Time course of myocardial necrosis.

abstract：:This study compares the electrophysiologic effects of amlodipine and diltiazem in patients with coronary artery disease concomitantly treated with background beta-blocking therapy. Thirty patients were included in an open-label parallel study in two phases. During phase 1, patients were screened and placed on maintena...

journal_title：Cardiovascular drugs and therapy

authors： Santarelli P,Biscione F,Natale A,Manzoli A,Lanza GA

更新日期：1994-08-01 00:00:00

abstract：:The combination of aspirin and clopidogrel is the mainstay antiplatelet therapy for acute coronary syndromes (ACS). However, the dosing of aspirin, the dosing of clopidogrel, the timing of clopidogrel initiation as well as the duration of clopidogrel therapy remain controversial matters. Clopidogrel resistance is an e...

journal_title：Cardiovascular drugs and therapy

authors： Hanna EB,Glancy DL,Saucedo JF

更新日期：2010-02-01 00:00:00

abstract：:Amlodipine increases NO levels in coronary vessels and aorta via bradykinin-dependent mechanisms in vitro. We have previously reported that a long-acting Ca channel blocker, benidipine, increases cardiac NO levels in ischemic canine hearts, suggesting that benidipine may also protect against ischemia and reperfusion i...

journal_title：Cardiovascular drugs and therapy

authors： Asanuma H,Kitakaze M,Node K,Takashima S,Sakata Y,Asakura M,Sanada S,Shinozaki Y,Mori H,Tada M,Kuzuya T,Hori M

更新日期：2001-01-01 00:00:00

abstract：:Pulmonary arterial hypertension is a rare disease, with drug-induced causes even more uncommon, accounting for only 10% of cases in large registry series. Predisposing factors for drug-induced PAH have not been completely defined. This review summarizes drugs with definite, possible, or likely association to pulmonary...

journal_title：Cardiovascular drugs and therapy

authors： Correale M,Tricarico L,Grazioli D,Formica ES,Petrucci R,Persichella P,Di Biase M,Brunetti ND

更新日期：2019-12-01 00:00:00

abstract：:The DAVIT-II trial has shown that the verapamil type of calcium antagonist can beneficially be used in post-infarct patients. A recent re-analysis suggests that verapamil may also prevent post-infarct sudden death. There are good theoretical reasons to suppose that calcium antagonists should help prevent ventricular f...

journal_title：Cardiovascular drugs and therapy

authors： Opie LH

更新日期：1991-08-01 00:00:00

abstract：:Concentrations of the circulating hepatocyte growth factor (HGF) increase in the very early phase of acute myocardial infarction, and are a marker of arterial thrombosis. A recently developed, highly sensitive HGF assay can detect the early stages of arterial thrombosis in patients with unstable angina pectoris, acute...

journal_title：Cardiovascular drugs and therapy

authors： Matsumori A

更新日期：2004-07-01 00:00:00

abstract：:The aim of this study was to compare the pharmacokinetics and antiarrhythmic activity of dihydroquinidine and quinidine in 14 patients (11 men, 3 women, aged 28 to 67 years) with heart disease and chronic, stable, high-frequency premature ventricular beats (PVB) (greater than 100/hr). A randomized, double-blind, cross...

journal_title：Cardiovascular drugs and therapy

authors： Chimienti M,Regazzi MB,La Rovere MT,Salerno JA,Previtali M,Montericcio V,Rondanelli R,Montemartini C

更新日期：1988-12-01 00:00:00

abstract：:The purpose of this study was to evaluate the effect of trimetazidine on late potentials in patients with acute myocardial infarction. A total of 60 patients (52 males, mean age 55 +/- 2 years, and 8 females, mean age 54 +/- 1.8 years) with the diagnosis of acute myocardial infarction were included in this study. The ...

journal_title：Cardiovascular drugs and therapy

authors： Ozdemir R,Tuncer C,Aladag M,Güven A,Sezgin AT,Pekdemir H,Korkmaz ME,Müderrisoglu H

更新日期：1999-04-01 00:00:00

abstract：PURPOSE:We tested if inhibition of phosphodiesterases (PDEs) with IBMX (1-methyl-3-isobutylxanthine) can modulate the mitochondrial permeability transition pore (mPTP) opening by inactivating glycogen synthase kinase 3β (GSK-3β). METHODS:H9c2 cells were exposed to 600 μM H(2)O(2) for 20 min to cause the mPTP opening. ...

journal_title：Cardiovascular drugs and therapy

authors： Chanoit G,Zhou J,Lee S,McIntosh R,Shen X,Zvara DA,Xu Z

更新日期：2011-08-01 00:00:00

abstract：:The modifying effect on exercise performance and neuroendocrine response of the nonselective beta blocker timolol (10 mg b.i.d. for 5 days) and the beta 1-selective beta blocker metoprolol (100 mg b.i.d. for 5 days) was studied. The hormones studied were growth hormone, prolactin, cortisol, renin, epinephrine, dopamin...

