Drug interactions with colesevelam hydrochloride, a novel, potent lipid-lowering agent.

abstract：:Cholesterol plays an essential role in cell membrane synthesis and in cell growth and differentiation. In mammalian cells, cholesterol can be synthesized from acetate precursors or taken up from dietary or exogenous sources. The major catabolic route for disposal of cholesterol involves conversion into excretable bile...

journal_title：Cardiovascular drugs and therapy

authors： Russell DW

更新日期：1992-04-01 00:00:00

abstract：PURPOSE:Platelets are essential for primary hemostasis; however, platelet activation also plays an important proinflammatory role. Inflammation promotes the development of cardiac fibrosis and heart failure induced by hypertension. In this study, we aimed to determine whether inhibiting platelet activation using clopid...

journal_title：Cardiovascular drugs and therapy

authors： Jia LX,Qi GM,Liu O,Li TT,Yang M,Cui W,Zhang WM,Qi YF,Du J

更新日期：2013-12-01 00:00:00

abstract：:Left ventricular dysfunction is in most cases the consequence of myocardial ischemia. It may occur transiently during an attack of angina and usually it is reversible. It may persist over hours or even days in patients after an episode of ischemia followed by reperfusion, leading to the so-called condition of stunning...

journal_title：Cardiovascular drugs and therapy

authors： Ferrari R,La Canna G,Giubbini R,Milan E,Ceconi C,de Giuli F,Berra P,Alfieri O,Visioli O

更新日期：1994-05-01 00:00:00

abstract：PURPOSE:To assess the effects of electro-acupuncture (EA) on glycemic control, myocardial inflammation, and the progression of diabetic cardiomyopathy in mice with type 2 diabetes. METHODS:Db/Db mice received EA at PC6+ST36 (DM-Acu), non-acupoint simulation (DM-Sham), or no treatment (DM). EA was applied for 30 min pe...

journal_title：Cardiovascular drugs and therapy

authors： Ye Y,Birnbaum Y,Widen SG,Zhang Z,Zhu S,Bajaj M,Chen H

更新日期：2020-12-01 00:00:00

abstract：:Encainide is a class IC antiarrhythmic agent having little or no effect on action-potential duration or maximum diastolic potential but decreasing the maximum rate of phase O depolarization as well as increasing atrial and ventricular effective refractory periods. In intact animals or humans, encainide increases the A...

journal_title：Cardiovascular drugs and therapy

authors： Antonaccio MJ,Gomoll AW,Byrne JE

更新日期：1989-10-01 00:00:00

abstract：:In order to compare and clarify the effects of various antiarrhythmic drugs when given as monotherapy, we reevaluated our previous data on antiarrhythmic drugs and recalculated antiarrhythmic plasma concentrations of drugs for several canine arrhythmia models. We used three spontaneously occurring arrhythmias: a) digi...

journal_title：Cardiovascular drugs and therapy

authors： Hashimoto K,Haruno A,Matsuzaki T,Sugiyama A,Akiyama K

更新日期：1991-08-01 00:00:00

abstract：:Mivazerol, 3-[1(H-imidazol-4-yl)methyl]-2-hydroxybenzamide hydrochloride, is a selective alpha 2-adrenoceptor agonist designed for the prevention of myocardial infarction in perioperative patients. Because unintended hypothermia occurs frequently during surgery, we were interested, in this study, to examine the relati...

journal_title：Cardiovascular drugs and therapy

authors： Kim SY,Raikoff K,Wülfert E,Hanin I

更新日期：1997-12-01 00:00:00

abstract：:Recent studies have questioned the safety of calcium antagonists in general, and short-acting dihydropyridine derivatives in particular. Reasons include excessive catecholamine stimulation after stress. We therefore wanted to assess whether amlodipine, a second generation dihydropyridine with a prolonged plasma half-l...

journal_title：Cardiovascular drugs and therapy

authors： Stankovic S,Panz V,Klug E,Di Nicola G,Joffe BI

更新日期：1999-11-01 00:00:00

abstract：PURPOSE:Although the role of angiotensin-converting enzyme (ACE) inhibitors for the treatment of hypertension has been well established, no data has been generated regarding the influence of ACE inhibitors for health-related quality-of-life (QOL) dimensions for Chinese patients. MATERIALS:A double-blind, active-contro...

journal_title：Cardiovascular drugs and therapy

authors： Chien KL,Huang PJ,Chen MF,Chiang FT,Lai LP,Lee YT

更新日期：2002-05-01 00:00:00

abstract：:Annual mortality from congestive heart failure ranges from 15% to 60%, depending on the severity of the left ventricular damage and underlying disease. Most controlled trials have been too small to detect any beneficial effect on survival from the newer vasodilator and inotropic drugs. However, the results of two rece...

