Ischemia at the crossroads?

abstract：:A rational approach to the treatment of chronic myocardial ischemia requires an appreciation of the pathophysiology of coronary artery disease and the treatment options available. Any factor that causes an imbalance between myocardial oxygen supply and demand can provoke ischemia. Myocardial oxygen requirements rise w...

journal_title：Cardiovascular drugs and therapy

authors： Cohn PF

更新日期：1998-10-01 00:00:00

abstract：PURPOSE:Dofetilide is class III antiarrhythmic agent which prolongs cardiac action potential duration because of selective inhibition of I (Kr), the rapid component of the delayed rectifier K(+) current. Although clinical studies reported on proarrhythmic risk associated with dofetilide treatment, the contributing elec...

journal_title：Cardiovascular drugs and therapy

authors： Osadchii OE

更新日期：2012-12-01 00:00:00

abstract：:Intravenous amiodarone has been found useful in the emergent management of life-threatening arrhythmias. Experimental studies have shown that its electrophysiologic effects are proportional to its myocardial concentration. However, early after its intravenous administration, the extent of the concentration of amiodaro...

journal_title：Cardiovascular drugs and therapy

authors： Anastasiou-Nana MI,Nanas JN,Alexopoulos G,Karli JN,Margari ZJ,Agapitos E,Patsi EN,Stamatelopoulos SF

更新日期：1999-05-01 00:00:00

abstract：:With the increased use of long-acting nitroglycerin preparations, there has been greater recognition of the problem of nitrate tolerance. In recent years extensive research has broadened our understanding of the mechanisms of nitroglycerin action and the mechanisms of drug attenuation. This paper reviews the current s...

journal_title：Cardiovascular drugs and therapy

authors： Katz RJ

更新日期：1990-02-01 00:00:00

abstract：:Ca2+ channel antagonists are agents that interact with the voltage-dependent Ca2+ channel in a highly specific way. The prototype agents of cardiovascular importance are verapamil, nifedipine, and diltiazem, in historical order of appearance. These agents all have different molecular structures and bind separately wit...

journal_title：Cardiovascular drugs and therapy

authors： Opie LH

更新日期：1987-12-01 00:00:00

abstract：:The purpose of the study was to determine whether a new KATP channel opener, Y 26763 (Y), can influence the electrophysiological properties in the ischemic myocardium as well as to determine whether the blunting effect of the alpha 1-adrenoceptor antagonist bunazosin (BN) on an ischemia-induced shortening of repolariz...

journal_title：Cardiovascular drugs and therapy

authors： Tanabe T,Aikawa M,Deguchi Y,Yoshioka K,Handa S

更新日期：2000-06-01 00:00:00

abstract：:Diuretics, either as monotherapy or in combination with other drugs in the management of hypertension, have retarded the development of left ventricular hypertrophy and congestive heart failure in many patients. Diuretics also remain one of the most effective therapies in the treatment of congestive heart failure, whe...

journal_title：Cardiovascular drugs and therapy

authors： Moser M

更新日期：1997-05-01 00:00:00

abstract：PURPOSE:Although the role of angiotensin-converting enzyme (ACE) inhibitors for the treatment of hypertension has been well established, no data has been generated regarding the influence of ACE inhibitors for health-related quality-of-life (QOL) dimensions for Chinese patients. MATERIALS:A double-blind, active-contro...

journal_title：Cardiovascular drugs and therapy

authors： Chien KL,Huang PJ,Chen MF,Chiang FT,Lai LP,Lee YT

更新日期：2002-05-01 00:00:00

abstract：:Inhibition of the renin-angiotensin system has been a highly successful therapeutic approach for the prevention of hypertension-related end organ damage. Angiotensin converting enzyme inhibitors and angiotensin II receptor blockers lower blood pressure and reduce morbidity and mortality in patients with cardiovascular...

journal_title：Cardiovascular drugs and therapy

authors： Siragy HM

更新日期：2011-02-01 00:00:00

abstract：:There can be no doubt that ACE inhibitors prolong survival in patients with a low ejection fraction. There is no evidence whether or not diuretics have the same effect. The pathophysiology of asymptomatic patients with poor left ventricular function differs from that of patients with the clinical syndrome of heart fai...

journal_title：Cardiovascular drugs and therapy

authors： Hampton JR

更新日期：1993-12-01 00:00:00

abstract：:In order to compare and clarify the effects of various antiarrhythmic drugs when given as monotherapy, we reevaluated our previous data on antiarrhythmic drugs and recalculated antiarrhythmic plasma concentrations of drugs for several canine arrhythmia models. We used three spontaneously occurring arrhythmias: a) digi...

