High-Density Lipoprotein Function and Dysfunction in Health and Disease.

abstract：INTRODUCTION:Surrogate markers represent a significant contribution to early diagnosis, longitudinal prognoses, and outcome prediction in cases of hypertension. They often enable detection of disease and disease potential when the disease is still subclinical and are useful noninvasive tools for designing and evaluatin...

journal_title：Cardiovascular drugs and therapy

authors： Maisel AS

更新日期：2009-08-01 00:00:00

abstract：:The effects of altered extracellular K+ concentrations ([K+]o) and pacing cycle lengths (CLs) on the electrophysiological actions of dofetilide (UK-68,798), a potent class III antiarrhythmic agent, were examined in isolated guinea-pig ventricular papillary muscle. At a normal [K+]o (4 mM) and at CL between 300 and 500...

journal_title：Cardiovascular drugs and therapy

authors： Yang T,Tande PM,Lathrop DA,Refsum H

更新日期：1992-08-01 00:00:00

abstract：BACKGROUND:The use of sodium-glucose co-transporter 2 inhibitors (SGLT2i) is currently expanding to cardiovascular risk reduction in non-diabetic subjects, but renal (side-)effects are less well studied in this setting. METHODS:Male non-diabetic Sprague Dawley rats underwent permanent coronary artery ligation to induc...

journal_title：Cardiovascular drugs and therapy

authors： Yurista SR,Silljé HHW,van Goor H,Hillebrands JL,Heerspink HJL,de Menezes Montenegro L,Oberdorf-Maass SU,de Boer RA,Westenbrink BD

更新日期：2020-06-01 00:00:00

abstract：PURPOSE:Treatment of pulmonary arterial hypertension (PAH) by vasodilator drug monotherapy is often limited in its effectiveness. Combination therapy may help to improve treatment and to reduce drug toxicity. This study assessed the combination of the endothelin receptor antagonist macitentan and the phosphodiesterase-...

journal_title：Cardiovascular drugs and therapy

authors： Hoenicka M,Golovchenko S,Englert L,Spaeth M,Shoshiashvili L,Großer C,Hofmann HS,Ried M

更新日期：2019-06-01 00:00:00

abstract：:In this review we attempt to determine the role of calcium channel blockers in preventing cardiovascular sequelae in patients with both hypertension and diabetes mellitus. The data have been collected from three sources: post-hoc analyses of subgroups of diabetic patients in placebo-controlled hypertension trials (SHE...

journal_title：Cardiovascular drugs and therapy

authors： Gasowski J,Birkenhäger WH,Staessen JA,de Leeuw PW

更新日期：2000-02-01 00:00:00

abstract：BACKGROUND:Recent studies in rabbits have demonstrated that platelet P2Y12 receptor antagonists are cardioprotective, and that the mechanism is surprisingly not related to blockade of platelet aggregation but rather to triggering of the same signal transduction pathway seen in pre- and postconditioning. We wanted to de...

journal_title：Cardiovascular drugs and therapy

authors： Yang XM,Liu Y,Cui L,Yang X,Liu Y,Tandon N,Kambayashi J,Downey JM,Cohen MV

更新日期：2013-04-01 00:00:00

abstract：PURPOSE:We tested if inhibition of phosphodiesterases (PDEs) with IBMX (1-methyl-3-isobutylxanthine) can modulate the mitochondrial permeability transition pore (mPTP) opening by inactivating glycogen synthase kinase 3β (GSK-3β). METHODS:H9c2 cells were exposed to 600 μM H(2)O(2) for 20 min to cause the mPTP opening. ...

journal_title：Cardiovascular drugs and therapy

authors： Chanoit G,Zhou J,Lee S,McIntosh R,Shen X,Zvara DA,Xu Z

更新日期：2011-08-01 00:00:00

abstract：:The aim of this study was to compare the pharmacokinetics and antiarrhythmic activity of dihydroquinidine and quinidine in 14 patients (11 men, 3 women, aged 28 to 67 years) with heart disease and chronic, stable, high-frequency premature ventricular beats (PVB) (greater than 100/hr). A randomized, double-blind, cross...

journal_title：Cardiovascular drugs and therapy

authors： Chimienti M,Regazzi MB,La Rovere MT,Salerno JA,Previtali M,Montericcio V,Rondanelli R,Montemartini C

更新日期：1988-12-01 00:00:00

abstract：PURPOSE:To investigate the associations of diuretics overall, non-potassium-sparing diuretics in specific, and laxative use with cardiovascular mortality (CVM) in subjects with antihypertensive treatment. METHODS:Analyses included 4253 participants, aged 50 to 75 years, from the German ESTHER cohort and 105,359 partic...

journal_title：Cardiovascular drugs and therapy

authors： Hoppe LK,Muhlack DC,Koenig W,Brenner H,Schöttker B

更新日期：2019-10-01 00:00:00

abstract：:The aim of the present study was to investigate the effects of almokalant on sustained reentrant supraventricular tachycardias. Reentrant tachycardias were induced, using transesophageal atrial stimulation, in 82 patients with atrioventricular reentrant tachycardia (n = 54) or AV nodal reentrant tachycardia (n = 28). ...

journal_title：Cardiovascular drugs and therapy

authors： Darpö B,Edvardsson N

更新日期：1997-07-01 00:00:00

abstract：BACKGROUND:Markers of thrombosis, inflammation, endothelial dysfunction and neurohumoral activation such as fibrinogen, D-dimer, C-reactive protein, von Willebrand factor, tumour necrosis factor-alpha and chromogranin-A are reported to be linked to the increase of cardiovascular risk for atherosclerosis progression and...

journal_title：Cardiovascular drugs and therapy

authors： Scientific Committee of the PERTINENT Sub-Study, EUROPA-PERTINENT Investigators.

