Carbachol prolongs ventricular repolarisation through nitric oxide release in an intact heart.

abstract：:Epidemiological studies in the seventies have put forward that dietary rather than genetic factors are responsible for the lower incidence of ischemic heart disease in Greenland Inuit and have generated a large body of both in vitro and in vivo experimental studies, exploring the putative favorable effects of fish (oi...

journal_title：Cardiovascular drugs and therapy

authors： Sassen LM,Lamers JM,Verdouw PD

更新日期：1994-04-01 00:00:00

abstract：OBJECTIVE:The natural history of pediatric patients with severely symptomatic neurocardiogenic syncope is poorly defined respect to the likelihood of remission or symptomatic recurrence along time. We undertook this study to investigate the likelihood of clinical relapse, and to assess the effect of prophylactic pharma...

journal_title：Cardiovascular drugs and therapy

authors： Biffi M,Boriani G,Bronzetti G,Frabetti L,Picchio FM,Branzi A

更新日期：2001-03-01 00:00:00

abstract：:This article considers the dominant role of trials involving thousands of patients--the mega-trials--in cardiovascular disease. Problems with large trials mean that alternative strategies must be developed to aid the introduction of new drugs. The limitations of meta-analysis, and of trials with combined and surrogate...

journal_title：Cardiovascular drugs and therapy

authors： Hampton JR

更新日期：1997-01-01 00:00:00

abstract：:The calcium antagonist (CA) controversy has been fueled in part by disagreements among scientists and clinicians over the scientific documentation required for drugs used to treat lifelong conditions. From a public health perspective, there are three unanswered questions: (1) Does long-term use of CAs convey health be...

journal_title：Cardiovascular drugs and therapy

authors： Furberg CD,Psaty BM

更新日期：1996-09-01 00:00:00

abstract：:Free radical injury may contribute to the delayed postoperative recovery of myocardial metabolism and ventricular function after elective coronary artery revascularization. This clinical study was designed to evaluate, in stable angina patients having aortocoronary bypass surgery, whether orally administered alpha-toc...

journal_title：Cardiovascular drugs and therapy

authors： Mickle DA,Weisel RD,Burton GW,Ingold KU

更新日期：1991-03-01 00:00:00

abstract：:The effects of altered extracellular K+ concentrations ([K+]o) and pacing cycle lengths (CLs) on the electrophysiological actions of dofetilide (UK-68,798), a potent class III antiarrhythmic agent, were examined in isolated guinea-pig ventricular papillary muscle. At a normal [K+]o (4 mM) and at CL between 300 and 500...

journal_title：Cardiovascular drugs and therapy

authors： Yang T,Tande PM,Lathrop DA,Refsum H

更新日期：1992-08-01 00:00:00

abstract：:Understanding and controlling the consequences of myocardial ischemia requires us to acknowledge that we are dealing with a complex, dynamic, and highly variable process. The severity and progression of ischemic injury is not solely determined by the extent of oxygen deprivation, but by many other factors, including t...

journal_title：Cardiovascular drugs and therapy

authors： Hearse DJ

更新日期：1988-05-01 00:00:00

abstract：PURPOSE:The benefits of statin treatment initiated in advanced age are largely unknown; however, good adherence to treatment is essential for beneficial effects to be achieved also when treating older people. This study characterizes older statin initiators, including their cardiovascular risk profiles and morbidity, a...

journal_title：Cardiovascular drugs and therapy

authors： Upmeier E,Korhonen MJ,Rikala M,Helin-Salmivaara A,Huupponen R

更新日期：2014-06-01 00:00:00

abstract：PURPOSE:The PPAR-alpha agonists (fibrates) are commonly used in the treatment of dyslipidemia. It has been hypothesized that the cardio-protective effects of fibrates are partially due to immunomodulatory effects. However, there is a paucity of data regarding the effect of fibrates on neutrophilic chemokines such as ep...

journal_title：Cardiovascular drugs and therapy

authors： Price ET,Welder GJ,Zineh I

更新日期：2012-04-01 00:00:00

abstract：:Thiazide diuretics are particularly efficacious in the treatment of hypertension in blacks. A number of observations suggest that many hypertensive blacks have features consistent with a status of "corrected" volume expansion. Our studies, as well as those of other investigators, show that the Na,K pump is inhibited i...

journal_title：Cardiovascular drugs and therapy

authors： Quintanilla AP,Wagener OE

更新日期：1990-03-01 00:00:00

abstract：:This study compares the electrophysiologic effects of amlodipine and diltiazem in patients with coronary artery disease concomitantly treated with background beta-blocking therapy. Thirty patients were included in an open-label parallel study in two phases. During phase 1, patients were screened and placed on maintena...

