Effect of trimetazidine on late potentials after acute myocardial infarction.

abstract：:Insertion (I)/deletion (D) polymorphism of the ACE gene has been reported to be involved in various cardiovascular diseases. We investigated prospectively whether the response to the ACE inhibitor fosinopril varied according to the ACE genotype in previously untreated Greek hypertensive patients. After a 4-week observ...

journal_title：Cardiovascular drugs and therapy

authors： Stavroulakis GA,Makris TK,Krespi PG,Hatzizacharias AN,Gialeraki AE,Anastasiadis G,Triposkiadis P,Kyriakidis M

更新日期：2000-08-01 00:00:00

abstract：PURPOSE:A multicentre, randomized, double-blind, placebo-controlled, parallel-group study aimed to define the potential positive effect of dipeptidyl peptidase-4 inhibition on left ventricular systolic function (LVSF) beyond glycemic control in type 2 diabetes mellitus (T2DM) (DYDA 2™ trial). METHODS:Individuals with ...

journal_title：Cardiovascular drugs and therapy

authors： Giorda CB,Cioffi G,Lucci D,Nada E,Ognibeni F,Mancusi C,Latini R,Maggioni AP,DYDA 2 Investigators.

更新日期：2019-10-01 00:00:00

abstract：:The clinical efficacy and safety of ibopamine and diuretic therapy were compared in a multicenter, multinational, parallel, positive-controlled, randomized, double-blind, 12-week study, involving 103 patients with mild CHF (NYHA Class II). Body weight, NYHA functional class, symptom assessment scores, laboratory blood...

journal_title：Cardiovascular drugs and therapy

authors：

更新日期：1989-12-01 00:00:00

abstract：:The aim of the present study was to investigate the effects of almokalant on sustained reentrant supraventricular tachycardias. Reentrant tachycardias were induced, using transesophageal atrial stimulation, in 82 patients with atrioventricular reentrant tachycardia (n = 54) or AV nodal reentrant tachycardia (n = 28). ...

journal_title：Cardiovascular drugs and therapy

authors： Darpö B,Edvardsson N

更新日期：1997-07-01 00:00:00

abstract：:High-density lipoprotein cholesterol (HDL-c) has long been referred to as 'good cholesterol' due to its apparent inverse relationship with future CVD risk. More recent research has questioned a causal role for HDL-c in this relationship, however, as both genetic studies and numerous large-scale randomised controlled t...

journal_title：Cardiovascular drugs and therapy

authors： Chiesa ST,Charakida M

更新日期：2019-04-01 00:00:00

abstract：:The present study was designed to evaluate the effects of oral verapamil and normal diet on regression of atherosclerotic plaque in cholesterol fed rabbits. Forty-three rabbits were separated into 6 groups and studied for 24 weeks. All groups had a cholesterol diet for the first 12 weeks. Group I was then sacrificed a...

journal_title：Cardiovascular drugs and therapy

authors： Sievers RE,Rashid T,Garrett J,Blumlein S,Parmley WW

更新日期：1987-01-01 00:00:00

abstract：:Calcium channel blockers are a group of drugs used for the treatment of hypertension. Carbonic anhydrase (CA) I detected in vascular smooth muscle and in other cells in the organism has a major role in the acid-base balance and in vascular processes. Our previous work has proven that verapamil inhibits CA activity by ...

journal_title：Cardiovascular drugs and therapy

authors： Puscas L,Gilau L,Coltau M,Pasca R,Domuta G,Baican M,Hecht A

更新日期：2000-10-01 00:00:00

abstract：:Cardiovascular disease is the leading cause of death in men and women in the USA. Once a patient experiences an acute coronary syndrome (ACS), they are at increased risk for hospital readmission within 30 days and 6 months after discharge and more importantly, they have worse survival. Hospital readmissions lead to po...

journal_title：Cardiovascular drugs and therapy

authors： Paruchuri V,Gaztanaga J,Rambhujun V,Smith R,Farkouh ME

更新日期：2018-12-01 00:00:00

abstract：PURPOSE:To evaluate whether aleglitazar (Ale), a dual PPARα/γ agonist, has additive effects on myocardial protection against ischemia-reperfusion injury. METHODS:Human cardiomyocytes (HCMs), cardiomyocytes from cardiac-specific PPARγ knockout (MCM-PPARγ (CKO) ) or wild type (MCM-WT) mice were incubated with different ...

journal_title：Cardiovascular drugs and therapy

authors： Qian J,Chen H,Birnbaum Y,Nanhwan MK,Bajaj M,Ye Y

更新日期：2016-04-01 00:00:00

abstract：:The effects of nifedipine on left ventricular function were evaluated in 17 patients with coronary artery disease with an ambulatory radionuclide detector (VEST). Hemodynamic data were recorded continuously at rest and during upright bicycle ergometer exercise before and 30 minutes after 10 mg of oral nifedipine admin...