journal_title：Cardiovascular drugs and therapy

authors： Hashimoto K,Haruno A,Matsuzaki T,Sugiyama A,Akiyama K

更新日期：1991-08-01 00:00:00

abstract：:Cardiac reperfusion injury after heart transplantation or cardiopulmonary bypass has been difficult to control due to the variable degree of myocardial damage with respect to the length of ischemia and the complexity of the surgical procedure. Here, we evaluated the myocardial metabolic and functional recovery of hear...

journal_title：Cardiovascular drugs and therapy

authors： Orita H,Shimanuki T,Fukasawa M,Abe H,Kuraoka S,Hirooka S,Washio M

更新日期：1991-08-01 00:00:00

abstract：PURPOSE:To assess the effects of electro-acupuncture (EA) on glycemic control, myocardial inflammation, and the progression of diabetic cardiomyopathy in mice with type 2 diabetes. METHODS:Db/Db mice received EA at PC6+ST36 (DM-Acu), non-acupoint simulation (DM-Sham), or no treatment (DM). EA was applied for 30 min pe...

journal_title：Cardiovascular drugs and therapy

authors： Ye Y,Birnbaum Y,Widen SG,Zhang Z,Zhu S,Bajaj M,Chen H

更新日期：2020-12-01 00:00:00

abstract：AIMS:The primary ain of this study was to investigate the effect of carbachol on ventricular repolarisation in an intact animal heart. METHODS:In five sheep, carbachol was administered to the left circumflex coronary artery (LCX) at 1.0 and 2.5 micromol/ml/min respectively for 3 min. Multiple unipolar ECGs were acquir...

journal_title：Cardiovascular drugs and therapy

authors： Wang L

更新日期：2003-07-01 00:00:00

abstract：PURPOSE:Homocysteine (Hcy) is an independent risk factor for cardiovascular diseases that impairs endothelial function. We investigated whether the impaired endothelial function can be restored by the eNOS transcription enhancer AVE3085 in porcine coronary arteries. The effects of AVE3085 against Hcy on eNOS-NO functio...

journal_title：Cardiovascular drugs and therapy

authors： Yang Q,Xue HM,Underwood MJ,Yu CM

更新日期：2013-12-01 00:00:00

abstract：:The present study was undertaken on 10 patients with angina undergoing percutaneous transluminal coronary angioplasty. The angioplasty procedure consisted of two successive 30-second balloon inflations at 5 minute intervals. After the first inflation, nicorandil (0.1 mg/kg) was given intravenously over a 2-minute peri...

journal_title：Cardiovascular drugs and therapy

authors： Saito S,Mizumura T,Takayama T,Honye J,Fukui T,Kamata T,Moriuchi M,Hibiya K,Tamura Y,Ozawa Y

更新日期：1995-03-01 00:00:00

abstract：:Thrombolytic therapy has gained widespread acceptance as a means of treating coronary artery thrombosis in patients with acute myocardial infarction. Although experimental data have demonstrated that timely reperfusion limits the extent of infarction caused by regional ischemia, there is growing evidence that reperfus...

journal_title：Cardiovascular drugs and therapy

authors： Werns SW,Lucchesi BR

更新日期：1989-01-01 00:00:00

abstract：:The purpose of this study was to define the role of beta-adrenergic blockade and direct membrane effects in the ability of dl-propranolol to alter ventricular repolarization and refractoriness in the intact heart. The effective refractory period (ERP) and the local Q-T interval were measured at an epicardial site in t...

journal_title：Cardiovascular drugs and therapy

authors： Euler DE,Scanlon PJ

更新日期：1988-03-01 00:00:00

abstract：:The clinical efficacy and safety of ibopamine and diuretic therapy were compared in a multicenter, multinational, parallel, positive-controlled, randomized, double-blind, 12-week study, involving 103 patients with mild CHF (NYHA Class II). Body weight, NYHA functional class, symptom assessment scores, laboratory blood...

journal_title：Cardiovascular drugs and therapy

authors：

更新日期：1989-12-01 00:00:00

abstract：:Blood pressure is controlled by many factors, and thus hypertension is a multifactorial disorder. This etiologic diversity is also reflected in the broad spectrum of different pharmacologic agents known to lower blood pressure. Most carefully controlled studies employing a single antihypertensive drug in unselected, u...

journal_title：Cardiovascular drugs and therapy

authors： Weinberger MH

更新日期：1990-03-01 00:00:00

abstract：:We studied the acute and chronic effects of propionyl-L-carnitine (PLC) on mechanical function of isolated rabbit heart. Propionyl-L-carnitine was either directly delivered in the perfusate (10(-9) to 10(-3) M) or intraperitoneally injected (250 mg/kg) for 10 days to the animals. When added acutely, propionyl-L-carnit...

