Effect of beta-adrenergic blockade on hormonal responses during continuous and intermittent exercise.


:The modifying effect on exercise performance and neuroendocrine response of the nonselective beta blocker timolol (10 mg b.i.d. for 5 days) and the beta 1-selective beta blocker metoprolol (100 mg b.i.d. for 5 days) was studied. The hormones studied were growth hormone, prolactin, cortisol, renin, epinephrine, dopamine, and norepinephrine. The response was studied during short-term maximal dynamic exercise, using two different exercise protocols; continuous (n = 11) and intermittent (n = 9) bicycle ergometry, in normal healthy young men. Accumulated work on placebo was nearly identical in the two studies, but was significantly reduced by 10.4% and 6.6% with timolol and by 4.7% and 6.7% with metoprolol, during continuous and intermittent exercise, respectively. During continuous exercise, accumulated work was 5.8% lower (p less than 0.05) with timolol than with metoprolol. The hormonal plasma concentrations of all hormones except renin were higher during continuous exercise than during intermittent exercise. Beta blockade had no effect on baseline hormonal levels, but the response was markedly changed during exercise. Maximum epinephrine, cortisol, and prolactin responses increased after beta blockade; dopamine remained nearly unchanged; while the renin responses were attenuated. Norepinephrine concentrations were slightly increased during continuous exercise by beta blockade and rose in direct proportion to the increase in workload. During intermittent exercise, maximum norepinephrine levels were significantly reduced by beta blockade compared with placebo. Thus the effect of beta 1-selective and nonselective beta receptor blockade on circulating hormones does not seem to explain the reduced exercise capacity following beta blockade.


Cardiovasc Drugs Ther


Gullestad L,Dolva LO,Kjeldsen SE,Eide I,Kjekshus J




Has Abstract


1989-03-01 00:00:00












  • Hemodynamic and antiischemic effects of intravenous elgodipine, a new dihydropyridine calcium channel blocker, in patients with chronic stable angina.

    abstract::Elgodipine is a new second-generation dihydropyridine calcium antagonist. Its hemodynamic and antiischemic properties were evaluated in a single-blind, placebo-controlled trial in 22 males with chronic stable angina. Coronary artery disease was angiographically confirmed. Measurements were performed with a Swan-Ganz t...

    journal_title:Cardiovascular drugs and therapy

    pub_type: 临床试验,杂志文章


    authors: Kuhn A,Carlsson J,Miketic S,Tebbe U

    更新日期:1995-08-01 00:00:00

  • Pharmacological Agents Targeting Myocardial Metabolism for the Management of Chronic Stable Angina : an Update.

    abstract::Despite continuous advances in myocardial revascularization procedures and intracoronary devices, patients with ischemic heart disease (IHD) still experience worse prognosis and poor quality of life (QoL). Indeed, chronic stable angina (CSA) is a common disease with a large burden on healthcare costs. Traditionally, C...

    journal_title:Cardiovascular drugs and therapy

    pub_type: 杂志文章,评审


    authors: Guarini G,Huqi A,Morrone D,Marzilli M

    更新日期:2016-08-01 00:00:00

  • The Associations of Diuretics and Laxatives Use with Cardiovascular Mortality. An Individual Patient-Data Meta-analysis of Two Large Cohort Studies.

    abstract:PURPOSE:To investigate the associations of diuretics overall, non-potassium-sparing diuretics in specific, and laxative use with cardiovascular mortality (CVM) in subjects with antihypertensive treatment. METHODS:Analyses included 4253 participants, aged 50 to 75 years, from the German ESTHER cohort and 105,359 partic...

    journal_title:Cardiovascular drugs and therapy

    pub_type: 杂志文章


    authors: Hoppe LK,Muhlack DC,Koenig W,Brenner H,Schöttker B

    更新日期:2019-10-01 00:00:00

  • Inhibition of platelet activation by clopidogrel prevents hypertension-induced cardiac inflammation and fibrosis.

    abstract:PURPOSE:Platelets are essential for primary hemostasis; however, platelet activation also plays an important proinflammatory role. Inflammation promotes the development of cardiac fibrosis and heart failure induced by hypertension. In this study, we aimed to determine whether inhibiting platelet activation using clopid...

