当前位置： SCI文献检索 > CARDIOVASCULAR DRUGS AND THERAPY期刊下所有文献 > Comparative study of time-course of hemodynamic effect of isosorbide dinitrate spray and sublingual tablets in patients with pulmonary congestion.

Comparative study of time-course of hemodynamic effect of isosorbide dinitrate spray and sublingual tablets in patients with pulmonary congestion.

Abstract：

:We compared the time-course of the hemodynamic effect of isosorbide dinitrate (ISDN), 5 mg, in the form of sublingual tablet and oral spray, in 15 patients with isolated chronic pulmonary congestion (pulmonary arterial end-diastolic pressure of 15 mmHg or more in the presence of normal or only slightly reduced cardiac index). Both formulations produced significant reductions in the pulmonary arterial end-diastolic pressure. The effect of ISDN tablet (sublingually) became evident at 10 minutes after administration and was maximal at 30 minutes. The effect of ISDN oral spray became evident at 3 minutes and reached a peak at 10 minutes. The magnitude of hemodynamic response was similar. These findings indicate that ISDN oral spray is superior to ISDN sublingual tablets for rapid relief of pulmonary congestion.

journal_name

Cardiovasc Drugs Ther

journal_title

Cardiovascular drugs and therapy

authors

Marchionni N,De Bari M,Ferrucci L,Moschi G,Schneeweiss A

doi

10.1007/BF00051192

subject

Has Abstract

pub_date

1988-11-01 00:00:00

pages

529-32

issue

4

eissn

0920-3206

issn

1573-7241

journal_volume

2

pub_type

杂志文章

相关文献

CARDIOVASCULAR DRUGS AND THERAPY文献大全
  • Verapamil and diet halt progression of atherosclerosis in cholesterol fed rabbits.

    abstract：:The present study was designed to evaluate the effects of oral verapamil and normal diet on regression of atherosclerotic plaque in cholesterol fed rabbits. Forty-three rabbits were separated into 6 groups and studied for 24 weeks. All groups had a cholesterol diet for the first 12 weeks. Group I was then sacrificed a...

    journal_title：Cardiovascular drugs and therapy

    pub_type： 杂志文章

    doi：10.1007/BF02125835

    authors： Sievers RE,Rashid T,Garrett J,Blumlein S,Parmley WW

    更新日期：1987-01-01 00:00:00

  • Assessment of quality of life in a double-blind, randomized clinical trial of imidapril and captopril for hypertensive Chinese in Taiwan.

    abstract：PURPOSE:Although the role of angiotensin-converting enzyme (ACE) inhibitors for the treatment of hypertension has been well established, no data has been generated regarding the influence of ACE inhibitors for health-related quality-of-life (QOL) dimensions for Chinese patients. MATERIALS:A double-blind, active-contro...

    journal_title：Cardiovascular drugs and therapy

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1023/a:1020648405680

    authors： Chien KL,Huang PJ,Chen MF,Chiang FT,Lai LP,Lee YT

    更新日期：2002-05-01 00:00:00

  • Combined treatment with ramipril and metoprolol prevents changes in the creatine kinase isoenzyme system and improves hemodynamic function in rat hearts after myocardial infarction.

    abstract：:Beneficial effects of monotherapy with ACE inhibitors or beta-blockers on hemodynamic function after myocardial infarction are well known. Until now, the effects of combined treatment on cardiac function and energy metabolism have been poorly described. This study examines the effects of combined ramipril and metoprol...

    journal_title：Cardiovascular drugs and therapy

    pub_type： 杂志文章

    doi：10.1023/a:1007846311040

    authors： Theres HP,Wagner KD,Romberg D,Feig C,Strube S,Leiterer KP,Günther J,Stangl K,Baumann G,Schimke I

    更新日期：2000-12-01 00:00:00

  • The effects of oral pretreatment with zofenopril, an angiotensin-converting enzyme inhibitor, on early reperfusion and subsequent electrophysiologic stability in the pig.

    abstract：:The effects of oral zofenopril pretreatment were investigated in a chronic closed-chest pig model of ischemia and reperfusion. Pigs (25-35 kg) were pretreated orally with zofenopril (15 mg/day) on the 2 days prior to ischemia, which was evoked by the inflation of a catheter balloon in the left anterior descending coro...

    journal_title：Cardiovascular drugs and therapy

    pub_type： 杂志文章

    doi：10.1007/BF01856557

    authors： Tio RA,de Langen CD,de Graeff PA,van Gilst WH,Bel KJ,Wolters KG,Mook PH,van Wijngaarden J,Wesseling H

