Mechanisms of nitrate tolerance: a review.

abstract：:The place of digoxin in the pediatric cardiologist's armamentarium remains uncertain. As an antiarrhythmic, its use in the Wolff-Parkinson-White syndrome is obsolete, but it remains useful in the treatment of the chronic atrial fibrillation seen in some patients postoperatively and in children with dilated cardiomyopa...

journal_title：Cardiovascular drugs and therapy

authors： Redington AN,Carvalho JS,Shinebourne EA

更新日期：1989-03-01 00:00:00

abstract：:Obesity is one of the most common lifestyle-related diseases. Being closely associated with insulin resistance, hypertension and dyslipidemia, it is also a component of metabolic syndrome and is involved in the development of atherosclerosis and cardiovascular and renal ailments. Obesity is also accompanied with a sta...

journal_title：Cardiovascular drugs and therapy

authors： Yan M,Mehta JL,Hu C

更新日期：2011-10-01 00:00:00

abstract：PURPOSE:Oxidative stress plays an important role in the pathogenesis of cardiovascular diseases. Azelnidipine is a novel dihydropyridine calcium channel blocker. Several studies have demonstrated that some dihydropyridine calcium channel blockers have antioxidant effects. We evaluated the antioxidant effects of azelnid...

journal_title：Cardiovascular drugs and therapy

authors： Koyama Y,Takeishi Y,Takahashi H,Shishido T,Arimoto T,Niizeki T,Harada M,Suzuki S,Kitahara T,Sasaki T,Kubota I

更新日期：2007-02-01 00:00:00

abstract：:The pathogenetic theories and treatment of Raynaud's phenomenon are reviewed. In primary Raynaud's disease, most evidence supports a local defect at the digital artery level, with vasoconstriction or vasospasm of the digital arteries inducing the color changes. Normal sympathetic activity, low transmural arterial dist...

journal_title：Cardiovascular drugs and therapy

authors： Coffman JD

更新日期：1990-01-01 00:00:00

abstract：PURPOSE:To determine the association between low molecular weight heparin (LMWH) use and mortality in hospitalized COVID-19 patients. METHODS:We conducted a retrospective study of patients consecutively enrolled from two major academic hospitals exclusively for COVID-19 in Wuhan, China, from January 26, 2020, to March...

journal_title：Cardiovascular drugs and therapy

authors： Shen L,Qiu L,Liu D,Wang L,Huang H,Ge H,Xiao Y,Liu Y,Jin J,Liu X,Wang DW,Peterson ED,He B,Zhou N

更新日期：2021-01-04 00:00:00

abstract：PURPOSE:In addition to lowering hemoglobin A1C, colesevelam has been shown to improve the atherogenic lipoprotein profile of subjects with type 2 diabetes mellitus (T2DM) when used in combination with metformin and/or sulfonylureas. A recent study evaluated the effects of colesevelam as antidiabetes monotherapy in adul...

journal_title：Cardiovascular drugs and therapy

authors： Rosenson RS,Rigby SP,Jones MR,Chou HS

更新日期：2014-06-01 00:00:00

abstract：:This article considers the dominant role of trials involving thousands of patients--the mega-trials--in cardiovascular disease. Problems with large trials mean that alternative strategies must be developed to aid the introduction of new drugs. The limitations of meta-analysis, and of trials with combined and surrogate...

journal_title：Cardiovascular drugs and therapy

authors： Hampton JR

更新日期：1997-01-01 00:00:00

abstract：:Twenty-nine patients with severe heart failure (NYHA III) were randomly assigned to receive therapy with an angiotensin converting enzyme inhibitor (ACE inhibitor), either captopril or enalapril. The mean daily dosage of captopril was 56 +/- 5 mg and of enalapril 9.5 +/- 0.4 mg. After a mean of 8 +/- 1 days, the influ...

