Roles of vertebrate Smc5 in sister chromatid cohesion and homologous recombinational repair.

abstract：:We provide evidence that the human DNA ligase III gene encodes a mitochondrial form of this enzyme. First, the DNA ligase III cDNA contains an in-frame ATG located upstream from the putative translation initiation start site. The DNA sequence between these two ATG sites encodes an amphipathic helix similar to previous...

journal_title：Molecular and cellular biology

authors： Lakshmipathy U,Campbell C

更新日期：1999-05-01 00:00:00

abstract：:Mutations in mitochondrial DNA (mtDNA) cause a variety of relatively rare human diseases and may contribute to the pathogenesis of other, more common degenerative diseases. This stimulates interest in the capacity of mitochondria to repair damage to mtDNA. Several recent studies have shown that some types of damage to...

journal_title：Molecular and cellular biology

authors： Pinz KG,Bogenhagen DF

更新日期：1998-03-01 00:00:00

abstract：:Ischemia in the heart deprives cardiomyocytes of oxygen, triggering cell death (myocardial infarction). Ischemia and its cell culture model, hypoxia, elicit a stress response program that contributes to cardiomyocyte death; however, the molecular components required to promote this process remain nebulous. Gene 33 is ...

journal_title：Molecular and cellular biology

authors： Xu D,Patten RD,Force T,Kyriakis JM

更新日期：2006-07-01 00:00:00

abstract：:The chimeric oncoprotein E2A-HLF, generated by the t(17;19) chromosomal translocation in pro-B-cell acute lymphoblastic leukemia, incorporates the transactivation domains of E2A and the basic leucine zipper (bZIP) DNA-binding and protein dimerization domain of HLF (hepatic leukemic factor). The ability of E2A-HLF to p...

journal_title：Molecular and cellular biology

authors： Inukai T,Inaba T,Ikushima S,Look AT

更新日期：1998-10-01 00:00:00

abstract：:The androgen receptor (AR) is a nuclear hormone receptor superfamily member that conveys both trans repression and ligand-dependent trans-activation function. Activation of the AR by dihydrotestosterone (DHT) regulates diverse physiological functions including secondary sexual differentiation in the male and the induc...

journal_title：Molecular and cellular biology

authors： Fu M,Wang C,Wang J,Zhang X,Sakamaki T,Yeung YG,Chang C,Hopp T,Fuqua SA,Jaffray E,Hay RT,Palvimo JJ,Jänne OA,Pestell RG

更新日期：2002-05-01 00:00:00

abstract：:Pseudo-exons are intronic sequences that are flanked by apparent consensus splice sites but that are not observed in spliced mRNAs. Pseudo-exons are often difficult to activate by mutation and have typically been viewed as a conceptual challenge to our understanding of how the spliceosome discriminates between authent...

journal_title：Molecular and cellular biology

authors： Grellscheid SN,Smith CW

更新日期：2006-03-01 00:00:00

abstract：:This paper presents a general means of eliminating the function of a single protein without relying on genetic alterations in its structure or level of synthesis. The strategy is based on the inducible cellular expression of neutralizing antibody to inactivate the protein selectively. The feasibility of this approach ...

journal_title：Molecular and cellular biology

authors： Carlson JR

更新日期：1988-06-01 00:00:00

abstract：:Ret/ptc2 is a constitutively active, oncogenic form of the c-Ret receptor tyrosine kinase. Like the other papillary thyroid carcinoma forms of Ret, Ret/ptc2 is activated through fusion of the Ret tyrosine kinase domain to the dimerization domain of another protein. Investigation of requirements for Ret/ptc2 mitogenic ...

journal_title：Molecular and cellular biology

authors： Durick K,Gill GN,Taylor SS

更新日期：1998-04-01 00:00:00

abstract：:Revertants were selected from aryl hydrocarbon hydroxylase (AHH)-deficient recessive mutants belonging to three complementation groups and from a dominant mutant of the Hepa-1 cell line. The recessive mutants had low spontaneous reversion frequencies (less than 4 X 10(-7] that were increased by mutagenesis. The majori...

journal_title：Molecular and cellular biology

authors： Van Gurp JR,Hankinson O

更新日期：1984-08-01 00:00:00

abstract：:The p20K gene is induced in conditions of reversible growth arrest in chicken embryo fibroblasts (CEF). This expression is dependent on transcriptional activation and on a region of the promoter designated the quiescence-responsive unit (QRU). In this report, we describe the regulatory elements of the QRU responsible ...

journal_title：Molecular and cellular biology

authors： Kim S,Mao PL,Gagliardi M,Bédard PA

更新日期：1999-08-01 00:00:00

abstract：:We determined the nature of mutations occurring at the autosomal APRT locus in mismatch-repair-proficient and -deficient colorectal carcinoma cell lines. The analysis of mutations that result in APRT deficiency in a mismatch-repair-deficient strain of DLD-1 heterozygous for this locus enabled us to measure the rate of...

