Abstract：
:In the latter half of the 20th century, among participants of the Framingham Heart Study, incidence of heart failure (HF) has declined by about a third in women but not in men and survival after the onset of HF has improved in both sexes; however, HF remains highly lethal with over 50% dying within 5 years after onset of HF. Overall, the 8-year relative risk of HF is 24% lower in women compared with men. The 8-year incidence rates of HF with preserved ejection fraction (HFPEF; EF >45%) and HF with reduced EF (HFREF; EF ≤ 45%) in women and HFPEF in men are similar; however, men have a 2-fold higher cumulative incidence of HFREF than HFPEF. The lifetime risk of HF is about 20% in both women and men at 40, 50, 60, 70, and 80 years of age. Contribution of hypertension and diabetes mellitus to the risk of HF was more prominent in women than in men. Serum levels of several biomarkers were distinctly different in women compared with men and had differential effects on left ventricular structure and function; however, the strength and direction of the association between biomarkers levels and HF risk were generally similar in women and men. In individuals with HF, about two-thirds of the underlying cause of death and about one-half of the immediate cause of death were due to cardiovascular causes. Non-cardiovascular underlying and immediate causes of death were more evident in HFPEF.
journal_name
Cardiovasc Drugs Therjournal_title
Cardiovascular drugs and therapyauthors
Kenchaiah S,Vasan RSdoi
10.1007/s10557-015-6599-0subject
Has Abstractpub_date
2015-08-01 00:00:00pages
377-90issue
4eissn
0920-3206issn
1573-7241journal_volume
29pub_type
杂志文章,评审abstract：:Intravenous amiodarone has been found useful in the emergent management of life-threatening arrhythmias. Experimental studies have shown that its electrophysiologic effects are proportional to its myocardial concentration. However, early after its intravenous administration, the extent of the concentration of amiodaro...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章
doi：10.1023/a:1007756411790
更新日期：1999-05-01 00:00:00
abstract：:Patients with mild to moderate hypertension (diastolic blood pressure > or = 95 and < or = 115 mmHg) and renal dysfunction entered one of two studies to assess the safety of efficacious daily doses of quinapril on renal function and blood pressure. Twenty-four patients with moderate renal impairment (MRI) (creatinine ...
journal_title：Cardiovascular drugs and therapy
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1007/BF00877336
更新日期：1994-04-01 00:00:00
abstract：:Recent studies have questioned the safety of calcium antagonists in general, and short-acting dihydropyridine derivatives in particular. Reasons include excessive catecholamine stimulation after stress. We therefore wanted to assess whether amlodipine, a second generation dihydropyridine with a prolonged plasma half-l...
journal_title：Cardiovascular drugs and therapy
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1023/a:1007875603969
更新日期：1999-11-01 00:00:00
abstract：PURPOSE:Rivaroxaban, an oral anticoagulant, undergoes the metabolism mediated by human cytochrome P450 (CYP). The present study is to quantitatively analyze and compare the contributions of multiple CYPs in the metabolism of rivaroxaban to provide new information for medication safety. METHODS:The metabolic stability ...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章
doi：10.1007/s10557-020-07129-z
更新日期：2021-01-07 00:00:00
abstract：OBJECTIVE:Percutaneous vascular interventions lead inevitably to a destruction of the endothelial lining at the site of injury. There are conflicting data on the therapeutic benefit of hematopoietic growth factors aiming at mobilisation of circulating endothelial cells to accelerate the reendothelialisation process. Ai...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章
doi：10.1007/s10557-008-6117-8
更新日期：2008-10-01 00:00:00
abstract：PURPOSE:The glucagon-like peptide-1 (GLP-1) has been shown to exert cardioprotective effects in animals and patients. This study tests the hypothesis that preservation of GLP-1 by the GLP-1 receptor agonist liraglutide or the dipeptidyl peptidase-4 (DPP-4) inhibitor linagliptin is associated with a reduction of angiote...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章
doi：10.1007/s10557-015-6592-7
更新日期：2015-06-01 00:00:00