    journal_title:Cardiovascular drugs and therapy

    pub_type: 杂志文章


    authors: Jia LX,Qi GM,Liu O,Li TT,Yang M,Cui W,Zhang WM,Qi YF,Du J

    更新日期:2013-12-01 00:00:00

  • Low-dose flecainide infusion followed by oral pilsicainide is highly effective and safe for paroxysmal atrial fibrillation.

    abstract:PURPOSE:The aim of this study was to evaluate the efficacy and safety of intravenous infusion of low-dose flecainide (50 mg) followed by oral pilsicainide (50 mg t.i.d.)in patients with paroxysmal atrial fibrillation (AF). METHODS:Thirty-one patients with symptomatic and hemodynamically stable AF lasting less than 48 ...

    journal_title:Cardiovascular drugs and therapy

    pub_type: 临床试验,信件


    authors: Nagai S,Takeishi Y,Kubota I

    更新日期:2003-01-01 00:00:00

  • Therapeutic advances in heart failure.

    abstract::Annual mortality from congestive heart failure ranges from 15% to 60%, depending on the severity of the left ventricular damage and underlying disease. Most controlled trials have been too small to detect any beneficial effect on survival from the newer vasodilator and inotropic drugs. However, the results of two rece...

    journal_title:Cardiovascular drugs and therapy

    pub_type: 杂志文章,评审


    authors: Meinertz T,Drexler H,Just H

    更新日期:1988-11-01 00:00:00

  • Cholesterol confusion in primary prevention of coronary artery disease.

    abstract::Despite the impressive relation between an increased blood cholesterol and increased mortality from coronary artery disease and despite the persuasive results of cholesterol-lowering trials in secondary prevention, there are increasing reservations about the wisdom of lowering moderately raised blood cholesterol level...

    journal_title:Cardiovascular drugs and therapy

    pub_type: 社论


    authors: Opie LH

    更新日期:1993-11-01 00:00:00

  • Effects of antiarrhythmic drugs on canine ventricular arrhythmia models: which electrophysiological characteristics of drugs are related to their effectiveness?

    abstract::In order to compare and clarify the effects of various antiarrhythmic drugs when given as monotherapy, we reevaluated our previous data on antiarrhythmic drugs and recalculated antiarrhythmic plasma concentrations of drugs for several canine arrhythmia models. We used three spontaneously occurring arrhythmias: a) digi...

    journal_title:Cardiovascular drugs and therapy

    pub_type: 杂志文章


    authors: Hashimoto K,Haruno A,Matsuzaki T,Sugiyama A,Akiyama K

    更新日期:1991-08-01 00:00:00

  • Asialoerythropoietin exerts stronger angiogenic activity than erythropoietin via its binding affinity to tissue.

    abstract:PURPOSE:Although erythropoietin (EPO) is known to express angiogenic and cardioprotective effects, it also induces hypertension, polycythemia, and platelet activation, which may cause serious adverse effects in patients with cardiovascular diseases. We compared the angiogenic effects of EPO and its nonerythropoietic de...

    journal_title:Cardiovascular drugs and therapy

    pub_type: 杂志文章


    authors: Yanagawa T,Toba K,Kato K,Suzuki T,Minagawa S,Saigawa T,Ozawa T,Oda M,Takayama T,Hanawa H,Higuchi M,Saito H,Aizawa Y

    更新日期:2013-04-01 00:00:00

  • Influence of antihypertensive therapy with cilazapril and hydrochlorothiazide on the stiffness of the aorta.

    abstract::The purpose of this study was to examine the effects of the angiotensin-converting enzyme (ACE) inhibitor cilazapril on the elastic properties of the aorta. A standard diuretic antihypertensive drug, hydrochlorothiazide, served for comparisons. Increased aortic stiffness leads to a reduction of the buffering windkesse...

    journal_title:Cardiovascular drugs and therapy

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Breithaupt-Grögler K,Leschinger M,Belz GG,Butzer R,Erb K,de May C,Sinn W

    更新日期:1996-03-01 00:00:00

  • Effects of altered extracellular potassium and pacing cycle length on the class III antiarrhythmic actions of dofetilide (UK-68,798) in guinea-pig papillary muscle.

    abstract::The effects of altered extracellular K+ concentrations ([K+]o) and pacing cycle lengths (CLs) on the electrophysiological actions of dofetilide (UK-68,798), a potent class III antiarrhythmic agent, were examined in isolated guinea-pig ventricular papillary muscle. At a normal [K+]o (4 mM) and at CL between 300 and 500...