journal_title：Molecular and cellular biology

authors： Phear G,Bhattacharyya NP,Meuth M

更新日期：1996-11-01 00:00:00

abstract：:Negative elongation factor (NELF) is a human transcription factor complex that cooperates with DRB sensitivity-inducing factor (DSIF)/hSpt4-hSpt5 to repress elongation by RNA polymerase II (RNAPII). NELF activity is associated with five polypeptides, including NELF-A, a candidate gene product for Wolf-Hirschhorn syndr...

journal_title：Molecular and cellular biology

authors： Yamaguchi Y,Inukai N,Narita T,Wada T,Handa H

更新日期：2002-05-01 00:00:00

abstract：:We have previously proposed that IQGAP1, an effector of Rac1 and Cdc42, negatively regulates cadherin-mediated cell-cell adhesion by interacting with beta-catenin and by causing the dissociation of alpha-catenin from cadherin-beta-catenin-alpha-catenin complexes and that activated Rac1 and Cdc42 positively regulate ca...

journal_title：Molecular and cellular biology

authors： Fukata M,Nakagawa M,Itoh N,Kawajiri A,Yamaga M,Kuroda S,Kaibuchi K

更新日期：2001-03-01 00:00:00

abstract：:TIN2 is an important regulator of telomere length, and mutations in TINF2, the gene encoding TIN2, cause short-telomere syndromes. While the genetics underscore the importance of TIN2, the mechanism through which TIN2 regulates telomere length remains unclear. Here, we tested the effects of human TIN2 on telomerase ac...

journal_title：Molecular and cellular biology

authors： Pike AM,Strong MA,Ouyang JPT,Greider CW

更新日期：2019-10-11 00:00:00

abstract：:The Polycomb group proteins are transcriptional repressors that are thought to act through multimeric nuclear complexes. We show that ph and Psc coprecipitate with Pc from nuclear extracts. We have analyzed the domains required for the association of Psc with ph and Pc by using the yeast two-hybrid system and an in vi...

journal_title：Molecular and cellular biology

authors： Kyba M,Brock HW

更新日期：1998-05-01 00:00:00

abstract：:The active beta-globin genes in chicken erythrocytes, like all active genes, reside in large chromatin domains which are preferentially sensitive to digestion by DNase I. We have recently proposed that the special structure of chromatin in active domains is maintained by torsional stress in the DNA (Villeponteau et al...

journal_title：Molecular and cellular biology

authors： Villeponteau B,Martinson HG

更新日期：1987-05-01 00:00:00

abstract：:The retinoblastoma protein (RB) represses RNA polymerase III transcription effectively both in vivo and in vitro. Here we demonstrate that the general transcription factors snRNA-activating protein complex (SNAP(c)) and TATA binding protein (TBP) are important for RB repression of human U6 snRNA gene transcription by ...

journal_title：Molecular and cellular biology

authors： Hirsch HA,Gu L,Henry RW

更新日期：2000-12-01 00:00:00

abstract：:The transcription factor LSF, identified as a HeLa protein that binds the simian virus 40 late promoter, recognizes direct repeats with a center-to-center spacing of 10 bp. The characterization of two human cDNAs, representing alternatively spliced mRNAs, provides insight into the unusual DNA-binding and oligomerizati...

journal_title：Molecular and cellular biology

authors： Shirra MK,Zhu Q,Huang HC,Pallas D,Hansen U

更新日期：1994-08-01 00:00:00

abstract：:PEX genes encode peroxins, which are required for the biogenesis of peroxisomes. The Yarrowia lipolytica PEX17 gene encodes the peroxin Pex17p, which is 671 amino acids in length and has a predicted molecular mass of 75,588 Da. Pex17p is peripherally associated with the peroxisomal membrane. The carboxyl-terminal trip...

journal_title：Molecular and cellular biology

authors： Smith JJ,Szilard RK,Marelli M,Rachubinski RA

更新日期：1997-05-01 00:00:00

abstract：:The MyoD gene can orchestrate the expression of the skeletal muscle differentiation program. We have identified the regions of the gene necessary to reproduce transcription specific to skeletal myoblasts and myotubes. A proximal regulatory region (PRR) contains a conserved TATA box, a CCAAT box, and a GC-rich region t...

journal_title：Molecular and cellular biology

authors： Tapscott SJ,Lassar AB,Weintraub H

更新日期：1992-11-01 00:00:00

abstract：:The fgr proto-oncogene encodes a nonreceptor protein-tyrosine kinase, designated p55c-fgr. In this study, we have isolated human fgr cDNA molecules from normal monocyte mRNA templates. Nucleotide sequence analysis of the longest fgr cDNA revealed a 5' untranslated region of 927 bp which included two Alu-like repeats a...

