Abstract:
:Cardiac reperfusion injury after heart transplantation or cardiopulmonary bypass has been difficult to control due to the variable degree of myocardial damage with respect to the length of ischemia and the complexity of the surgical procedure. Here, we evaluated the myocardial metabolic and functional recovery of hearts infused with a nicorandil vasodilator-magnesium (Mg) solution just prior to reperfusion (terminal cardioplegia). Donor hearts (20 dogs) were removed and immersed in a 4 degrees C water bath containing 20 mEq/l KCL-5% glucose for 6 hours, and then were transplanted to recipient dogs. Orthotopically transplanted dog hearts were either reperfused without any further treatment or received a terminal cardioplegic solution containing 8 mg/l nicorandil, 30 mEq/l Mg, and 50 g/l glucose, which was infused at a pressure of 75 cm H2O for 2 minutes. During the reperfusion period, myocardial tissue PCO2 (t-PCO2) and calcium ion (t-Ca) were continuously monitored by an ISFET (ion-sensitive field effect transistor) sensor. Myocardial oxygen consumption and lactate flux were calculated/monitored at 5, 10, 20 and 40 minutes of reperfusion. Thereafter, myocardial function was evaluated at 45 minutes of reperfusion using LVSWI. Just after reperfusion, the treatment group (group B, n = 10) had a significantly greater coronary flow than the control group (Group A, n = 10, 35.0 +/- 10.1; group B, 47.4 +/- 8.5 ml/100 g/min, p less than 0.025).(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Cardiovasc Drugs Therjournal_title
Cardiovascular drugs and therapyauthors
Orita H,Shimanuki T,Fukasawa M,Abe H,Kuraoka S,Hirooka S,Washio Mdoi
10.1007/BF03029747subject
Has Abstractpub_date
1991-08-01 00:00:00pages
727-32issue
4eissn
0920-3206issn
1573-7241journal_volume
5pub_type
杂志文章abstract::When choosing antihypertensive agents for the treatment of hypertension, it is necessary to consider the predisposition of individuals to renal damage, which may be associated with the long-term effect of such agents. In this respect, this study examined the effect of two commonly used antihypertensive drugs (Brinerdi...
journal_title:Cardiovascular drugs and therapy
pub_type: 杂志文章
doi:10.1007/BF00879029
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journal_title:Cardiovascular drugs and therapy
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journal_title:Cardiovascular drugs and therapy
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journal_title:Cardiovascular drugs and therapy
pub_type: 杂志文章,评审
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journal_title:Cardiovascular drugs and therapy
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journal_title:Cardiovascular drugs and therapy
pub_type: 社论,评审
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journal_title:Cardiovascular drugs and therapy
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journal_title:Cardiovascular drugs and therapy
pub_type: 杂志文章,评审
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journal_title:Cardiovascular drugs and therapy
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Cardiovascular drugs and therapy
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journal_title:Cardiovascular drugs and therapy
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