Abstract：
:Resistance arteries depolarize and constrict to elevations in intravascular pressure. However, many of the molecular aspects of this phenomenon are not known. We present evidence that large conductance calcium-dependent potassium (KCa) channels, which are activated by intracellular calcium and membrane depolarization, play a fundamental role in regulating the degree of intravascular pressure-induced, myogenic tone. We found that blockers of KCa channels, charybdotoxin (CTX, < 100 nM) and TEA+ (< 0.5 mM), further depolarized pressurized arteries by as much as 12 mV and decreased diameter by up to 40%. CTX blocked KCa channels in outside-out patches from arterial smooth muscles with half-block constant of 10 nM and external TEA+ caused a flickery block, with a half-block constant of 200 microM. We propose that KCa channels serve as a negative feedback pathway to limit the degree of membrane depolarization and hence vasoconstriction to pressure. In contrast, CTX and TEA+ (< 1 mM) were without effect on membrane hyperpolarization and dilation to a wide variety of synthetic (cromakalim, pinacidil, diazoxide, minoxidil sulfate) and endogenous agents [calcitonin gene-related peptide (CGRP), vasoactive intestinal peptide, an endothelial-derived hyperpolarizing factor]. Glibenclamide and low concentrations of external barium that inhibit ATP-sensitive potassium (KATP) channels, however, blocked the hyperpolarizations and dilations to these substances. We have identified KATP channels as well as high-affinity glibenclamide binding sites in arterial smooth muscle.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Cardiovasc Drugs Therjournal_title
Cardiovascular drugs and therapyauthors
Nelson MT,Brayden JEdoi
10.1007/BF00877627subject
Has Abstractpub_date
1993-08-01 00:00:00pages
605-10eissn
0920-3206issn
1573-7241journal_volume
7 Suppl 3pub_type
杂志文章,评审abstract：:Milrinone is shown in 10 patients to be a valuable pharmacological bridge to heart transplantation; it can stabilize and improve decompensated chronic heart failure (CHF) in cases where the response to beta-agonists is inadequate. One patient who had suffered an acute myocardial infarction with heart failure resistant...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章,评审
doi：10.1007/BF00877820
更新日期：1993-08-01 00:00:00
abstract：PURPOSE:For patients with heart failure with reduced ejection fraction (HFrEF), guidelines recommend use of beta-blockers with gradual up-titration. However, many patients with HFrEF do not use beta-blockers and up-titration is rare. Our purpose was to identify and rank barriers to beta-blocker use and up-titration fro...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章
doi：10.1007/s10557-017-6764-8
更新日期：2017-12-01 00:00:00
abstract：PURPOSE:Treatment of atherosclerotic rabbits with intravenous methotrexate or etoposide carried in lipid nanoemulsions (LDE) markedly reduced the lesions in the aorta. Here, the combined treatment with LDE-methotrexate and LDE-etoposide was investigated aiming to increase the anti-atherosclerosis effect. METHODS:Thirt...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章
doi：10.1007/s10557-014-6566-1
更新日期：2015-02-01 00:00:00
abstract：OBJECTIVE:Percutaneous vascular interventions lead inevitably to a destruction of the endothelial lining at the site of injury. There are conflicting data on the therapeutic benefit of hematopoietic growth factors aiming at mobilisation of circulating endothelial cells to accelerate the reendothelialisation process. Ai...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章
doi：10.1007/s10557-008-6117-8
更新日期：2008-10-01 00:00:00
abstract：:Vascular endothelium gene expression regulates blood-vessel wall interactions, vascular permeability, smooth muscle cell growth and tone. The possibility to introduce exogenous DNA or RNA sequences in endothelial cells represents a novel therapeutic approach of vascular disease. The aim of the work was to investigate ...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章
doi：10.1023/a:1011154616992
更新日期：2001-01-01 00:00:00
abstract：:The aim of the present study was to investigate the effects of almokalant on sustained reentrant supraventricular tachycardias. Reentrant tachycardias were induced, using transesophageal atrial stimulation, in 82 patients with atrioventricular reentrant tachycardia (n = 54) or AV nodal reentrant tachycardia (n = 28). ...
journal_title：Cardiovascular drugs and therapy
pub_type： 临床试验,杂志文章
doi：10.1023/a:1007761825414
更新日期：1997-07-01 00:00:00
abstract：PURPOSE:Single- and multiple-dose studies were conducted to assess the pharmacokinetics, pharmacodynamics and safety of tolvaptan in healthy Japanese subjects. METHODS:All studies were single-center, randomized, placebo-controlled, single-blind or double-blind. In an ascending single-dose study, subjects were given a ...