    更新日期：1990-06-01 00:00:00

  • The Role of MKP-1 in Insulin-Induced Cardioprotection.

    abstract：PURPOSE:The mitogen-activated protein kinase phosphatases (MKPs) are a family of dual-specificity phosphatases that inactivate MAPKs by dephosphorylation. Impairment of MKP-1 expression in insulin resistance has been suggested to affect the cardioprotective properties of insulin. We hypothesized that manipulation of it...

    journal_title：Cardiovascular drugs and therapy

    pub_type： 杂志文章

    doi：10.1007/s10557-017-6731-4

    authors： Webster I,Smith A,Lochner A,Huisamen B

    更新日期：2017-06-01 00:00:00

  • Association of Regulatory Genetic Variants for Protein Kinase Cα with Mortality and Drug Efficacy in Patients with Heart Failure.

    abstract：PURPOSE:Protein kinase C alpha (gene: PRKCA) is a key regulator of cardiac contractility. Two genetic variants have recently been discovered to regulate PRKCA expression in failing human heart tissue (rs9909004 [T → C] and rs9303504 [C → G]). The association of those variants with clinical outcomes in patients with hea...

    journal_title：Cardiovascular drugs and therapy

    pub_type： 杂志文章

    doi：10.1007/s10557-019-06909-6

    authors： Luzum JA,Ting C,Peterson EL,Gui H,Shugg T,Williams LK,Li L,Sadee W,Wang D,Lanfear DE

    更新日期：2019-12-01 00:00:00

  • Preservation of Glucagon-Like Peptide-1 Level Attenuates Angiotensin II-Induced Tissue Fibrosis by Altering AT1/AT 2 Receptor Expression and Angiotensin-Converting Enzyme 2 Activity in Rat Heart.

    abstract：PURPOSE:The glucagon-like peptide-1 (GLP-1) has been shown to exert cardioprotective effects in animals and patients. This study tests the hypothesis that preservation of GLP-1 by the GLP-1 receptor agonist liraglutide or the dipeptidyl peptidase-4 (DPP-4) inhibitor linagliptin is associated with a reduction of angiote...

    journal_title：Cardiovascular drugs and therapy

    pub_type： 杂志文章

    doi：10.1007/s10557-015-6592-7

    authors： Zhang LH,Pang XF,Bai F,Wang NP,Shah AI,McKallip RJ,Li XW,Wang X,Zhao ZQ

    更新日期：2015-06-01 00:00:00

  • Drug-Induced Pulmonary Arterial Hypertension: Mechanisms and Clinical Management.

    abstract：:Pulmonary arterial hypertension is a rare disease, with drug-induced causes even more uncommon, accounting for only 10% of cases in large registry series. Predisposing factors for drug-induced PAH have not been completely defined. This review summarizes drugs with definite, possible, or likely association to pulmonary...

    journal_title：Cardiovascular drugs and therapy

    pub_type： 杂志文章,评审

    doi：10.1007/s10557-019-06920-x

    authors： Correale M,Tricarico L,Grazioli D,Formica ES,Petrucci R,Persichella P,Di Biase M,Brunetti ND

    更新日期：2019-12-01 00:00:00

  • Methods of assessing the functional status of patients with left ventricular systolic dysfunction in interventional studies: can brain natriuretic peptide measurement be used as surrogate for the traditional methods?

    abstract：AIM:To review whether brain natriuretic peptides (BNP) can be used as a surrogate for the traditional methods of assessing functional status in interventional studies of patients with left ventricular systolic dysfunction (LVSD). METHODS AND RESULTS:The traditional methods for assessing functional status including New...

    journal_title：Cardiovascular drugs and therapy

    pub_type： 杂志文章,评审

    doi：10.1023/B:CARD.0000033643.93393.46

    authors： Abdulla J,Køber L,Torp-Pedersen C

    更新日期：2004-05-01 00:00:00

  • Effects of transdermal nicotine patches on ambulatory ECG monitoring findings: a double-blind study in healthy smokers.

    abstract：:The cardiovascular effects and safety of transdermal nicotine patches were assessed in 50 healthy smokers using repeated 48 hour ambulatory electrocardiographic monitoring as a part of a smoking cessation program. Following baseline measurements, subjects were randomized to active (n = 25) or placebo (n = 25) treatmen...