journal_title：Cardiovascular drugs and therapy

authors： Ferrari R,Pasini E,Condorelli E,Boraso A,Lisciani R,Marzo A,Visiou O

更新日期：1991-02-01 00:00:00

abstract：PURPOSE:This study tested if the protective anti-remodeling effect of GLP-1 agonist Exendin-4 after an acute myocardial infarction (MI) in rats involves inhibition of the Wnt1/β-catenin signaling pathway. METHODS:Rats were divided into sham, sham + Exendin-4 (10 μg/day, i.p), MI, and MI + Exendin-4. MI was introduced ...

journal_title：Cardiovascular drugs and therapy

authors： Eid RA,Khalil MA,Alkhateeb MA,Eleawa SM,Zaki MSA,El-Kott AF,Al-Shraim M,El-Sayed F,Eldeen MA,Bin-Meferij MM,Awaji KME,Shatoor AS

更新日期：2020-05-30 00:00:00

abstract：:Chronic renal failure (CRF) patients with a stable course were asked to participate in a follow-up program in which they were randomized into two groups: 1) the placebo group taking their standard antihypertensive therapy without any calcium ion blocker: and 2) the nisoldipine group, those patients taking the calcium ...

journal_title：Cardiovascular drugs and therapy

authors： Eliahou HE,Cohen D,Ben-David A,Herzog D,Serban I,Gavendo S,Kapuler S,Kogan N,Hellberg B

更新日期：1988-01-01 00:00:00

abstract：:An 82-year old man was admitted with acute pulmonary edema. Myocardial ischemia and electrolyte abnormalities were excluded and he responded promptly to frusemide, nitrates and morphine. On admission, the duration of the QRS interval was markedly abnormal at 240 ms with a nonspecific intraventricular conduction defect...

journal_title：Cardiovascular drugs and therapy

authors： Kolettis TM,Naka KK,Katsouras C,Michalis LK,Bourantas K

更新日期：2003-07-01 00:00:00

abstract：:When severely ischemic myocardium is reperfused, prolonged myocardial dysfunction--a phenomenon named myocardial stunning--frequently occurs. Stunning also occurs in a variety of other situations. These include myocardium located adjacent to infarcted tissue, transient increase in myocardial O2 demands in the presence...

journal_title：Cardiovascular drugs and therapy

authors： Braunwald E

更新日期：1991-10-01 00:00:00

abstract：:This study compares the electrophysiologic effects of amlodipine and diltiazem in patients with coronary artery disease concomitantly treated with background beta-blocking therapy. Thirty patients were included in an open-label parallel study in two phases. During phase 1, patients were screened and placed on maintena...

journal_title：Cardiovascular drugs and therapy

authors： Santarelli P,Biscione F,Natale A,Manzoli A,Lanza GA

更新日期：1994-08-01 00:00:00

abstract：:Reducing elevated levels of low-density-lipoprotein cholesterol (LDL-C) significantly reduces the incidence of coronary heart disease (CHD) events and mortality in hypercholesterolemic patients. CHD risk reduction is proportional to LDL-C reduction. Despite this knowledge, many physicians are not applying existing tre...

journal_title：Cardiovascular drugs and therapy

authors： McKenney JM

更新日期：2001-09-01 00:00:00

abstract：:Milrinone is shown in 10 patients to be a valuable pharmacological bridge to heart transplantation; it can stabilize and improve decompensated chronic heart failure (CHF) in cases where the response to beta-agonists is inadequate. One patient who had suffered an acute myocardial infarction with heart failure resistant...

journal_title：Cardiovascular drugs and therapy

authors： Sherry KM,Locke TJ

更新日期：1993-08-01 00:00:00

abstract：:Thiazide diuretics are particularly efficacious in the treatment of hypertension in blacks. A number of observations suggest that many hypertensive blacks have features consistent with a status of "corrected" volume expansion. Our studies, as well as those of other investigators, show that the Na,K pump is inhibited i...

journal_title：Cardiovascular drugs and therapy

authors： Quintanilla AP,Wagener OE

更新日期：1990-03-01 00:00:00

abstract：:There is still uncertainty of whether combined therapy with a beta-blocker and calcium-channel antagonist provides additive or synergistic clinical benefits in most patients with stable angina pectoris. The comparative antianginal effect of atenolol 50 mg and atenolol 50 mg and slow release nifedipine (20 mg) twice a ...

journal_title：Cardiovascular drugs and therapy

authors： Meyer TE,Adnams C,Commerford P

更新日期：1993-12-01 00:00:00