journal_title：Cardiovascular drugs and therapy
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s10557-011-6299-3
更新日期：2011-12-01 00:00:00
abstract：:The hypothesis tested was that enhanced entry of calcium into cardiac cells would increase the susceptibility to ventricular fibrillation as measured by the ventricular fibrillation threshold (VFT) of the isolated perfused rat heart. Bay-K-8644 was used as a calcium-channel agonist. There was a biphasic effect with a ...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章
doi：10.1007/BF00052561
更新日期：1992-12-01 00:00:00
abstract：BACKGROUND:Although Takotsubo syndrome (TS) was once considered to be rare and largely benign, it is now recognized to represent a major cause of cardiac morbidity and mortality, especially in ageing women. The biochemical precipitant of attacks of TS is an increase in catecholamine concentrations within the myocardium...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章
doi：10.1007/s10557-019-06918-5
更新日期：2020-02-01 00:00:00
abstract：:Suppression of formation of angiotensin II (A-II) is thought to be a major contributor to the hemodynamic response to angiotensin-converting enzyme inhibition (ACE-in) therapy. However, angiotensin II (A-II) plasma levels may rebound during ACE-in treatment. The study sought to verify the feasibility, safety, and tole...
journal_title：Cardiovascular drugs and therapy
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1023/a:1007739412802
更新日期：1998-05-01 00:00:00
abstract：:The effects of altered extracellular K+ concentrations ([K+]o) and pacing cycle lengths (CLs) on the electrophysiological actions of dofetilide (UK-68,798), a potent class III antiarrhythmic agent, were examined in isolated guinea-pig ventricular papillary muscle. At a normal [K+]o (4 mM) and at CL between 300 and 500...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章
doi：10.1007/BF00054193
更新日期：1992-08-01 00:00:00
abstract：INTRODUCTION:Irisin is a newly identified 112 amino acid hormone, derived as a product of fibronectin type III domain containing 5 (FNDC5), which is highly related to metabolic activity in skeletal muscle and brown fat. The effects of irisin on cardiovascular functions are unknown. PURPOSE:To explore the effects of ce...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章
doi：10.1007/s10557-015-6580-y
更新日期：2015-04-01 00:00:00
abstract：:To evaluate cordiodepressive risks of antiarrhythmic treatment with diprafenone, we monitored, in addition to conventional hemodynamic parameters, end-systolic pressure-volume relations to assess potential negative inotropic effects. Thirteen patients underwent hemodynamic analysis with and without the influence of di...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章
doi：10.1007/BF01883858
更新日期：1989-04-01 00:00:00
abstract：:Eighteen hypertensive patients (13 males, 5 females; age 48 +/- 13; diastolic blood pressure greater than 95 mmHg), either previously untreated or who had been off treatment for more than 3 months, underwent M-mode echocardiography before (DO) and after (D90) 3 months of nicardipine therapy (60-90 mg/day). All echocar...
journal_title：Cardiovascular drugs and therapy
pub_type： 临床试验,杂志文章
doi：10.1007/BF01865511
更新日期：1989-08-01 00:00:00
abstract：:Patients with mild to moderate hypertension (diastolic blood pressure > or = 95 and < or = 115 mmHg) and renal dysfunction entered one of two studies to assess the safety of efficacious daily doses of quinapril on renal function and blood pressure. Twenty-four patients with moderate renal impairment (MRI) (creatinine ...
journal_title：Cardiovascular drugs and therapy
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1007/BF00877336
更新日期：1994-04-01 00:00:00
abstract：INTRODUCTION:Several beta blocking drugs (BB) reduce mortality in systolic heart failure (LVSD). We have compared the initial response to introduction of carvedilol and bisoprolol during the standard dose titration protocols for each drug. METHODS:Approximately 31 unselected patients with stable LVSD were randomised t...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章,随机对照试验
doi：10.1007/s10557-007-6055-x
更新日期：2007-12-01 00:00:00
abstract：AIMS:The primary ain of this study was to investigate the effect of carbachol on ventricular repolarisation in an intact animal heart. METHODS:In five sheep, carbachol was administered to the left circumflex coronary artery (LCX) at 1.0 and 2.5 micromol/ml/min respectively for 3 min. Multiple unipolar ECGs were acquir...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章
doi：10.1023/a:1027324412869
更新日期：2003-07-01 00:00:00
abstract：:The effects of nifedipine on left ventricular function were evaluated in 17 patients with coronary artery disease with an ambulatory radionuclide detector (VEST). Hemodynamic data were recorded continuously at rest and during upright bicycle ergometer exercise before and 30 minutes after 10 mg of oral nifedipine admin...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章
doi：10.1007/BF02018293
更新日期：1990-08-01 00:00:00
abstract：:Inhibition of then renin-angiotensin system (RAS) ranks among the best established and most used cardiovascular therapies. By providing protection against hypertension and heart failure, and also the microvascular complications of diabetes, RAS inhibitors have contributed to the longer life-expectancy now found in hig...