    journal_title：Cardiovascular drugs and therapy

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/BF00823596

    authors： Khoury Z,Comans P,Keren A,Lerer T,Gavish A,Tzivoni D

    更新日期：1996-05-01 00:00:00

  • Postinfarct heart failure: role of diuretic therapy.

    abstract：:There can be no doubt that ACE inhibitors prolong survival in patients with a low ejection fraction. There is no evidence whether or not diuretics have the same effect. The pathophysiology of asymptomatic patients with poor left ventricular function differs from that of patients with the clinical syndrome of heart fai...

    journal_title：Cardiovascular drugs and therapy

    pub_type： 杂志文章,评审

    doi：10.1007/BF00877716

    authors： Hampton JR

    更新日期：1993-12-01 00:00:00

  • Ranolazine treatment for myocardial infarction? Effects on the development of necrosis, left ventricular function and arrhythmias in experimental models.

    abstract：:Ranolazine, an inhibitor of the late current of the cardiac action potential (late I(Na)), is a well established clinical treatment for chronic angina. The late INa in cardiac myocytes also plays an important role in the pathophysiology of acute myocardial ischemia and reperfusion, and thus is a potential therapeutic ...

    journal_title：Cardiovascular drugs and therapy

    pub_type： 杂志文章,评审

    doi：10.1007/s10557-014-6548-3

    authors： Hale SL,Kloner RA

    更新日期：2014-10-01 00:00:00

  • Infarct size as estimated from peak creatine kinase and lactate dehydrogenase is probably reduced in patients using calcium antagonists at the onset of symptoms.

    abstract：:In animal models, calcium antagonists (Ca-A) administered before ischemia and reperfusion reduced myocardial necrosis, attenuated postischemic contractile dysfunction, and reduced tissue calcium. In 753 patients with acute myocardial infarction (AMI), we examined if use of Ca-A at the onset of symptoms (n = 127 patien...

    journal_title：Cardiovascular drugs and therapy

    pub_type： 杂志文章

    doi：10.1023/a:1007727518684

    authors： Landmark K,Abdelnoor M,Kilhovd B,Dørum HP

    更新日期：1997-09-01 00:00:00

  • Stunning of the myocardium: an update.

    abstract：:When severely ischemic myocardium is reperfused, prolonged myocardial dysfunction--a phenomenon named myocardial stunning--frequently occurs. Stunning also occurs in a variety of other situations. These include myocardium located adjacent to infarcted tissue, transient increase in myocardial O2 demands in the presence...

    journal_title：Cardiovascular drugs and therapy

    pub_type： 杂志文章,评审

    doi：10.1007/BF00053546

    authors： Braunwald E

    更新日期：1991-10-01 00:00:00

  • KT-362 related effects on intracellular calcium release and associated clinical potential: arrhythmias, myocardial ischemia, and hypertension.

    abstract：:The following discourse addresses the pharmacologic profile of KT-362, its clinical potential as an anti-arrhythmic agent with associated hypotensive effects, as well as its additional related potential in myocardial ischemia and related sequellae, and the specific cellular actions that may be responsible for these po...

    journal_title：Cardiovascular drugs and therapy

    pub_type： 杂志文章,评审

    doi：10.1007/BF02018262

    authors： Hester RK,Shibata S

    更新日期：1990-10-01 00:00:00

  • Torsades de pointes: arrhythmia, syndrome, or chimera?

    abstract：:Although torsades de pointes is not a tightly demarcated entity, the diagnosis has important clinical implications. The concept should be retained. ...

    journal_title：Cardiovascular drugs and therapy

    pub_type： 杂志文章

    doi：10.1007/BF03029821

    authors： Millar RN

    更新日期：1991-02-01 00:00:00

  • Simvastatin ameliorates angiotensin II-induced endothelial dysfunction through restoration of Rho-BH4-eNOS-NO pathway.

    abstract：:Endothelial dysfunction contributes to the initiation and development of hypertension. We previously found that simvastatin moderately decreases blood pressure in 2-kidney-2-clip (2k2c) renal hypertension, but the precise mechanisms are still unclear. The present study was designed to examine the protective actions of...

    journal_title：Cardiovascular drugs and therapy

    pub_type： 杂志文章

    doi：10.1007/s10557-011-6351-3

    authors： Zhang Z,Wang M,Xue SJ,Liu DH,Tang YB

    更新日期：2012-02-01 00:00:00

  • Enoximone: true inotropic effects? Do they cause ischemia? Analysis of end-systolic pressure-volume relations using the conductance (volume) catheter technique.