journal_title：Cardiovascular drugs and therapy

authors： Gullestad L,Dolva LO,Kjeldsen SE,Eide I,Kjekshus J

更新日期：1989-03-01 00:00:00

abstract：:The majority of calcium antagonists used clinically belong to three distinct chemical classes: the phenylalkylamines, the dihydropyridines, and the benzothiazepines. In recent years their mode of action has been unravelled, their limitations recognized, and their efficacy and use in the management of patients with a b...

journal_title：Cardiovascular drugs and therapy

authors： Ferrari R,Cucchini F,Bolognesi R,Bachetti T,Boraso A,Bernocchi P,Gaia G,Visioli O

更新日期：1994-08-01 00:00:00

abstract：:Investment in cardiovascular drug development is on the decline as large cardiovascular outcomes trials require considerable investments in time, efforts and financial resources. Pharmacogenomics has the potential to help revive the cardiovascular drug development pipeline by providing new and better drug targets at a...

journal_title：Cardiovascular drugs and therapy

authors： Dubé MP,de Denus S,Tardif JC

更新日期：2016-02-01 00:00:00

abstract：:The efficacy of a fixed combination of 10 mg nifedipine and 100 mg acebutolol was tested in 21 patients with angiographically proven coronary artery disease (CAD). Ejection fraction (EF), emptying and filling rate (VS and VD), and end-systolic volume (ESV) were assessed by means of radionuclide ventriculography at res...

journal_title：Cardiovascular drugs and therapy

authors： Bauer R,Busch U,Lutilsky L,van de Flierdt E,Langhammer HR,Pabst HW

更新日期：1989-06-01 00:00:00

abstract：:Inhibition of the renin-angiotensin system has been a highly successful therapeutic approach for the prevention of hypertension-related end organ damage. Angiotensin converting enzyme inhibitors and angiotensin II receptor blockers lower blood pressure and reduce morbidity and mortality in patients with cardiovascular...

journal_title：Cardiovascular drugs and therapy

authors： Siragy HM

更新日期：2011-02-01 00:00:00

abstract：:Heart rate variability is a noninvasive indicator of autonomic nervous system activity. The role of the autonomic nervous system in the genesis of atrial or ventricular arrhythmias is now well established. Little is known about the effects of flecainide on heart rate variability in patients with normal heart structure...

journal_title：Cardiovascular drugs and therapy

authors： Fauchier L,Babuty D,Autret ML,Poret P,Cosnay P,Fauchier JP

更新日期：1998-10-01 00:00:00

abstract：AIM:To study the relationship between Daxx expression and the antiapoptotic effects of probucol in THP-1 macrophage. MATERIALS AND METHODS:Apoptosis of THP-1 derived macrophages was induced by exposure to oxidized low density lipoprotein (oxLDL). The development of apoptosis was determined by flow cytometry analysis a...

journal_title：Cardiovascular drugs and therapy

authors： Su B,Yang YB,Tuo QH,Zhu BY,Lei XY,Yin W,Liao DF

更新日期：2007-02-01 00:00:00

abstract：OBJECTIVE:Percutaneous vascular interventions lead inevitably to a destruction of the endothelial lining at the site of injury. There are conflicting data on the therapeutic benefit of hematopoietic growth factors aiming at mobilisation of circulating endothelial cells to accelerate the reendothelialisation process. Ai...

journal_title：Cardiovascular drugs and therapy

authors： Hack M,Mascha FG,Jobst BJ,Riegger GA,Griese DP

更新日期：2008-10-01 00:00:00

abstract：INTRODUCTION:Several beta blocking drugs (BB) reduce mortality in systolic heart failure (LVSD). We have compared the initial response to introduction of carvedilol and bisoprolol during the standard dose titration protocols for each drug. METHODS:Approximately 31 unselected patients with stable LVSD were randomised t...

journal_title：Cardiovascular drugs and therapy

authors： Hamaad A,Lip GY,Nicholls D,MacFadyen RJ

更新日期：2007-12-01 00:00:00

abstract：:The direct myocardial protective effects of intracoronary infusions of cromakalim and pinacidil were determined in an anesthetized canine model of coronary occlusion and reperfusion. The left circumflex coronary artery was occluded for 90 minutes and reperfused for 5 hours, at which time the infarct size was determine...

journal_title：Cardiovascular drugs and therapy

authors： Grover GJ,Dzwonczyk S,Parham CS,Sleph PG

更新日期：1990-04-01 00:00:00

abstract：:Piperanometozine (OPC-8212) is a new, orally effective inotropic agent. To evaluate the efficacy of this agent on systemic hemodynamics and clinical symptoms in patients with congestive heart failure, a multicenter study was performed. Thirty four patients with New York Heart Association (NYHA) functional classes II t...

