The economic efficiency of amlodipine in the treatment of coronary atherosclerosis--an analysis based on the PREVENT study.

abstract：PURPOSE:Morphine has been used for several decades in cases of acute pulmonary edema (APE) due to the anxiolytic and vasodilatory properties of the drug. The non-specific depression of the central nervous system is probably the most significant factor for the changes in hemodynamics in APE. Retrospective studies have s...

journal_title：Cardiovascular drugs and therapy

authors： Dominguez-Rodriguez A,Burillo-Putze G,Garcia-Saiz MDM,Aldea-Perona A,Harmand MG,Mirò O,Abreu-Gonzalez P,MIMO investigators.

更新日期：2017-04-01 00:00:00

abstract：:The effects of nifedipine on left ventricular function were evaluated in 17 patients with coronary artery disease with an ambulatory radionuclide detector (VEST). Hemodynamic data were recorded continuously at rest and during upright bicycle ergometer exercise before and 30 minutes after 10 mg of oral nifedipine admin...

journal_title：Cardiovascular drugs and therapy

authors： Kambara H,Mohiuddin IH,Tamaki N,Fudo T,Hayashi M,Nohara R,Konishi J,Kawai C

更新日期：1990-08-01 00:00:00

abstract：PURPOSE:Platelets are essential for primary hemostasis; however, platelet activation also plays an important proinflammatory role. Inflammation promotes the development of cardiac fibrosis and heart failure induced by hypertension. In this study, we aimed to determine whether inhibiting platelet activation using clopid...

journal_title：Cardiovascular drugs and therapy

authors： Jia LX,Qi GM,Liu O,Li TT,Yang M,Cui W,Zhang WM,Qi YF,Du J

更新日期：2013-12-01 00:00:00

abstract：:The DAVIT-II trial has shown that the verapamil type of calcium antagonist can beneficially be used in post-infarct patients. A recent re-analysis suggests that verapamil may also prevent post-infarct sudden death. There are good theoretical reasons to suppose that calcium antagonists should help prevent ventricular f...

journal_title：Cardiovascular drugs and therapy

authors： Opie LH

更新日期：1991-08-01 00:00:00

abstract：:Nicorandil (N) and isosorbide dinitrate (ISDN) are vasodilator drugs used in patients with angina. In 24 healthy male volunteers (18-32 years), the acute effect of a single oral dose (20 mg) of N and ISDN on arterial diameter (D), distensibility, and compliance of the elastic common carotid artery (CCA) and the muscul...

journal_title：Cardiovascular drugs and therapy

authors： Kool MJ,Spek JJ,Struyker Boudier HA,Hoeks AP,Reneman RS,van Herwaarden RH,Van Bortel LM

更新日期：1995-04-01 00:00:00

abstract：:The present study was performed in order to compare the efficacy, safety, and tolerability of lisinopril, a long-acting angiotensin-converting enzyme (ACE) inhibitor, with captopril, the shorter acting ACE inhibitor available, in the treatment of elderly patients (mean age 70 +/- 0.5 years) with congestive heart failu...

journal_title：Cardiovascular drugs and therapy

authors： Morisco C,Condorelli M,Crepaldi G,Rizzon P,Zardini P,Villa G,Argenziano L,Trimarco B

更新日期：1997-03-01 00:00:00

abstract：:To characterize the effects of OPC-8212, a quinolone inotropic agent, in patients with heart failure, we utilized invasive hemodynamics, exercise testing, 24-hour ambulatory electrocardiograms, and two patient self-assessment questionnaires, before and after 1 month of treatment with OPC-8212, in 17 patients with mode...

journal_title：Cardiovascular drugs and therapy

authors： Kubo SH,Rector TS,Strobeck JE,Cohn JN

更新日期：1988-12-01 00:00:00

abstract：:Reducing elevated levels of low-density-lipoprotein cholesterol (LDL-C) significantly reduces the incidence of coronary heart disease (CHD) events and mortality in hypercholesterolemic patients. CHD risk reduction is proportional to LDL-C reduction. Despite this knowledge, many physicians are not applying existing tre...

journal_title：Cardiovascular drugs and therapy

authors： McKenney JM

更新日期：2001-09-01 00:00:00

abstract：:Despite the impressive relation between an increased blood cholesterol and increased mortality from coronary artery disease and despite the persuasive results of cholesterol-lowering trials in secondary prevention, there are increasing reservations about the wisdom of lowering moderately raised blood cholesterol level...

journal_title：Cardiovascular drugs and therapy

authors： Opie LH

更新日期：1993-11-01 00:00:00

abstract：:In the latter half of the 20th century, among participants of the Framingham Heart Study, incidence of heart failure (HF) has declined by about a third in women but not in men and survival after the onset of HF has improved in both sexes; however, HF remains highly lethal with over 50% dying within 5 years after onset...

