Abstract：
:To characterize the effects of OPC-8212, a quinolone inotropic agent, in patients with heart failure, we utilized invasive hemodynamics, exercise testing, 24-hour ambulatory electrocardiograms, and two patient self-assessment questionnaires, before and after 1 month of treatment with OPC-8212, in 17 patients with moderate to severe congestive heart failure. There were no significant changes from baseline in heart rate (83 +/- 8 beats/min), mean arterial pressure (70 +/- 15 mmHg), pulmonary wedge pressure (18 +/- 7 mmHg), or cardiac index (2.3 +/- 0.4 L/min/m2) following treatment with OPC-8212. Both exercise duration (5.3 +/- 1.6 min) and peak oxygen consumption (12.0 +/- 2.9 mL/kg/min) were unchanged by OPC-8212. Two independent patient self-assessment scores, the Sickness Impact Profile and the Minnesota Living with Heart Failure Questionnaire, showed improvements from 6.8 to 5.4 and 49 to 38, respectively (both p less than .05), suggesting that the patients reported an improvement in daily functioning. The median ventricular premature contraction count and frequency were reduced from 1,118 beats to 243 beats (p less than 0.05) and 11/1,000 beats to 2.4/1,000 beats (0.05 less than p less than 0.10), respectively. Two patients developed agranulocytosis during longer-term treatment following this 1-month study. These data demonstrate that OPC-8212 did not have significant effects on hemodynamics or exercise tolerance. However, the improvement in patient self-assessment scores and the trend for improvement in ventricular arrhythmia profiles suggest that OPC-8212 may have some benefit for patients with congestive heart failure, but additional placebo-controlled, double-blind studies are necessary.
journal_name
Cardiovasc Drugs Therjournal_title
Cardiovascular drugs and therapyauthors
Kubo SH,Rector TS,Strobeck JE,Cohn JNdoi
10.1007/BF00054205subject
Has Abstractpub_date
1988-12-01 00:00:00pages
653-60issue
5eissn
0920-3206issn
1573-7241journal_volume
2pub_type
杂志文章abstract：:Although torsades de pointes is not a tightly demarcated entity, the diagnosis has important clinical implications. The concept should be retained. ...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章
doi：10.1007/BF03029821
更新日期：1991-02-01 00:00:00
abstract：:The effects of orally administered captopril, enalapril and lisinopril on plasma concentrations of angiotensin converting enzyme (ACE), angiotensin II (ANGII) and renin (PRC) were studied over a period of 6 hours in 6 normal subjects. A further 4 subjects received intravenous enalapril and enalaprilic acid (enalaprila...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章
doi：10.1007/BF02125832
更新日期：1987-01-01 00:00:00
abstract：:The modifying effect on exercise performance and neuroendocrine response of the nonselective beta blocker timolol (10 mg b.i.d. for 5 days) and the beta 1-selective beta blocker metoprolol (100 mg b.i.d. for 5 days) was studied. The hormones studied were growth hormone, prolactin, cortisol, renin, epinephrine, dopamin...
journal_title：Cardiovascular drugs and therapy
pub_type： 临床试验,杂志文章
doi：10.1007/BF01881530
更新日期：1989-03-01 00:00:00
abstract：:As damage to the pulmonary vascular endothelium may be responsible for the lung toxicity of amiodarone, we evaluated the cytolytic toxicity of the drug in cultures of endothelial cells. Cells were cultured from human umbilical cord veins. Amiodarone caused a vacuolization of the cells with liberation of both lactate d...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章
doi：10.1007/BF00050996
更新日期：1996-11-01 00:00:00
abstract：PURPOSE:To assess whether glycoprotein IIb/IIIa inhibition using tirofiban in low risk patients undergoing percutaneous coronary intervention (PCI) may reduce the risk of periprocedural myocardial infarction compared to standard care in poor responders to aspirin and/or clopidogrel. METHODS:We will enroll patients at ...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1007/s10557-008-6121-z
更新日期：2008-08-01 00:00:00
abstract：PURPOSE:To investigate the associations of diuretics overall, non-potassium-sparing diuretics in specific, and laxative use with cardiovascular mortality (CVM) in subjects with antihypertensive treatment. METHODS:Analyses included 4253 participants, aged 50 to 75 years, from the German ESTHER cohort and 105,359 partic...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章
doi：10.1007/s10557-019-06894-w
更新日期：2019-10-01 00:00:00
abstract：:Inhibition of then renin-angiotensin system (RAS) ranks among the best established and most used cardiovascular therapies. By providing protection against hypertension and heart failure, and also the microvascular complications of diabetes, RAS inhibitors have contributed to the longer life-expectancy now found in hig...