journal_title：Cardiovascular drugs and therapy

authors： Inoue M,Hori M,Yasuda H,Takishima T,Sugimoto T,Sasayama S,Sakurai T,Nonogi H,Kodama K,Kusukawa R

更新日期：1987-08-01 00:00:00

abstract：OBJECTIVE:The aim was to study the pharmacodynamic interactions and safety of the co-administration of the calcium sensitizer levosimendan and the calcium antagonist felodipine in patients with coronary heart disease (CHD) and with normal ejection fraction (EF). METHODS:The study was a randomized, double blind, placeb...

journal_title：Cardiovascular drugs and therapy

authors： Põder P,Eha J,Antila S,Heinpalu M,Planken U,Loogna I,Mesikepp A,Akkila J,Lehtonen L

更新日期：2003-09-01 00:00:00

abstract：:In order to compare and clarify the effects of various antiarrhythmic drugs when given as monotherapy, we reevaluated our previous data on antiarrhythmic drugs and recalculated antiarrhythmic plasma concentrations of drugs for several canine arrhythmia models. We used three spontaneously occurring arrhythmias: a) digi...

journal_title：Cardiovascular drugs and therapy

authors： Hashimoto K,Haruno A,Matsuzaki T,Sugiyama A,Akiyama K

更新日期：1991-08-01 00:00:00

abstract：:The present study was performed in order to compare the efficacy, safety, and tolerability of lisinopril, a long-acting angiotensin-converting enzyme (ACE) inhibitor, with captopril, the shorter acting ACE inhibitor available, in the treatment of elderly patients (mean age 70 +/- 0.5 years) with congestive heart failu...

journal_title：Cardiovascular drugs and therapy

authors： Morisco C,Condorelli M,Crepaldi G,Rizzon P,Zardini P,Villa G,Argenziano L,Trimarco B

更新日期：1997-03-01 00:00:00

abstract：:This article considers the dominant role of trials involving thousands of patients--the mega-trials--in cardiovascular disease. Problems with large trials mean that alternative strategies must be developed to aid the introduction of new drugs. The limitations of meta-analysis, and of trials with combined and surrogate...

journal_title：Cardiovascular drugs and therapy

authors： Hampton JR

更新日期：1997-01-01 00:00:00

abstract：PURPOSE:To evaluate whether aleglitazar (Ale), a dual PPARα/γ agonist, has additive effects on myocardial protection against ischemia-reperfusion injury. METHODS:Human cardiomyocytes (HCMs), cardiomyocytes from cardiac-specific PPARγ knockout (MCM-PPARγ (CKO) ) or wild type (MCM-WT) mice were incubated with different ...

journal_title：Cardiovascular drugs and therapy

authors： Qian J,Chen H,Birnbaum Y,Nanhwan MK,Bajaj M,Ye Y

更新日期：2016-04-01 00:00:00

abstract：:The calcium antagonist (CA) controversy has been fueled in part by disagreements among scientists and clinicians over the scientific documentation required for drugs used to treat lifelong conditions. From a public health perspective, there are three unanswered questions: (1) Does long-term use of CAs convey health be...

journal_title：Cardiovascular drugs and therapy

authors： Furberg CD,Psaty BM

更新日期：1996-09-01 00:00:00

abstract：:Recent surveys in the U.S. have reported, for the first time, that a significant number of patients with hypertension are finding that the cost of medication and treatment in general is an obstacle to treatment. The cost of management of hypertension can be contained if: a) the diagnostic workup is kept simple (this d...

journal_title：Cardiovascular drugs and therapy

authors： Moser M

更新日期：1989-10-01 00:00:00

abstract：BACKGROUND:High health service expenditure on the one hand, and the politically declared objective of stability of statutory contributions and restriction of public funds on the other hand, have been central points of the political and social discussion for several years. The over-proportional increase in health servic...

journal_title：Cardiovascular drugs and therapy

authors： Cathomas G,Erne P,Schwenkglenks M,Szucs TD

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Heart failure (HF) is considered to be a prothrombotic condition and it has been suggested that coagulation factors contribute to maladaptive cardiac remodelling via activation of the protease-activated receptor 1 (PAR1). We tested the hypothesis that anticoagulation with the factor Xa (FXa) inhibitor apixab...

journal_title：Cardiovascular drugs and therapy

authors： Yurista SR,Silljé HHW,Nijholt KT,Dokter MM,van Veldhuisen DJ,de Boer RA,Westenbrink BD

更新日期：2020-05-26 00:00:00

abstract：:Beneficial effects of monotherapy with ACE inhibitors or beta-blockers on hemodynamic function after myocardial infarction are well known. Until now, the effects of combined treatment on cardiac function and energy metabolism have been poorly described. This study examines the effects of combined ramipril and metoprol...

journal_title：Cardiovascular drugs and therapy

authors： Theres HP,Wagner KD,Romberg D,Feig C,Strube S,Leiterer KP,Günther J,Stangl K,Baumann G,Schimke I

更新日期：2000-12-01 00:00:00