journal_title：Cardiovascular drugs and therapy

authors： Osterziel KJ,Dietz R,Harder K,Kübler W

更新日期：1992-04-01 00:00:00

abstract：:We compared the time-course of the hemodynamic effect of isosorbide dinitrate (ISDN), 5 mg, in the form of sublingual tablet and oral spray, in 15 patients with isolated chronic pulmonary congestion (pulmonary arterial end-diastolic pressure of 15 mmHg or more in the presence of normal or only slightly reduced cardiac...

journal_title：Cardiovascular drugs and therapy

authors： Marchionni N,De Bari M,Ferrucci L,Moschi G,Schneeweiss A

更新日期：1988-11-01 00:00:00

abstract：PURPOSE:The melatonin receptor (MT) agonist ramelteon has a higher affinity to MT1 than for MT2 receptors and induces cardioprotection by involvement of mitochondrial potassium channels. Activation of mitochondrial potassium channels leads to release of free radicals. We investigated whether (1) ramelteon-induced cardi...

journal_title：Cardiovascular drugs and therapy

authors： Stroethoff M,Goetze L,Torregroza C,Bunte S,Raupach A,Heinen A,Mathes A,Hollmann MW,Huhn R

更新日期：2020-06-01 00:00:00

abstract：:The purpose of this study was to examine the effects of the angiotensin-converting enzyme (ACE) inhibitor cilazapril on the elastic properties of the aorta. A standard diuretic antihypertensive drug, hydrochlorothiazide, served for comparisons. Increased aortic stiffness leads to a reduction of the buffering windkesse...

journal_title：Cardiovascular drugs and therapy

authors： Breithaupt-Grögler K,Leschinger M,Belz GG,Butzer R,Erb K,de May C,Sinn W

更新日期：1996-03-01 00:00:00

abstract：INTRODUCTION:Atrial dilatation is commonly associated with atrial fibrillation (AF), but the electrophysiological mechanisms and the implications for anti-arrhythmic therapy are poorly understood. In a model of acute stretch-related AF in isolated rabbit hearts, we evaluated the electrophysiological effects of three di...

journal_title：Cardiovascular drugs and therapy

authors： Kalifa J,Bernard M,Gout B,Bril A,Cozma D,Laurent P,Chalvidan T,Deharo JC,Djiane P,Cozzone P,Maixent JM

更新日期：2007-02-01 00:00:00

abstract：:To characterize the effects of OPC-8212, a quinolone inotropic agent, in patients with heart failure, we utilized invasive hemodynamics, exercise testing, 24-hour ambulatory electrocardiograms, and two patient self-assessment questionnaires, before and after 1 month of treatment with OPC-8212, in 17 patients with mode...

journal_title：Cardiovascular drugs and therapy

authors： Kubo SH,Rector TS,Strobeck JE,Cohn JN

更新日期：1988-12-01 00:00:00

abstract：:The novel insights provided by the molecular genetic applied to the study of cardiac arrhythmias have just started to scratch the surface of the complex relationships between the genetic abnormalities of ion channel structure and the susceptibility to life threatening ventricular arrhythmias. These crucial pieces of i...

journal_title：Cardiovascular drugs and therapy

authors： Priori SG,Napolitano C

更新日期：2002-03-01 00:00:00

abstract：PURPOSE:Although erythropoietin (EPO) is known to express angiogenic and cardioprotective effects, it also induces hypertension, polycythemia, and platelet activation, which may cause serious adverse effects in patients with cardiovascular diseases. We compared the angiogenic effects of EPO and its nonerythropoietic de...

journal_title：Cardiovascular drugs and therapy

authors： Yanagawa T,Toba K,Kato K,Suzuki T,Minagawa S,Saigawa T,Ozawa T,Oda M,Takayama T,Hanawa H,Higuchi M,Saito H,Aizawa Y

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:Heart failure (HF) is considered to be a prothrombotic condition and it has been suggested that coagulation factors contribute to maladaptive cardiac remodelling via activation of the protease-activated receptor 1 (PAR1). We tested the hypothesis that anticoagulation with the factor Xa (FXa) inhibitor apixab...