journal_title：Cardiovascular drugs and therapy
pub_type： 社论
doi：10.1007/s10557-011-6316-6
更新日期：2011-08-01 00:00:00
abstract：INTRODUCTION:Most circulating fatty acids are contained in lipoprotein triglycerides. For the heart to acquire these lipids, they must be broken down into free fatty acids via the enzyme lipoprotein lipase (LpL). Although it has long been known that hearts primarily use esterified fatty acids as fuel, different sources...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章,评审
doi：10.1007/s10557-006-0633-1
更新日期：2006-12-01 00:00:00
abstract：:Nicorandil (N) and isosorbide dinitrate (ISDN) are vasodilator drugs used in patients with angina. In 24 healthy male volunteers (18-32 years), the acute effect of a single oral dose (20 mg) of N and ISDN on arterial diameter (D), distensibility, and compliance of the elastic common carotid artery (CCA) and the muscul...
journal_title：Cardiovascular drugs and therapy
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF00878678
更新日期：1995-04-01 00:00:00
abstract：PURPOSE:The aim of this study was to investigate the impact of granulocyte-colony stimulating factor (G-CSF) administration on cardiac function of rats with chronic myocardial infarction through two different protocols: high dose short term and low dose long term protocols. METHODS:Wistar rats were submitted to MI sur...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章
doi：10.1007/s10557-010-6215-2
更新日期：2010-04-01 00:00:00
abstract：:A survey of the pharmacokinetic properties of the three prototypical calcium antagonist agents shows that they have in common a very high rate of hepatic first-pass metabolism with, in the case of verapamil and diltiazem, the formation of an active metabolite that affects the dose during chronic therapy. Therefore, th...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章,评审
doi：10.1007/BF01865507
更新日期：1989-08-01 00:00:00
abstract：INTRODUCTION:Surrogate markers represent a significant contribution to early diagnosis, longitudinal prognoses, and outcome prediction in cases of hypertension. They often enable detection of disease and disease potential when the disease is still subclinical and are useful noninvasive tools for designing and evaluatin...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章,评审
doi：10.1007/s10557-009-6177-4
更新日期：2009-08-01 00:00:00
abstract：:This study was designed to compare once-daily administration of 5-10 mg amlodipine with two daily doses of 40 mg sustained-release isosorbide dinitrate in 59 patients with stable angina using a randomized, double-blind, crossover study design. Anginal episodes, nitroglycerin consumption, and possible adverse events we...
journal_title：Cardiovascular drugs and therapy
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1023/a:1007726722284
更新日期：1997-11-01 00:00:00
abstract：PURPOSE:A multicentre, randomized, double-blind, placebo-controlled, parallel-group study aimed to define the potential positive effect of dipeptidyl peptidase-4 inhibition on left ventricular systolic function (LVSF) beyond glycemic control in type 2 diabetes mellitus (T2DM) (DYDA 2™ trial). METHODS:Individuals with ...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章
doi：10.1007/s10557-019-06898-6
更新日期：2019-10-01 00:00:00
abstract：:The results of the European Working Party for Hypertension in the Elderly Study showed that treatment of high blood pressure reduced the morbidity and mortality from strokes and myocardial infarction and reduced the incidence of heart failure in elderly patients. The largest number of hypertensive patients are elderly...
journal_title：Cardiovascular drugs and therapy
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF00053441
更新日期：1990-01-01 00:00:00
abstract：:Thiazide diuretics are particularly efficacious in the treatment of hypertension in blacks. A number of observations suggest that many hypertensive blacks have features consistent with a status of "corrected" volume expansion. Our studies, as well as those of other investigators, show that the Na,K pump is inhibited i...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章,评审
doi：10.1007/BF02603181
更新日期：1990-03-01 00:00:00
abstract：PURPOSE:Rivaroxaban, an oral anticoagulant, undergoes the metabolism mediated by human cytochrome P450 (CYP). The present study is to quantitatively analyze and compare the contributions of multiple CYPs in the metabolism of rivaroxaban to provide new information for medication safety. METHODS:The metabolic stability ...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章
doi：10.1007/s10557-020-07129-z
更新日期：2021-01-07 00:00:00
abstract：:There is still uncertainty of whether combined therapy with a beta-blocker and calcium-channel antagonist provides additive or synergistic clinical benefits in most patients with stable angina pectoris. The comparative antianginal effect of atenolol 50 mg and atenolol 50 mg and slow release nifedipine (20 mg) twice a ...