abstract：:In vitro and in vivo studies have demonstrated many similarities between the three calcium antagonists verapamil, nifedipine, and diltiazem in relation to protection of the myocardium during hypoxia. Important clinical differences exist between the three drugs when they are used during or after an acute myocardial inf...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章,评审
doi：10.1007/BF03029738
更新日期：1991-08-01 00:00:00
abstract：:Excess activity of the sympathetic nervous system (SNS) is linked to human obese hypertension and to salt-sensitive hypertension. Paradoxically, reduced SNS activity has been implicated as a contributor to obesity, particularly in animal models, and salt loading usually inhibits SNS activity. We have investigated the ...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章
doi：10.1007/BF00120497
更新日期：1996-06-01 00:00:00
abstract：:Annual mortality from congestive heart failure ranges from 15% to 60%, depending on the severity of the left ventricular damage and underlying disease. Most controlled trials have been too small to detect any beneficial effect on survival from the newer vasodilator and inotropic drugs. However, the results of two rece...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章,评审
doi：
更新日期：1988-11-01 00:00:00
abstract：PURPOSE:To compare the lifetime cost and effectiveness of five alternative chronic atrial fibrillation (AF) management strategies: rivaroxaban, warfarin, aspirin plus clopidogrel, aspirin and no prevention. METHODS:An individual-level state-transition model was developed to track the lifetime disease course associated...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章
doi：10.1007/s10557-013-6490-9
更新日期：2014-02-01 00:00:00
abstract：AIMS:The primary ain of this study was to investigate the effect of carbachol on ventricular repolarisation in an intact animal heart. METHODS:In five sheep, carbachol was administered to the left circumflex coronary artery (LCX) at 1.0 and 2.5 micromol/ml/min respectively for 3 min. Multiple unipolar ECGs were acquir...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章
doi：10.1023/a:1027324412869
更新日期：2003-07-01 00:00:00
abstract：:To compare the antiischemic effects of intracoronary administration of a beta blocker, atenolol, and of a calcium antagonist, nifedipine, on the clinical and electrocardiographic signs of myocardial ischemia induced by balloon occlusion of the coronary artery, we studied 32 consecutive patients undergoing routine PTCA...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章
doi：10.1007/BF00051147
更新日期：1992-06-01 00:00:00
abstract：PURPOSE:The PPAR-alpha agonists (fibrates) are commonly used in the treatment of dyslipidemia. It has been hypothesized that the cardio-protective effects of fibrates are partially due to immunomodulatory effects. However, there is a paucity of data regarding the effect of fibrates on neutrophilic chemokines such as ep...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章
doi：10.1007/s10557-011-6368-7
更新日期：2012-04-01 00:00:00
abstract：PURPOSE:In addition to lowering hemoglobin A1C, colesevelam has been shown to improve the atherogenic lipoprotein profile of subjects with type 2 diabetes mellitus (T2DM) when used in combination with metformin and/or sulfonylureas. A recent study evaluated the effects of colesevelam as antidiabetes monotherapy in adul...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1007/s10557-014-6516-y
更新日期：2014-06-01 00:00:00
abstract：:Early reperfusion after an organ ischemia is essential to salvage tissue from eventual death. However, abundant evidence suggests that reperfusion also elicits pathophysiological changes responsible for additional tissue injury after restoration of blood flow. Postconditioning (Postcon) defined as rapid sequential int...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章,评审
doi：10.1007/s10557-010-6240-1
更新日期：2010-06-01 00:00:00
abstract：:To evaluate cordiodepressive risks of antiarrhythmic treatment with diprafenone, we monitored, in addition to conventional hemodynamic parameters, end-systolic pressure-volume relations to assess potential negative inotropic effects. Thirteen patients underwent hemodynamic analysis with and without the influence of di...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章
doi：10.1007/BF01883858
更新日期：1989-04-01 00:00:00
abstract：:The aim of the present study was to investigate the effects of almokalant on sustained reentrant supraventricular tachycardias. Reentrant tachycardias were induced, using transesophageal atrial stimulation, in 82 patients with atrioventricular reentrant tachycardia (n = 54) or AV nodal reentrant tachycardia (n = 28). ...