更新日期：2003-01-01 00:00:00

abstract：:Forty-one chronically T. cruzi-infected male adult albino rats with normal resting ECG were submitted to the ajmaline test (1 mg/kg body weight injected into the dorsal vein of the penis). Twenty-one similar noninfected animals served as controls. Ajmaline induced the following ECG alterations in control rats: A decre...

journal_title：Cardiovascular drugs and therapy

authors： Bestetti RB,Soares EG,Sales-Neto VN,Oliveira JS

更新日期：1989-04-01 00:00:00

abstract：:Mitochondrial health is critically dependent on the ability of mitochondria to undergo changes in mitochondrial morphology, a process which is regulated by mitochondrial shaping proteins. Mitochondria undergo fission to generate fragmented discrete organelles, a process which is mediated by the mitochondrial fission p...

journal_title：Cardiovascular drugs and therapy

authors： Ong SB,Kalkhoran SB,Hernández-Reséndiz S,Samangouei P,Ong SG,Hausenloy DJ

更新日期：2017-02-01 00:00:00

abstract：:Despite the fact that beta blockers were introduced into clinical practice 25 years ago, new beta blockers with differing kinetic and dynamic profiles continue to be developed and marketed. This overview assesses some of the more extensively studied agents from the point of view of proof of utility and the validity of...

journal_title：Cardiovascular drugs and therapy

authors： Fitzgerald JD

更新日期：1991-06-01 00:00:00

abstract：:Tracer techniques have provided new insight in cardiology by allowing noninvasive studies of myocardial perfusion, function, metabolism, and, more recently, ligand-receptor interaction. Positron emission tomography allows accurate quantification and the use of natural substrates labelled with 11C, 13N, or 15O. Myocard...

journal_title：Cardiovascular drugs and therapy

authors： Rigo P,de Landsheere C,Melon P,Kulbertus H

更新日期：1990-08-01 00:00:00

abstract：:This study compares the electrophysiologic effects of amlodipine and diltiazem in patients with coronary artery disease concomitantly treated with background beta-blocking therapy. Thirty patients were included in an open-label parallel study in two phases. During phase 1, patients were screened and placed on maintena...

journal_title：Cardiovascular drugs and therapy

authors： Santarelli P,Biscione F,Natale A,Manzoli A,Lanza GA

更新日期：1994-08-01 00:00:00

abstract：PURPOSE:Acute myocardial infarction (AMI) drives an intense inflammatory response that contributes to infarct healing and cardiac remodeling. Recently, different studies have identified a role of interleukin-1 (IL-1) in the development of adverse cardiac remodeling. However, in animal models of AMI IL-1 has been shown ...

journal_title：Cardiovascular drugs and therapy

authors： Toldo S,Schatz AM,Mezzaroma E,Chawla R,Stallard TW,Stallard WC,Jahangiri A,Van Tassell BW,Abbate A

更新日期：2012-06-01 00:00:00

abstract：INTRODUCTION:Irisin is a newly identified 112 amino acid hormone, derived as a product of fibronectin type III domain containing 5 (FNDC5), which is highly related to metabolic activity in skeletal muscle and brown fat. The effects of irisin on cardiovascular functions are unknown. PURPOSE:To explore the effects of ce...

journal_title：Cardiovascular drugs and therapy

authors： Zhang W,Chang L,Zhang C,Zhang R,Li Z,Chai B,Li J,Chen E,Mulholland M

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:Although Takotsubo syndrome (TS) was once considered to be rare and largely benign, it is now recognized to represent a major cause of cardiac morbidity and mortality, especially in ageing women. The biochemical precipitant of attacks of TS is an increase in catecholamine concentrations within the myocardium...

journal_title：Cardiovascular drugs and therapy

authors： Ong GJ,Nguyen TH,Stansborough J,Surikow SY,Horowitz JD

更新日期：2020-02-01 00:00:00

abstract：PURPOSE:Ranolazine (RAN) added to amiodarone (AMIO) has been shown to accelerate termination of postoperative atrial fibrillation (POAF) following coronary artery bypass surgery in patients without heart failure (HF). This study aimed to investigate if treatment efficacy with AMIO or AMIO + RAN differs between patients...

journal_title：Cardiovascular drugs and therapy

authors： Simopoulos V,Hevas A,Hatziefthimiou A,Dipla K,Skoularigis I,Tsilimingas N,Aidonidis I