    journal_title:Cardiovascular drugs and therapy

    pub_type: 杂志文章


    authors: Yang T,Tande PM,Lathrop DA,Refsum H

    更新日期:1992-08-01 00:00:00

  • Cardiovascular and renal surrogate markers in the clinical management of hypertension.

    abstract:INTRODUCTION:Surrogate markers represent a significant contribution to early diagnosis, longitudinal prognoses, and outcome prediction in cases of hypertension. They often enable detection of disease and disease potential when the disease is still subclinical and are useful noninvasive tools for designing and evaluatin...

    journal_title:Cardiovascular drugs and therapy

    pub_type: 杂志文章,评审


    authors: Maisel AS

    更新日期:2009-08-01 00:00:00

  • Effect of an educational program (PEGASE) on cardiovascular risk in hypercholesterolaemic patients.

    abstract:BACKGROUND:Many studies have demonstrated a gap between guidelines for the prevention of cardiovascular disease (CVD) and their implementation in clinical practice. AIM:The PEGASE education program has been devised with an aim to improve the management of patients at high risk of CVD. METHODS:In a multicentre study c...

    journal_title:Cardiovascular drugs and therapy

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Bruckert E,Giral P,Paillard F,Ferrières J,Schlienger JL,Renucci JF,Abdennbi K,Durack I,Chadarevian R,PEGASE group.

    更新日期:2008-12-01 00:00:00

  • Heart rate and heart rate variability, a pharmacological target.

    abstract::Heart rate varies with respiration, blood pressure, emotion, etc., and heart rate variability (HRV) is presently one of the best indices to predict fatal issues in cardiac failure and after myocardial infarction. HRV depends on various reflexes. In addition, parallel studies of HRV and the myocardial adrenergic and mu...

    journal_title:Cardiovascular drugs and therapy

    pub_type: 杂志文章,评审


    authors: Swynghedauw B,Jasson S,Chevalier B,Clairambault J,Hardouin S,Heymes C,Mangin L,Mansier P,Médigue C,Moalic JM,Thibault N,Carré F

    更新日期:1997-01-01 00:00:00

  • Preconditioning myocardium with ischemia.

    abstract::Preconditioning and stunning are the chief adaptive changes induced in myocardium by a brief episode of reversible ischemia followed by arterial reperfusion. In the dog heart, both coexist for a period of at least 20 minutes of reperfusion, but after 120 minutes of reflow, preconditioning is much diminished, while stu...

    journal_title:Cardiovascular drugs and therapy

    pub_type: 杂志文章,评审


    authors: Jennings RB,Murry CE,Reimer KA

    更新日期:1991-10-01 00:00:00

  • Effect of propranolol on ventricular repolarization and refractoriness: role of beta-blockade versus direct membrane effects.

    abstract::The purpose of this study was to define the role of beta-adrenergic blockade and direct membrane effects in the ability of dl-propranolol to alter ventricular repolarization and refractoriness in the intact heart. The effective refractory period (ERP) and the local Q-T interval were measured at an epicardial site in t...

    journal_title:Cardiovascular drugs and therapy

    pub_type: 杂志文章


    authors: Euler DE,Scanlon PJ

    更新日期:1988-03-01 00:00:00

  • A cost-minimization of heart failure therapy with bisoprolol in the French setting: an analysis from CIBIS trial data. Cardiac Insufficiency Bisoprolol Study.

    abstract::Beta-blocker-induced benefit in heart failure is under intense evaluation. Several large-scale mortality trials are currently being performed, with CIBIS II evaluating bisoprolol. The economic impact of beta-blocker therapy in heart failure has not been previously determined. The present study is a cost-effectiveness ...

    journal_title:Cardiovascular drugs and therapy

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Levy P,Lechat P,Leizorovicz A,Levy E

    更新日期:1998-07-01 00:00:00

  • Inhibitory effect of clentiazem (TA-3090), a new calcium antagonist, on balloon catheter-induced intimal thickening of rabbit aorta.

    abstract::Male Japanese white rabbits were fed a restricted amount (100 g/head/day) of an atherogenic diet containing 0.2% cholesterol and 6% peanut oil during an 8-week experimental period. Atherosclerotic lesions, characterized by intimal thickening with lipid deposition, were produced by de-endothelialization of the rabbit a...