journal_title：Cardiovascular drugs and therapy

authors： Kambara H,Mohiuddin IH,Tamaki N,Fudo T,Hayashi M,Nohara R,Konishi J,Kawai C

更新日期：1990-08-01 00:00:00

abstract：:The modifying effect on exercise performance and neuroendocrine response of the nonselective beta blocker timolol (10 mg b.i.d. for 5 days) and the beta 1-selective beta blocker metoprolol (100 mg b.i.d. for 5 days) was studied. The hormones studied were growth hormone, prolactin, cortisol, renin, epinephrine, dopamin...

journal_title：Cardiovascular drugs and therapy

authors： Gullestad L,Dolva LO,Kjeldsen SE,Eide I,Kjekshus J

更新日期：1989-03-01 00:00:00

abstract：:There is considerable evidence implicating a key role for p38 mitogen-activated protein kinase (MAPK) in ischemic and pharmacological preconditioning against myocardial infarction. However, there have been few, if any, studies examining the role of p38 MAPK in the protection of stunned myocardium. The purpose of this ...

journal_title：Cardiovascular drugs and therapy

authors： Yoshimura Y,Kristo G,Keith BJ,Jahania SA,Mentzer RM Jr,Lasley RD

更新日期：2004-11-01 00:00:00

abstract：:The time course of myocardial ischemia was studied in canine myocardium by electron microscopy. Ischemia of the myocardium produces ultrastructural alterations of mitochondria, nuclei, contractile apparatus, and the SR- and T-tubular system that are accompanied by loss of glycogen and intracellular edema. These change...

journal_title：Cardiovascular drugs and therapy

authors： Schaper J,Schaper W

更新日期：1988-05-01 00:00:00

abstract：:The DAVIT-II trial has shown that the verapamil type of calcium antagonist can beneficially be used in post-infarct patients. A recent re-analysis suggests that verapamil may also prevent post-infarct sudden death. There are good theoretical reasons to suppose that calcium antagonists should help prevent ventricular f...

journal_title：Cardiovascular drugs and therapy

authors： Opie LH

更新日期：1991-08-01 00:00:00

abstract：:The aim of this study was to compare the pharmacokinetics and antiarrhythmic activity of dihydroquinidine and quinidine in 14 patients (11 men, 3 women, aged 28 to 67 years) with heart disease and chronic, stable, high-frequency premature ventricular beats (PVB) (greater than 100/hr). A randomized, double-blind, cross...

journal_title：Cardiovascular drugs and therapy

authors： Chimienti M,Regazzi MB,La Rovere MT,Salerno JA,Previtali M,Montericcio V,Rondanelli R,Montemartini C

更新日期：1988-12-01 00:00:00

abstract：INTRODUCTION:Most circulating fatty acids are contained in lipoprotein triglycerides. For the heart to acquire these lipids, they must be broken down into free fatty acids via the enzyme lipoprotein lipase (LpL). Although it has long been known that hearts primarily use esterified fatty acids as fuel, different sources...

journal_title：Cardiovascular drugs and therapy

authors： Noh HL,Yamashita H,Goldberg IJ

更新日期：2006-12-01 00:00:00

abstract：:The calcium antagonist (CA) controversy has been fueled in part by disagreements among scientists and clinicians over the scientific documentation required for drugs used to treat lifelong conditions. From a public health perspective, there are three unanswered questions: (1) Does long-term use of CAs convey health be...

journal_title：Cardiovascular drugs and therapy

authors： Furberg CD,Psaty BM

更新日期：1996-09-01 00:00:00

abstract：:The direct myocardial protective effects of intracoronary infusions of cromakalim and pinacidil were determined in an anesthetized canine model of coronary occlusion and reperfusion. The left circumflex coronary artery was occluded for 90 minutes and reperfused for 5 hours, at which time the infarct size was determine...

journal_title：Cardiovascular drugs and therapy

authors： Grover GJ,Dzwonczyk S,Parham CS,Sleph PG

更新日期：1990-04-01 00:00:00

abstract：PURPOSE:The benefits of statin treatment initiated in advanced age are largely unknown; however, good adherence to treatment is essential for beneficial effects to be achieved also when treating older people. This study characterizes older statin initiators, including their cardiovascular risk profiles and morbidity, a...

journal_title：Cardiovascular drugs and therapy

authors： Upmeier E,Korhonen MJ,Rikala M,Helin-Salmivaara A,Huupponen R

更新日期：2014-06-01 00:00:00

abstract：:Forty-one chronically T. cruzi-infected male adult albino rats with normal resting ECG were submitted to the ajmaline test (1 mg/kg body weight injected into the dorsal vein of the penis). Twenty-one similar noninfected animals served as controls. Ajmaline induced the following ECG alterations in control rats: A decre...

