Postinfarct heart failure: role of diuretic therapy.


:There can be no doubt that ACE inhibitors prolong survival in patients with a low ejection fraction. There is no evidence whether or not diuretics have the same effect. The pathophysiology of asymptomatic patients with poor left ventricular function differs from that of patients with the clinical syndrome of heart failure, and different treatments may well be needed. Diuretics still have a crucial role in the relief of symptoms.


Cardiovasc Drugs Ther


Hampton JR




Has Abstract


1993-12-01 00:00:00












  • Recovery of left ventricular function following early reperfusion in acute myocardial infarction: a potential role for the calcium antagonist nisoldipine.

    abstract::The purpose of the present study was to test whether the administration of a vascular-selective organic calcium antagonist (nisoldipine) at the onset of early mechanical reperfusion (by coronary angioplasty) in acute myocardial infarction could prevent or attenuate postischemic stunning and enhance the recovery of lef...

    journal_title:Cardiovascular drugs and therapy

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Sheiban I,Tonni S,Chizzoni A,Marini A,Trevi G

    更新日期:1997-03-01 00:00:00

  • Combination Therapy of Pulmonary Arterial Hypertension with Vardenafil and Macitentan Assessed in a Human Ex Vivo Model.

    abstract:PURPOSE:Treatment of pulmonary arterial hypertension (PAH) by vasodilator drug monotherapy is often limited in its effectiveness. Combination therapy may help to improve treatment and to reduce drug toxicity. This study assessed the combination of the endothelin receptor antagonist macitentan and the phosphodiesterase-...

    journal_title:Cardiovascular drugs and therapy

    pub_type: 杂志文章


    authors: Hoenicka M,Golovchenko S,Englert L,Spaeth M,Shoshiashvili L,Großer C,Hofmann HS,Ried M

    更新日期:2019-06-01 00:00:00

  • LOX-1 and obesity.

    abstract::Obesity is one of the most common lifestyle-related diseases. Being closely associated with insulin resistance, hypertension and dyslipidemia, it is also a component of metabolic syndrome and is involved in the development of atherosclerosis and cardiovascular and renal ailments. Obesity is also accompanied with a sta...

    journal_title:Cardiovascular drugs and therapy

    pub_type: 杂志文章,评审


    authors: Yan M,Mehta JL,Hu C

    更新日期:2011-10-01 00:00:00

  • Comparative dose titration responses to the introduction of bisoprolol or carvedilol in stable chronic systolic heart failure.

    abstract:INTRODUCTION:Several beta blocking drugs (BB) reduce mortality in systolic heart failure (LVSD). We have compared the initial response to introduction of carvedilol and bisoprolol during the standard dose titration protocols for each drug. METHODS:Approximately 31 unselected patients with stable LVSD were randomised t...

    journal_title:Cardiovascular drugs and therapy

    pub_type: 杂志文章,随机对照试验


    authors: Hamaad A,Lip GY,Nicholls D,MacFadyen RJ

    更新日期:2007-12-01 00:00:00

  • Role of ischemia in postinfarction heart failure: hypothetical considerations based on use of verapamil in the DAVIT II Study. Danish Study Group on Verapamil in Myocardial Infarction.

    abstract::Based on a retrospective analysis of the DAVIT II database, we attempted to propose subgroups of post-infarction patients with heart failure, who might benefit or not benefit from antiischemic medical intervention. In DAVIT II, patients were randomized in a double-blind fashion to either verapamil 360 mg/day or placeb...

    journal_title:Cardiovascular drugs and therapy

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Jespersen CM

    更新日期:1994-12-01 00:00:00

  • Assessment of quality of life in a double-blind, randomized clinical trial of imidapril and captopril for hypertensive Chinese in Taiwan.

    abstract:PURPOSE:Although the role of angiotensin-converting enzyme (ACE) inhibitors for the treatment of hypertension has been well established, no data has been generated regarding the influence of ACE inhibitors for health-related quality-of-life (QOL) dimensions for Chinese patients. MATERIALS:A double-blind, active-contro...

    journal_title:Cardiovascular drugs and therapy

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Chien KL,Huang PJ,Chen MF,Chiang FT,Lai LP,Lee YT

    更新日期:2002-05-01 00:00:00

  • The problem of defining heart failure.

    abstract::A succession of theories arising from last century has attempted to explain why patients with damaged hearts develop peripheral edema. Opposed to the original simple concepts of backward failure, a number of theories of forward failure have been proposed, the cardiac output being considered inadequate for capillary pe...

    journal_title:Cardiovascular drugs and therapy

    pub_type: 杂志文章,评审


    authors: Harris P

    更新日期:1994-06-01 00:00:00

  • TAK1-AMPK Pathway in Macrophages Regulates Hypothyroid Atherosclerosis.