journal_title：Cardiovascular drugs and therapy

authors： Meinertz T,Drexler H,Just H

更新日期：1988-11-01 00:00:00

abstract：:Milrinone is shown in 10 patients to be a valuable pharmacological bridge to heart transplantation; it can stabilize and improve decompensated chronic heart failure (CHF) in cases where the response to beta-agonists is inadequate. One patient who had suffered an acute myocardial infarction with heart failure resistant...

journal_title：Cardiovascular drugs and therapy

authors： Sherry KM,Locke TJ

更新日期：1993-08-01 00:00:00

abstract：:In animal models, calcium antagonists (Ca-A) administered before ischemia and reperfusion reduced myocardial necrosis, attenuated postischemic contractile dysfunction, and reduced tissue calcium. In 753 patients with acute myocardial infarction (AMI), we examined if use of Ca-A at the onset of symptoms (n = 127 patien...

journal_title：Cardiovascular drugs and therapy

authors： Landmark K,Abdelnoor M,Kilhovd B,Dørum HP

更新日期：1997-09-01 00:00:00

abstract：:The effects of altered extracellular K+ concentrations ([K+]o) and pacing cycle lengths (CLs) on the electrophysiological actions of dofetilide (UK-68,798), a potent class III antiarrhythmic agent, were examined in isolated guinea-pig ventricular papillary muscle. At a normal [K+]o (4 mM) and at CL between 300 and 500...

journal_title：Cardiovascular drugs and therapy

authors： Yang T,Tande PM,Lathrop DA,Refsum H

更新日期：1992-08-01 00:00:00

abstract：OBJECTIVE:This review aims at updating the results of cardiac resynchronization therapy (CRT) in mild heart failure patients, and investigating whether CRT can prevent or reverse heart failure progression in an earlier stage. METHODS:Randomized controlled trials of CRT in patients with New York Heart Association (NYHA...

journal_title：Cardiovascular drugs and therapy

authors： Tu R,Zhong G,Zeng Z,Wu W,Wu H,Cao X,Aung LH

更新日期：2011-08-01 00:00:00

abstract：PURPOSE:To assess whether glycoprotein IIb/IIIa inhibition using tirofiban in low risk patients undergoing percutaneous coronary intervention (PCI) may reduce the risk of periprocedural myocardial infarction compared to standard care in poor responders to aspirin and/or clopidogrel. METHODS:We will enroll patients at ...

journal_title：Cardiovascular drugs and therapy

authors： Valgimigli M,Campo G,de Cesare N,Vranckx P,Hamon M,Angiolillo DJ,Sabatè M,Ferrari F,Furgieri A,Tumscitz C,Repetto A,Colangelo S,Meliga E,Kubbajeh M,Parrinello G,Percoco G,Ferrari R

更新日期：2008-08-01 00:00:00

abstract：:Based on a retrospective analysis of the DAVIT II database, we attempted to propose subgroups of post-infarction patients with heart failure, who might benefit or not benefit from antiischemic medical intervention. In DAVIT II, patients were randomized in a double-blind fashion to either verapamil 360 mg/day or placeb...

journal_title：Cardiovascular drugs and therapy

authors： Jespersen CM

更新日期：1994-12-01 00:00:00

abstract：:The effects of equipotent concentrations of diltiazem, verapamil, and nifedipine upon the accumulation of extracellular potassium [K+]out and the left ventricular pressure (LVP) were studied during global ischemia in isolated perfused rat hearts. Measurement of [K+]out and LVP were performed in two series of experimen...

journal_title：Cardiovascular drugs and therapy

authors： Heijnis JB,Coronel R,van Zwieten PA

更新日期：1991-12-01 00:00:00

abstract：:People who consume a diet rich in fruit and vegetables have lower risks of cancer, cardiovascular disease and all-cause mortality. Many prospective cohort studies have reported inverse associations between dietary intake or blood levels of beta-carotene and risks of cancer. Several large-scale trials were set up to as...

journal_title：Cardiovascular drugs and therapy

authors： Clarke R,Armitage J

更新日期：2002-09-01 00:00:00

abstract：PURPOSE:Oxidative stress plays an important role in the pathogenesis of cardiovascular diseases. Azelnidipine is a novel dihydropyridine calcium channel blocker. Several studies have demonstrated that some dihydropyridine calcium channel blockers have antioxidant effects. We evaluated the antioxidant effects of azelnid...

journal_title：Cardiovascular drugs and therapy

authors： Koyama Y,Takeishi Y,Takahashi H,Shishido T,Arimoto T,Niizeki T,Harada M,Suzuki S,Kitahara T,Sasaki T,Kubota I

更新日期：2007-02-01 00:00:00

abstract：BACKGROUND:Recent studies in rabbits have demonstrated that platelet P2Y12 receptor antagonists are cardioprotective, and that the mechanism is surprisingly not related to blockade of platelet aggregation but rather to triggering of the same signal transduction pathway seen in pre- and postconditioning. We wanted to de...

