and DNA clones derived from a novel genetic locus, termed lyn, were obtained. Nucleotide sequencing revealed that lyn could encode a novel tyrosine kinase that was very similar to mouse T-lymphocyte-specifi...

journal_title：Molecular and cellular biology

authors： Yamanashi Y,Fukushige S,Semba K,Sukegawa J,Miyajima N,Matsubara K,Yamamoto T,Toyoshima K

更新日期：1987-01-01 00:00:00

abstract：:The phosphoinositide phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] regulates the activity of many actin-binding proteins and as such is an important modulator of cytoskeleton organization during cell migration, for example. In migrating cells actin remodeling is tightly regulated and localized; therefore, how the ...

journal_title：Molecular and cellular biology

authors： Kisseleva M,Feng Y,Ward M,Song C,Anderson RA,Longmore GD

更新日期：2005-05-01 00:00:00

abstract：:Simultaneous resistance to an array of drugs with different cytotoxic activities is a property of Saccharomyces cerevisiae, in which the protein Pdr3p has recently been shown to play a role as a transcriptional regulator. We provide evidence that the yeast PDR3 gene, which encodes a zinc finger transcription factor im...

journal_title：Molecular and cellular biology

authors： Delahodde A,Delaveau T,Jacq C

更新日期：1995-08-01 00:00:00

abstract：:The alternatively spliced 290-nucleotide NS2-specific exon of the parvovirus minute virus of mice (MVM), which is flanked by a large intron upstream and a small intron downstream, constitutively appears both in the R1 mRNA as part of a large 5'-terminal exon (where it is translated in open reading frame 3 [ORF3]), and...

journal_title：Molecular and cellular biology

authors： Gersappe A,Pintel DJ

更新日期：1999-01-01 00:00:00

abstract：:The structural maintenance of chromosomes (Smc) family members Smc5 and Smc6 are both essential in budding and fission yeasts. Yeast smc5/6 mutants are hypersensitive to DNA damage, and Smc5/6 is recruited to HO-induced double-strand breaks (DSBs), facilitating intersister chromatid recombinational repair. To determin...

journal_title：Molecular and cellular biology

authors： Stephan AK,Kliszczak M,Dodson H,Cooley C,Morrison CG

更新日期：2011-04-01 00:00:00

abstract：:The RGT1 gene of Saccharomyces cerevisiae plays a central role in the glucose-induced expression of hexose transporter (HXT) genes. Genetic evidence suggests that it encodes a repressor of the HXT genes whose function is inhibited by glucose. Here, we report the isolation of RGT1 and demonstrate that it encodes a bifu...

journal_title：Molecular and cellular biology

authors： Ozcan S,Leong T,Johnston M

更新日期：1996-11-01 00:00:00

abstract：:The tumor suppressor WT1 represses and activates transcription. The loss and/or imbalance of the dual transcriptional activity of WT1 may contribute to Wilms' tumor. In this study, we identified par-4 (for prostate apoptosis response) as a WT1-interacting protein that itself functions as a transcriptional repressor. p...

journal_title：Molecular and cellular biology

authors： Johnstone RW,See RH,Sells SF,Wang J,Muthukkumar S,Englert C,Haber DA,Licht JD,Sugrue SP,Roberts T,Rangnekar VM,Shi Y

更新日期：1996-12-01 00:00:00

abstract：:Small nucleolar RNAs (snoRNAs) orchestrate the modification and cleavage of pre-rRNA and are essential for ribosome biogenesis. Recent data suggest that after nucleoplasmic synthesis, snoRNAs transiently localize to the Cajal body (in plant and animal cells) or the homologous nucleolar body (in budding yeast) for matu...

journal_title：Molecular and cellular biology

authors： Qiu H,Eifert J,Wacheul L,Thiry M,Berger AC,Jakovljevic J,Woolford JL Jr,Corbett AH,Lafontaine DL,Terns RM,Terns MP

更新日期：2008-06-01 00:00:00

abstract：:DNA supercoiling in the chloroplast of the unicellular green alga Chlamydomonas reinhardtii was found to change with a diurnal rhythm in cells growing in alternating 12-h dark-12-h light periods. Highest and lowest DNA superhelicities occurred at the beginning and towards the end of the 12-h light periods, respectivel...

journal_title：Molecular and cellular biology

authors： Salvador ML,Klein U,Bogorad L

更新日期：1998-12-01 00:00:00

abstract：:All-trans retinoic acid (RA) induces transforming growth factor beta (TGF-beta)-dependent autocrine growth of mouse embryonic fibroblasts (MEFs). We have used chromatin immunoprecipitation to map 354 RA receptor (RAR) binding loci in MEFs, most of which were similarly occupied by the RAR alpha and RAR gamma receptors....

journal_title：Molecular and cellular biology

authors： Delacroix L,Moutier E,Altobelli G,Legras S,Poch O,Choukrallah MA,Bertin I,Jost B,Davidson I

更新日期：2010-01-01 00:00:00

abstract：:The Wnt signaling pathway plays a pivotal role in vertebrate early development and morphogenesis. Duplin (axis duplication inhibitor) interacts with beta-catenin and prevents its binding to Tcf, thereby inhibiting downstream Wnt signaling. Here we show that Duplin is expressed predominantly from early- to mid-stage mo...