    abstract:PURPOSE:Hypothyroidism (HT) is associated with accelerated atherosclerosis (AS). The efficacy of traditional strategies of hypothyroid AS remains controversial. Here, we aimed to deepen the understanding of the HT-induced acceleration of AS, to decrease the residual risk of coronary artery disease (CAD) and to find a n...

    journal_title:Cardiovascular drugs and therapy

    pub_type: 杂志文章


    authors: Yang Y,Jia Y,Ning Y,Wen W,Qin Y,Zhang H,Du Y,Li L,Jiao X,Yang Y,Liu G,Huang M,Zhang M

    更新日期:2020-06-03 00:00:00

  • Effect of propranolol on ventricular repolarization and refractoriness: role of beta-blockade versus direct membrane effects.

    abstract::The purpose of this study was to define the role of beta-adrenergic blockade and direct membrane effects in the ability of dl-propranolol to alter ventricular repolarization and refractoriness in the intact heart. The effective refractory period (ERP) and the local Q-T interval were measured at an epicardial site in t...

    journal_title:Cardiovascular drugs and therapy

    pub_type: 杂志文章


    authors: Euler DE,Scanlon PJ

    更新日期:1988-03-01 00:00:00

  • Effect of beta-adrenergic blockade on hormonal responses during continuous and intermittent exercise.

    abstract::The modifying effect on exercise performance and neuroendocrine response of the nonselective beta blocker timolol (10 mg b.i.d. for 5 days) and the beta 1-selective beta blocker metoprolol (100 mg b.i.d. for 5 days) was studied. The hormones studied were growth hormone, prolactin, cortisol, renin, epinephrine, dopamin...

    journal_title:Cardiovascular drugs and therapy

    pub_type: 临床试验,杂志文章


    authors: Gullestad L,Dolva LO,Kjeldsen SE,Eide I,Kjekshus J

    更新日期:1989-03-01 00:00:00

  • Pharmacological Agents Targeting Myocardial Metabolism for the Management of Chronic Stable Angina : an Update.

    abstract::Despite continuous advances in myocardial revascularization procedures and intracoronary devices, patients with ischemic heart disease (IHD) still experience worse prognosis and poor quality of life (QoL). Indeed, chronic stable angina (CSA) is a common disease with a large burden on healthcare costs. Traditionally, C...

    journal_title:Cardiovascular drugs and therapy

    pub_type: 杂志文章,评审


    authors: Guarini G,Huqi A,Morrone D,Marzilli M

    更新日期:2016-08-01 00:00:00

  • Similar antiischemic effects of intracoronary atenolol and nifedipine during brief coronary occlusions in humans.

    abstract::To compare the antiischemic effects of intracoronary administration of a beta blocker, atenolol, and of a calcium antagonist, nifedipine, on the clinical and electrocardiographic signs of myocardial ischemia induced by balloon occlusion of the coronary artery, we studied 32 consecutive patients undergoing routine PTCA...

    journal_title:Cardiovascular drugs and therapy

    pub_type: 杂志文章


    authors: Ghio S,De Servi S,Angoli L,Bramucci E,Eleuteri E,Raffaghello S,Specchia G

    更新日期:1992-06-01 00:00:00

  • Renal effects of calcium entry blockers.

    abstract::Calcium entry blockers exert several characteristic effects on renal function that contribute to their blood-pressure lowering capacity. They are able to dilate renal vasculature and, in certain circumstances, can increase the glomerular filtration rate, both effects being dependent on the preexisting vascular tone. C...

    journal_title:Cardiovascular drugs and therapy

    pub_type: 杂志文章,评审


    authors: Ruilope LM,Alcazar JM

    更新日期:1990-08-01 00:00:00

  • Mitochondrial-Shaping Proteins in Cardiac Health and Disease - the Long and the Short of It!

    abstract::Mitochondrial health is critically dependent on the ability of mitochondria to undergo changes in mitochondrial morphology, a process which is regulated by mitochondrial shaping proteins. Mitochondria undergo fission to generate fragmented discrete organelles, a process which is mediated by the mitochondrial fission p...

    journal_title:Cardiovascular drugs and therapy

    pub_type: 杂志文章,评审


    authors: Ong SB,Kalkhoran SB,Hernández-Reséndiz S,Samangouei P,Ong SG,Hausenloy DJ

    更新日期:2017-02-01 00:00:00

  • Combined treatment with ramipril and metoprolol prevents changes in the creatine kinase isoenzyme system and improves hemodynamic function in rat hearts after myocardial infarction.

    abstract::Beneficial effects of monotherapy with ACE inhibitors or beta-blockers on hemodynamic function after myocardial infarction are well known. Until now, the effects of combined treatment on cardiac function and energy metabolism have been poorly described. This study examines the effects of combined ramipril and metoprol...

