Hypercalcemia due to talc granulomatosis.

Abstract:

:Pulmonary disease due to talc, a group of hydrous magnesium silicates, is almost exclusively encountered after occupational exposure. One form of this rare disorder is talc granulomatosis. In varying degrees, hypercalcemia is typical of granulomatous disease but has not yet been reported in talcosis. We report the case of a former mold maker who presented with hypercalcemia. Laboratory findings indicated extra-renal 1-alpha-hydroxylation of 25-hydroxyvitamin D. Pulmonary infiltrates prompted a lung biopsy that disclosed talc granulomatosis. We suggest that talc granulomatosis should be added to the list of granulomatous disorders capable of causing hypercalcemia due to increased extra-renal 1-alpha-hydroxylation of 25-hydroxyvitamin D.

journal_name

Chest

journal_title

Chest

authors

Woywodt A,Schneider W,Goebel U,Luft FC

doi

10.1378/chest.117.4.1195

subject

Has Abstract

pub_date

2000-04-01 00:00:00

pages

1195-6

issue

4

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(15)32826-9

journal_volume

117

pub_type

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