journal_title：Cardiovascular drugs and therapy

authors： Yurista SR,Silljé HHW,Nijholt KT,Dokter MM,van Veldhuisen DJ,de Boer RA,Westenbrink BD

更新日期：2020-05-26 00:00:00

abstract：:In two separate, double-blind, multicenter antiarrhythmic studies, sotalol was compared with propranolol or quinidine using placebo for baseline and/or washout periods. The comparison with quinidine was a crossover study. To be enrolled in these studies, patients were required to have a premature ventricular contracti...

journal_title：Cardiovascular drugs and therapy

authors： Hanyok JJ,MacNeil DJ

更新日期：1990-06-01 00:00:00

abstract：:Nicorandil (N) and isosorbide dinitrate (ISDN) are vasodilator drugs used in patients with angina. In 24 healthy male volunteers (18-32 years), the acute effect of a single oral dose (20 mg) of N and ISDN on arterial diameter (D), distensibility, and compliance of the elastic common carotid artery (CCA) and the muscul...

journal_title：Cardiovascular drugs and therapy

authors： Kool MJ,Spek JJ,Struyker Boudier HA,Hoeks AP,Reneman RS,van Herwaarden RH,Van Bortel LM

更新日期：1995-04-01 00:00:00

abstract：:The purpose of this study was to evaluate the effect of trimetazidine on late potentials in patients with acute myocardial infarction. A total of 60 patients (52 males, mean age 55 +/- 2 years, and 8 females, mean age 54 +/- 1.8 years) with the diagnosis of acute myocardial infarction were included in this study. The ...

journal_title：Cardiovascular drugs and therapy

authors： Ozdemir R,Tuncer C,Aladag M,Güven A,Sezgin AT,Pekdemir H,Korkmaz ME,Müderrisoglu H

更新日期：1999-04-01 00:00:00

abstract：:Forty-one chronically T. cruzi-infected male adult albino rats with normal resting ECG were submitted to the ajmaline test (1 mg/kg body weight injected into the dorsal vein of the penis). Twenty-one similar noninfected animals served as controls. Ajmaline induced the following ECG alterations in control rats: A decre...

journal_title：Cardiovascular drugs and therapy

authors： Bestetti RB,Soares EG,Sales-Neto VN,Oliveira JS

更新日期：1989-04-01 00:00:00

abstract：PURPOSE:A multicentre, randomized, double-blind, placebo-controlled, parallel-group study aimed to define the potential positive effect of dipeptidyl peptidase-4 inhibition on left ventricular systolic function (LVSF) beyond glycemic control in type 2 diabetes mellitus (T2DM) (DYDA 2™ trial). METHODS:Individuals with ...

journal_title：Cardiovascular drugs and therapy

authors： Giorda CB,Cioffi G,Lucci D,Nada E,Ognibeni F,Mancusi C,Latini R,Maggioni AP,DYDA 2 Investigators.

更新日期：2019-10-01 00:00:00

abstract：PURPOSE:Treatment of atherosclerotic rabbits with intravenous methotrexate or etoposide carried in lipid nanoemulsions (LDE) markedly reduced the lesions in the aorta. Here, the combined treatment with LDE-methotrexate and LDE-etoposide was investigated aiming to increase the anti-atherosclerosis effect. METHODS:Thirt...

journal_title：Cardiovascular drugs and therapy

authors： Leite AC Jr,Solano TV,Tavares ER,Maranhão RC

更新日期：2015-02-01 00:00:00

abstract：RATIONALE:Pulmonary hypertension (PH) represents a serious health complication accompanied with hypoxic conditions, elevated levels of asymmetric dimethylarginine (ADMA), and overall dysfunction of pulmonary vascular endothelium. Since the prevention strategies for treatment of PH remain largely unknown, our study aime...

