Abstract：
:Recent studies have questioned the safety of calcium antagonists in general, and short-acting dihydropyridine derivatives in particular. Reasons include excessive catecholamine stimulation after stress. We therefore wanted to assess whether amlodipine, a second generation dihydropyridine with a prolonged plasma half-life, would show a more favourable haemodynamic and biochemical profile after strenuous exercise. For this purpose, we studied 9 healthy volunteers in a double-blind, randomized, placebo-controlled trial. After 10 days of amlodipine, 5 mg orally daily or placebo therapy, volunteers performed a treadmill effort test; the sequence was repeated after a 2-week washout period. Amlodipine caused a significant increase in mean resting heart rate (HR) (from 65 +/- 3 to 70 +/- 3 beats/min, p < 0.05), without changing systolic or diastolic blood pressure (SBP, DBP). Post-exercise haemodynamic responses were similar while on amlodipine or placebo therapy. Amlodipine did not alter the normal profile of resting or exercise-induced metabolic [plasma glucose, serum K+, serum free fatty acid (FFA)] and hormonal [plasma cortisol, growth hormone, prolactin, insulin, epinephrine (EPI) and norepinephrine (NE)] responses--although plasma EPI concentrations dropped significantly lower (p < 0.05) at 5 min and 15 min post-exercise while on the calcium antagonist. We conclude that amlodipine has a largely neutral effect on the physiological profile after brisk exercise in healthy young subjects and that this may prove to be a useful property for a vasodilator drug.
journal_name
Cardiovasc Drugs Therjournal_title
Cardiovascular drugs and therapyauthors
Stankovic S,Panz V,Klug E,Di Nicola G,Joffe BIdoi
10.1023/a:1007875603969subject
Has Abstractpub_date
1999-11-01 00:00:00pages
513-7issue
6eissn
0920-3206issn
1573-7241journal_volume
13pub_type
临床试验,杂志文章,随机对照试验abstract：PURPOSE:In addition to lowering hemoglobin A1C, colesevelam has been shown to improve the atherogenic lipoprotein profile of subjects with type 2 diabetes mellitus (T2DM) when used in combination with metformin and/or sulfonylureas. A recent study evaluated the effects of colesevelam as antidiabetes monotherapy in adul...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1007/s10557-014-6516-y
更新日期：2014-06-01 00:00:00
abstract：AIMS:The primary ain of this study was to investigate the effect of carbachol on ventricular repolarisation in an intact animal heart. METHODS:In five sheep, carbachol was administered to the left circumflex coronary artery (LCX) at 1.0 and 2.5 micromol/ml/min respectively for 3 min. Multiple unipolar ECGs were acquir...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章
doi：10.1023/a:1027324412869
更新日期：2003-07-01 00:00:00
abstract：:Eighteen hypertensive patients (13 males, 5 females; age 48 +/- 13; diastolic blood pressure greater than 95 mmHg), either previously untreated or who had been off treatment for more than 3 months, underwent M-mode echocardiography before (DO) and after (D90) 3 months of nicardipine therapy (60-90 mg/day). All echocar...
journal_title：Cardiovascular drugs and therapy
pub_type： 临床试验,杂志文章
doi：10.1007/BF01865511
更新日期：1989-08-01 00:00:00
abstract：PURPOSE:The PPAR-alpha agonists (fibrates) are commonly used in the treatment of dyslipidemia. It has been hypothesized that the cardio-protective effects of fibrates are partially due to immunomodulatory effects. However, there is a paucity of data regarding the effect of fibrates on neutrophilic chemokines such as ep...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章
doi：10.1007/s10557-011-6368-7
更新日期：2012-04-01 00:00:00
abstract：:With the increased use of long-acting nitroglycerin preparations, there has been greater recognition of the problem of nitrate tolerance. In recent years extensive research has broadened our understanding of the mechanisms of nitroglycerin action and the mechanisms of drug attenuation. This paper reviews the current s...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章,评审
doi：10.1007/BF01857640
更新日期：1990-02-01 00:00:00
abstract：:In the latter half of the 20th century, among participants of the Framingham Heart Study, incidence of heart failure (HF) has declined by about a third in women but not in men and survival after the onset of HF has improved in both sexes; however, HF remains highly lethal with over 50% dying within 5 years after onset...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章,评审
doi：10.1007/s10557-015-6599-0
更新日期：2015-08-01 00:00:00
abstract：:Major advances have been established in the handling of hypertensive vascular disease in recent years. However, drug compliance, drug costs, and the side effects of antihypertensive agents have prompted the question of whether intermittent therapy or even possible removal of medication represents an alternative to lif...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章,评审
doi：10.1007/BF02026496
更新日期：1990-12-01 00:00:00