journal_title：Molecular and cellular biology

authors： Nishiyama M,Nakayama K,Tsunematsu R,Tsukiyama T,Kikuchi A,Nakayama KI

更新日期：2004-10-01 00:00:00

abstract：:RSC is an essential chromatin remodeling complex in Saccharomyces cerevisiae that performs central roles in transcriptional regulation and cell cycle progression. Here we identify Htl1 as a novel factor that associates with the RSC complex both physically and functionally. We isolated HTL1 through a genetic screen for...

journal_title：Molecular and cellular biology

authors： Romeo MJ,Angus-Hill ML,Sobering AK,Kamada Y,Cairns BR,Levin DE

更新日期：2002-12-01 00:00:00

abstract：:The punc gene, encoding a member of the neural cell adhesion molecule family expressed in the developing central nervous system, limbs, and inner ear, was identified. To extend studies of the normal expression pattern of punc and to determine its function, a mouse strain bearing a lacZ/neo insertion in a 5' coding exo...

journal_title：Molecular and cellular biology

authors： Yang W,Li C,Mansour SL

更新日期：2001-09-01 00:00:00

abstract：:The transcriptional regulating protein of 132 kDa (TReP-132) has been identified in steroidogenic tissues, where it acts as a coactivator of steroidogenic factor 1 (SF-1). We show here that TReP-132 plays a role in the control of cell proliferation. In human HeLa cells, TReP-132 knockdown by using small interfering RN...

journal_title：Molecular and cellular biology

authors： Gizard F,Robillard R,Barbier O,Quatannens B,Faucompré A,Révillion F,Peyrat JP,Staels B,Hum DW

更新日期：2005-06-01 00:00:00

abstract：:The SMRT corepressor complex participates in transcriptional repression by a diverse array of vertebrate transcription factors. The ability to recruit SMRT appears to play a crucial role in leukemogenesis by the PML-retinoic acid receptor alpha (RARalpha) oncoprotein, an aberrant nuclear hormone receptor implicated in...

journal_title：Molecular and cellular biology

authors： Hong SH,Yang Z,Privalsky ML

更新日期：2001-11-01 00:00:00

abstract：:Sphingolipid metabolism is implicated to play an important role in apoptosis. Here we show that dihydrosphingosine (DHS) and phytosphingosine (PHS), two major sphingoid bases of fungi, have potent fungicidal activity with remarkably high structural and stereochemical specificity against Aspergillus nidulans. In fact, ...

journal_title：Molecular and cellular biology

authors： Cheng J,Park TS,Chio LC,Fischl AS,Ye XS

更新日期：2003-01-01 00:00:00

abstract：:Ecdysoneless (ECD) is an evolutionarily conserved protein whose germ line deletion is embryonic lethal. Deletion of Ecd in cells causes cell cycle arrest, which is rescued by exogenous ECD, demonstrating a requirement of ECD for normal mammalian cell cycle progression. However, the exact mechanism by which ECD regulat...

journal_title：Molecular and cellular biology

authors： Mir RA,Bele A,Mirza S,Srivastava S,Olou AA,Ammons SA,Kim JH,Gurumurthy CB,Qiu F,Band H,Band V

更新日期：2015-12-28 00:00:00

abstract：:We report the development of a novel in vivo transcription assay for trans-acting factors regulating the human gamma- and beta-globin genes. A cDNA coding for the human tissue-type plasminogen activator (t-PA) was inserted into the globin genes. Simian virus 40 small T-antigen splice and polyadenylation signals were i...

journal_title：Molecular and cellular biology

authors： Wrighton N,Grosveld F

更新日期：1988-01-01 00:00:00

abstract：:Members of the cytokine receptor superfamily have structurally similar extracellular ligand-binding domains yet diverse cytoplasmic regions lacking any obvious catalytic domains. Many of these receptors form ligand-induced oligomers which are likely to participate in transmembrane signaling. A constitutively active (f...

journal_title：Molecular and cellular biology

authors： Watowich SS,Hilton DJ,Lodish HF

更新日期：1994-06-01 00:00:00

abstract：:Two-dimensional protein gels were used to systematically assess changes in gene expression in Friend erythroleukemia cells after exposure to inducers of differentiation. A rapid decrease in expression of the stress protein HSP70 was observed after exposure to inducers. The kinetics of this change suggest that it may b...

journal_title：Molecular and cellular biology

authors： Hensold JO,Housman DE

更新日期：1988-05-01 00:00:00

abstract：:The function of the p53 tumor suppressor to inhibit proliferation or initiate apoptosis is often abrogated in tumor cells. Mdm2 and its homolog, Mdm4, are critical inhibitors of p53 that are often overexpressed in human tumors. In mice, loss of Mdm2 or Mdm4 leads to embryonic lethal phenotypes that are completely resc...

journal_title：Molecular and cellular biology

authors： Grier JD,Xiong S,Elizondo-Fraire AC,Parant JM,Lozano G

更新日期：2006-01-01 00:00:00