journal_title：Cardiovascular drugs and therapy

authors： Bestetti RB,Soares EG,Sales-Neto VN,Oliveira JS

更新日期：1989-04-01 00:00:00

abstract：OBJECTIVE:The aim was to study the pharmacodynamic interactions and safety of the co-administration of the calcium sensitizer levosimendan and the calcium antagonist felodipine in patients with coronary heart disease (CHD) and with normal ejection fraction (EF). METHODS:The study was a randomized, double blind, placeb...

journal_title：Cardiovascular drugs and therapy

authors： Põder P,Eha J,Antila S,Heinpalu M,Planken U,Loogna I,Mesikepp A,Akkila J,Lehtonen L

更新日期：2003-09-01 00:00:00

abstract：PURPOSE:We tested if inhibition of phosphodiesterases (PDEs) with IBMX (1-methyl-3-isobutylxanthine) can modulate the mitochondrial permeability transition pore (mPTP) opening by inactivating glycogen synthase kinase 3β (GSK-3β). METHODS:H9c2 cells were exposed to 600 μM H(2)O(2) for 20 min to cause the mPTP opening. ...

journal_title：Cardiovascular drugs and therapy

authors： Chanoit G,Zhou J,Lee S,McIntosh R,Shen X,Zvara DA,Xu Z

更新日期：2011-08-01 00:00:00

abstract：:To further evaluate the significance of p38 MAPK as trigger or mediator in ischaemic preconditioning, anisomycin and SB 203580 were used to manipulate its activation status. Special attention was given to the concentration of the drugs and protocols used. The isolated perfused rat heart, subjected to either 25 min glo...

journal_title：Cardiovascular drugs and therapy

authors： Lochner A,Genade S,Hattingh S,Marais E,Huisamen B,Moolman JA

更新日期：2003-05-01 00:00:00

abstract：:Unselective and beta 1-selective beta-blockers may induce vasoconstriction of normal and stenotic epicardial coronary arteries. To analyze the influence of the "vasodilatory" beta-blocker celiprolol on coronary vasomotility, 0.4 mg celiprolol/kg were intravenously infused over 4 minutes in 13 patients with coronary ar...

journal_title：Cardiovascular drugs and therapy

authors： Jost S,Hausmann D,Lippolt P,Sturm M

更新日期：1997-04-01 00:00:00

abstract：:Tracer techniques have provided new insight in cardiology by allowing noninvasive studies of myocardial perfusion, function, metabolism, and, more recently, ligand-receptor interaction. Positron emission tomography allows accurate quantification and the use of natural substrates labelled with 11C, 13N, or 15O. Myocard...

journal_title：Cardiovascular drugs and therapy

authors： Rigo P,de Landsheere C,Melon P,Kulbertus H

更新日期：1990-08-01 00:00:00

abstract：:Resistance arteries depolarize and constrict to elevations in intravascular pressure. However, many of the molecular aspects of this phenomenon are not known. We present evidence that large conductance calcium-dependent potassium (KCa) channels, which are activated by intracellular calcium and membrane depolarization,...

journal_title：Cardiovascular drugs and therapy

authors： Nelson MT,Brayden JE

更新日期：1993-08-01 00:00:00

abstract：:The original version of this article unfortunately contained a mistake. There was a typo in the second sentence of the paragraph under the section Was the Dose of Drugs Fair?; "320 mg twice a day" should read "160mg twice a day". The corrected paragraph is shown below. ...

journal_title：Cardiovascular drugs and therapy

authors： Ahn R,Prasad V

更新日期：2018-12-01 00:00:00

abstract：:Twenty-nine patients with severe heart failure (NYHA III) were randomly assigned to receive therapy with an angiotensin converting enzyme inhibitor (ACE inhibitor), either captopril or enalapril. The mean daily dosage of captopril was 56 +/- 5 mg and of enalapril 9.5 +/- 0.4 mg. After a mean of 8 +/- 1 days, the influ...

journal_title：Cardiovascular drugs and therapy

authors： Osterziel KJ,Dietz R,Harder K,Kübler W

更新日期：1992-04-01 00:00:00

abstract：:There can be no doubt that ACE inhibitors prolong survival in patients with a low ejection fraction. There is no evidence whether or not diuretics have the same effect. The pathophysiology of asymptomatic patients with poor left ventricular function differs from that of patients with the clinical syndrome of heart fai...

journal_title：Cardiovascular drugs and therapy

authors： Hampton JR

更新日期：1993-12-01 00:00:00

abstract：:There is still uncertainty of whether combined therapy with a beta-blocker and calcium-channel antagonist provides additive or synergistic clinical benefits in most patients with stable angina pectoris. The comparative antianginal effect of atenolol 50 mg and atenolol 50 mg and slow release nifedipine (20 mg) twice a ...

journal_title：Cardiovascular drugs and therapy

authors： Meyer TE,Adnams C,Commerford P

更新日期：1993-12-01 00:00:00