journal_title：Cardiovascular drugs and therapy

authors： Kenchaiah S,Vasan RS

更新日期：2015-08-01 00:00:00

abstract：:The purpose of this study was to define the role of beta-adrenergic blockade and direct membrane effects in the ability of dl-propranolol to alter ventricular repolarization and refractoriness in the intact heart. The effective refractory period (ERP) and the local Q-T interval were measured at an epicardial site in t...

journal_title：Cardiovascular drugs and therapy

authors： Euler DE,Scanlon PJ

更新日期：1988-03-01 00:00:00

abstract：:Specific antiarrhythmic therapy with class I and III drugs for atrial fibrillation (AF) conversion and prevention of its recurrence is frequently utilized in clinical practice. Besides being only moderate effective, the utilization of antiarrhythmic drugs may be associated with serious side effects. In the clinical se...

journal_title：Cardiovascular drugs and therapy

authors： Husser D,Stridh M,Sornmo L,Platonov P,Olsson SB,Bollmann A

更新日期：2004-09-01 00:00:00

abstract：:The effects of equipotent concentrations of diltiazem, verapamil, and nifedipine upon the accumulation of extracellular potassium [K+]out and the left ventricular pressure (LVP) were studied during global ischemia in isolated perfused rat hearts. Measurement of [K+]out and LVP were performed in two series of experimen...

journal_title：Cardiovascular drugs and therapy

authors： Heijnis JB,Coronel R,van Zwieten PA

更新日期：1991-12-01 00:00:00

abstract：:Pulmonary arterial hypertension is a rare disease, with drug-induced causes even more uncommon, accounting for only 10% of cases in large registry series. Predisposing factors for drug-induced PAH have not been completely defined. This review summarizes drugs with definite, possible, or likely association to pulmonary...

journal_title：Cardiovascular drugs and therapy

authors： Correale M,Tricarico L,Grazioli D,Formica ES,Petrucci R,Persichella P,Di Biase M,Brunetti ND

更新日期：2019-12-01 00:00:00

abstract：:Ranolazine, an inhibitor of the late current of the cardiac action potential (late I(Na)), is a well established clinical treatment for chronic angina. The late INa in cardiac myocytes also plays an important role in the pathophysiology of acute myocardial ischemia and reperfusion, and thus is a potential therapeutic ...

journal_title：Cardiovascular drugs and therapy

authors： Hale SL,Kloner RA

更新日期：2014-10-01 00:00:00

abstract：RATIONALE:Pulmonary hypertension (PH) represents a serious health complication accompanied with hypoxic conditions, elevated levels of asymmetric dimethylarginine (ADMA), and overall dysfunction of pulmonary vascular endothelium. Since the prevention strategies for treatment of PH remain largely unknown, our study aime...

journal_title：Cardiovascular drugs and therapy

authors： Koudelka A,Ambrozova G,Klinke A,Fidlerova T,Martiskova H,Kuchta R,Rudolph TK,Kadlec J,Kuchtova Z,Woodcock SR,Freeman BA,Kubala L,Pekarova M

更新日期：2016-12-01 00:00:00

abstract：:Cardiovascular disease is the leading cause of death in men and women in the USA. Once a patient experiences an acute coronary syndrome (ACS), they are at increased risk for hospital readmission within 30 days and 6 months after discharge and more importantly, they have worse survival. Hospital readmissions lead to po...

journal_title：Cardiovascular drugs and therapy

authors： Paruchuri V,Gaztanaga J,Rambhujun V,Smith R,Farkouh ME

更新日期：2018-12-01 00:00:00

abstract：:This study compares the electrophysiologic effects of amlodipine and diltiazem in patients with coronary artery disease concomitantly treated with background beta-blocking therapy. Thirty patients were included in an open-label parallel study in two phases. During phase 1, patients were screened and placed on maintena...

journal_title：Cardiovascular drugs and therapy

authors： Santarelli P,Biscione F,Natale A,Manzoli A,Lanza GA

更新日期：1994-08-01 00:00:00

abstract：OBJECTIVE:The natural history of pediatric patients with severely symptomatic neurocardiogenic syncope is poorly defined respect to the likelihood of remission or symptomatic recurrence along time. We undertook this study to investigate the likelihood of clinical relapse, and to assess the effect of prophylactic pharma...

journal_title：Cardiovascular drugs and therapy

authors： Biffi M,Boriani G,Bronzetti G,Frabetti L,Picchio FM,Branzi A

更新日期：2001-03-01 00:00:00

abstract：:Heart rate varies with respiration, blood pressure, emotion, etc., and heart rate variability (HRV) is presently one of the best indices to predict fatal issues in cardiac failure and after myocardial infarction. HRV depends on various reflexes. In addition, parallel studies of HRV and the myocardial adrenergic and mu...

journal_title：Cardiovascular drugs and therapy

authors： Swynghedauw B,Jasson S,Chevalier B,Clairambault J,Hardouin S,Heymes C,Mangin L,Mansier P,Médigue C,Moalic JM,Thibault N,Carré F