    journal_title:Cardiovascular drugs and therapy

    pub_type: 杂志文章


    authors: Theres HP,Wagner KD,Romberg D,Feig C,Strube S,Leiterer KP,Günther J,Stangl K,Baumann G,Schimke I

    更新日期:2000-12-01 00:00:00

  • Antioxidant vitamins and risk of cardiovascular disease. Review of large-scale randomised trials.

    abstract::People who consume a diet rich in fruit and vegetables have lower risks of cancer, cardiovascular disease and all-cause mortality. Many prospective cohort studies have reported inverse associations between dietary intake or blood levels of beta-carotene and risks of cancer. Several large-scale trials were set up to as...

    journal_title:Cardiovascular drugs and therapy

    pub_type: 杂志文章,评审


    authors: Clarke R,Armitage J

    更新日期:2002-09-01 00:00:00

  • Cholesterol biosynthesis and metabolism.

    abstract::Cholesterol plays an essential role in cell membrane synthesis and in cell growth and differentiation. In mammalian cells, cholesterol can be synthesized from acetate precursors or taken up from dietary or exogenous sources. The major catabolic route for disposal of cholesterol involves conversion into excretable bile...

    journal_title:Cardiovascular drugs and therapy

    pub_type: 社论,评审


    authors: Russell DW

    更新日期:1992-04-01 00:00:00

  • Key factors in the treatment of the elderly hypertensive.

    abstract::Cardiovascular diseases are of fundamental importance in the cause of death and morbidity in the elderly as a group. If the successful management of blood pressure can effect a reduction in morbid events as well as death, as has been indicated by recent trials, the elderly have more to gain than any other group within...

    journal_title:Cardiovascular drugs and therapy

    pub_type: 杂志文章,评审


    authors: Dall JL

    更新日期:1991-01-01 00:00:00

  • Effect of antihypertensive therapy on aortic distensibility in patients with essential hypertension: comparison with trichlormethiazide, nicardipine and alacepril.

    abstract::To assess the effect of antihypertensive drugs on aortic distensibility, we evaluated the aortic distensibility of 33 hypertensive patients before and after antihypertensive treatment by using cine magnetic resonance imaging. Thirty three hypertensive patients were divided into three groups and treated for 12 weeks wi...

    journal_title:Cardiovascular drugs and therapy

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Honda T,Hamada M,Shigematsu Y,Matsumoto Y,Matsuoka H,Hiwada K

    更新日期:1999-07-01 00:00:00

  • Recombinant human interleukin-1 receptor antagonist provides cardioprotection during myocardial ischemia reperfusion in the mouse.

    abstract:PURPOSE:Acute myocardial infarction (AMI) drives an intense inflammatory response that contributes to infarct healing and cardiac remodeling. Recently, different studies have identified a role of interleukin-1 (IL-1) in the development of adverse cardiac remodeling. However, in animal models of AMI IL-1 has been shown ...

    journal_title:Cardiovascular drugs and therapy

    pub_type: 杂志文章


    authors: Toldo S,Schatz AM,Mezzaroma E,Chawla R,Stallard TW,Stallard WC,Jahangiri A,Van Tassell BW,Abbate A

    更新日期:2012-06-01 00:00:00

  • Hemodynamic effects of celiprolol at rest and during exercise; a comparison with enalapril.

    abstract::The antihypertensive effects of once-daily administration of celiprolol 400 mg were compared with those of once-daily enalapril 20 mg in 20 mild to moderate essential hypertensives in a single-blind study in which the subjects were randomized to 2 weeks' treatment with either drug, preceded by 2 weeks of placebo admin...

    journal_title:Cardiovascular drugs and therapy

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Ghiringhelli S,Cozzi E,Tsialtas D

    更新日期:1988-07-01 00:00:00

  • Low-dose flecainide infusion followed by oral pilsicainide is highly effective and safe for paroxysmal atrial fibrillation.

    abstract:PURPOSE:The aim of this study was to evaluate the efficacy and safety of intravenous infusion of low-dose flecainide (50 mg) followed by oral pilsicainide (50 mg t.i.d.)in patients with paroxysmal atrial fibrillation (AF). METHODS:Thirty-one patients with symptomatic and hemodynamically stable AF lasting less than 48 ...

    journal_title:Cardiovascular drugs and therapy

    pub_type: 临床试验,信件


    authors: Nagai S,Takeishi Y,Kubota I

    更新日期:2003-01-01 00:00:00

  • The p38 MAPK inhibitor SB203580 blocks adenosine A(1) receptor-induced attenuation of in vivo myocardial stunning.