journal_title：Cardiovascular drugs and therapy
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF00877726
更新日期：1993-12-01 00:00:00
abstract：:Angiotensin-converting enzyme (ACE) inhibitor therapy has been associated with a substantial (> or = 20%) reduction in the risk of major ischemic events in two recent clinical trials with long-term follow-up: Studies of Left Ventricular Dysfunction (SOLVD) and the Survival and Ventricular Enlargement (SAVE) study. Par...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章,评审
doi：10.1007/BF00877749
更新日期：1995-02-01 00:00:00
abstract：:A rational approach to the treatment of chronic myocardial ischemia requires an appreciation of the pathophysiology of coronary artery disease and the treatment options available. Any factor that causes an imbalance between myocardial oxygen supply and demand can provoke ischemia. Myocardial oxygen requirements rise w...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章,评审
doi：10.1023/a:1007782210758
更新日期：1998-10-01 00:00:00
abstract：:During acute myocardial ischemia, passage of potassium ions across the sarcolemma to the extracellular space is a well-established phenomenon. A recent hypothesis is that the ATP-dependent potassium channel plays a role in contributing to the potassium loss. As the potassium loss starts while the overall level of ATP ...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章,评审
doi：10.1007/BF00877615
更新日期：1993-08-01 00:00:00
abstract：OBJECTIVES:To evaluate and compare the functional type and the degree of antagonism of the selective angiotensin II type 1 receptor blockers (ARB) losartan, EXP 3174 (the active metabolite of losartan), valsartan and candesartan in human internal mammary arteries. METHODS:Human internal mammary arteries were obtained ...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章
doi：10.1023/a:1021729909456
更新日期：2002-07-01 00:00:00
abstract：:To further evaluate the significance of p38 MAPK as trigger or mediator in ischaemic preconditioning, anisomycin and SB 203580 were used to manipulate its activation status. Special attention was given to the concentration of the drugs and protocols used. The isolated perfused rat heart, subjected to either 25 min glo...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章
doi：10.1023/a:1026116022552
更新日期：2003-05-01 00:00:00
abstract：:There is considerable evidence implicating a key role for p38 mitogen-activated protein kinase (MAPK) in ischemic and pharmacological preconditioning against myocardial infarction. However, there have been few, if any, studies examining the role of p38 MAPK in the protection of stunned myocardium. The purpose of this ...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章
doi：10.1007/s10557-004-6220-4
更新日期：2004-11-01 00:00:00
abstract：BACKGROUND:Heart failure (HF) is considered to be a prothrombotic condition and it has been suggested that coagulation factors contribute to maladaptive cardiac remodelling via activation of the protease-activated receptor 1 (PAR1). We tested the hypothesis that anticoagulation with the factor Xa (FXa) inhibitor apixab...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章
doi：10.1007/s10557-020-06999-7
更新日期：2020-05-26 00:00:00
abstract：:The aim of the present study was to investigate the effects of almokalant on sustained reentrant supraventricular tachycardias. Reentrant tachycardias were induced, using transesophageal atrial stimulation, in 82 patients with atrioventricular reentrant tachycardia (n = 54) or AV nodal reentrant tachycardia (n = 28). ...
journal_title：Cardiovascular drugs and therapy
pub_type： 临床试验,杂志文章
doi：10.1023/a:1007761825414
更新日期：1997-07-01 00:00:00
abstract：:The effects of administration of guava and papaya fruit (100 g/day), vegetables, and mustard oil (5 g/day) (group A); antioxidant vitamins C (50 mg/day) and E (30 mg/day), plus betacarotene (10 mg/day) (group B); a high-fat (5-10 g/day) (group C); or a low-fat (4-5 g/day) diet (group D) were compared over 24 diet week...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章
doi：10.1007/BF00879869
更新日期：1995-12-01 00:00:00
abstract：PURPOSE:Dofetilide is class III antiarrhythmic agent which prolongs cardiac action potential duration because of selective inhibition of I (Kr), the rapid component of the delayed rectifier K(+) current. Although clinical studies reported on proarrhythmic risk associated with dofetilide treatment, the contributing elec...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章
doi：10.1007/s10557-012-6405-1
更新日期：2012-12-01 00:00:00
abstract：:The effects of equipotent concentrations of diltiazem, verapamil, and nifedipine upon the accumulation of extracellular potassium [K+]out and the left ventricular pressure (LVP) were studied during global ischemia in isolated perfused rat hearts. Measurement of [K+]out and LVP were performed in two series of experimen...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章
doi：10.1007/BF00143532
更新日期：1991-12-01 00:00:00
abstract：:The purpose of this study was to examine the effects of the angiotensin-converting enzyme (ACE) inhibitor cilazapril on the elastic properties of the aorta. A standard diuretic antihypertensive drug, hydrochlorothiazide, served for comparisons. Increased aortic stiffness leads to a reduction of the buffering windkesse...
journal_title：Cardiovascular drugs and therapy
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF00051130
更新日期：1996-03-01 00:00:00