journal_title：Cardiovascular drugs and therapy

authors： Koudelka A,Ambrozova G,Klinke A,Fidlerova T,Martiskova H,Kuchta R,Rudolph TK,Kadlec J,Kuchtova Z,Woodcock SR,Freeman BA,Kubala L,Pekarova M

更新日期：2016-12-01 00:00:00

abstract：:Angiotensin converting enzyme inhibitors have greatly improved the treatment of patients with chronic heart failure but they are not effective in all patients, and their use may be limited by side effects. There is, therefore, a need to investigate new drugs and to compare their efficacy with angiotensin converting en...

journal_title：Cardiovascular drugs and therapy

authors： Cowley AJ,Wynne RD,Swami A,Birkhead J,Skene A,Hampton JR

更新日期：1992-10-01 00:00:00

abstract：:Inhibition of the renin-angiotensin system has been a highly successful therapeutic approach for the prevention of hypertension-related end organ damage. Angiotensin converting enzyme inhibitors and angiotensin II receptor blockers lower blood pressure and reduce morbidity and mortality in patients with cardiovascular...

journal_title：Cardiovascular drugs and therapy

authors： Siragy HM

更新日期：2011-02-01 00:00:00

abstract：:Angiotensin-converting enzyme (ACE) inhibitor therapy has been associated with a substantial (> or = 20%) reduction in the risk of major ischemic events in two recent clinical trials with long-term follow-up: Studies of Left Ventricular Dysfunction (SOLVD) and the Survival and Ventricular Enlargement (SAVE) study. Par...

journal_title：Cardiovascular drugs and therapy

authors： Young JB

更新日期：1995-02-01 00:00:00

abstract：PURPOSE:The progressive shortening of the atrial effective refractory period (ERP) during atrial fibrillation (AF) might be due to the activation of the KATP channels by rapid atrial rates. We tested the hypothesis that the cardioselective, sarcolemmal KATP channel blocker HMR 1098 would prevent atrial ERP shortening d...

journal_title：Cardiovascular drugs and therapy

authors： Vereckei A,Gögelein H,Wirth KJ,Zipes DP

更新日期：2004-01-01 00:00:00

abstract：:The pyrimidine base, orotic acid (OA), markedly improves the function of recently infarcted hearts subjected to global ischemia. The mechanism of cardiac action of OA is unclear, but it has been proposed that OA acts by correcting a relative deficiency of nucleotide precursors required for RNA synthesis in the stresse...

journal_title：Cardiovascular drugs and therapy

authors： Rosenfeldt FL,Richards SM,Lin Z,Pepe S,Conyers RA

更新日期：1998-09-01 00:00:00

abstract：AIMS:We evaluated a generic quality of life (QoL) Functional Status Questionnaire (FSQ), in patients with chronic heart failure (CHF). The FSQ assesses the 3 main dimensions of QoL: physical functioning, mental health and social role. It also includes 6 single item questions about: work status, frequency of social inte...

journal_title：Cardiovascular drugs and therapy

authors： Gallanagh S,Castagno D,Wilson B,Erdmann E,Zannad F,Remme WJ,Lopez-Sendon JL,Lechat P,Follath F,Höglund C,Mareev V,Sadowski Z,Seabra-Gomes RJ,Dargie HJ,McMurray JJ

更新日期：2011-02-01 00:00:00

abstract：PURPOSE:We tested if inhibition of phosphodiesterases (PDEs) with IBMX (1-methyl-3-isobutylxanthine) can modulate the mitochondrial permeability transition pore (mPTP) opening by inactivating glycogen synthase kinase 3β (GSK-3β). METHODS:H9c2 cells were exposed to 600 μM H(2)O(2) for 20 min to cause the mPTP opening. ...

journal_title：Cardiovascular drugs and therapy

authors： Chanoit G,Zhou J,Lee S,McIntosh R,Shen X,Zvara DA,Xu Z

更新日期：2011-08-01 00:00:00