    abstract::There is considerable evidence implicating a key role for p38 mitogen-activated protein kinase (MAPK) in ischemic and pharmacological preconditioning against myocardial infarction. However, there have been few, if any, studies examining the role of p38 MAPK in the protection of stunned myocardium. The purpose of this ...

    journal_title:Cardiovascular drugs and therapy

    pub_type: 杂志文章


    authors: Yoshimura Y,Kristo G,Keith BJ,Jahania SA,Mentzer RM Jr,Lasley RD

    更新日期:2004-11-01 00:00:00

  • Racial differences in antihypertensive therapy: evidence and implications.

    abstract::Blood pressure is controlled by many factors, and thus hypertension is a multifactorial disorder. This etiologic diversity is also reflected in the broad spectrum of different pharmacologic agents known to lower blood pressure. Most carefully controlled studies employing a single antihypertensive drug in unselected, u...

    journal_title:Cardiovascular drugs and therapy

    pub_type: 杂志文章,评审


    authors: Weinberger MH

    更新日期:1990-03-01 00:00:00

  • OPC-8212 in the treatment of congestive heart failure: results of a pilot study.

    abstract::To characterize the effects of OPC-8212, a quinolone inotropic agent, in patients with heart failure, we utilized invasive hemodynamics, exercise testing, 24-hour ambulatory electrocardiograms, and two patient self-assessment questionnaires, before and after 1 month of treatment with OPC-8212, in 17 patients with mode...

    journal_title:Cardiovascular drugs and therapy

    pub_type: 杂志文章


    authors: Kubo SH,Rector TS,Strobeck JE,Cohn JN

    更新日期:1988-12-01 00:00:00

  • Ranolazine treatment for myocardial infarction? Effects on the development of necrosis, left ventricular function and arrhythmias in experimental models.

    abstract::Ranolazine, an inhibitor of the late current of the cardiac action potential (late I(Na)), is a well established clinical treatment for chronic angina. The late INa in cardiac myocytes also plays an important role in the pathophysiology of acute myocardial ischemia and reperfusion, and thus is a potential therapeutic ...

    journal_title:Cardiovascular drugs and therapy

    pub_type: 杂志文章,评审


    authors: Hale SL,Kloner RA

    更新日期:2014-10-01 00:00:00

  • The ajmaline test as a method to disclose latent experimental Chagas' heart disease.

    abstract::Forty-one chronically T. cruzi-infected male adult albino rats with normal resting ECG were submitted to the ajmaline test (1 mg/kg body weight injected into the dorsal vein of the penis). Twenty-one similar noninfected animals served as controls. Ajmaline induced the following ECG alterations in control rats: A decre...

    journal_title:Cardiovascular drugs and therapy

    pub_type: 杂志文章


    authors: Bestetti RB,Soares EG,Sales-Neto VN,Oliveira JS

    更新日期:1989-04-01 00:00:00

  • The efficacy of nifedipine and acebutolol in coronary artery disease assessed by radionuclide ventriculography.

    abstract::The efficacy of a fixed combination of 10 mg nifedipine and 100 mg acebutolol was tested in 21 patients with angiographically proven coronary artery disease (CAD). Ejection fraction (EF), emptying and filling rate (VS and VD), and end-systolic volume (ESV) were assessed by means of radionuclide ventriculography at res...

    journal_title:Cardiovascular drugs and therapy

    pub_type: 杂志文章


    authors: Bauer R,Busch U,Lutilsky L,van de Flierdt E,Langhammer HR,Pabst HW

    更新日期:1989-06-01 00:00:00

  • Central and peripheral irisin differentially regulate blood pressure.

    abstract:INTRODUCTION:Irisin is a newly identified 112 amino acid hormone, derived as a product of fibronectin type III domain containing 5 (FNDC5), which is highly related to metabolic activity in skeletal muscle and brown fat. The effects of irisin on cardiovascular functions are unknown. PURPOSE:To explore the effects of ce...

    journal_title:Cardiovascular drugs and therapy

    pub_type: 杂志文章


    authors: Zhang W,Chang L,Zhang C,Zhang R,Li Z,Chai B,Li J,Chen E,Mulholland M

    更新日期:2015-04-01 00:00:00

  • Effect of orally administered alpha-tocopheryl acetate on human myocardial alpha-tocopherol levels.

    abstract::Free radical injury may contribute to the delayed postoperative recovery of myocardial metabolism and ventricular function after elective coronary artery revascularization. This clinical study was designed to evaluate, in stable angina patients having aortocoronary bypass surgery, whether orally administered alpha-toc...

    journal_title:Cardiovascular drugs and therapy

    pub_type: 临床试验,杂志文章


    authors: Mickle DA,Weisel RD,Burton GW,Ingold KU

    更新日期:1991-03-01 00:00:00