journal_title：Cardiovascular drugs and therapy

authors： Santarelli P,Biscione F,Natale A,Manzoli A,Lanza GA

更新日期：1994-08-01 00:00:00

abstract：:Ca2+ channel antagonists are agents that interact with the voltage-dependent Ca2+ channel in a highly specific way. The prototype agents of cardiovascular importance are verapamil, nifedipine, and diltiazem, in historical order of appearance. These agents all have different molecular structures and bind separately wit...

journal_title：Cardiovascular drugs and therapy

authors： Opie LH

更新日期：1987-12-01 00:00:00

abstract：PURPOSE:In addition to lowering hemoglobin A1C, colesevelam has been shown to improve the atherogenic lipoprotein profile of subjects with type 2 diabetes mellitus (T2DM) when used in combination with metformin and/or sulfonylureas. A recent study evaluated the effects of colesevelam as antidiabetes monotherapy in adul...

journal_title：Cardiovascular drugs and therapy

authors： Rosenson RS,Rigby SP,Jones MR,Chou HS

更新日期：2014-06-01 00:00:00

abstract：:Based on a retrospective analysis of the DAVIT II database, we attempted to propose subgroups of post-infarction patients with heart failure, who might benefit or not benefit from antiischemic medical intervention. In DAVIT II, patients were randomized in a double-blind fashion to either verapamil 360 mg/day or placeb...

journal_title：Cardiovascular drugs and therapy

authors： Jespersen CM

更新日期：1994-12-01 00:00:00

abstract：:Colesevelam hydrochloride (colesevelam) is a novel, potent, bile acid-binding agent that has been shown to lower LDL cholesterol a mean of 19% at a dose of 3.8 g/d. We studied the pharmacokinetics of colesevelam coadministered with six drugs: digoxin and warfarin, agents with narrow therapeutic indices; sustained-rele...

journal_title：Cardiovascular drugs and therapy

authors： Donovan JM,Stypinski D,Stiles MR,Olson TA,Burke SK

更新日期：2000-12-01 00:00:00

abstract：:The effects of administration of guava and papaya fruit (100 g/day), vegetables, and mustard oil (5 g/day) (group A); antioxidant vitamins C (50 mg/day) and E (30 mg/day), plus betacarotene (10 mg/day) (group B); a high-fat (5-10 g/day) (group C); or a low-fat (4-5 g/day) diet (group D) were compared over 24 diet week...

journal_title：Cardiovascular drugs and therapy

authors： Singh RB,Niaz AM,Ghosh S,Agarwal P,Ahmad S,Begum R,Onouchi Z,Kummerow FA

更新日期：1995-12-01 00:00:00

abstract：INTRODUCTION:Atrial dilatation is commonly associated with atrial fibrillation (AF), but the electrophysiological mechanisms and the implications for anti-arrhythmic therapy are poorly understood. In a model of acute stretch-related AF in isolated rabbit hearts, we evaluated the electrophysiological effects of three di...

journal_title：Cardiovascular drugs and therapy

authors： Kalifa J,Bernard M,Gout B,Bril A,Cozma D,Laurent P,Chalvidan T,Deharo JC,Djiane P,Cozzone P,Maixent JM

更新日期：2007-02-01 00:00:00

abstract：:Angiotensin-converting enzyme (ACE) inhibitor therapy has been associated with a substantial (> or = 20%) reduction in the risk of major ischemic events in two recent clinical trials with long-term follow-up: Studies of Left Ventricular Dysfunction (SOLVD) and the Survival and Ventricular Enlargement (SAVE) study. Par...

journal_title：Cardiovascular drugs and therapy

authors： Young JB

更新日期：1995-02-01 00:00:00

abstract：:Excess activity of the sympathetic nervous system (SNS) is linked to human obese hypertension and to salt-sensitive hypertension. Paradoxically, reduced SNS activity has been implicated as a contributor to obesity, particularly in animal models, and salt loading usually inhibits SNS activity. We have investigated the ...

journal_title：Cardiovascular drugs and therapy

authors： Ernsberger P,Koletsky RJ,Collins LA,Bedol D

更新日期：1996-06-01 00:00:00

abstract：:The pyrimidine base, orotic acid (OA), markedly improves the function of recently infarcted hearts subjected to global ischemia. The mechanism of cardiac action of OA is unclear, but it has been proposed that OA acts by correcting a relative deficiency of nucleotide precursors required for RNA synthesis in the stresse...

journal_title：Cardiovascular drugs and therapy

authors： Rosenfeldt FL,Richards SM,Lin Z,Pepe S,Conyers RA

更新日期：1998-09-01 00:00:00

abstract：OBJECTIVE:This review aims at updating the results of cardiac resynchronization therapy (CRT) in mild heart failure patients, and investigating whether CRT can prevent or reverse heart failure progression in an earlier stage. METHODS:Randomized controlled trials of CRT in patients with New York Heart Association (NYHA...

