Abstract:
:Pulmonary disease due to talc, a group of hydrous magnesium silicates, is almost exclusively encountered after occupational exposure. One form of this rare disorder is talc granulomatosis. In varying degrees, hypercalcemia is typical of granulomatous disease but has not yet been reported in talcosis. We report the case of a former mold maker who presented with hypercalcemia. Laboratory findings indicated extra-renal 1-alpha-hydroxylation of 25-hydroxyvitamin D. Pulmonary infiltrates prompted a lung biopsy that disclosed talc granulomatosis. We suggest that talc granulomatosis should be added to the list of granulomatous disorders capable of causing hypercalcemia due to increased extra-renal 1-alpha-hydroxylation of 25-hydroxyvitamin D.
journal_name
Chestjournal_title
Chestauthors
Woywodt A,Schneider W,Goebel U,Luft FCdoi
10.1378/chest.117.4.1195subject
Has Abstractpub_date
2000-04-01 00:00:00pages
1195-6issue
4eissn
0012-3692issn
1931-3543pii
S0012-3692(15)32826-9journal_volume
117pub_type
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