journal_title：Molecular and cellular biology

authors： Gutkind JS,Link DC,Katamine S,Lacal P,Miki T,Ley TJ,Robbins KC

更新日期：1991-03-01 00:00:00

abstract：:The cytoplasmic domain of the cloned erythropoietin (EPO) receptor (EPOR) contains no protein kinase motif, yet addition of EPO to EPO-responsive cells causes an increase in protein-tyrosine phosphorylation. Here we show that addition of EPO or interleukin-3 (IL-3) to an IL-3-dependent cell line expressing the wild-ty...

journal_title：Molecular and cellular biology

authors： Yoshimura A,Lodish HF

更新日期：1992-02-01 00:00:00

abstract：:Bone morphogenetic protein 7 (BMP7) stimulates renal branching morphogenesis via p38 mitogen-activated protein kinase (p38(MAPK)) and activating transcription factor 2 (ATF-2) (M. C. Hu, D. Wasserman, S. Hartwig, and N. D. Rosenblum, J. Biol. Chem. 279:12051-12059, 2004). Here, we demonstrate a novel role for integrin...

journal_title：Molecular and cellular biology

authors： Leung-Hagesteijn C,Hu MC,Mahendra AS,Hartwig S,Klamut HJ,Rosenblum ND,Hannigan GE

更新日期：2005-05-01 00:00:00

abstract：:Double-stranded RNA (dsRNA) accumulates in virus-infected mammalian cells and signals the activation of host defense pathways of the interferon system. We describe here a novel form of dsRNA-triggered signaling that leads to the stimulation of the p38 mitogen-activated protein kinase (p38 MAPK) and the c-Jun NH(2)-ter...

journal_title：Molecular and cellular biology

authors： Iordanov MS,Paranjape JM,Zhou A,Wong J,Williams BR,Meurs EF,Silverman RH,Magun BE

更新日期：2000-01-01 00:00:00

abstract：:Ikaros (Ik) is a critical regulator of hematopoietic gene expression. Here, we established that the Ik interactions with GATA transcription factors and cyclin-dependent kinase 9 (Cdk9), a component of the positive transcription elongation factor b (P-TEFb), are required for transcriptional activation of Ik target gene...

journal_title：Molecular and cellular biology

authors： Bottardi S,Mavoungou L,Bourgoin V,Mashtalir N,Affar el B,Milot E

更新日期：2013-08-01 00:00:00

abstract：:We previously identified an RNA binding protein, CUGBP1, which binds to GCN repeats located within the 5' region of C/EBPbeta mRNAs and regulates translation of C/EBPbeta isoforms. To further investigate the role of RNA binding proteins in the posttranscriptional control of C/EBP proteins, we purified additional RNA b...

journal_title：Molecular and cellular biology

authors： Timchenko LT,Iakova P,Welm AL,Cai ZJ,Timchenko NA

更新日期：2002-10-01 00:00:00

abstract：:Microtubule-associated serine/threonine kinase like (MASTL), also known as Greatwall (Gwl) kinase, has an important role in the regulation of mitosis. By inhibiting protein phosphatase 2A (PP2A), it plays a crucial role in activating one of the most important mitotic kinases, known as cyclin-dependent kinase 1 (CDK1)....

journal_title：Molecular and cellular biology

authors： Reshi I,Nisa MU,Farooq U,Gillani SQ,Bhat SA,Sarwar Z,Nabi N,Fazili KM,Andrabi S

更新日期：2020-04-28 00:00:00

abstract：:Quantitative immunoelectron microscopy and subcellular fractionation established the site of endoplasmic reticulum (ER)-Golgi transport arrest induced by the phosphatase inhibitor okadaic acid (OA). OA induced the disappearance of transitional element tubules and accumulation of the anterograde-transported Chandipura ...

journal_title：Molecular and cellular biology

authors： Pryde JG,Farmaki T,Lucocq JM

更新日期：1998-02-01 00:00:00

abstract：:We have examined the expression of chimeric plasmids containing coding sequences for the herpes simplex virus thymidine kinase (tk) gene or the Tn5 gene for neomycin resistance (neo) linked to the late promoter of polyoma DNA. Although polyoma late genes are generally not expressed in transformed cells containing only...

journal_title：Molecular and cellular biology

authors： Kern FG,Basilico C

更新日期：1985-04-01 00:00:00

abstract：:The Saccharomyces cerevisiae RAD18 gene is essential for postreplication repair but is not required for homologous recombination (HR), which is the major double-strand break (DSB) repair pathway in yeast. Accordingly, yeast rad18 mutants are tolerant of camptothecin (CPT), a topoisomerase I inhibitor, which induces DS...

journal_title：Molecular and cellular biology

authors： Saberi A,Hochegger H,Szuts D,Lan L,Yasui A,Sale JE,Taniguchi Y,Murakawa Y,Zeng W,Yokomori K,Helleday T,Teraoka H,Arakawa H,Buerstedde JM,Takeda S

更新日期：2007-04-01 00:00:00