    journal_title:Cardiovascular drugs and therapy

    pub_type: 杂志文章


    authors: Saso Y,Ohtani A,Odawara A,Iwasaki H,Takashima K,Morita T

    更新日期:1993-04-01 00:00:00

  • Enoximone: true inotropic effects? Do they cause ischemia? Analysis of end-systolic pressure-volume relations using the conductance (volume) catheter technique.

    abstract::True positive inotropy of enoximone is hard to prove clinically. It could increase the risk of myocardial ischemia when used in coronary artery disease (CAD). The analysis of the end-systolic pressure-volume relationship (ESPVR) as a load-independent parameter of the contractile left ventricular function (LVF) allows ...

    journal_title:Cardiovascular drugs and therapy

    pub_type: 杂志文章


    authors: Thormann J,Hueting J,Kremer P,Wissemann J,Mitrovic V,Dieterich HA,Schlepper M

    更新日期:1990-10-01 00:00:00

  • Navigating the Future of Cardiovascular Drug Development-Leveraging Novel Approaches to Drive Innovation and Drug Discovery: Summary of Findings from the Novel Cardiovascular Therapeutics Conference.

    abstract:PURPOSE:The need for novel approaches to cardiovascular drug development served as the impetus to convene an open meeting of experts from the pharmaceutical industry and academia to assess the challenges and develop solutions for drug discovery in cardiovascular disease. METHODS:The Novel Cardiovascular Therapeutics S...

    journal_title:Cardiovascular drugs and therapy

    pub_type: 杂志文章,评审


    authors: Povsic TJ,Scott R,Mahaffey KW,Blaustein R,Edelberg JM,Lefkowitz MP,Solomon SD,Fox JC,Healy KE,Khakoo AY,Losordo DW,Malik FI,Monia BP,Montgomery RL,Riesmeyer J,Schwartz GG,Zelenkofske SL,Wu JC,Wasserman SM,Roe MT

    更新日期:2017-08-01 00:00:00

  • Pharmacodynamic interactions of levosimendan and felodipine in patients with coronary heart disease.

    abstract:OBJECTIVE:The aim was to study the pharmacodynamic interactions and safety of the co-administration of the calcium sensitizer levosimendan and the calcium antagonist felodipine in patients with coronary heart disease (CHD) and with normal ejection fraction (EF). METHODS:The study was a randomized, double blind, placeb...

    journal_title:Cardiovascular drugs and therapy

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Põder P,Eha J,Antila S,Heinpalu M,Planken U,Loogna I,Mesikepp A,Akkila J,Lehtonen L

    更新日期:2003-09-01 00:00:00

  • Bradycardia induced by mivazerol, a selective alpha 2-adrenoceptor agonist, is amplified during mild hypothermia in the pentobarbital-anesthetized rat.

    abstract::Mivazerol, 3-[1(H-imidazol-4-yl)methyl]-2-hydroxybenzamide hydrochloride, is a selective alpha 2-adrenoceptor agonist designed for the prevention of myocardial infarction in perioperative patients. Because unintended hypothermia occurs frequently during surgery, we were interested, in this study, to examine the relati...

    journal_title:Cardiovascular drugs and therapy

    pub_type: 杂志文章


    authors: Kim SY,Raikoff K,Wülfert E,Hanin I

    更新日期:1997-12-01 00:00:00

  • The effects of calcium antagonists on extracellular potassium accumulation during global ischaemia in isolated perfused rat hearts.

    abstract::The effects of equipotent concentrations of diltiazem, verapamil, and nifedipine upon the accumulation of extracellular potassium [K+]out and the left ventricular pressure (LVP) were studied during global ischemia in isolated perfused rat hearts. Measurement of [K+]out and LVP were performed in two series of experimen...

    journal_title:Cardiovascular drugs and therapy

    pub_type: 杂志文章


    authors: Heijnis JB,Coronel R,van Zwieten PA

    更新日期:1991-12-01 00:00:00

  • Alternatives to mega-trials in cardiovascular disease.

    abstract::This article considers the dominant role of trials involving thousands of patients--the mega-trials--in cardiovascular disease. Problems with large trials mean that alternative strategies must be developed to aid the introduction of new drugs. The limitations of meta-analysis, and of trials with combined and surrogate...