    abstract：:True positive inotropy of enoximone is hard to prove clinically. It could increase the risk of myocardial ischemia when used in coronary artery disease (CAD). The analysis of the end-systolic pressure-volume relationship (ESPVR) as a load-independent parameter of the contractile left ventricular function (LVF) allows ...

    journal_title：Cardiovascular drugs and therapy

    pub_type： 杂志文章

    doi：10.1007/BF02018269

    authors： Thormann J,Hueting J,Kremer P,Wissemann J,Mitrovic V,Dieterich HA,Schlepper M

    更新日期：1990-10-01 00:00:00

  • Does digoxin have a place in the treatment of the child with congenital heart disease?

    abstract：:The place of digoxin in the pediatric cardiologist's armamentarium remains uncertain. As an antiarrhythmic, its use in the Wolff-Parkinson-White syndrome is obsolete, but it remains useful in the treatment of the chronic atrial fibrillation seen in some patients postoperatively and in children with dilated cardiomyopa...

    journal_title：Cardiovascular drugs and therapy

    pub_type： 杂志文章,评审

    doi：10.1007/BF01881525

    authors： Redington AN,Carvalho JS,Shinebourne EA

    更新日期：1989-03-01 00:00:00

  • Incremental "Therapeutic" Myocardial Exposure to Catecholamines: Incidence and Impact in Takotsubo Syndrome.

    abstract：BACKGROUND:Although Takotsubo syndrome (TS) was once considered to be rare and largely benign, it is now recognized to represent a major cause of cardiac morbidity and mortality, especially in ageing women. The biochemical precipitant of attacks of TS is an increase in catecholamine concentrations within the myocardium...

    journal_title：Cardiovascular drugs and therapy

    pub_type： 杂志文章

    doi：10.1007/s10557-019-06918-5

    authors： Ong GJ,Nguyen TH,Stansborough J,Surikow SY,Horowitz JD

    更新日期：2020-02-01 00:00:00

  • A cost-minimization of heart failure therapy with bisoprolol in the French setting: an analysis from CIBIS trial data. Cardiac Insufficiency Bisoprolol Study.

    abstract：:Beta-blocker-induced benefit in heart failure is under intense evaluation. Several large-scale mortality trials are currently being performed, with CIBIS II evaluating bisoprolol. The economic impact of beta-blocker therapy in heart failure has not been previously determined. The present study is a cost-effectiveness ...

    journal_title：Cardiovascular drugs and therapy

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1023/a:1007773901631

    authors： Levy P,Lechat P,Leizorovicz A,Levy E

    更新日期：1998-07-01 00:00:00

  • Pharmacotherapy of dyslipidemia.

    abstract：:Reducing elevated levels of low-density-lipoprotein cholesterol (LDL-C) significantly reduces the incidence of coronary heart disease (CHD) events and mortality in hypercholesterolemic patients. CHD risk reduction is proportional to LDL-C reduction. Despite this knowledge, many physicians are not applying existing tre...

    journal_title：Cardiovascular drugs and therapy

    pub_type： 杂志文章,评审

    doi：10.1023/a:1013341606476

    authors： McKenney JM

    更新日期：2001-09-01 00:00:00

  • Randomized, controlled trial of antioxidant vitamins and cardioprotective diet on hyperlipidemia, oxidative stress, and development of experimental atherosclerosis: the diet and antioxidant trial on atherosclerosis (DATA).

    abstract：:The effects of administration of guava and papaya fruit (100 g/day), vegetables, and mustard oil (5 g/day) (group A); antioxidant vitamins C (50 mg/day) and E (30 mg/day), plus betacarotene (10 mg/day) (group B); a high-fat (5-10 g/day) (group C); or a low-fat (4-5 g/day) diet (group D) were compared over 24 diet week...

    journal_title：Cardiovascular drugs and therapy

    pub_type： 杂志文章

    doi：10.1007/BF00879869

    authors： Singh RB,Niaz AM,Ghosh S,Agarwal P,Ahmad S,Begum R,Onouchi Z,Kummerow FA

    更新日期：1995-12-01 00:00:00

  • Effects of nifedipine on cardiac function in patients with coronary artery disease evaluated with ambulatory radionuclide monitoring.

    abstract：:The effects of nifedipine on left ventricular function were evaluated in 17 patients with coronary artery disease with an ambulatory radionuclide detector (VEST). Hemodynamic data were recorded continuously at rest and during upright bicycle ergometer exercise before and 30 minutes after 10 mg of oral nifedipine admin...