journal_title：Cardiovascular drugs and therapy
pub_type： 临床试验,杂志文章
doi：10.1023/a:1007761825414
更新日期：1997-07-01 00:00:00
abstract：:Tracer techniques have provided new insight in cardiology by allowing noninvasive studies of myocardial perfusion, function, metabolism, and, more recently, ligand-receptor interaction. Positron emission tomography allows accurate quantification and the use of natural substrates labelled with 11C, 13N, or 15O. Myocard...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章,评审
doi：10.1007/BF00051291
更新日期：1990-08-01 00:00:00
abstract：PURPOSE:Platelets are essential for primary hemostasis; however, platelet activation also plays an important proinflammatory role. Inflammation promotes the development of cardiac fibrosis and heart failure induced by hypertension. In this study, we aimed to determine whether inhibiting platelet activation using clopid...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章
doi：10.1007/s10557-013-6471-z
更新日期：2013-12-01 00:00:00
abstract：:Reducing elevated levels of low-density-lipoprotein cholesterol (LDL-C) significantly reduces the incidence of coronary heart disease (CHD) events and mortality in hypercholesterolemic patients. CHD risk reduction is proportional to LDL-C reduction. Despite this knowledge, many physicians are not applying existing tre...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章,评审
doi：10.1023/a:1013341606476
更新日期：2001-09-01 00:00:00
abstract：:Calcium channel blockers are a group of drugs used for the treatment of hypertension. Carbonic anhydrase (CA) I detected in vascular smooth muscle and in other cells in the organism has a major role in the acid-base balance and in vascular processes. Our previous work has proven that verapamil inhibits CA activity by ...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章
doi：10.1023/a:1007893207279
更新日期：2000-10-01 00:00:00
abstract：BACKGROUND:Recent studies in rabbits have demonstrated that platelet P2Y12 receptor antagonists are cardioprotective, and that the mechanism is surprisingly not related to blockade of platelet aggregation but rather to triggering of the same signal transduction pathway seen in pre- and postconditioning. We wanted to de...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章
doi：10.1007/s10557-012-6436-7
更新日期：2013-04-01 00:00:00
abstract：:Elgodipine is a new second-generation dihydropyridine calcium antagonist. Its hemodynamic and antiischemic properties were evaluated in a single-blind, placebo-controlled trial in 22 males with chronic stable angina. Coronary artery disease was angiographically confirmed. Measurements were performed with a Swan-Ganz t...
journal_title：Cardiovascular drugs and therapy
pub_type： 临床试验,杂志文章
doi：10.1007/BF00878092
更新日期：1995-08-01 00:00:00
abstract：:Nicorandil (N) and isosorbide dinitrate (ISDN) are vasodilator drugs used in patients with angina. In 24 healthy male volunteers (18-32 years), the acute effect of a single oral dose (20 mg) of N and ISDN on arterial diameter (D), distensibility, and compliance of the elastic common carotid artery (CCA) and the muscul...
journal_title：Cardiovascular drugs and therapy
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF00878678
更新日期：1995-04-01 00:00:00
abstract：:True positive inotropy of enoximone is hard to prove clinically. It could increase the risk of myocardial ischemia when used in coronary artery disease (CAD). The analysis of the end-systolic pressure-volume relationship (ESPVR) as a load-independent parameter of the contractile left ventricular function (LVF) allows ...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章
doi：10.1007/BF02018269
更新日期：1990-10-01 00:00:00
abstract：:In order to compare and clarify the effects of various antiarrhythmic drugs when given as monotherapy, we reevaluated our previous data on antiarrhythmic drugs and recalculated antiarrhythmic plasma concentrations of drugs for several canine arrhythmia models. We used three spontaneously occurring arrhythmias: a) digi...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章
doi：10.1007/BF00120829
更新日期：1991-08-01 00:00:00
abstract：:The effects of nifedipine on left ventricular function were evaluated in 17 patients with coronary artery disease with an ambulatory radionuclide detector (VEST). Hemodynamic data were recorded continuously at rest and during upright bicycle ergometer exercise before and 30 minutes after 10 mg of oral nifedipine admin...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章
doi：10.1007/BF02018293
更新日期：1990-08-01 00:00:00
abstract：:Inhibition of the renin-angiotensin system has been a highly successful therapeutic approach for the prevention of hypertension-related end organ damage. Angiotensin converting enzyme inhibitors and angiotensin II receptor blockers lower blood pressure and reduce morbidity and mortality in patients with cardiovascular...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章,评审
doi：10.1007/s10557-010-6278-0
更新日期：2011-02-01 00:00:00
abstract：:Ouabain, when applied to rings of the left circumflex coronary artery of the dog (which contains both alpha 1-adrenoceptors leading to contraction and beta 1-adrenoceptors leading to relaxation) caused an initial contraction which peaked within 15 minutes and a later secondary increase in tension which peaked within 6...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章
doi：10.1007/BF00051242
更新日期：1988-07-01 00:00:00
abstract：PURPOSE:Although the role of angiotensin-converting enzyme (ACE) inhibitors for the treatment of hypertension has been well established, no data has been generated regarding the influence of ACE inhibitors for health-related quality-of-life (QOL) dimensions for Chinese patients. MATERIALS:A double-blind, active-contro...
journal_title：Cardiovascular drugs and therapy
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1023/a:1020648405680
更新日期：2002-05-01 00:00:00