    journal_title:Cardiovascular drugs and therapy

    pub_type: 杂志文章,评审


    authors: Hampton JR

    更新日期:1997-01-01 00:00:00

  • Pathways and Drugs in Pulmonary Arterial Hypertension - Focus on the Role of Endothelin Receptor Antagonists.

    abstract::Pulmonary arterial hypertension (PAH) is a group of diseases characterized by a progressive increase of pulmonary vascular resistance (PVR), initially due to abnormal pulmonary vasoconstriction in response to endothelial injury. Recent studies have here confirmed the prominent role of endothelin (ET)-1 in vasoconstric...

    journal_title:Cardiovascular drugs and therapy

    pub_type: 杂志文章,评审


    authors: Madonna R,Cocco N,De Caterina R

    更新日期:2015-01-01 00:00:00

  • Exendin-4 Attenuates Remodeling in the Remote Myocardium of Rats After an Acute Myocardial Infarction by Activating β-Arrestin-2, Protein Phosphatase 2A, and Glycogen Synthase Kinase-3 and Inhibiting β-Catenin.

    abstract:PURPOSE:This study tested if the protective anti-remodeling effect of GLP-1 agonist Exendin-4 after an acute myocardial infarction (MI) in rats involves inhibition of the Wnt1/β-catenin signaling pathway. METHODS:Rats were divided into sham, sham + Exendin-4 (10 μg/day, i.p), MI, and MI + Exendin-4. MI was introduced ...

    journal_title:Cardiovascular drugs and therapy

    pub_type: 杂志文章


    authors: Eid RA,Khalil MA,Alkhateeb MA,Eleawa SM,Zaki MSA,El-Kott AF,Al-Shraim M,El-Sayed F,Eldeen MA,Bin-Meferij MM,Awaji KME,Shatoor AS

    更新日期:2020-05-30 00:00:00

  • Accelerated myocardial metabolic and functional recovery with terminal nicorandil-Mg cardioplegia in heart transplantation.

    abstract::Cardiac reperfusion injury after heart transplantation or cardiopulmonary bypass has been difficult to control due to the variable degree of myocardial damage with respect to the length of ischemia and the complexity of the surgical procedure. Here, we evaluated the myocardial metabolic and functional recovery of hear...

    journal_title:Cardiovascular drugs and therapy

    pub_type: 杂志文章


    authors: Orita H,Shimanuki T,Fukasawa M,Abe H,Kuraoka S,Hirooka S,Washio M

    更新日期:1991-08-01 00:00:00

  • Direct Oral Anticoagulants Versus Vitamin K Antagonists in Patients Undergoing Cardioversion for Atrial Fibrillation: a Systematic Review and Meta-analysis.

    abstract:BACKGROUND:Clinical guidelines recommend peri-cardioversion anticoagulation in patients with atrial fibrillation (AF). We performed a systematic review and meta-analysis to compare the safety and efficacy of direct oral anticoagulants (DOACs) versus vitamin K antagonists (VKAs) in patients with AF undergoing cardiovers...

    journal_title:Cardiovascular drugs and therapy

    pub_type: 杂志文章,meta分析


    authors: Gupta S,Um KJ,Pandey A,McIntyre WF,Ivanova M,Allahverdi Y,Agahi P,Pandya F,Lopez A,Sachdeva A,Whitlock RP,Belley-Cote EP

    更新日期:2019-06-01 00:00:00

  • The economic efficiency of amlodipine in the treatment of coronary atherosclerosis--an analysis based on the PREVENT study.

    abstract:BACKGROUND:High health service expenditure on the one hand, and the politically declared objective of stability of statutory contributions and restriction of public funds on the other hand, have been central points of the political and social discussion for several years. The over-proportional increase in health servic...

    journal_title:Cardiovascular drugs and therapy

    pub_type: 杂志文章


    authors: Cathomas G,Erne P,Schwenkglenks M,Szucs TD

    更新日期:2002-01-01 00:00:00

  • Diabetic cardiomyopathy.

    abstract::Diabetic cardiomyopathy as a distinct entity was first recognized by Rubler et al. in diabetics with congestive heart failure (CHF), who had no evidence of coronary atherosclerosis. The Framingham study showed a 2.4-fold increased incidence of CHF in diabetic men and a 5.1-fold increase in diabetic women over 18 years...

    journal_title:Cardiovascular drugs and therapy

    pub_type: 杂志文章,评审


    authors: Fein FS,Sonnenblick EH

    更新日期:1994-02-01 00:00:00