    journal_title：Cardiovascular drugs and therapy

    pub_type： 杂志文章

    doi：10.1007/BF02018293

    authors： Kambara H,Mohiuddin IH,Tamaki N,Fudo T,Hayashi M,Nohara R,Konishi J,Kawai C

    更新日期：1990-08-01 00:00:00

  • Calcium channel antagonists: Part VI: Clinical pharmacokinetics of first and second-generation agents.

    abstract：:A survey of the pharmacokinetic properties of the three prototypical calcium antagonist agents shows that they have in common a very high rate of hepatic first-pass metabolism with, in the case of verapamil and diltiazem, the formation of an active metabolite that affects the dose during chronic therapy. Therefore, th...

    journal_title：Cardiovascular drugs and therapy

    pub_type： 杂志文章,评审

    doi：10.1007/BF01865507

    authors： Opie LH

    更新日期：1989-08-01 00:00:00

  • A systemic combination therapy with granulocyte-colony stimulating factor plus erythropoietin aggravates the healing process of balloon-injured rat carotid arteries.

    abstract：OBJECTIVE:Percutaneous vascular interventions lead inevitably to a destruction of the endothelial lining at the site of injury. There are conflicting data on the therapeutic benefit of hematopoietic growth factors aiming at mobilisation of circulating endothelial cells to accelerate the reendothelialisation process. Ai...

    journal_title：Cardiovascular drugs and therapy

    pub_type： 杂志文章

    doi：10.1007/s10557-008-6117-8

    authors： Hack M,Mascha FG,Jobst BJ,Riegger GA,Griese DP

    更新日期：2008-10-01 00:00:00

  • Use of combined chemotherapy with etoposide and methotrexate, both associated to lipid nanoemulsions for atherosclerosis treatment in cholesterol-fed rabbits.

    abstract：PURPOSE:Treatment of atherosclerotic rabbits with intravenous methotrexate or etoposide carried in lipid nanoemulsions (LDE) markedly reduced the lesions in the aorta. Here, the combined treatment with LDE-methotrexate and LDE-etoposide was investigated aiming to increase the anti-atherosclerosis effect. METHODS:Thirt...

    journal_title：Cardiovascular drugs and therapy

    pub_type： 杂志文章

    doi：10.1007/s10557-014-6566-1

    authors： Leite AC Jr,Solano TV,Tavares ER,Maranhão RC

    更新日期：2015-02-01 00:00:00

  • Alterations in the prognosis of chronic heart failure: an overview of the major mortality trials.

    abstract：:Treatment of chronic heart failure (CHF) remains a major medical problem. Although in the last decades the benefits of several therapies in different patient populations with left ventricular dysfunction have been established, morbidity and mortality of CHF patients are high. Consequently, in the last decade improveme...

    journal_title：Cardiovascular drugs and therapy

    pub_type： 杂志文章,meta分析

    doi：10.1023/a:1007786019054

    authors： Szabó BM,van Veldhuisen DJ,de Graeff PA,Lie KI

    更新日期：1997-07-01 00:00:00

  • The efficacy of nifedipine and acebutolol in coronary artery disease assessed by radionuclide ventriculography.

    abstract：:The efficacy of a fixed combination of 10 mg nifedipine and 100 mg acebutolol was tested in 21 patients with angiographically proven coronary artery disease (CAD). Ejection fraction (EF), emptying and filling rate (VS and VD), and end-systolic volume (ESV) were assessed by means of radionuclide ventriculography at res...

    journal_title：Cardiovascular drugs and therapy

    pub_type： 杂志文章

    doi：10.1007/BF00148473

    authors： Bauer R,Busch U,Lutilsky L,van de Flierdt E,Langhammer HR,Pabst HW

    更新日期：1989-06-01 00:00:00

  • Antiischemic effects of nicorandil during coronary angioplasty in humans.

    abstract：:The present study was undertaken on 10 patients with angina undergoing percutaneous transluminal coronary angioplasty. The angioplasty procedure consisted of two successive 30-second balloon inflations at 5 minute intervals. After the first inflation, nicorandil (0.1 mg/kg) was given intravenously over a 2-minute peri...

    journal_title：Cardiovascular drugs and therapy

    pub_type： 临床试验,杂志文章

    doi：10.1007/BF00878473

    authors： Saito S,Mizumura T,Takayama T,Honye J,Fukui T,Kamata T,Moriuchi M,Hibiya K,Tamura Y,Ozawa Y

    更新日期：1995-03-01 00:00:00