abstract：:Diuretics, either as monotherapy or in combination with other drugs in the management of hypertension, have retarded the development of left ventricular hypertrophy and congestive heart failure in many patients. Diuretics also remain one of the most effective therapies in the treatment of congestive heart failure, whe...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章,评审
doi：10.1023/a:1007791814100
更新日期：1997-05-01 00:00:00
abstract：PURPOSE:This study tested if the protective anti-remodeling effect of GLP-1 agonist Exendin-4 after an acute myocardial infarction (MI) in rats involves inhibition of the Wnt1/β-catenin signaling pathway. METHODS:Rats were divided into sham, sham + Exendin-4 (10 μg/day, i.p), MI, and MI + Exendin-4. MI was introduced ...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章
doi：10.1007/s10557-020-07006-9
更新日期：2020-05-30 00:00:00
abstract：:True positive inotropy of enoximone is hard to prove clinically. It could increase the risk of myocardial ischemia when used in coronary artery disease (CAD). The analysis of the end-systolic pressure-volume relationship (ESPVR) as a load-independent parameter of the contractile left ventricular function (LVF) allows ...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章
doi：10.1007/BF02018269
更新日期：1990-10-01 00:00:00
abstract：:Angiotensin-converting enzyme (ACE) inhibitor therapy has been associated with a substantial (> or = 20%) reduction in the risk of major ischemic events in two recent clinical trials with long-term follow-up: Studies of Left Ventricular Dysfunction (SOLVD) and the Survival and Ventricular Enlargement (SAVE) study. Par...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章,评审
doi：10.1007/BF00877749
更新日期：1995-02-01 00:00:00
abstract：:To assess the effect of antihypertensive drugs on aortic distensibility, we evaluated the aortic distensibility of 33 hypertensive patients before and after antihypertensive treatment by using cine magnetic resonance imaging. Thirty three hypertensive patients were divided into three groups and treated for 12 weeks wi...
journal_title：Cardiovascular drugs and therapy
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1023/a:1007711617112
更新日期：1999-07-01 00:00:00
abstract：PURPOSE:Single- and multiple-dose studies were conducted to assess the pharmacokinetics, pharmacodynamics and safety of tolvaptan in healthy Japanese subjects. METHODS:All studies were single-center, randomized, placebo-controlled, single-blind or double-blind. In an ascending single-dose study, subjects were given a ...
journal_title：Cardiovascular drugs and therapy
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s10557-011-6299-3
更新日期：2011-12-01 00:00:00
abstract：:A succession of theories arising from last century has attempted to explain why patients with damaged hearts develop peripheral edema. Opposed to the original simple concepts of backward failure, a number of theories of forward failure have been proposed, the cardiac output being considered inadequate for capillary pe...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章,评审
doi：10.1007/BF00877921
更新日期：1994-06-01 00:00:00
abstract：:There is considerable evidence implicating a key role for p38 mitogen-activated protein kinase (MAPK) in ischemic and pharmacological preconditioning against myocardial infarction. However, there have been few, if any, studies examining the role of p38 MAPK in the protection of stunned myocardium. The purpose of this ...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章
doi：10.1007/s10557-004-6220-4
更新日期：2004-11-01 00:00:00
abstract：:The combination of aspirin and clopidogrel is the mainstay antiplatelet therapy for acute coronary syndromes (ACS). However, the dosing of aspirin, the dosing of clopidogrel, the timing of clopidogrel initiation as well as the duration of clopidogrel therapy remain controversial matters. Clopidogrel resistance is an e...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章,评审
doi：10.1007/s10557-009-6212-5
更新日期：2010-02-01 00:00:00
abstract：PURPOSE:The glucose-lowering drug metformin has recently been shown to reduce myocardial oxygen consumption and increase myocardial efficiency in chronic heart failure (HF) patients without diabetes. However, it remains to be established whether these beneficial myocardial effects are associated with metformin-induced ...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章
doi：10.1007/s10557-020-07050-5
更新日期：2020-08-08 00:00:00
abstract：:Milrinone is shown in 10 patients to be a valuable pharmacological bridge to heart transplantation; it can stabilize and improve decompensated chronic heart failure (CHF) in cases where the response to beta-agonists is inadequate. One patient who had suffered an acute myocardial infarction with heart failure resistant...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章,评审
doi：10.1007/BF00877820
更新日期：1993-08-01 00:00:00
abstract：PURPOSE:Rivaroxaban, an oral anticoagulant, undergoes the metabolism mediated by human cytochrome P450 (CYP). The present study is to quantitatively analyze and compare the contributions of multiple CYPs in the metabolism of rivaroxaban to provide new information for medication safety. METHODS:The metabolic stability ...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章