journal_title：Cardiovascular drugs and therapy

authors： Yang XM,Liu Y,Cui L,Yang X,Liu Y,Tandon N,Kambayashi J,Downey JM,Cohen MV

更新日期：2013-04-01 00:00:00

abstract：PURPOSE:A multicentre, randomized, double-blind, placebo-controlled, parallel-group study aimed to define the potential positive effect of dipeptidyl peptidase-4 inhibition on left ventricular systolic function (LVSF) beyond glycemic control in type 2 diabetes mellitus (T2DM) (DYDA 2™ trial). METHODS:Individuals with ...

journal_title：Cardiovascular drugs and therapy

authors： Giorda CB,Cioffi G,Lucci D,Nada E,Ognibeni F,Mancusi C,Latini R,Maggioni AP,DYDA 2 Investigators.

更新日期：2019-10-01 00:00:00

abstract：:The aim of this study was to compare the pharmacokinetics and antiarrhythmic activity of dihydroquinidine and quinidine in 14 patients (11 men, 3 women, aged 28 to 67 years) with heart disease and chronic, stable, high-frequency premature ventricular beats (PVB) (greater than 100/hr). A randomized, double-blind, cross...

journal_title：Cardiovascular drugs and therapy

authors： Chimienti M,Regazzi MB,La Rovere MT,Salerno JA,Previtali M,Montericcio V,Rondanelli R,Montemartini C

更新日期：1988-12-01 00:00:00

abstract：:Cardiovascular disease is the leading cause of death in men and women in the USA. Once a patient experiences an acute coronary syndrome (ACS), they are at increased risk for hospital readmission within 30 days and 6 months after discharge and more importantly, they have worse survival. Hospital readmissions lead to po...

journal_title：Cardiovascular drugs and therapy

authors： Paruchuri V,Gaztanaga J,Rambhujun V,Smith R,Farkouh ME

更新日期：2018-12-01 00:00:00

abstract：:Piperanometozine (OPC-8212) is a new, orally effective inotropic agent. To evaluate the efficacy of this agent on systemic hemodynamics and clinical symptoms in patients with congestive heart failure, a multicenter study was performed. Thirty four patients with New York Heart Association (NYHA) functional classes II t...

journal_title：Cardiovascular drugs and therapy

authors： Inoue M,Hori M,Yasuda H,Takishima T,Sugimoto T,Sasayama S,Sakurai T,Nonogi H,Kodama K,Kusukawa R

更新日期：1987-08-01 00:00:00

abstract：:When severely ischemic myocardium is reperfused, prolonged myocardial dysfunction--a phenomenon named myocardial stunning--frequently occurs. Stunning also occurs in a variety of other situations. These include myocardium located adjacent to infarcted tissue, transient increase in myocardial O2 demands in the presence...

journal_title：Cardiovascular drugs and therapy

authors： Braunwald E

更新日期：1991-10-01 00:00:00

abstract：:Tracer techniques have provided new insight in cardiology by allowing noninvasive studies of myocardial perfusion, function, metabolism, and, more recently, ligand-receptor interaction. Positron emission tomography allows accurate quantification and the use of natural substrates labelled with 11C, 13N, or 15O. Myocard...

journal_title：Cardiovascular drugs and therapy

authors： Rigo P,de Landsheere C,Melon P,Kulbertus H

更新日期：1990-08-01 00:00:00

abstract：:A rational approach to the treatment of chronic myocardial ischemia requires an appreciation of the pathophysiology of coronary artery disease and the treatment options available. Any factor that causes an imbalance between myocardial oxygen supply and demand can provoke ischemia. Myocardial oxygen requirements rise w...

journal_title：Cardiovascular drugs and therapy

authors： Cohn PF

更新日期：1998-10-01 00:00:00

abstract：:Quality of life in heart failure patients is receiving increased attention as a reflection of a treatment's potential secondary benefit of general well-being and daily functioning. The Metoprolol in Dilated Cardiomyopathy (MDC) trial was conducted as a large, multicenter trial to establish the effects of metoprolol on...

journal_title：Cardiovascular drugs and therapy

authors： Wiklund I,Waagstein F,Swedberg K,Hjalmarsson A

更新日期：1996-07-01 00:00:00

abstract：:Although torsades de pointes is not a tightly demarcated entity, the diagnosis has important clinical implications. The concept should be retained. ...

journal_title：Cardiovascular drugs and therapy

authors： Millar RN

更新日期：1991-02-01 00:00:00

abstract：:The aim of the present study was to investigate the effects of almokalant on sustained reentrant supraventricular tachycardias. Reentrant tachycardias were induced, using transesophageal atrial stimulation, in 82 patients with atrioventricular reentrant tachycardia (n = 54) or AV nodal reentrant tachycardia (n = 28). ...

journal_title：Cardiovascular drugs and therapy

authors： Darpö B,Edvardsson N

更新日期：1997-07-01 00:00:00