更新日期：1997-01-01 00:00:00

abstract：INTRODUCTION:Atrial dilatation is commonly associated with atrial fibrillation (AF), but the electrophysiological mechanisms and the implications for anti-arrhythmic therapy are poorly understood. In a model of acute stretch-related AF in isolated rabbit hearts, we evaluated the electrophysiological effects of three di...

journal_title：Cardiovascular drugs and therapy

authors： Kalifa J,Bernard M,Gout B,Bril A,Cozma D,Laurent P,Chalvidan T,Deharo JC,Djiane P,Cozzone P,Maixent JM

更新日期：2007-02-01 00:00:00

abstract：:This article considers the dominant role of trials involving thousands of patients--the mega-trials--in cardiovascular disease. Problems with large trials mean that alternative strategies must be developed to aid the introduction of new drugs. The limitations of meta-analysis, and of trials with combined and surrogate...

journal_title：Cardiovascular drugs and therapy

authors： Hampton JR

更新日期：1997-01-01 00:00:00

abstract：:We compared the time-course of the hemodynamic effect of isosorbide dinitrate (ISDN), 5 mg, in the form of sublingual tablet and oral spray, in 15 patients with isolated chronic pulmonary congestion (pulmonary arterial end-diastolic pressure of 15 mmHg or more in the presence of normal or only slightly reduced cardiac...

journal_title：Cardiovascular drugs and therapy

authors： Marchionni N,De Bari M,Ferrucci L,Moschi G,Schneeweiss A

更新日期：1988-11-01 00:00:00

abstract：BACKGROUND:Markers of thrombosis, inflammation, endothelial dysfunction and neurohumoral activation such as fibrinogen, D-dimer, C-reactive protein, von Willebrand factor, tumour necrosis factor-alpha and chromogranin-A are reported to be linked to the increase of cardiovascular risk for atherosclerosis progression and...

journal_title：Cardiovascular drugs and therapy

authors： Scientific Committee of the PERTINENT Sub-Study, EUROPA-PERTINENT Investigators.

更新日期：2003-01-01 00:00:00

abstract：:Heart rate variability is a noninvasive indicator of autonomic nervous system activity. The role of the autonomic nervous system in the genesis of atrial or ventricular arrhythmias is now well established. Little is known about the effects of flecainide on heart rate variability in patients with normal heart structure...

journal_title：Cardiovascular drugs and therapy

authors： Fauchier L,Babuty D,Autret ML,Poret P,Cosnay P,Fauchier JP

更新日期：1998-10-01 00:00:00

abstract：:The hypothesis tested was that enhanced entry of calcium into cardiac cells would increase the susceptibility to ventricular fibrillation as measured by the ventricular fibrillation threshold (VFT) of the isolated perfused rat heart. Bay-K-8644 was used as a calcium-channel agonist. There was a biphasic effect with a ...

journal_title：Cardiovascular drugs and therapy

authors： Worthington MG,Opie LH

更新日期：1992-12-01 00:00:00

abstract：AIMS:Rapid restoration of sinus rhythm using pharmacological cardioversion is commonly indicated in patients with symptomatic recent-onset atrial fibrillation (AF). The objectives of this large, international, multicenter observational study were to determine the safety and effectiveness of intravenous (IV) vernakalant...

journal_title：Cardiovascular drugs and therapy

authors： Lévy S,Hartikainen J,Ritz B,Juhlin T,Carbajosa-Dalmau J,Domanovits H

更新日期：2020-11-18 00:00:00

abstract：PURPOSE:The prevalence and consequences of prediabetic dysglycemia and undiagnosed diabetes is unknown in patients with heart failure (HF) and preserved ejection fraction (HFpEF) and has not been compared to heart failure and reduced ejection fraction (HFrEF). METHODS:We examined the prevalence and outcomes associated...

journal_title：Cardiovascular drugs and therapy

authors： Kristensen SL,Jhund PS,Lee MMY,Køber L,Solomon SD,Granger CB,Yusuf S,Pfeffer MA,Swedberg K,McMurray JJV,CHARM Investigators and Committees.

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:The use of sodium-glucose co-transporter 2 inhibitors (SGLT2i) is currently expanding to cardiovascular risk reduction in non-diabetic subjects, but renal (side-)effects are less well studied in this setting. METHODS:Male non-diabetic Sprague Dawley rats underwent permanent coronary artery ligation to induc...

journal_title：Cardiovascular drugs and therapy

authors： Yurista SR,Silljé HHW,van Goor H,Hillebrands JL,Heerspink HJL,de Menezes Montenegro L,Oberdorf-Maass SU,de Boer RA,Westenbrink BD

更新日期：2020-06-01 00:00:00

abstract：:Thiazide diuretics are particularly efficacious in the treatment of hypertension in blacks. A number of observations suggest that many hypertensive blacks have features consistent with a status of "corrected" volume expansion. Our studies, as well as those of other investigators, show that the Na,K pump is inhibited i...

journal_title：Cardiovascular drugs and therapy

authors： Quintanilla AP,Wagener OE

更新日期：1990-03-01 00:00:00