doi：10.1007/s10557-020-07129-z
更新日期：2021-01-07 00:00:00
abstract：:Heart rate variability is a noninvasive indicator of autonomic nervous system activity. The role of the autonomic nervous system in the genesis of atrial or ventricular arrhythmias is now well established. Little is known about the effects of flecainide on heart rate variability in patients with normal heart structure...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章
doi：10.1023/a:1007710301259
更新日期：1998-10-01 00:00:00
abstract：PURPOSE:The melatonin receptor (MT) agonist ramelteon has a higher affinity to MT1 than for MT2 receptors and induces cardioprotection by involvement of mitochondrial potassium channels. Activation of mitochondrial potassium channels leads to release of free radicals. We investigated whether (1) ramelteon-induced cardi...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章
doi：10.1007/s10557-020-06972-4
更新日期：2020-06-01 00:00:00
abstract：:Heart rate varies with respiration, blood pressure, emotion, etc., and heart rate variability (HRV) is presently one of the best indices to predict fatal issues in cardiac failure and after myocardial infarction. HRV depends on various reflexes. In addition, parallel studies of HRV and the myocardial adrenergic and mu...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章,评审
doi：10.1007/BF00053024
更新日期：1997-01-01 00:00:00
abstract：:Levosimendan, a calcium sensitizer and potassium channel-opener, is widely appreciated by many specialist heart failure practitioners for its effects on systemic and pulmonary hemodynamics and for the relief of symptoms of acute heart failure. The drug's impact on mortality in large randomized controlled trials has be...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章,评审
doi：10.1007/s10557-018-6838-2
更新日期：2018-12-01 00:00:00
abstract：PURPOSE:The ischemic/bleeding trade-off of continuing dual antiplatelet therapy (DAPT) beyond 1 year after PCI for patients with high thrombotic risk (HTR) as endorsed by 2018 ESC/EACTS myocardial revascularization guidelines remain unknown. METHODS:Patients undergoing coronary stenting between January 2013 and Decemb...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章
doi：10.1007/s10557-020-07030-9
更新日期：2020-10-01 00:00:00
abstract：:In animal models, calcium antagonists (Ca-A) administered before ischemia and reperfusion reduced myocardial necrosis, attenuated postischemic contractile dysfunction, and reduced tissue calcium. In 753 patients with acute myocardial infarction (AMI), we examined if use of Ca-A at the onset of symptoms (n = 127 patien...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章
doi：10.1023/a:1007727518684
更新日期：1997-09-01 00:00:00
abstract：:Investment in cardiovascular drug development is on the decline as large cardiovascular outcomes trials require considerable investments in time, efforts and financial resources. Pharmacogenomics has the potential to help revive the cardiovascular drug development pipeline by providing new and better drug targets at a...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章,评审
doi：10.1007/s10557-015-6637-y
更新日期：2016-02-01 00:00:00
abstract：:Elgodipine is a new second-generation dihydropyridine calcium antagonist. Its hemodynamic and antiischemic properties were evaluated in a single-blind, placebo-controlled trial in 22 males with chronic stable angina. Coronary artery disease was angiographically confirmed. Measurements were performed with a Swan-Ganz t...
journal_title：Cardiovascular drugs and therapy
pub_type： 临床试验,杂志文章
doi：10.1007/BF00878092
更新日期：1995-08-01 00:00:00
abstract：:People who consume a diet rich in fruit and vegetables have lower risks of cancer, cardiovascular disease and all-cause mortality. Many prospective cohort studies have reported inverse associations between dietary intake or blood levels of beta-carotene and risks of cancer. Several large-scale trials were set up to as...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章,评审
doi：10.1023/a:1022134418372
更新日期：2002-09-01 00:00:00
abstract：PURPOSE:To investigate the protective effects of hydrogen sulfide (H(2)S) against chronic alcohol intake-induced left ventricular remodeling and explore the potential mechanisms involved. METHODS:Rats were randomly divided into 4 groups: alcohol group, NaHS group, alcohol + NaHS group, and control group. The echocardi...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章
doi：10.1007/s10557-013-6441-5
更新日期：2013-06-01 00:00:00
abstract：:The VHAS (Verapamil-Hypertension Atherosclerosis Study) Investigators entered 1464 patients with essential hypertension and blood pressure (BP) values > or = 160 mmHg systolic and 95 mmHg diastolic (DBP) but excluded those with a DBP > or = 115 mmHg, and those with diabetes mellitus or previous myocardial infarction o...
journal_title：Cardiovascular drugs and therapy
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1007/BF00877865
更新日期：1995-08-01 00:00:00