更新日期：2018-12-01 00:00:00

abstract：:The purpose of this study was to examine the effects of the angiotensin-converting enzyme (ACE) inhibitor cilazapril on the elastic properties of the aorta. A standard diuretic antihypertensive drug, hydrochlorothiazide, served for comparisons. Increased aortic stiffness leads to a reduction of the buffering windkesse...

journal_title：Cardiovascular drugs and therapy

authors： Breithaupt-Grögler K,Leschinger M,Belz GG,Butzer R,Erb K,de May C,Sinn W

更新日期：1996-03-01 00:00:00

abstract：:Of 17 patients with mild to moderate essential hypertension, 8 showed echocardiographic evidence of left ventricular hypertrophy. Cardiac and renal function evaluated by glomerular filtration rate (GFR) were studied in all patients before and after 20 weeks of quinapril treatment. Systolic pressure decreased from 174....

journal_title：Cardiovascular drugs and therapy

authors： De Caprio L,De Rosa ML,Di Palma A,Lirato C,Caccese P,Sestito M,Lastoria S,Cicatiello AM,Rengo F

更新日期：1994-10-01 00:00:00

abstract：:Cardiovascular disease is the leading cause of death in men and women in the USA. Once a patient experiences an acute coronary syndrome (ACS), they are at increased risk for hospital readmission within 30 days and 6 months after discharge and more importantly, they have worse survival. Hospital readmissions lead to po...

journal_title：Cardiovascular drugs and therapy

authors： Paruchuri V,Gaztanaga J,Rambhujun V,Smith R,Farkouh ME

更新日期：2018-12-01 00:00:00

abstract：:Diuretics, either as monotherapy or in combination with other drugs in the management of hypertension, have retarded the development of left ventricular hypertrophy and congestive heart failure in many patients. Diuretics also remain one of the most effective therapies in the treatment of congestive heart failure, whe...

journal_title：Cardiovascular drugs and therapy

authors： Moser M

更新日期：1997-05-01 00:00:00

abstract：PURPOSE:Although erythropoietin (EPO) is known to express angiogenic and cardioprotective effects, it also induces hypertension, polycythemia, and platelet activation, which may cause serious adverse effects in patients with cardiovascular diseases. We compared the angiogenic effects of EPO and its nonerythropoietic de...

journal_title：Cardiovascular drugs and therapy

authors： Yanagawa T,Toba K,Kato K,Suzuki T,Minagawa S,Saigawa T,Ozawa T,Oda M,Takayama T,Hanawa H,Higuchi M,Saito H,Aizawa Y

更新日期：2013-04-01 00:00:00

abstract：OBJECTIVE:The aim was to study the pharmacodynamic interactions and safety of the co-administration of the calcium sensitizer levosimendan and the calcium antagonist felodipine in patients with coronary heart disease (CHD) and with normal ejection fraction (EF). METHODS:The study was a randomized, double blind, placeb...

journal_title：Cardiovascular drugs and therapy

authors： Põder P,Eha J,Antila S,Heinpalu M,Planken U,Loogna I,Mesikepp A,Akkila J,Lehtonen L

更新日期：2003-09-01 00:00:00

abstract：:Vascular endothelium gene expression regulates blood-vessel wall interactions, vascular permeability, smooth muscle cell growth and tone. The possibility to introduce exogenous DNA or RNA sequences in endothelial cells represents a novel therapeutic approach of vascular disease. The aim of the work was to investigate ...

journal_title：Cardiovascular drugs and therapy

authors： Colombo MG,Citti L,Basta G,De Caterina R,Biagini A,Rainaldi G

更新日期：2001-01-01 00:00:00

abstract：:Annual mortality from congestive heart failure ranges from 15% to 60%, depending on the severity of the left ventricular damage and underlying disease. Most controlled trials have been too small to detect any beneficial effect on survival from the newer vasodilator and inotropic drugs. However, the results of two rece...

journal_title：Cardiovascular drugs and therapy

authors： Meinertz T,Drexler H,Just H

更新日期：1988-11-01 00:00:00

abstract：PURPOSE:The prevalence and consequences of prediabetic dysglycemia and undiagnosed diabetes is unknown in patients with heart failure (HF) and preserved ejection fraction (HFpEF) and has not been compared to heart failure and reduced ejection fraction (HFrEF). METHODS:We examined the prevalence and outcomes associated...

journal_title：Cardiovascular drugs and therapy

authors： Kristensen SL,Jhund PS,Lee MMY,Køber L,Solomon SD,Granger CB,Yusuf S,Pfeffer MA,Swedberg K,McMurray JJV,CHARM Investigators and Committees.

更新日期：2017-12-01 00:00:00

abstract：:In animal models, calcium antagonists (Ca-A) administered before ischemia and reperfusion reduced myocardial necrosis, attenuated postischemic contractile dysfunction, and reduced tissue calcium. In 753 patients with acute myocardial infarction (AMI), we examined if use of Ca-A at the onset of symptoms (n = 127 patien...

journal_title：Cardiovascular drugs and therapy

authors： Landmark K,Abdelnoor M,Kilhovd B,Dørum HP

更新日期：1997-09-01 00:00:00