journal_title：Cardiovascular drugs and therapy

authors： Tu R,Zhong G,Zeng Z,Wu W,Wu H,Cao X,Aung LH

更新日期：2011-08-01 00:00:00

abstract：PURPOSE:Single- and multiple-dose studies were conducted to assess the pharmacokinetics, pharmacodynamics and safety of tolvaptan in healthy Japanese subjects. METHODS:All studies were single-center, randomized, placebo-controlled, single-blind or double-blind. In an ascending single-dose study, subjects were given a ...

journal_title：Cardiovascular drugs and therapy

authors： Kim SR,Hasunuma T,Sato O,Okada T,Kondo M,Azuma J

更新日期：2011-12-01 00:00:00

abstract：:Beneficial effects of monotherapy with ACE inhibitors or beta-blockers on hemodynamic function after myocardial infarction are well known. Until now, the effects of combined treatment on cardiac function and energy metabolism have been poorly described. This study examines the effects of combined ramipril and metoprol...

journal_title：Cardiovascular drugs and therapy

authors： Theres HP,Wagner KD,Romberg D,Feig C,Strube S,Leiterer KP,Günther J,Stangl K,Baumann G,Schimke I

更新日期：2000-12-01 00:00:00

abstract：:Despite the fact that beta blockers were introduced into clinical practice 25 years ago, new beta blockers with differing kinetic and dynamic profiles continue to be developed and marketed. This overview assesses some of the more extensively studied agents from the point of view of proof of utility and the validity of...

journal_title：Cardiovascular drugs and therapy

authors： Fitzgerald JD

更新日期：1991-06-01 00:00:00

abstract：:Specific antiarrhythmic therapy with class I and III drugs for atrial fibrillation (AF) conversion and prevention of its recurrence is frequently utilized in clinical practice. Besides being only moderate effective, the utilization of antiarrhythmic drugs may be associated with serious side effects. In the clinical se...

journal_title：Cardiovascular drugs and therapy

authors： Husser D,Stridh M,Sornmo L,Platonov P,Olsson SB,Bollmann A

更新日期：2004-09-01 00:00:00

abstract：:There is considerable evidence implicating a key role for p38 mitogen-activated protein kinase (MAPK) in ischemic and pharmacological preconditioning against myocardial infarction. However, there have been few, if any, studies examining the role of p38 MAPK in the protection of stunned myocardium. The purpose of this ...

journal_title：Cardiovascular drugs and therapy

authors： Yoshimura Y,Kristo G,Keith BJ,Jahania SA,Mentzer RM Jr,Lasley RD

更新日期：2004-11-01 00:00:00

abstract：:The hypothesis tested was that enhanced entry of calcium into cardiac cells would increase the susceptibility to ventricular fibrillation as measured by the ventricular fibrillation threshold (VFT) of the isolated perfused rat heart. Bay-K-8644 was used as a calcium-channel agonist. There was a biphasic effect with a ...

journal_title：Cardiovascular drugs and therapy

authors： Worthington MG,Opie LH

更新日期：1992-12-01 00:00:00

abstract：:Encainide is a class IC antiarrhythmic agent having little or no effect on action-potential duration or maximum diastolic potential but decreasing the maximum rate of phase O depolarization as well as increasing atrial and ventricular effective refractory periods. In intact animals or humans, encainide increases the A...

journal_title：Cardiovascular drugs and therapy

authors： Antonaccio MJ,Gomoll AW,Byrne JE

更新日期：1989-10-01 00:00:00

abstract：:An 82-year old man was admitted with acute pulmonary edema. Myocardial ischemia and electrolyte abnormalities were excluded and he responded promptly to frusemide, nitrates and morphine. On admission, the duration of the QRS interval was markedly abnormal at 240 ms with a nonspecific intraventricular conduction defect...

journal_title：Cardiovascular drugs and therapy

authors： Kolettis TM,Naka KK,Katsouras C,Michalis LK,Bourantas K

更新日期：2003-07-01 00:00:00

abstract：PURPOSE:Mechanical stretch is an arrhythmogenic factor found in situations of cardiac overload or dyssynchronic contraction. Ranolazine is an antianginal agent that inhibits the late Na (+) current and has been shown to exert a protective effect against arrhythmias. The present study aims to determine whether ranolazin...

journal_title：Cardiovascular drugs and therapy

authors： Chorro FJ,del Canto I,Brines L,Such-Miquel L,Calvo C,Soler C,Parra G,Zarzoso M,Trapero I,Tormos Á,Alberola A,Such L

更新日期：2015-06-01 00:00:00