journal_title：Cardiovascular drugs and therapy
pub_type： 社论
doi：10.1007/s10557-011-6316-6
更新日期：2011-08-01 00:00:00
abstract：INTRODUCTION:During and following cardiac ischemia the levels of circulating fatty acids are elevated, resulting in fatty acid oxidation dominating as a source of oxidative metabolism at the expense of pyruvate oxidation. A decrease in the levels of myocardial malonyl-CoA (an endogenous inhibitor of mitochondrial fatty...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章,评审
doi：10.1007/s10557-006-0634-0
更新日期：2006-12-01 00:00:00
abstract：PURPOSE:Acute myocardial infarction (AMI) drives an intense inflammatory response that contributes to infarct healing and cardiac remodeling. Recently, different studies have identified a role of interleukin-1 (IL-1) in the development of adverse cardiac remodeling. However, in animal models of AMI IL-1 has been shown ...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章
doi：10.1007/s10557-012-6389-x
更新日期：2012-06-01 00:00:00
abstract：AIMS:Rapid restoration of sinus rhythm using pharmacological cardioversion is commonly indicated in patients with symptomatic recent-onset atrial fibrillation (AF). The objectives of this large, international, multicenter observational study were to determine the safety and effectiveness of intravenous (IV) vernakalant...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章
doi：10.1007/s10557-020-07103-9
更新日期：2020-11-18 00:00:00
abstract：PURPOSE:Protein kinase C alpha (gene: PRKCA) is a key regulator of cardiac contractility. Two genetic variants have recently been discovered to regulate PRKCA expression in failing human heart tissue (rs9909004 [T → C] and rs9303504 [C → G]). The association of those variants with clinical outcomes in patients with hea...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章
doi：10.1007/s10557-019-06909-6
更新日期：2019-12-01 00:00:00
abstract：:Encainide is a class IC antiarrhythmic agent having little or no effect on action-potential duration or maximum diastolic potential but decreasing the maximum rate of phase O depolarization as well as increasing atrial and ventricular effective refractory periods. In intact animals or humans, encainide increases the A...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章,评审
doi：10.1007/BF01857621
更新日期：1989-10-01 00:00:00
abstract：:Though the exact physiology and pathology of lipoprotein(a) [Lp(a)] remains unknown, it has been demonstrated that increased serum Lp(a) levels are correlated with an increased risk of atherosclerotic vascular disease. The effects of lipid-lowering drugs on Lp(a) levels is unclear because of inconsistencies between st...
journal_title：Cardiovascular drugs and therapy
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1007/BF00878550
更新日期：1995-10-01 00:00:00
abstract：:Cardiovascular diseases are of fundamental importance in the cause of death and morbidity in the elderly as a group. If the successful management of blood pressure can effect a reduction in morbid events as well as death, as has been indicated by recent trials, the elderly have more to gain than any other group within...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章,评审
doi：10.1007/BF00114231
更新日期：1991-01-01 00:00:00
abstract：:In order to compare and clarify the effects of various antiarrhythmic drugs when given as monotherapy, we reevaluated our previous data on antiarrhythmic drugs and recalculated antiarrhythmic plasma concentrations of drugs for several canine arrhythmia models. We used three spontaneously occurring arrhythmias: a) digi...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章
doi：10.1007/BF00120829
更新日期：1991-08-01 00:00:00
abstract：:An 82-year old man was admitted with acute pulmonary edema. Myocardial ischemia and electrolyte abnormalities were excluded and he responded promptly to frusemide, nitrates and morphine. On admission, the duration of the QRS interval was markedly abnormal at 240 ms with a nonspecific intraventricular conduction defect...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章
doi：10.1023/a:1027384731525
更新日期：2003-07-01 00:00:00
abstract：AIMS:We evaluated a generic quality of life (QoL) Functional Status Questionnaire (FSQ), in patients with chronic heart failure (CHF). The FSQ assesses the 3 main dimensions of QoL: physical functioning, mental health and social role. It also includes 6 single item questions about: work status, frequency of social inte...
journal_title：Cardiovascular drugs and therapy
pub_type： 杂志文章,随机对照试验
doi：10.1007/s10557-011-6284-x
更新日期：2011-02-01 00:00:00
abstract：:The purpose of this study was to evaluate the effect of trimetazidine on late potentials in patients with acute myocardial infarction. A total of 60 patients (52 males, mean age 55 +/- 2 years, and 8 females, mean age 54 +/- 1.8 years) with the diagnosis of acute myocardial infarction were included in this study. The ...
journal_title：Cardiovascular drugs and therapy
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1023/a:1007740311072
更新日期：1999-04-01 00:00:00
